ATE324113T1 - Verwendung von 2,6-dialkyl-4-silyl-phenol derivaten zur behandlung von xanthom - Google Patents

Verwendung von 2,6-dialkyl-4-silyl-phenol derivaten zur behandlung von xanthom

Info

Publication number
ATE324113T1
ATE324113T1 AT04016883T AT04016883T ATE324113T1 AT E324113 T1 ATE324113 T1 AT E324113T1 AT 04016883 T AT04016883 T AT 04016883T AT 04016883 T AT04016883 T AT 04016883T AT E324113 T1 ATE324113 T1 AT E324113T1
Authority
AT
Austria
Prior art keywords
xanthoma
silyl
dialkyl
treatment
phenol derivatives
Prior art date
Application number
AT04016883T
Other languages
English (en)
Inventor
Simon Jen Tan Mao
Mark Thirston Yates
Roger Alan Parker
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of ATE324113T1 publication Critical patent/ATE324113T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
AT04016883T 1993-12-10 1994-11-03 Verwendung von 2,6-dialkyl-4-silyl-phenol derivaten zur behandlung von xanthom ATE324113T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16528193A 1993-12-10 1993-12-10

Publications (1)

Publication Number Publication Date
ATE324113T1 true ATE324113T1 (de) 2006-05-15

Family

ID=22598245

Family Applications (2)

Application Number Title Priority Date Filing Date
AT04016883T ATE324113T1 (de) 1993-12-10 1994-11-03 Verwendung von 2,6-dialkyl-4-silyl-phenol derivaten zur behandlung von xanthom
AT95901141T ATE285238T1 (de) 1993-12-10 1994-11-03 Verfahren zur senkung des serumcholesterinspiegels mit 2,6-dialkyl-4 silyl- phenol derivaten

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT95901141T ATE285238T1 (de) 1993-12-10 1994-11-03 Verfahren zur senkung des serumcholesterinspiegels mit 2,6-dialkyl-4 silyl- phenol derivaten

Country Status (16)

Country Link
EP (3) EP1468693A3 (de)
JP (1) JPH09511222A (de)
CN (1) CN1092517C (de)
AT (2) ATE324113T1 (de)
AU (1) AU681731B2 (de)
CA (1) CA2177968C (de)
DE (2) DE69434198T2 (de)
DK (2) DK1468692T3 (de)
ES (2) ES2263094T3 (de)
HU (1) HU220761B1 (de)
IL (1) IL111905A (de)
NO (1) NO311868B1 (de)
NZ (1) NZ276285A (de)
PT (2) PT732928E (de)
WO (1) WO1995015760A1 (de)
ZA (1) ZA949663B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1275596C (zh) 1997-05-14 2006-09-20 阿特罗吉尼克斯公司 普罗布考单酯在制备用于治疗心血管疾病和炎性疾病的药物中的应用
US6670398B2 (en) 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
AU731278B2 (en) * 1997-06-24 2001-03-29 Aventis Pharmaceuticals Inc. Alkyl-4-silylheterocyclic phenols and thiophenols as antioxidant agents
WO1998058937A1 (en) * 1997-06-25 1998-12-30 Hoechst Marion Roussel, Inc. 2,6-DI-t-BUTYL-4-[ (DIMETHYL-4-METHOXYPHENYLSILYL) -METHYLOXY]PHENOL AND 2,6-DI-t-BUTYL-4-[ (DIMETHYL-2-METHOXY-PHENYLSILYL) -METHYLOXY]PHENOL
US6133467A (en) * 1997-06-25 2000-10-17 Hoechst Marion Roussel, Inc. 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol
CN1261803A (zh) 1997-07-01 2000-08-02 埃瑟若詹尼克斯公司 抗氧化剂增强对细胞过度增生性疾病的治疗
US6887712B1 (en) 1998-11-09 2005-05-03 Atherogenics, Inc. Methods and compositions to lower plasma cholesterol levels
ATE326014T1 (de) * 1998-11-09 2006-06-15 Atherogenics Inc Methode und zusammensetzungen zum vermindern des cholesterolspiegels im plasma
US6821738B2 (en) 1999-01-20 2004-11-23 The Board Of Regents For Oklahoma State University Broad spectrum bio-detection of nerve agents, organophosphates, and other chemical warfare agents
EP1343502A2 (de) 2000-11-17 2003-09-17 Idenix (Cayman) Limited Verfahren zur verhinderung der übertragung von hiv durch die topische anwendung substituierter 6-benzyl-4-oxopyrimide
MXPA04005864A (es) 2001-12-19 2004-10-29 Atherogenics Inc Derivados de charcona y su uso para tratar enfermedades.
JP4467429B2 (ja) 2002-07-12 2010-05-26 アセロジエニクス・インコーポレイテツド 低溶解性プロブコールエステル類およびエーテル類の新規な塩形態
US7173129B2 (en) 2003-06-06 2007-02-06 Athero Genics, Inc. Sulfonamide-substituted chalcone derivatives and their use to treat diseases
WO2005039596A1 (en) * 2003-10-17 2005-05-06 Amylin Pharmaceuticals, Inc. Silyl phenols for promoting vascular health
WO2005112914A2 (en) 2004-04-20 2005-12-01 Atherogenics, Inc. Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
JP2010522762A (ja) 2007-03-26 2010-07-08 サルトリア・フアーマシユーテイカルズ・エル・エル・シー 糖尿病の治療のための方法及びプロブコール誘導体の組成物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE349046B (de) * 1966-12-23 1972-09-18 C Guevne
FR2230376A1 (en) * 1973-05-24 1974-12-20 Gueyne Jean Stable solutions of siloxanic polysilanols - prepd. by hydrolysis of a silane and having pharmaceutical activity
FR2308372A2 (fr) * 1975-04-21 1976-11-19 Cortial Produits pharmaceutiques contenant un compose organosilicie en tant qu'agent actif
US4670421A (en) * 1982-07-12 1987-06-02 American Cyanamid Company Antiatherosclerotic silanes
US4900757A (en) * 1988-12-08 1990-02-13 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic and antiatherosclerotic uses of bix(3,5-di-tertiary-butyl-4-hydroxyphenylthio)methane
NZ238807A (en) * 1990-07-05 1994-03-25 Merrell Dow Pharma Bis[4-(2,6-dialkyl)phenol]silane derivatives and antiatherosclerotic compositions
US5155250A (en) * 1990-07-05 1992-10-13 Merrell Dow Pharmaceuticals Inc. 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents

Also Published As

Publication number Publication date
EP0732928A1 (de) 1996-09-25
NO962415D0 (no) 1996-06-07
EP0732928B1 (de) 2004-12-22
WO1995015760A1 (en) 1995-06-15
ZA949663B (en) 1995-08-15
NO311868B1 (no) 2002-02-11
EP1468693A2 (de) 2004-10-20
DE69434720D1 (de) 2006-06-01
DE69434198D1 (de) 2005-01-27
ES2233937T3 (es) 2005-06-16
NO962415L (no) 1996-06-07
DK0732928T3 (da) 2005-04-18
EP1468693A3 (de) 2004-11-03
JPH09511222A (ja) 1997-11-11
CA2177968C (en) 2000-03-28
CA2177968A1 (en) 1995-06-15
ATE285238T1 (de) 2005-01-15
AU1049995A (en) 1995-06-27
PT732928E (pt) 2005-03-31
ES2263094T3 (es) 2006-12-01
NZ276285A (en) 2004-11-26
HUT74015A (en) 1996-10-28
EP1468692A3 (de) 2004-11-03
HU9601590D0 (en) 1996-08-28
IL111905A (en) 2001-04-30
DE69434720T2 (de) 2007-05-16
IL111905A0 (en) 1995-03-15
EP1468692B1 (de) 2006-04-26
DK1468692T3 (da) 2006-08-28
CN1092517C (zh) 2002-10-16
HU220761B1 (hu) 2002-05-28
PT1468692E (pt) 2006-09-29
DE69434198T2 (de) 2005-12-29
CN1140995A (zh) 1997-01-22
AU681731B2 (en) 1997-09-04
EP1468692A2 (de) 2004-10-20

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