EA201171328A1 - Производное замещенного изохинолина - Google Patents

Производное замещенного изохинолина

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Publication number
EA201171328A1
EA201171328A1 EA201171328A EA201171328A EA201171328A1 EA 201171328 A1 EA201171328 A1 EA 201171328A1 EA 201171328 A EA201171328 A EA 201171328A EA 201171328 A EA201171328 A EA 201171328A EA 201171328 A1 EA201171328 A1 EA 201171328A1
Authority
EA
Eurasian Patent Office
Prior art keywords
derivative
isoquinoline
independently represent
group
hydrogen atom
Prior art date
Application number
EA201171328A
Other languages
English (en)
Other versions
EA019523B1 (ru
Inventor
Хироеси Хидака
Коуити Такахаси
Йосихиро Иноуэ
Кенго Суми
Риохей Накамура
Original Assignee
Д. Вестерн Терапьютикс Инститьют, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Д. Вестерн Терапьютикс Инститьют, Инк. filed Critical Д. Вестерн Терапьютикс Инститьют, Инк.
Publication of EA201171328A1 publication Critical patent/EA201171328A1/ru
Publication of EA019523B1 publication Critical patent/EA019523B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Abstract

Настоящее изобретение относится к производному изохинолин-6-сульфонамида, которое применяют в качестве нового фармацевтического средства. Настоящее изобретение относится к производному изохинолин-6-сульфонамида, представленному формулой (1), его солью или сольватом производного, или солигде Х и Y, каждый независимо, представляют прямую связь, NH, СН=СН, О или S; Rи R, каждый независимо, представляют атом водорода, атом галогена, цианогруппу, алкильную группу или другие подобные группы; Rи R, каждый независимо, представляют атом водорода, алкильную группу или другие подобные группы, или Rи Rвместе образуют алкиленовую группу или алкениленовую группу, которая может образовывать мостик между двумя углеродными атомами в произвольном положении; и l, m и n представляют целое число от 1 до 4.
EA201171328A 2009-06-19 2010-06-18 Производное замещенного изохинолина, содержащая его фармацевтическая композиция и применение для лечения заболеваний EA019523B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009146040 2009-06-19
PCT/JP2010/004101 WO2010146881A1 (ja) 2009-06-19 2010-06-18 置換されたイソキノリン誘導体

Publications (2)

Publication Number Publication Date
EA201171328A1 true EA201171328A1 (ru) 2012-05-30
EA019523B1 EA019523B1 (ru) 2014-04-30

Family

ID=43356211

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201171328A EA019523B1 (ru) 2009-06-19 2010-06-18 Производное замещенного изохинолина, содержащая его фармацевтическая композиция и применение для лечения заболеваний

Country Status (19)

Country Link
US (1) US8951997B2 (ru)
EP (1) EP2444395B1 (ru)
JP (1) JP4915010B2 (ru)
KR (1) KR101732907B1 (ru)
CN (1) CN102448941B (ru)
AU (1) AU2010261206B2 (ru)
BR (1) BRPI1011683B8 (ru)
CA (1) CA2764124C (ru)
CY (1) CY1117157T1 (ru)
DK (1) DK2444395T3 (ru)
EA (1) EA019523B1 (ru)
ES (1) ES2560603T3 (ru)
HR (1) HRP20160096T1 (ru)
HU (1) HUE028684T2 (ru)
MX (1) MX2011013857A (ru)
NZ (1) NZ596615A (ru)
PL (1) PL2444395T3 (ru)
TW (1) TWI527798B (ru)
WO (1) WO2010146881A1 (ru)

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US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
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CA2929545C (en) 2009-05-01 2019-04-09 Aerie Pharmaceuticals, Inc. Dual mechanism inhibitors for the treatment of disease
EA022646B1 (ru) 2010-12-22 2016-02-29 Д. Вестерн Терапьютикс Инститьют, Инк. Замещенное производное изохинолина
JP2013035802A (ja) * 2011-08-10 2013-02-21 D Western Therapeutics Institute Inc 緑内障又は高眼圧症の予防又は治療剤
EP3461484B9 (en) 2013-03-15 2021-06-09 Aerie Pharmaceuticals, Inc. Dimesylate salts of 4-(3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl, their combinations with prostaglandins and the use thereof in the treatment of ocular disorders
CN105050600B (zh) * 2013-04-24 2018-09-28 国立大学法人九州大学 眼底疾病治疗剂
CN105085478B (zh) * 2014-04-28 2019-04-12 南京明德新药研发股份有限公司 异喹啉磺胺衍生物及其药物组合物和制药用途
CN105906609A (zh) * 2016-05-19 2016-08-31 武昌理工学院 一种1，4-二氮杂环庚烷衍生物的制备方法
CN113912586B (zh) 2016-08-31 2023-04-07 江苏恒瑞医药股份有限公司 氧代吡啶酰胺类衍生物、其制备方法及其在医药上的应用
BR112019003945A2 (pt) 2016-08-31 2019-05-21 Aerie Pharmaceuticals, Inc. composições oftálmicas
US9840468B1 (en) 2016-12-30 2017-12-12 Aerie Pharmaceuticals, Inc. Methods for the preparation of 6-aminoisoquinoline
CN110506037A (zh) 2017-03-31 2019-11-26 爱瑞制药公司 芳基环丙基-氨基-异喹啉酰胺化合物
CN109134433B (zh) * 2017-06-16 2021-05-25 成都先导药物开发股份有限公司 一种抑制rock的化合物及其应用
CN108929270B (zh) * 2018-08-15 2021-06-08 上海罕道医药科技有限公司 一种药物中间体双取代含氮杂环的胺类化合物的合成
AU2019337703B2 (en) 2018-09-14 2023-02-02 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
WO2020091054A1 (ja) * 2018-11-01 2020-05-07 株式会社デ・ウエスタン・セラピテクス研究所 １，４－ジアゾカン化合物又はその塩
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WO2022047315A1 (en) * 2020-08-31 2022-03-03 Viewpoint Therapeutics, Inc. Compounds and formulations for treating ophthalmic diseases

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Also Published As

Publication number Publication date
AU2010261206A1 (en) 2011-12-15
CY1117157T1 (el) 2017-04-05
ES2560603T3 (es) 2016-02-22
US8951997B2 (en) 2015-02-10
BRPI1011683B8 (pt) 2021-05-25
HUE028684T2 (en) 2016-12-28
US20120035159A1 (en) 2012-02-09
BRPI1011683B1 (pt) 2020-10-20
CA2764124A1 (en) 2010-12-23
EA019523B1 (ru) 2014-04-30
HRP20160096T1 (hr) 2016-02-26
CN102448941B (zh) 2016-04-06
CN102448941A (zh) 2012-05-09
WO2010146881A1 (ja) 2010-12-23
EP2444395B1 (en) 2016-01-06
EP2444395A4 (en) 2012-11-28
CA2764124C (en) 2016-12-13
NZ596615A (en) 2013-07-26
TW201100385A (en) 2011-01-01
MX2011013857A (es) 2012-01-30
BRPI1011683A2 (pt) 2016-03-22
PL2444395T3 (pl) 2016-06-30
TWI527798B (zh) 2016-04-01
DK2444395T3 (en) 2016-03-14
JPWO2010146881A1 (ja) 2012-12-06
KR101732907B1 (ko) 2017-05-08
JP4915010B2 (ja) 2012-04-11
EP2444395A1 (en) 2012-04-25
KR20120069609A (ko) 2012-06-28
AU2010261206B2 (en) 2015-10-08

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