NZ596615A - Substituted isoquinoline derivative - Google Patents
Substituted isoquinoline derivativeInfo
- Publication number
- NZ596615A NZ596615A NZ596615A NZ59661510A NZ596615A NZ 596615 A NZ596615 A NZ 596615A NZ 596615 A NZ596615 A NZ 596615A NZ 59661510 A NZ59661510 A NZ 59661510A NZ 596615 A NZ596615 A NZ 596615A
- Authority
- NZ
- New Zealand
- Prior art keywords
- independently represent
- derivative
- group
- isoquinoline
- salt
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009146040 | 2009-06-19 | ||
| PCT/JP2010/004101 WO2010146881A1 (ja) | 2009-06-19 | 2010-06-18 | 置換されたイソキノリン誘導体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ596615A true NZ596615A (en) | 2013-07-26 |
Family
ID=43356211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ596615A NZ596615A (en) | 2009-06-19 | 2010-06-18 | Substituted isoquinoline derivative |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8951997B2 (xx) |
| EP (1) | EP2444395B1 (xx) |
| JP (1) | JP4915010B2 (xx) |
| KR (1) | KR101732907B1 (xx) |
| CN (1) | CN102448941B (xx) |
| AU (1) | AU2010261206B2 (xx) |
| BR (1) | BRPI1011683B8 (xx) |
| CA (1) | CA2764124C (xx) |
| CY (1) | CY1117157T1 (xx) |
| DK (1) | DK2444395T3 (xx) |
| EA (1) | EA019523B1 (xx) |
| ES (1) | ES2560603T3 (xx) |
| HR (1) | HRP20160096T1 (xx) |
| HU (1) | HUE028684T2 (xx) |
| MX (1) | MX2011013857A (xx) |
| NZ (1) | NZ596615A (xx) |
| PL (1) | PL2444395T3 (xx) |
| TW (1) | TWI527798B (xx) |
| WO (1) | WO2010146881A1 (xx) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| ES2672624T3 (es) | 2009-05-01 | 2018-06-15 | Aerie Pharmaceuticals, Inc. | Inhibidores de mecanismo doble para el tratamiento de enfermedades |
| KR101911324B1 (ko) | 2010-12-22 | 2018-10-25 | 가부시키가이샤 디. 웨스턴 세라퓨틱스 겡큐쇼 | 신규한 치환 이소퀴놀린 유도체 |
| JP2013035802A (ja) * | 2011-08-10 | 2013-02-21 | D Western Therapeutics Institute Inc | 緑内障又は高眼圧症の予防又は治療剤 |
| ES2852377T3 (es) | 2013-03-15 | 2021-09-13 | Aerie Pharmaceuticals Inc | Sales dimesilato de 4-(3-amino-1-(isoquinolin-6-ilamino)-1-oxopropan-2-il)bencilo, sus combinaciones con prostaglandinas y el uso de las mismas en el tratamiento de trastornos oculares |
| EP3626245B1 (en) * | 2013-04-24 | 2021-05-05 | Kyushu University, National University Corporation | Therapeutic agent for eyeground disease |
| CN105085478B (zh) * | 2014-04-28 | 2019-04-12 | 南京明德新药研发股份有限公司 | 异喹啉磺胺衍生物及其药物组合物和制药用途 |
| CN105906609A (zh) * | 2016-05-19 | 2016-08-31 | 武昌理工学院 | 一种1，4-二氮杂环庚烷衍生物的制备方法 |
| JP7032814B2 (ja) | 2016-08-31 | 2022-03-09 | ジエンス ヘンルイ メデイシンカンパニー リミテッド | オキソピコリンアミド誘導体、その製造方法およびその医薬用途 |
| MX2019002396A (es) | 2016-08-31 | 2019-07-08 | Aerie Pharmaceuticals Inc | Composiciones oftalmicas. |
| US9840468B1 (en) | 2016-12-30 | 2017-12-12 | Aerie Pharmaceuticals, Inc. | Methods for the preparation of 6-aminoisoquinoline |
| SG11201908179UA (en) | 2017-03-31 | 2019-10-30 | Aerie Pharmaceuticals Inc | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| CN109134433B (zh) * | 2017-06-16 | 2021-05-25 | 成都先导药物开发股份有限公司 | 一种抑制rock的化合物及其应用 |
| CN108929270B (zh) * | 2018-08-15 | 2021-06-08 | 上海罕道医药科技有限公司 | 一种药物中间体双取代含氮杂环的胺类化合物的合成 |
| US11427563B2 (en) | 2018-09-14 | 2022-08-30 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
| EP3875449A4 (en) * | 2018-11-01 | 2022-07-06 | D. Western Therapeutics Institute, Inc. | 1,4-DIAZOCANE COMPOUND OR SALT THEREOF |
| CN113194949A (zh) * | 2018-12-18 | 2021-07-30 | 株式会社D.西医疗法研究所 | 异喹啉磺酰氯酸加成盐和其制造方法 |
| WO2022047315A1 (en) * | 2020-08-31 | 2022-03-03 | Viewpoint Therapeutics, Inc. | Compounds and formulations for treating ophthalmic diseases |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4456757A (en) | 1981-03-20 | 1984-06-26 | Asahi Kasei Kogyo Kabushiki Kaisha | Isoquinolinesulfonyl derivatives and process for the preparation thereof |
| JPS5993054A (ja) | 1982-11-18 | 1984-05-29 | Asahi Chem Ind Co Ltd | イソキノリンスルホン酸アミド誘導体 |
| US4678783B1 (en) | 1983-11-04 | 1995-04-04 | Asahi Chemical Ind | Substituted isoquinolinesulfonyl compounds |
| JPH0667926B2 (ja) | 1985-11-12 | 1994-08-31 | 旭化成工業株式会社 | 環状のイソキノリンスルホンアミド誘導体 |
| JPH0215067A (ja) | 1988-07-04 | 1990-01-18 | Hokuriku Seiyaku Co Ltd | イソキノリンスルホンアミド誘導体 |
| US5216150A (en) | 1988-12-26 | 1993-06-01 | Hiroyoshi Hidaka | Derivatives of isoquinoline (and naphthalene) sulfonamides |
| US5245034A (en) | 1988-12-26 | 1993-09-14 | Kiroyoshi Hidaka | Compound having vessel smooth muscle relaxation activity |
| JPH069402A (ja) | 1991-05-15 | 1994-01-18 | Hiroyoshi Hidaka | 抗潰瘍剤 |
| AU1557497A (en) | 1996-02-02 | 1997-08-22 | Nippon Shinyaku Co. Ltd. | Isoquinoline derivatives and drugs |
| CA2450167A1 (en) * | 2001-06-12 | 2002-12-19 | Elan Pharmaceuticals, Inc. | Macrocycles useful in the treatment of alzheimer's disease |
| EP1720874A4 (en) * | 2004-02-24 | 2010-03-03 | Bioaxone Therapeutique Inc | SUBSTITUTED PIPERIDINE DERIVATIVES IN POSITION 4 |
| US20050272723A1 (en) | 2004-04-27 | 2005-12-08 | The Regents Of The University Of Michigan | Methods and compositions for treating diseases and conditions associated with mitochondrial function |
| US7517991B2 (en) * | 2004-10-12 | 2009-04-14 | Bristol-Myers Squibb Company | N-sulfonylpiperidine cannabinoid receptor 1 antagonists |
| WO2006115244A1 (ja) | 2005-04-25 | 2006-11-02 | D. Western Therapeutics Institute, Inc. | ４－ブロモイソキノリン誘導体及びこれを含有する医薬 |
| DE602006005351D1 (de) | 2005-04-25 | 2009-04-09 | Western Therapeutics Inst Inc | Hochselektiver rho-kinase-inhibitor |
| WO2007026664A1 (ja) | 2005-08-30 | 2007-03-08 | Asahi Kasei Pharma Corporation | スルホンアミド化合物 |
| US20080064681A1 (en) * | 2006-09-11 | 2008-03-13 | Hiroyoshi Hidaka | Therapeutic agent for treating glaucoma |
| AU2007338410B2 (en) | 2006-12-27 | 2012-08-16 | Sanofi-Aventis | Cycloalkylamine substituted isoquinoline derivatives |
| KR20090103903A (ko) | 2006-12-27 | 2009-10-01 | 사노피-아벤티스 | 사이클로알킬아민 치환된 이소퀴놀론 및 이소퀴놀리논 유도체 |
| AU2008220104B2 (en) | 2007-02-28 | 2012-09-27 | Asahi Kasei Pharma Corporation | Sulfonamide derivative |
-
2010
- 2010-06-18 TW TW099120004A patent/TWI527798B/zh active
- 2010-06-18 BR BRPI1011683A patent/BRPI1011683B8/pt active IP Right Grant
- 2010-06-18 MX MX2011013857A patent/MX2011013857A/es active IP Right Grant
- 2010-06-18 DK DK10789260.6T patent/DK2444395T3/en active
- 2010-06-18 NZ NZ596615A patent/NZ596615A/xx unknown
- 2010-06-18 JP JP2011519583A patent/JP4915010B2/ja active Active
- 2010-06-18 AU AU2010261206A patent/AU2010261206B2/en active Active
- 2010-06-18 KR KR1020117028931A patent/KR101732907B1/ko active IP Right Grant
- 2010-06-18 EP EP10789260.6A patent/EP2444395B1/en active Active
- 2010-06-18 WO PCT/JP2010/004101 patent/WO2010146881A1/ja active Application Filing
- 2010-06-18 ES ES10789260.6T patent/ES2560603T3/es active Active
- 2010-06-18 CN CN201080023516.8A patent/CN102448941B/zh active Active
- 2010-06-18 US US13/265,246 patent/US8951997B2/en active Active
- 2010-06-18 CA CA2764124A patent/CA2764124C/en active Active
- 2010-06-18 HU HUE10789260A patent/HUE028684T2/en unknown
- 2010-06-18 EA EA201171328A patent/EA019523B1/ru unknown
- 2010-06-18 PL PL10789260T patent/PL2444395T3/pl unknown
-
2016
- 2016-01-21 CY CY20161100066T patent/CY1117157T1/el unknown
- 2016-01-28 HR HRP20160096TT patent/HRP20160096T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1117157T1 (el) | 2017-04-05 |
| WO2010146881A1 (ja) | 2010-12-23 |
| EP2444395A4 (en) | 2012-11-28 |
| PL2444395T3 (pl) | 2016-06-30 |
| CN102448941B (zh) | 2016-04-06 |
| MX2011013857A (es) | 2012-01-30 |
| ES2560603T3 (es) | 2016-02-22 |
| AU2010261206B2 (en) | 2015-10-08 |
| EP2444395B1 (en) | 2016-01-06 |
| AU2010261206A1 (en) | 2011-12-15 |
| EA019523B1 (ru) | 2014-04-30 |
| BRPI1011683A2 (pt) | 2016-03-22 |
| HUE028684T2 (en) | 2016-12-28 |
| TW201100385A (en) | 2011-01-01 |
| EA201171328A1 (ru) | 2012-05-30 |
| KR101732907B1 (ko) | 2017-05-08 |
| CN102448941A (zh) | 2012-05-09 |
| BRPI1011683B8 (pt) | 2021-05-25 |
| US20120035159A1 (en) | 2012-02-09 |
| TWI527798B (zh) | 2016-04-01 |
| JPWO2010146881A1 (ja) | 2012-12-06 |
| HRP20160096T1 (hr) | 2016-02-26 |
| DK2444395T3 (en) | 2016-03-14 |
| JP4915010B2 (ja) | 2012-04-11 |
| EP2444395A1 (en) | 2012-04-25 |
| CA2764124C (en) | 2016-12-13 |
| US8951997B2 (en) | 2015-02-10 |
| KR20120069609A (ko) | 2012-06-28 |
| CA2764124A1 (en) | 2010-12-23 |
| BRPI1011683B1 (pt) | 2020-10-20 |
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