NZ598516A - Quinazolines as potassium ion channel inhibitors - Google Patents
Quinazolines as potassium ion channel inhibitorsInfo
- Publication number
- NZ598516A NZ598516A NZ598516A NZ59851610A NZ598516A NZ 598516 A NZ598516 A NZ 598516A NZ 598516 A NZ598516 A NZ 598516A NZ 59851610 A NZ59851610 A NZ 59851610A NZ 598516 A NZ598516 A NZ 598516A
- Authority
- NZ
- New Zealand
- Prior art keywords
- ion channel
- quinazolines
- potassium ion
- channel inhibitors
- disorders
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Abstract
Disclosed is a compound of formula I, such as 5-phenyl-N-(pyridine-2-ylmethyl)-2-(pyrimidin-5-yl)quinazolin-4-amine, which is useful for treating arrhythmia, Ikur-associated disorders and other disorders mediated by ion channel function.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23945209P | 2009-09-03 | 2009-09-03 | |
PCT/US2010/047430 WO2011028741A1 (en) | 2009-09-03 | 2010-09-01 | Quinazolines as potassium ion channel inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ598516A true NZ598516A (en) | 2013-02-22 |
Family
ID=42942118
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ598516A NZ598516A (en) | 2009-09-03 | 2010-09-01 | Quinazolines as potassium ion channel inhibitors |
Country Status (32)
Country | Link |
---|---|
US (8) | US8575184B2 (en) |
EP (3) | EP2473487B1 (en) |
JP (2) | JP5643312B2 (en) |
KR (1) | KR101698631B1 (en) |
CN (1) | CN102753535B (en) |
AR (1) | AR078326A1 (en) |
AU (1) | AU2010289641B2 (en) |
BR (1) | BR112012008330B1 (en) |
CA (1) | CA2772642C (en) |
CL (1) | CL2012000583A1 (en) |
CO (1) | CO6511220A2 (en) |
CY (2) | CY1118488T1 (en) |
DK (2) | DK3575288T3 (en) |
EA (1) | EA021113B1 (en) |
ES (3) | ES2900504T3 (en) |
HR (2) | HRP20211973T1 (en) |
HU (2) | HUE032983T2 (en) |
IL (1) | IL218169A (en) |
LT (2) | LT2473487T (en) |
MX (1) | MX2012002099A (en) |
MY (1) | MY160243A (en) |
NZ (1) | NZ598516A (en) |
PE (1) | PE20121153A1 (en) |
PL (2) | PL3575288T3 (en) |
PT (2) | PT3575288T (en) |
SG (1) | SG178592A1 (en) |
SI (2) | SI3575288T1 (en) |
SM (1) | SMT201700026B (en) |
TN (1) | TN2012000063A1 (en) |
TW (1) | TWI488851B (en) |
WO (1) | WO2011028741A1 (en) |
ZA (1) | ZA201202383B (en) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112012008330B1 (en) * | 2009-09-03 | 2022-03-22 | Bristol-Myers Squibb Company | Quinazoline compounds, their pharmaceutical compositions and their uses |
AR079814A1 (en) * | 2009-12-31 | 2012-02-22 | Otsuka Pharma Co Ltd | HETEROCICLICAL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USES |
JP6121658B2 (en) * | 2011-06-29 | 2017-04-26 | 大塚製薬株式会社 | Therapeutic compounds and related methods of use |
EA201490177A1 (en) * | 2011-06-29 | 2014-08-29 | Оцука Фармасьютикал Ко., Лтд. | QUINAZOLINS AS A THERAPEUTIC CONNECTION AND RELATED METHODS |
CN103360382B (en) * | 2012-03-26 | 2016-04-27 | 中国科学院福建物质结构研究所 | Quinazoline derivant and uses thereof |
ES2675314T3 (en) * | 2012-06-11 | 2018-07-10 | Bristol-Myers Squibb Company | Phosphoramic acid prodrugs of 5- [5-phenyl-4- (pyridin-2-ylmethylamino) quinazolin-2-yl] pyridin-3-sulfonamide |
CN105143187B (en) | 2013-02-28 | 2018-04-03 | 武田药品工业株式会社 | The method for preparing sulfonyl chloride compound |
US9242966B2 (en) | 2013-03-11 | 2016-01-26 | Bristol-Myers Squibb Company | Phthalazines as potassium ion channel inhibitors |
US9050345B2 (en) | 2013-03-11 | 2015-06-09 | Bristol-Myers Squibb Company | Pyrrolotriazines as potassium ion channel inhibitors |
CN105008347A (en) * | 2013-03-11 | 2015-10-28 | 百时美施贵宝公司 | Isoquinolines as potassium ion channel inhibitors |
ES2616026T3 (en) * | 2013-03-11 | 2017-06-09 | Bristol-Myers Squibb Company | Pyrrolopyridazines as potassium ion channel inhibitors |
ES2616025T3 (en) * | 2013-03-11 | 2017-06-09 | Bristol-Myers Squibb Company | Pyrrolotriazines as potassium ion channel inhibitors |
WO2015056811A1 (en) * | 2013-10-17 | 2015-04-23 | 住友化学株式会社 | Tetrazolinone compound and application for same |
JP6572891B2 (en) | 2014-06-10 | 2019-09-11 | 宇部興産株式会社 | N-substituted sulfonamide compound and process for producing the same |
US10519112B2 (en) | 2014-06-10 | 2019-12-31 | Ube Industries, Ltd. | Method for producing heteroaromatic sulfonamide compound |
US10774072B2 (en) | 2014-06-10 | 2020-09-15 | Ube Industries, Ltd. | Crystal of N-substituted sulfonamide compound |
WO2016090296A1 (en) * | 2014-12-05 | 2016-06-09 | Subramaniam Ananthan | Heterocyclic compounds as biogenic amine transport modulators |
US10087148B2 (en) | 2014-12-05 | 2018-10-02 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services Office Of Technology Transfer, National Institute Of Health | Quinazolines as biogenic amine transport modulators |
US20180338980A1 (en) * | 2015-06-10 | 2018-11-29 | Bayer Pharma Aktiengesellschaft | Aromatic sulfonamide derivatives |
CN114984003A (en) | 2016-05-03 | 2022-09-02 | 拜耳制药股份公司 | Aromatic sulfonamide derivatives |
CN106432067B (en) * | 2016-09-18 | 2019-04-19 | 北京天弘天达医药科技有限公司 | A kind of green chemical synthesis method of 3- pyridine sulfonyl chloride |
SG11202003565PA (en) * | 2017-10-29 | 2020-05-28 | Bayer Ag | Aromatic sulfonamide derivatives for the treatment of ischemic stroke |
SG11202009464PA (en) * | 2018-04-20 | 2020-10-29 | Bayer Ag | Heteroaryl-triazole and heteroaryl-tetrazole compounds as pesticides |
EP3972963A1 (en) | 2019-05-21 | 2022-03-30 | Bayer Aktiengesellschaft | Identification and use of kras inhibitors |
EP4214204A1 (en) | 2020-09-18 | 2023-07-26 | Bayer Aktiengesellschaft | Pyrido[2,3-d]pyrimidin-4-amines as sos1 inhibitors |
EP4074317A1 (en) | 2021-04-14 | 2022-10-19 | Bayer AG | Phosphorus derivatives as novel sos1 inhibitors |
WO2023212181A1 (en) * | 2022-04-28 | 2023-11-02 | University Of Miami | Compounds for proliferative disorders |
WO2024056782A1 (en) | 2022-09-16 | 2024-03-21 | Bayer Aktiengesellschaft | Sulfone-substituted pyrido[3,4-d]pyrimidine derivatives for the treatment of cancer |
Family Cites Families (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3843791A (en) | 1973-01-11 | 1974-10-22 | Pfizer | Method of killing insects with quinazolinones and quinazoline-thiones |
ATE156120T1 (en) | 1991-02-07 | 1997-08-15 | Roussel Uclaf | BIZYCLIC NITROGEN COMPOUNDS, THEIR PRODUCTION, INTERMEDIATE PRODUCTS OBTAINED, THEIR USE AS MEDICINAL PRODUCTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
US5710158A (en) | 1991-05-10 | 1998-01-20 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
US6645969B1 (en) | 1991-05-10 | 2003-11-11 | Aventis Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase |
GB9300059D0 (en) | 1992-01-20 | 1993-03-03 | Zeneca Ltd | Quinazoline derivatives |
JP2657760B2 (en) | 1992-07-15 | 1997-09-24 | 小野薬品工業株式会社 | 4-aminoquinazoline derivatives and pharmaceuticals containing them |
GB9323290D0 (en) | 1992-12-10 | 1994-01-05 | Zeneca Ltd | Quinazoline derivatives |
EP0655456B1 (en) | 1993-06-17 | 2000-09-06 | Otsuka Pharmaceutical Factory, Inc. | Phosphonic diester derivative |
GB9314884D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Tricyclic derivatives |
GB9314893D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
IL112248A0 (en) | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
US5679683A (en) | 1994-01-25 | 1997-10-21 | Warner-Lambert Company | Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
IL112249A (en) | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
JPH083144A (en) | 1994-06-21 | 1996-01-09 | Chugai Pharmaceut Co Ltd | Quinazoline and quinoline derivative |
TW414798B (en) | 1994-09-07 | 2000-12-11 | Thomae Gmbh Dr K | Pyrimido (5,4-d) pyrimidines, medicaments comprising these compounds, their use and processes for their preparation |
GB9510757D0 (en) | 1994-09-19 | 1995-07-19 | Wellcome Found | Therapeuticaly active compounds |
GB9424233D0 (en) | 1994-11-30 | 1995-01-18 | Zeneca Ltd | Quinazoline derivatives |
GB9514265D0 (en) | 1995-07-13 | 1995-09-13 | Wellcome Found | Hetrocyclic compounds |
AU7692996A (en) * | 1995-12-01 | 1997-06-27 | Ciba-Geigy Ag | Receptor antagonists |
NZ325248A (en) * | 1995-12-23 | 1999-09-29 | Pfizer Res & Dev | Quinoline and quinazoline compounds useful in therapy |
AU3766897A (en) | 1996-07-13 | 1998-02-09 | Glaxo Group Limited | Fused heterocyclic compounds as protein tyrosine kinase inhibitors |
WO1998029397A1 (en) | 1996-12-27 | 1998-07-09 | Yoshitomi Pharmaceutical Industries, Ltd. | Fused pyrimidine compounds and medicinal use thereof |
ES2384551T3 (en) | 1997-03-05 | 2012-07-06 | Sugen, Inc. | Formulations for hydrophobic pharmaceutical agents |
US6184226B1 (en) | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
CA2384291A1 (en) | 1999-09-21 | 2001-03-29 | Astrazeneca Ab | Quinazoline derivatives and their use as pharmaceuticals |
HUP0202636A3 (en) * | 1999-09-30 | 2004-06-28 | Pfizer | Certain alkylene diamine-substituted heterocycles |
AU2001245401A1 (en) | 2000-03-01 | 2001-09-12 | Sumitomo Pharmaceuticals Company, Limited | Hydrazones and analogs as cholesterol lowering agents |
JP3649395B2 (en) | 2000-04-27 | 2005-05-18 | 山之内製薬株式会社 | Fused heteroaryl derivatives |
MXPA03002410A (en) | 2000-09-20 | 2003-06-19 | Merck Patent Gmbh | 4-amino-quinazolines. |
BR0114021A (en) | 2000-09-20 | 2003-08-19 | Merck Patent Gmbh | 4-amino-quinazolines |
WO2002062767A1 (en) | 2001-02-07 | 2002-08-15 | Sumitomo Pharmaceuticals Company, Limited | Novel quinazoline derivatives |
WO2002092579A1 (en) | 2001-05-14 | 2002-11-21 | Astrazeneca Ab | 4-anilinoquinazoline derivatives |
US7829566B2 (en) | 2001-09-17 | 2010-11-09 | Werner Mederski | 4-amino-quinazolines |
US7645878B2 (en) | 2002-03-22 | 2010-01-12 | Bayer Healthcare Llc | Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof |
AU2003255845A1 (en) | 2002-08-22 | 2004-03-11 | Piramed Limited | Phosphadidylinositol 3,5-biphosphate inhibitors as anti-viral agents |
AU2003258662A1 (en) | 2002-10-02 | 2004-04-23 | Merck Patent Gmbh | Use of 4-amino-quinazolines as anti cancer agents |
AU2003255482A1 (en) | 2002-10-02 | 2004-04-23 | Merck Patent Gmbh | Use of 4 amino-quinazolines as anti cancer agents |
WO2004056812A1 (en) | 2002-12-23 | 2004-07-08 | Astrazeneca Ab | 4- (pyridin-4-ylamino) -quinazoline derivatives as anti-tumor agents |
AU2003290279A1 (en) | 2002-12-23 | 2004-07-14 | Astrazeneca Ab | Quinazoline derivatives |
WO2004069145A2 (en) | 2003-02-07 | 2004-08-19 | Dr. Reddy's Laboratories Ltd. | Anticancer compounds, process for their preparation and pharmaceutical compositions containing them |
CL2004000409A1 (en) * | 2003-03-03 | 2005-01-07 | Vertex Pharma | COMPOUNDS DERIVED FROM 2- (REPLACED CILO) -1- (AMINO OR REPLACED OXI) -CHINAZOLINE, INHIBITORS OF IONIC SODIUM AND CALCIUM VOLTAGE DEPENDENTS; PHARMACEUTICAL COMPOSITION; AND USE OF THE COMPOUND IN THE TREATMENT OF ACUTE PAIN, CHRONIC, NEU |
ZA200507979B (en) * | 2003-03-03 | 2007-03-28 | Vertex Pharma Inc | Quinazolines useful as modulators of ion channels |
US7713983B2 (en) | 2003-03-03 | 2010-05-11 | Vertex Pharmaceuticals Incorporated | Quinazolines useful as modulators of ion channels |
CN100475793C (en) | 2003-03-31 | 2009-04-08 | 大正制药株式会社 | Quinazoline derivatives and use for preparing medicine |
DK1641803T3 (en) | 2003-06-11 | 2009-06-29 | Xention Ltd | Thienopyrimidine derivatives as potassium channel inhibitors |
BRPI0411514A (en) | 2003-06-20 | 2006-08-01 | Coley Pharm Gmbh | small molecule toll-like receptor antagonists |
CA2531327A1 (en) | 2003-07-03 | 2005-01-13 | Myriad Genetics, Inc. | Compounds and therapeutical use thereof |
AU2004275718B2 (en) * | 2003-09-23 | 2008-02-07 | Merck Sharp & Dohme Corp. | Quinazoline potassium channel inhibitors |
CA2543710A1 (en) | 2003-11-03 | 2005-05-12 | Warner-Lambert Company Llc | Novel norepinephrine reuptake inhibitors for the treatment of central nervous system disorders |
EP1724268A4 (en) | 2004-02-20 | 2010-04-21 | Kirin Pharma Kk | Compound having tgf-beta inhibitory activity and pharmaceutical composition containing same |
WO2005087742A1 (en) | 2004-03-08 | 2005-09-22 | Exelixis, Inc. | Metabolic kinase modulators and methods of use as pesticides |
US20070225308A1 (en) | 2004-03-15 | 2007-09-27 | Kyowa Hakko Kogyo Co.,Ltd. | 2-Amino Quinazoline Derivative |
KR20070055486A (en) | 2004-06-10 | 2007-05-30 | 젠션 디스커버리 리미티드 | Furanopyrimidene compounds effective as potassium channel inhibitors |
US20060014705A1 (en) | 2004-06-30 | 2006-01-19 | Howitz Konrad T | Compositions and methods for selectively activating human sirtuins |
CA2573103A1 (en) | 2004-07-06 | 2006-02-09 | Angion Biomedica Corporation | Quinazoline modulators of hepatocyte growth factor / c-met activity for the treatment of cancer |
EP1879899B1 (en) | 2004-12-09 | 2010-08-04 | Xention Limited | Thienopyridine derivatives as potassium channel inhibitors |
KR20060079121A (en) | 2004-12-31 | 2006-07-05 | 에스케이케미칼주식회사 | Quinazoline derivatives for the treatment or prevention of diabetes and obesity |
JP2008530239A (en) | 2005-02-18 | 2008-08-07 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス インコーポレイテッド | Anti-angiogenic agents containing aldesleukin |
EP1861388B1 (en) | 2005-03-14 | 2017-07-05 | Saniona A/S | Potassium channel modulating agents and their medical use |
BRPI0609719B8 (en) | 2005-03-23 | 2021-05-25 | Hoffmann La Roche | acetylenyl-pyrazole-pyrimidine derivatives as mgbur2 antagonists |
WO2006100310A1 (en) | 2005-03-25 | 2006-09-28 | Tibotec Pharmaceuticals Ltd | Heterobicylic inhibitors of hcv |
CN101189234B (en) | 2005-03-25 | 2011-08-17 | 泰博特克药品有限公司 | Heterobicyclic inhibitors of HCV |
US7906522B2 (en) | 2005-04-28 | 2011-03-15 | Kyowa Hakko Kirin Co., Ltd | 2-aminoquinazoline derivatives |
JP2008544988A (en) | 2005-06-28 | 2008-12-11 | ボーシュ アンド ローム インコーポレイティド | Formulations comprising arylazines substituted with carbonyl moieties for increasing gelatinase A activity in ocular cells |
GB0525164D0 (en) | 2005-12-09 | 2006-01-18 | Xention Discovery Ltd | Compounds |
JP2009519995A (en) | 2005-12-20 | 2009-05-21 | ノイロサーチ アクティーゼルスカブ | 2-Pyridin-2-yl-quinazoline derivatives as potassium channel modulators for the treatment of respiratory diseases |
WO2007071055A1 (en) | 2005-12-21 | 2007-06-28 | Painceptor Pharma Corporation | Compositions and methods for modulating gated ion channels |
DE102006012251A1 (en) | 2006-03-15 | 2007-11-08 | Grünenthal GmbH | Substituted 4-aminoquinazoline derivatives and their use for the preparation of medicaments |
CA2657702A1 (en) | 2006-07-03 | 2008-01-10 | Vereniging Voor Christelijk Hoger Onderwijs Wetenschappelijk Onderzoek E N Patieentenzorg | Quinazolines and related heterocyclic comp0unds, and their therapeutic use |
US8541428B2 (en) | 2006-08-22 | 2013-09-24 | Technion Research And Development Foundation Ltd. | Heterocyclic derivatives, pharmaceutical compositions and methods of use thereof |
WO2008030120A1 (en) | 2006-09-07 | 2008-03-13 | Auckland Uniservices Limited | A method for the fluorescent detection of nitroreductase activity using nitro-substituted aromatic compounds |
WO2008045529A1 (en) | 2006-10-12 | 2008-04-17 | Serenex, Inc. | Purine and pyrimidine derivatives for treatment of cancer and inflammatory diseases |
US8039505B2 (en) | 2007-04-11 | 2011-10-18 | University Of Utah Research Foundation | Compounds for modulating T-cells |
PE20090717A1 (en) | 2007-05-18 | 2009-07-18 | Smithkline Beecham Corp | QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS |
EP2154965A4 (en) | 2007-05-29 | 2011-08-17 | Glaxosmithkline Llc | Naphthyridine, derivatives as p13 kinase inhibitors |
US9603848B2 (en) | 2007-06-08 | 2017-03-28 | Senomyx, Inc. | Modulation of chemosensory receptors and ligands associated therewith |
WO2009006141A2 (en) | 2007-07-05 | 2009-01-08 | Bausch & Lomb Incorporated | Authority to read as follows: compositions and methods for treating or controlling infections of the eye a sequelae thereof |
CN101575333B (en) | 2008-05-09 | 2011-06-22 | 和记黄埔医药(上海)有限公司 | Quinazoline derivatives and medical application thereof |
US7829574B2 (en) | 2008-05-09 | 2010-11-09 | Hutchison Medipharma Enterprises Limited | Substituted quinazoline compounds and their use in treating angiogenesis-related diseases |
US20110098305A1 (en) | 2008-05-21 | 2011-04-28 | Jonathan Bayldon Baell | Arylsulfonamide compounds, compositions and methods of use |
BR112012008330B1 (en) * | 2009-09-03 | 2022-03-22 | Bristol-Myers Squibb Company | Quinazoline compounds, their pharmaceutical compositions and their uses |
EP2473054B1 (en) | 2009-09-04 | 2017-06-14 | The Regents of the University of Michigan | Compositions and methods for treatment of leukemia |
AR079814A1 (en) | 2009-12-31 | 2012-02-22 | Otsuka Pharma Co Ltd | HETEROCICLICAL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USES |
-
2010
- 2010-09-01 BR BR112012008330-9A patent/BR112012008330B1/en active IP Right Grant
- 2010-09-01 HR HRP20211973TT patent/HRP20211973T1/en unknown
- 2010-09-01 SG SG2012013918A patent/SG178592A1/en unknown
- 2010-09-01 WO PCT/US2010/047430 patent/WO2011028741A1/en active Application Filing
- 2010-09-01 MX MX2012002099A patent/MX2012002099A/en active IP Right Grant
- 2010-09-01 SI SI201032099T patent/SI3575288T1/en unknown
- 2010-09-01 US US13/393,328 patent/US8575184B2/en active Active
- 2010-09-01 JP JP2012527985A patent/JP5643312B2/en active Active
- 2010-09-01 MY MYPI2012000987A patent/MY160243A/en unknown
- 2010-09-01 EP EP10754824.0A patent/EP2473487B1/en active Active
- 2010-09-01 HU HUE10754824A patent/HUE032983T2/en unknown
- 2010-09-01 LT LTEP10754824.0T patent/LT2473487T/en unknown
- 2010-09-01 PT PT191861293T patent/PT3575288T/en unknown
- 2010-09-01 AU AU2010289641A patent/AU2010289641B2/en active Active
- 2010-09-01 ES ES19186129T patent/ES2900504T3/en active Active
- 2010-09-01 EP EP16180810.0A patent/EP3124475B1/en active Active
- 2010-09-01 SI SI201031326T patent/SI2473487T1/en unknown
- 2010-09-01 CA CA2772642A patent/CA2772642C/en active Active
- 2010-09-01 PL PL19186129T patent/PL3575288T3/en unknown
- 2010-09-01 KR KR1020127008470A patent/KR101698631B1/en active IP Right Grant
- 2010-09-01 EA EA201270378A patent/EA021113B1/en not_active IP Right Cessation
- 2010-09-01 LT LTEP19186129.3T patent/LT3575288T/en unknown
- 2010-09-01 TW TW099129546A patent/TWI488851B/en active
- 2010-09-01 HU HUE19186129A patent/HUE057433T2/en unknown
- 2010-09-01 PE PE2012000290A patent/PE20121153A1/en active IP Right Grant
- 2010-09-01 EP EP19186129.3A patent/EP3575288B1/en active Active
- 2010-09-01 DK DK19186129.3T patent/DK3575288T3/en active
- 2010-09-01 DK DK10754824.0T patent/DK2473487T3/en active
- 2010-09-01 CN CN201080049632.7A patent/CN102753535B/en active Active
- 2010-09-01 ES ES10754824.0T patent/ES2609335T3/en active Active
- 2010-09-01 PL PL10754824T patent/PL2473487T3/en unknown
- 2010-09-01 ES ES16180810T patent/ES2750598T3/en active Active
- 2010-09-01 NZ NZ598516A patent/NZ598516A/en unknown
- 2010-09-01 PT PT107548240T patent/PT2473487T/en unknown
- 2010-09-03 AR ARP100103247A patent/AR078326A1/en active IP Right Grant
-
2012
- 2012-02-10 TN TNP2012000063A patent/TN2012000063A1/en unknown
- 2012-02-16 IL IL218169A patent/IL218169A/en active IP Right Grant
- 2012-03-02 CL CL2012000583A patent/CL2012000583A1/en unknown
- 2012-03-07 CO CO12040232A patent/CO6511220A2/en active IP Right Grant
- 2012-04-02 ZA ZA2012/02383A patent/ZA201202383B/en unknown
-
2013
- 2013-09-27 US US14/038,814 patent/US9458114B2/en active Active
-
2014
- 2014-10-30 JP JP2014221908A patent/JP5950978B2/en active Active
-
2016
- 2016-08-29 US US15/249,710 patent/US9822096B2/en active Active
- 2016-12-08 HR HRP20161669TT patent/HRP20161669T1/en unknown
-
2017
- 2017-01-16 SM SM201700026T patent/SMT201700026B/en unknown
- 2017-01-23 CY CY20171100095T patent/CY1118488T1/en unknown
- 2017-10-04 US US15/724,566 patent/US10214511B2/en active Active
-
2019
- 2019-01-09 US US16/243,400 patent/US10676460B2/en active Active
-
2020
- 2020-05-01 US US16/864,825 patent/US11008306B2/en active Active
-
2021
- 2021-04-15 US US17/231,088 patent/US20220324836A1/en not_active Abandoned
- 2021-12-16 CY CY20211101107T patent/CY1125021T1/en unknown
-
2023
- 2023-03-24 US US18/125,826 patent/US20230322726A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NZ598516A (en) | Quinazolines as potassium ion channel inhibitors | |
MX340756B (en) | Quinazoline compounds as serine/threonine kinase inhibitors. | |
MX2012004114A (en) | Heterocyclic compounds useful as pdk1 inhibitors. | |
UA104885C2 (en) | Isothiazolyloxyphenyl amidines and use thereof as fungicides | |
GEP20146169B (en) | N1-pyrazolospiroketone acetyl-coa carboxylase inhibitors | |
JO3025B1 (en) | Oxazole substituted indazoles as pi3 - kinase inhibitors | |
SG171593A1 (en) | Inhibitors of c-fms kinase | |
MX2019012007A (en) | Processes of making and crystalline forms of a mdm2 inhibitor. | |
MX2014001879A (en) | Amino quinazolines as kinase inhibitors. | |
SG190819A1 (en) | Nampt and rock inhibitors | |
WO2011080568A8 (en) | Novel pyrimidine compounds as mtor and pi3k inhibitors | |
MX2012004313A (en) | Amino - pyrimidine compounds as inhibitors of tbkl and/or ikk epsilon. | |
EP2170337A4 (en) | Novel triazolopyridazines | |
MX2013010946A (en) | Substituted diaminocarboxamide and diaminocarbonitrile pyrimidines, compositions thereof, and methods of treatment therewith. | |
MY164776A (en) | Heterocyclic compound | |
MX341456B (en) | Amino-quinolines as kinase inhibitors. | |
MX2011009456A (en) | Use of rosuvastatin lactols as medicaments. | |
EP2566477A4 (en) | Amino-quinolines as kinase inhibitors | |
AU2011326186A8 (en) | Selective glycosidase inhibitors and uses thereof | |
PH12015500363A1 (en) | Prodrugs of amino quinazoline kinase inhibitor | |
AU2009319796A8 (en) | Substituted octahydrocyclopnta (c) pyrrol-4 -amines as calcium channel blockers | |
GEP201706687B (en) | Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme | |
TN2012000469A1 (en) | Use of novel pan-cdk inhibitors for treating tumors | |
IN2012DN03846A (en) | ||
PH12014502747A1 (en) | Phosphoramidic acid prodrugs of 5 - [5 - phenyl- 4 - (pyridin- 2 - ylmethylamino) quinazolin- 2 - yl] pyridine- 3 - sulfonamide |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PSEA | Patent sealed | ||
RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 01 SEP 2023 BY CPA GLOBAL Effective date: 20140908 Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 01 SEP 2020 BY CPA GLOBAL Effective date: 20140906 Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 01 SEP 2017 BY CPA GLOBAL Effective date: 20140903 Free format text: PATENT RENEWED FOR 7 YEARS UNTIL 01 SEP 2030 BY CPA GLOBAL Effective date: 20140909 |