IN2012DN03846A - - Google Patents

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IN2012DN03846A
IN2012DN03846A IN3846DEN2012A IN2012DN03846A IN 2012DN03846 A IN2012DN03846 A IN 2012DN03846A IN 3846DEN2012 A IN3846DEN2012 A IN 3846DEN2012A IN 2012DN03846 A IN2012DN03846 A IN 2012DN03846A
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India
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compounds
formula
syndromes
disorders
compositions
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Inventor
J Coats Steven
Bian Haiyan
Cai Chaozhong
L Decorte Bart
Liu Li
J Macielag Mark
L Dax Scott
M Pitis Philip
J Connolly Peter
He Wei
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Janssen Pharmaceutica Nv
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Publication of IN2012DN03846A publication Critical patent/IN2012DN03846A/en

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    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: Formula I wherein R1, R2, R3, Ra, and Y are defined herein.
IN3846DEN2012 2009-10-30 2010-10-28 IN2012DN03846A (en)

Applications Claiming Priority (2)

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US25641209P 2009-10-30 2009-10-30
PCT/US2010/054497 WO2011053706A1 (en) 2009-10-30 2010-10-28 4-substituted-2-phenoxy-phenylamine delta opioid receptor modulators

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IN2012DN03846A true IN2012DN03846A (en) 2015-08-28

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US (1) US8846655B2 (en)
EP (1) EP2493852B1 (en)
JP (1) JP5781527B2 (en)
CN (1) CN102741226B (en)
AU (1) AU2010313402B2 (en)
BR (1) BR112012011443A2 (en)
CA (1) CA2779108C (en)
IN (1) IN2012DN03846A (en)
RU (1) RU2553453C2 (en)
WO (1) WO2011053706A1 (en)

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WO2011053701A1 (en) * 2009-10-30 2011-05-05 Janssen Pharmaceutica Nv Phenoxy-substituted pyrimidines as opioid receptor modulators
CA2779083C (en) * 2009-10-30 2017-07-04 Peter J. Connolly Pyrazines as delta opioid receptor modulators
RU2686101C2 (en) 2013-03-12 2019-04-24 Селтакссис, Инк. Methods of inhibiting leucotreen-a4-hydrolases
BR112015022226A2 (en) * 2013-03-14 2017-07-18 Celtaxsys Inc leukotriene a4 hydrolase inhibitors
MX2015011678A (en) 2013-03-14 2016-07-08 Celtaxsys Inc Inhibitors of leukotriene a4 hydrolase.
CN103788019B (en) * 2014-01-22 2015-10-07 苏州明锐医药科技有限公司 The fertile preparation method for Xi Ting
EP3307725A1 (en) * 2015-06-11 2018-04-18 Basilea Pharmaceutica International AG Efflux-pump inhibitors and therapeutic uses thereof
US10898484B2 (en) 2018-05-31 2021-01-26 Celltaxis, Llc Method of reducing pulmonary exacerbations in respiratory disease patients

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT86407B (en) * 1986-12-31 1990-11-20 Fujisawa Pharmaceutical Co METHOD FOR PREPARING NEW ALCANO-SULFONANILIDA DERIVATIVES, AND OF PHARMACEUTICAL COMPOSITIONS UNDERSTANDING THE SAME
JP4302207B2 (en) * 1997-08-04 2009-07-22 大正製薬株式会社 Aryloxyaniline derivatives
AU2009799A (en) * 1997-12-24 1999-07-19 Ortho-Mcneil Pharmaceutical, Inc. 4-(aryl(piperidin-4-yl)) aminobenzamides which bind to the delta-opioid receptor
UA81749C2 (en) * 2001-10-04 2008-02-11 Х. Луннбек А/С Derivated of phenylpiperazine as serotonin reuptake inhibitorS
ATE432279T1 (en) * 2004-12-22 2009-06-15 Janssen Pharmaceutica Nv TRICYCLIC DELTA OPIOID MODULATORS
JP2008526878A (en) * 2005-01-06 2008-07-24 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Tricyclic δ-opioid regulator
JP2010502688A (en) * 2006-09-08 2010-01-28 ファイザー・プロダクツ・インク Diaryl ether derivatives and uses thereof

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