NO891837D0 - Forbedringer i fremstilling av polypeptider. - Google Patents
Forbedringer i fremstilling av polypeptider.Info
- Publication number
- NO891837D0 NO891837D0 NO891837A NO891837A NO891837D0 NO 891837 D0 NO891837 D0 NO 891837D0 NO 891837 A NO891837 A NO 891837A NO 891837 A NO891837 A NO 891837A NO 891837 D0 NO891837 D0 NO 891837D0
- Authority
- NO
- Norway
- Prior art keywords
- polypeptides
- preparation
- production
- yeast strains
- transformed
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Liquid Crystal Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB888810524A GB8810524D0 (en) | 1988-05-04 | 1988-05-04 | Improvements in production of polypeptides |
GB888812627A GB8812627D0 (en) | 1988-05-27 | 1988-05-27 | Improvements in production of polypeptides |
GB898907110A GB8907110D0 (en) | 1988-05-04 | 1989-03-29 | Improvements in the production of polypeptides |
Publications (4)
Publication Number | Publication Date |
---|---|
NO891837D0 true NO891837D0 (no) | 1989-05-03 |
NO891837L NO891837L (no) | 1989-11-06 |
NO180593B NO180593B (no) | 1997-02-03 |
NO180593C NO180593C (no) | 1997-05-14 |
Family
ID=27263890
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO891837A NO180593C (no) | 1988-05-04 | 1989-05-03 | Fremgangsmåte for fremstilling, i Saccharomyces cerevisiae, av et heterologt protein i homogen form |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0341215B1 (no) |
JP (1) | JPH0824565B2 (no) |
AT (1) | ATE124086T1 (no) |
AU (1) | AU614121B2 (no) |
CA (1) | CA1340016C (no) |
DE (1) | DE68923123T2 (no) |
DK (1) | DK175701B1 (no) |
ES (1) | ES2072918T3 (no) |
FI (1) | FI103129B1 (no) |
HU (1) | HU218731B (no) |
IE (1) | IE66044B1 (no) |
IL (1) | IL90170A (no) |
MX (1) | MX169508B (no) |
NO (1) | NO180593C (no) |
NZ (1) | NZ228955A (no) |
PT (1) | PT90436B (no) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8809860D0 (en) * | 1988-04-26 | 1988-06-02 | Ciba Geigy Ag | Process for production of polypeptides |
FR2645174B1 (fr) * | 1989-03-31 | 1994-01-07 | Transgene Sa | Souches de levure ameliorees pour la production de proteines heterologues matures en particulier d'hirudine et procede de preparation d'hirudine correspondant |
US5879926A (en) * | 1989-03-31 | 1999-03-09 | Transgene S.A. | Yeast strains for the production of mature heterologous proteins, especially hirudin |
FR2645175B1 (fr) * | 1989-03-31 | 1994-02-18 | Transgene Sa | Souche de saccharomyces cerevisiaeproductrice d'une proteine heterologue et procede de preparation de ladite proteine heterologue par fermentation de ladite souche |
US5663141A (en) * | 1989-12-01 | 1997-09-02 | Basf Aktiengesellschaft | Hirudin/polyalkylene glycol conjugates and hirudin muteins |
US5580734A (en) * | 1990-07-13 | 1996-12-03 | Transkaryotic Therapies, Inc. | Method of producing a physical map contigous DNA sequences |
MY106504A (en) * | 1990-07-13 | 1995-06-30 | Transkaryotic Therapies Inc | Library screening method. |
US5612198A (en) * | 1990-09-04 | 1997-03-18 | The Salk Institute | Production of insulin-like growth factor-1 in methylotrophic yeast cells |
WO1992004363A1 (en) * | 1990-09-04 | 1992-03-19 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Production of insulin-like growth factor-1 in methylotrophic yeast cells |
CA2255396A1 (en) | 1990-11-08 | 1992-05-09 | Nippon Mining Company Limited | Hirudin analog, method of manufacturing thereof and anti-coagulant composition, and secretion vector, transformed microorganisms containing said vector and manufacturing method ofproducts which is produced from said microorganism |
SG84484A1 (en) * | 1991-02-25 | 2001-11-20 | Ciba Geigy Ag | Improved yeast vectors |
JPH06506117A (ja) * | 1991-04-01 | 1994-07-14 | メルク エンド カンパニー インコーポレーテッド | ピキア(Pichia)蛋白質分解活性に影響する遺伝子およびその使用 |
HU214698B (hu) * | 1992-04-09 | 1998-06-29 | Gyógyszerkutató Intézet Kft. | Eljárás rekombináns deszulfátó-hirudin HV-1 peptidek előállítására |
EP0592358B1 (en) * | 1992-09-04 | 2000-10-11 | Novartis AG | Process for the production of protease inhibitors |
TW282490B (no) * | 1992-12-15 | 1996-08-01 | Ciba Geigy Ag | |
HUT72926A (en) * | 1993-08-04 | 1996-06-28 | Ciba Geigy Ag | High molecular weight desulphatohirudin |
DE4404168A1 (de) * | 1994-02-10 | 1995-08-17 | Hoechst Ag | Hirudinderivate und Verfahren zu deren Herstellung |
WO1996024678A1 (en) * | 1995-02-09 | 1996-08-15 | Novartis Ag | Process for the production of proteins |
CN1225550C (zh) * | 1995-03-20 | 2005-11-02 | 诺沃奇梅兹有限公司 | 表达降低水平的金属蛋白酶的宿主细胞和在蛋白质产生中使用该宿主细胞的方法 |
DE19529997C1 (de) * | 1995-08-16 | 1997-04-10 | Hoechst Ag | Verfahren zur Inaktivierung von Carboxypeptidase Y in hirudinhaltigen Kulturbrühen |
AU7112796A (en) * | 1995-09-27 | 1997-04-17 | Chiron Corporation | Method of making a protease deficient host |
EP0787569B1 (en) | 1996-01-31 | 2002-10-02 | Sumitomo Bakelite Company Limited | Method of producing epoxy resin-encapsulated semiconductor device |
FR2768743B1 (fr) * | 1997-09-23 | 2001-09-14 | Bio Merieux | Procede de lyse de micro-organisme |
GB2338236B (en) | 1998-06-13 | 2003-04-09 | Aea Technology Plc | Microbiological cell processing |
US7795205B2 (en) | 2004-04-12 | 2010-09-14 | Canyon Pharmaceuticals, Inc. | Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor |
CN102639559B (zh) | 2009-11-25 | 2015-04-29 | 诺沃—诺迪斯克有限公司 | 用于制备多肽的方法 |
EP3696274A4 (en) | 2017-10-10 | 2021-07-28 | Ajinomoto Co., Inc. | PROTEIN MANUFACTURING PROCESS |
KR20230023751A (ko) | 2020-06-11 | 2023-02-17 | 아지노모토 가부시키가이샤 | 단백질의 제조법 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3342139A1 (de) * | 1983-11-22 | 1985-05-30 | Ciba-Geigy Ag, Basel | Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel |
JPS62224284A (ja) * | 1986-03-25 | 1987-10-02 | Agency Of Ind Science & Technol | 微生物 |
GB8809860D0 (en) * | 1988-04-26 | 1988-06-02 | Ciba Geigy Ag | Process for production of polypeptides |
GB8817160D0 (en) * | 1988-07-19 | 1988-08-24 | Ciba Geigy Ag | Novel proteins |
GB8817161D0 (en) * | 1988-07-19 | 1988-08-24 | Ciba Geigy Ag | Modified proteins |
-
1989
- 1989-04-28 AU AU33828/89A patent/AU614121B2/en not_active Expired
- 1989-05-01 DE DE68923123T patent/DE68923123T2/de not_active Expired - Lifetime
- 1989-05-01 AT AT89810335T patent/ATE124086T1/de not_active IP Right Cessation
- 1989-05-01 EP EP89810335A patent/EP0341215B1/en not_active Expired - Lifetime
- 1989-05-01 ES ES89810335T patent/ES2072918T3/es not_active Expired - Lifetime
- 1989-05-02 JP JP1112294A patent/JPH0824565B2/ja not_active Expired - Lifetime
- 1989-05-02 CA CA000598488A patent/CA1340016C/en not_active Expired - Lifetime
- 1989-05-02 MX MX015887A patent/MX169508B/es unknown
- 1989-05-02 NZ NZ228955A patent/NZ228955A/en unknown
- 1989-05-02 PT PT90436A patent/PT90436B/pt not_active IP Right Cessation
- 1989-05-03 FI FI892114A patent/FI103129B1/fi not_active IP Right Cessation
- 1989-05-03 IE IE145189A patent/IE66044B1/en not_active IP Right Cessation
- 1989-05-03 IL IL9017089A patent/IL90170A/en active IP Right Grant
- 1989-05-03 NO NO891837A patent/NO180593C/no not_active IP Right Cessation
- 1989-05-03 DK DK198902175A patent/DK175701B1/da not_active IP Right Cessation
- 1989-05-03 HU HU077/89A patent/HU218731B/hu unknown
Also Published As
Publication number | Publication date |
---|---|
EP0341215A2 (en) | 1989-11-08 |
DE68923123D1 (de) | 1995-07-27 |
MX169508B (es) | 1993-07-08 |
NZ228955A (en) | 1991-06-25 |
EP0341215A3 (en) | 1992-01-15 |
NO180593C (no) | 1997-05-14 |
EP0341215B1 (en) | 1995-06-21 |
DK217589A (da) | 1989-11-05 |
ES2072918T3 (es) | 1995-08-01 |
HUT54210A (en) | 1991-01-28 |
IL90170A (en) | 1995-12-31 |
DK175701B1 (da) | 2005-01-24 |
AU3382889A (en) | 1989-11-09 |
FI892114A0 (fi) | 1989-05-03 |
IE66044B1 (en) | 1995-12-13 |
IL90170A0 (en) | 1989-12-15 |
FI103129B (fi) | 1999-04-30 |
IE891451L (en) | 1989-11-04 |
DE68923123T2 (de) | 1995-11-30 |
NO180593B (no) | 1997-02-03 |
JPH02104279A (ja) | 1990-04-17 |
NO891837L (no) | 1989-11-06 |
FI103129B1 (fi) | 1999-04-30 |
DK217589D0 (da) | 1989-05-03 |
PT90436B (pt) | 1994-11-30 |
CA1340016C (en) | 1998-08-25 |
JPH0824565B2 (ja) | 1996-03-13 |
FI892114A (fi) | 1989-11-05 |
ATE124086T1 (de) | 1995-07-15 |
AU614121B2 (en) | 1991-08-22 |
HU218731B (hu) | 2000-11-28 |
PT90436A (pt) | 1989-11-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK1K | Patent expired |