NO322252B1 - Anti-EGFR-enkeltkjede-Fv-er, DNA-molekyl som koder for denne, fremgangsmate for fremstilling av denne, kimert anti-EGFR-antistoff, fremgangsmate for fremstilling av helt kimert anti-EGFR-antistoff, farmasoytisk preparat som omfatter disse og anvendelse av disse for fremstilling av legemiddel mot tumorer. - Google Patents

Anti-EGFR-enkeltkjede-Fv-er, DNA-molekyl som koder for denne, fremgangsmate for fremstilling av denne, kimert anti-EGFR-antistoff, fremgangsmate for fremstilling av helt kimert anti-EGFR-antistoff, farmasoytisk preparat som omfatter disse og anvendelse av disse for fremstilling av legemiddel mot tumorer. Download PDF

Info

Publication number
NO322252B1
NO322252B1 NO19954626A NO954626A NO322252B1 NO 322252 B1 NO322252 B1 NO 322252B1 NO 19954626 A NO19954626 A NO 19954626A NO 954626 A NO954626 A NO 954626A NO 322252 B1 NO322252 B1 NO 322252B1
Authority
NO
Norway
Prior art keywords
egfr
chain
antibody
cells
light chain
Prior art date
Application number
NO19954626A
Other languages
English (en)
Norwegian (no)
Other versions
NO954626D0 (no
NO954626L (no
Inventor
Mary M Bendig
Cathrine A Kettleborough
Keith H Ansell
Detlef Guessow
Jaume Adan
Francesc Mitjans
Elisabet Rosell
Francesc Blasco
Jaume Piulats
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of NO954626D0 publication Critical patent/NO954626D0/no
Publication of NO954626L publication Critical patent/NO954626L/no
Publication of NO322252B1 publication Critical patent/NO322252B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
NO19954626A 1994-03-17 1995-11-16 Anti-EGFR-enkeltkjede-Fv-er, DNA-molekyl som koder for denne, fremgangsmate for fremstilling av denne, kimert anti-EGFR-antistoff, fremgangsmate for fremstilling av helt kimert anti-EGFR-antistoff, farmasoytisk preparat som omfatter disse og anvendelse av disse for fremstilling av legemiddel mot tumorer. NO322252B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP94104160 1994-03-17
EP94118970 1994-12-02
PCT/EP1995/000978 WO1995025167A1 (en) 1994-03-17 1995-03-16 Anti-egfr single-chain fvs and anti-egfr antibodies

Publications (3)

Publication Number Publication Date
NO954626D0 NO954626D0 (no) 1995-11-16
NO954626L NO954626L (no) 1995-11-16
NO322252B1 true NO322252B1 (no) 2006-09-04

Family

ID=26135522

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19954626A NO322252B1 (no) 1994-03-17 1995-11-16 Anti-EGFR-enkeltkjede-Fv-er, DNA-molekyl som koder for denne, fremgangsmate for fremstilling av denne, kimert anti-EGFR-antistoff, fremgangsmate for fremstilling av helt kimert anti-EGFR-antistoff, farmasoytisk preparat som omfatter disse og anvendelse av disse for fremstilling av legemiddel mot tumorer.

Country Status (20)

Country Link
US (1) US5844093A (es)
EP (1) EP0699237B1 (es)
JP (2) JPH08510922A (es)
KR (1) KR100376038B1 (es)
AT (1) ATE232902T1 (es)
AU (1) AU2071695A (es)
CA (1) CA2163012C (es)
CZ (1) CZ292061B6 (es)
DE (1) DE69529649T2 (es)
DK (1) DK0699237T3 (es)
ES (1) ES2191702T3 (es)
HU (1) HU221001B1 (es)
MX (1) MX9504802A (es)
NO (1) NO322252B1 (es)
PL (1) PL181342B1 (es)
PT (1) PT699237E (es)
RU (1) RU2170257C2 (es)
SK (1) SK283889B6 (es)
UA (1) UA41929C2 (es)
WO (1) WO1995025167A1 (es)

Families Citing this family (126)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2166368T3 (es) * 1993-12-24 2002-04-16 Merck Patent Gmbh Inmunoconjugados.
US7060808B1 (en) * 1995-06-07 2006-06-13 Imclone Systems Incorporated Humanized anti-EGF receptor monoclonal antibody
WO1998012227A1 (en) * 1996-09-19 1998-03-26 Diagnocure Inc. Recombinant single chain antibodies directed against the gp54 cancer marker, composition comprising same and use thereof
EP1500329B1 (en) * 1996-12-03 2012-03-21 Amgen Fremont Inc. Human antibodies that specifically bind human TNF alpha
US6562599B1 (en) 1997-09-02 2003-05-13 Sumitomo Pharmaceuticals Company, Limited Single-stranded antibody against hepatitis B virus core protein, gene thereof, and therapeutic agent for hepatitis B containing these
DE19744531A1 (de) * 1997-10-09 1999-05-27 Klaus Dr Rer Nat Bosslet Bindemoleküle gegen Rezeptor-Ligand-Komplexe
ATE447613T1 (de) 1997-11-17 2009-11-15 Micromet Ag Verfahren zur identifikation von bindestellendomänen, die ihre epitopbindefähigkeit beibehalten
US20030224001A1 (en) * 1998-03-19 2003-12-04 Goldstein Neil I. Antibody and antibody fragments for inhibiting the growth of tumors
ZA200007412B (en) * 1998-05-15 2002-03-12 Imclone Systems Inc Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases.
CN1183160C (zh) 1998-08-28 2005-01-05 基因技术股份有限公司 人抗因子IX/IXa抗体
IL146480A0 (en) * 1999-05-14 2002-07-25 Imclone Systems Inc Treatment of refractory human tumors with epidermal growth factor receptor antagonists
US7144991B2 (en) 1999-06-07 2006-12-05 Aletheon Pharmaceuticals, Inc. Streptavidin expressed gene fusions and methods of use thereof
US6790631B1 (en) * 1999-10-05 2004-09-14 Agensys, Inc. G protein-coupled receptor up-regulated in prostate cancer and uses thereof
US7361338B2 (en) * 1999-10-05 2008-04-22 Agensys, Inc. Methods to inhibit growth of prostate cancer cells
US20040091485A1 (en) * 2000-05-19 2004-05-13 Ellis John Robert Maxwell Humanised antibodies to the epidermal growth factor receptor
AU2001262750A1 (en) * 2000-06-14 2001-12-24 Medical And Biological Laboratories Co., Ltd. Method of constructing scfv antibody fused with fluorescent protein
US7449308B2 (en) 2000-06-28 2008-11-11 Glycofi, Inc. Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
US7598055B2 (en) * 2000-06-28 2009-10-06 Glycofi, Inc. N-acetylglucosaminyltransferase III expression in lower eukaryotes
US8697394B2 (en) 2000-06-28 2014-04-15 Glycofi, Inc. Production of modified glycoproteins having multiple antennary structures
DE60139720D1 (de) * 2000-06-28 2009-10-08 Glycofi Inc Verfahren für die Herstellung modifizierter Glykoproteine
JP2004527456A (ja) * 2000-08-09 2004-09-09 イムクローン システムズ インコーポレイティド Egf受容体拮抗剤による過増殖性の疾患の治療
JP2004520011A (ja) * 2000-08-21 2004-07-08 スミスクライン・ビーチャム・コーポレイション Rankリガンド介在障害の治療において有用な抗−rankリガンドモノクローナル抗体
US20030133939A1 (en) * 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
WO2002056910A1 (en) * 2001-01-17 2002-07-25 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US7829084B2 (en) * 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
GB0103389D0 (en) * 2001-02-12 2001-03-28 Novartis Ag Organic compounds
ES2328796T3 (es) 2001-03-14 2009-11-18 Myriad Genetics, Inc. Interaccion tsg101-gag y uso de la misma.
US20080008704A1 (en) * 2001-03-16 2008-01-10 Mark Rubin Methods of treating colorectal cancer with anti-epidermal growth factor antibodies
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
WO2002092771A2 (en) 2001-05-11 2002-11-21 Ludwig Institute For Cancer Research Specific binding proteins and uses thereof
US20020193569A1 (en) * 2001-06-04 2002-12-19 Idec Pharmaceuticals Corporation Bispecific fusion protein and method of use for enhancing effector cell killing of target cells
US7595378B2 (en) 2001-06-13 2009-09-29 Genmab A/S Human monoclonal antibodies to epidermal growth factor receptor (EGFR)
CN100497389C (zh) * 2001-06-13 2009-06-10 根马布股份公司 表皮生长因子受体(egfr)的人单克隆抗体
CA2472937C (en) 2002-01-11 2014-06-17 Biomarin Pharmaceutical, Inc. Use of p97 as an enzyme delivery system for the delivery of therapeutic lysosomal enzymes
US20050276812A1 (en) 2004-06-01 2005-12-15 Genentech, Inc. Antibody-drug conjugates and methods
US8034904B2 (en) * 2002-06-14 2011-10-11 Immunogen Inc. Anti-IGF-I receptor antibody
MXPA05000403A (es) 2002-07-15 2005-07-22 Genentech Inc Metodos para identificar tumores que responden al tratamiento con anticuerpos contra erbb2.
US10919956B2 (en) 2002-11-12 2021-02-16 The Brigham And Women's Hospital, Inc. Polysaccharide vaccine for staphylococcal infections
US20040147428A1 (en) * 2002-11-15 2004-07-29 Pluenneke John D. Methods of treatment using an inhibitor of epidermal growth factor receptor
US7332299B2 (en) 2003-02-20 2008-02-19 Glycofi, Inc. Endomannosidases in the modification of glycoproteins in eukaryotes
EP1622941A2 (en) * 2003-03-20 2006-02-08 ImClone Systems Incorporated Method of producing an antibody to epidermal growth factor receptor
US7754209B2 (en) 2003-07-26 2010-07-13 Trubion Pharmaceuticals Binding constructs and methods for use thereof
DK1687338T3 (da) 2003-11-07 2011-02-07 Ablynx Nv Camelidae enkeltdomæne-antistoffer VHH, der er rettet mod epidermal vækstfaktor-receptor og anvendelser deraf
JP4734319B2 (ja) * 2004-03-19 2011-07-27 イムクローン・リミテッド・ライアビリティ・カンパニー ヒト抗上皮成長因子受容体抗体
PL1745075T3 (pl) 2004-04-21 2013-09-30 Brigham & Womens Hospital Inc Peptydy wiążące poli-N-acetyloglukozaminę (PNAG/DPNAG) i sposoby ich zastosowania
GB0410627D0 (en) * 2004-05-12 2004-06-16 Scancell Ltd Specific binding members
US20100111856A1 (en) 2004-09-23 2010-05-06 Herman Gill Zirconium-radiolabeled, cysteine engineered antibody conjugates
NZ580115A (en) 2004-09-23 2010-10-29 Genentech Inc Cysteine engineered antibody light chains and conjugates
SI1912675T1 (sl) 2005-07-25 2014-07-31 Emergent Product Development Seattle, Llc zmanjšanje števila celic B z uporabo molekul, ki se specifično vežejo na CD37 in CD20
US20100056439A1 (en) * 2005-12-06 2010-03-04 Domantis Limited Ligands that have binding specificity for egfr and/or vegf and methods of use therefor
US7503217B2 (en) * 2006-01-27 2009-03-17 Weatherford/Lamb, Inc. Sonar sand detection
WO2007102787A1 (en) 2006-03-06 2007-09-13 Agency For Science, Technology & Research Human embryonic stem cell methods and podxl expression
MX363905B (es) 2006-06-12 2019-04-08 Aptevo Res & Development Llc Proteinas de union multivalentes monocatenarias con funcion efectora.
EP2975057A1 (en) 2006-07-10 2016-01-20 Fujita Health University Novel anti-cd73 antibody
WO2008070780A1 (en) 2006-12-07 2008-06-12 Novartis Ag Antagonist antibodies against ephb3
WO2008077171A1 (en) * 2006-12-22 2008-07-03 Novelix Therapeutics Gmbh Treatment of diabetes by at least one epidermal growth factor receptor specific antibody or a derivative thereof
MX2009007987A (es) 2007-01-25 2010-03-01 Dana Farber Cancer Inst Inc Uso de anticuerpos anti-egfr en el tratamiento de enfermedad mediada por egfr mutante.
US9023356B2 (en) 2007-03-15 2015-05-05 Ludwig Institute For Cancer Research Ltd Treatment method using EGFR antibodies and SRC inhibitors and related formulations
WO2008154927A1 (en) * 2007-06-21 2008-12-24 Genmab A/S Novel methods for treating egfr-associated tumors
JP5532486B2 (ja) 2007-08-14 2014-06-25 ルードヴィッヒ インスティテュート フォー キャンサー リサーチ Egf受容体を標的とするモノクローナル抗体175ならびにその誘導体および用途
MX2010003099A (es) 2007-09-21 2010-05-17 Univ California Interferon de objetivo demuestra actividades potentes apoptoticas y antitumorales.
EP2132228B1 (en) 2008-04-11 2011-06-22 Emergent Product Development Seattle, LLC Cd37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof
CA2722466A1 (en) 2008-04-29 2009-11-05 Tariq Ghayur Dual variable domain immunoglobulins and uses thereof
CA2725666A1 (en) 2008-06-03 2009-12-10 Abbott Laboratories Dual variable domain immunoglobulins and uses thereof
AU2009256250B2 (en) 2008-06-03 2013-05-30 Abbvie Inc. Dual variable domain immunoglobulins and uses thereof
NZ590074A (en) 2008-07-08 2012-12-21 Abbott Lab Prostaglandin e2 dual variable domain immunoglobulins and uses thereof
KR20110031393A (ko) 2008-07-21 2011-03-25 더 브리검 앤드 우먼즈 하스피털, 인크. 합성 베타-1,6 글루코사민 올리고당에 관한 방법 및 조성물
KR101108642B1 (ko) * 2009-09-29 2012-02-09 주식회사 녹십자 표피 성장 인자 수용체에 특이적으로 결합하는 항체
KR20140015139A (ko) 2009-10-15 2014-02-06 애브비 인코포레이티드 이원 가변 도메인 면역글로불린 및 이의 용도
UY32979A (es) 2009-10-28 2011-02-28 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
US20120282274A1 (en) * 2009-11-20 2012-11-08 Northshore University Health System Research Institute Targeting of the c-terminal segment of c.difficile toxin b for improved clinical diagnosis, prevention, and treatment
CA2781682A1 (en) 2009-12-04 2011-06-09 Genentech, Inc. Multispecific antibodies, antibody analogs, compositions, and methods
CN102167743B (zh) * 2010-02-25 2014-05-14 上海百迈博制药有限公司 一种全人源抗egfr单克隆抗体、其制备方法及用途
RU2624027C2 (ru) 2010-04-23 2017-06-30 Дженентек, Инк. Получение гетеромультимерных белков
WO2011152525A1 (ja) * 2010-06-04 2011-12-08 東亞合成株式会社 抗体およびその利用
CA2807014A1 (en) 2010-08-03 2012-02-09 Abbvie Inc. Dual variable domain immunoglobulins and uses thereof
TW201211252A (en) 2010-08-26 2012-03-16 Abbott Lab Dual variable domain immunoglobulins and uses thereof
KR101273918B1 (ko) * 2010-09-17 2013-06-13 강원대학교산학협력단 인간 항-상피세포성 성장인자수용체 Fab 항체 및 이를 포함하는 종양 치료용 약학 조성물
EA201390472A1 (ru) 2010-10-29 2014-02-28 Иммьюноджен, Инк. Новые молекулы, связывающиеся с egfr, и их иммуноконъюгаты
AU2011320318B9 (en) 2010-10-29 2015-11-19 Immunogen, Inc. Non-antagonistic EGFR-binding molecules and immunoconjugates thereof
US10689447B2 (en) 2011-02-04 2020-06-23 Genentech, Inc. Fc variants and methods for their production
CA2825064C (en) 2011-02-04 2022-08-30 Genentech, Inc. Fc variants and methods for their production
CN103561771B (zh) 2011-03-17 2019-01-04 伯明翰大学 重新定向的免疫治疗
JP6208658B2 (ja) 2011-07-05 2017-10-04 バイオアシス テクノロジーズ インコーポレイテッド p97−抗体結合体および使用方法
EP2739649B1 (en) 2011-08-05 2017-09-27 Bioasis Technologies Inc. P97 fragments with transfer activity
MX357391B (es) 2011-09-30 2018-07-06 Regeneron Pharma Anticuerpos anti-erbb3 y usos de los mismos.
US9273143B2 (en) 2011-09-30 2016-03-01 Regeneron Pharmaceuticals, Inc. Methods and compositions comprising a combination of an anti-ErbB3 antibody and an anti-EGFR antibody
KR102037541B1 (ko) 2011-10-28 2019-10-29 테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 폴리펩티드 구축물 및 이의 용도
CA2856411A1 (en) 2011-11-21 2013-05-30 Immunogen, Inc. Method of treatment of tumors that are resistant to egfr therapies by egfr antibody cytotoxic agent conjugate
UY34558A (es) 2011-12-30 2013-07-31 Abbvie Inc Proteínas de unión específicas duales dirigidas contra il-13 y/o il-17
EP2827906A1 (en) * 2012-03-21 2015-01-28 Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung e.V. Novel photoimmunoconjugates for use in photodynamic therapy
CN104918956A (zh) * 2012-05-17 2015-09-16 索伦托治疗有限公司 与egfr结合的抗原结合蛋白
TWI641619B (zh) 2012-06-25 2018-11-21 美商再生元醫藥公司 抗-egfr抗體及其用途
EP2880156B1 (en) 2012-07-31 2017-08-23 biOasis Technologies Inc Dephosphorylated lysosomal storage disease proteins and methods of use thereof
AU2013337775B2 (en) 2012-11-01 2017-03-30 Abbvie Inc. Anti-VEGF/DLL4 dual variable domain immunoglobulins and uses thereof
CN105263958B (zh) 2013-03-13 2019-09-27 比奥阿赛斯技术有限公司 p97片段及其应用
CN105324396A (zh) 2013-03-15 2016-02-10 艾伯维公司 针对IL-1β和/或IL-17的双重特异性结合蛋白
EA033115B1 (ru) 2013-04-29 2019-08-30 Тева Фармасьютикалз Острэйлиа Пти Лтд. АНТИТЕЛА ПРОТИВ CD38 И СЛИТЫЕ БЕЛКИ С ОСЛАБЛЕННЫМ ИНТЕРФЕРОНОМ АЛЬФА-2b
US11117975B2 (en) 2013-04-29 2021-09-14 Teva Pharmaceuticals Australia Pty Ltd Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B
EP3038657A2 (en) 2013-08-28 2016-07-06 Bioasis Technologies Inc. Cns-targeted conjugates having modified fc regions and methods of use thereof
JP6603227B2 (ja) 2014-02-03 2019-11-06 バイオアシス テクノロジーズ インコーポレイテッド P97融合タンパク質
DK3107562T3 (da) 2014-02-19 2019-12-16 Bioasis Technologies Inc P97-ids-fusionsproteiner
UA119352C2 (uk) 2014-05-01 2019-06-10 Тева Фармасьютикалз Острейліа Пті Лтд Комбінація леналідоміду або помалідоміду і конструкції анти-cd38 антитіло-атенуйований інтерферон альфа-2b та спосіб лікування суб'єкта, який має cd38-експресуючу пухлину
US10058619B2 (en) 2014-05-01 2018-08-28 Bioasis Technologies, Inc. P97-polynucleotide conjugates
CN106456768B (zh) 2014-06-13 2019-12-03 腾博龙公司 含有抗egfr1抗体的缀合物
IL251822B2 (en) 2014-10-29 2023-03-01 Teva Pharmaceuticals Australia Pty Ltd Variants of interferon alpha-2-b
US10093733B2 (en) 2014-12-11 2018-10-09 Abbvie Inc. LRP-8 binding dual variable domain immunoglobulin proteins
TW201710286A (zh) 2015-06-15 2017-03-16 艾伯維有限公司 抗vegf、pdgf及/或其受體之結合蛋白
WO2017053469A2 (en) 2015-09-21 2017-03-30 Aptevo Research And Development Llc Cd3 binding polypeptides
WO2017201488A1 (en) 2016-05-20 2017-11-23 Harpoon Therapeutics, Inc. Single domain serum albumin binding protein
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
US11618784B2 (en) 2016-07-19 2023-04-04 Teva Pharmaceuticals Australia Pty Ltd. Anti-CD47 combination therapy
WO2018152033A1 (en) * 2017-02-14 2018-08-23 Promab Biotechnologies, Inc. Cd47-car-t cells
EP3589662A4 (en) 2017-02-28 2020-12-30 Harpoon Therapeutics, Inc. INDUCTIBLE MONOVALENT ANTIGBINDING PROTEIN
JP7090347B2 (ja) 2017-05-12 2022-06-24 ハープーン セラピューティクス,インク. メソテリン結合タンパク質
CR20200195A (es) 2017-10-13 2020-08-14 Harpoon Therapeutics Inc Proteínas de unión a antigenos de maduraciòn de celulas b
CN109879964B (zh) * 2017-12-06 2022-08-05 北京科立思维生物科技有限公司 抗egfr单链抗体、抗pd1单链抗体及融合蛋白
WO2019195959A1 (en) 2018-04-08 2019-10-17 Cothera Biosciences, Inc. Combination therapy for cancers with braf mutation
US10815311B2 (en) 2018-09-25 2020-10-27 Harpoon Therapeutics, Inc. DLL3 binding proteins and methods of use
JP2022514262A (ja) 2018-12-17 2022-02-10 レビトープ リミテッド 双子型免疫細胞エンゲージャー
EP4142778A1 (en) * 2020-04-30 2023-03-08 Board of Regents, The University of Texas System Anti-cd79b antibodies and chimeric antigen receptors and methods of use thereof
EP3954393A1 (en) 2020-08-13 2022-02-16 Bioasis Technologies Inc. Combination therapies for delivery across the blood brain barrier
CA3187272A1 (en) 2020-10-08 2022-04-14 Thorsten Ross Trispecific binders
CA3216098A1 (en) 2021-07-30 2023-02-02 Uwe Reusch Duplexbodies
AU2022382368A1 (en) 2021-11-03 2024-05-02 Affimed Gmbh Bispecific cd16a binders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2016842A1 (en) * 1989-05-16 1990-11-16 Richard A. Lerner Method for tapping the immunological repertoire
US5395750A (en) * 1992-02-28 1995-03-07 Hoffmann-La Roche Inc. Methods for producing proteins which bind to predetermined antigens
GB9401182D0 (en) * 1994-01-21 1994-03-16 Inst Of Cancer The Research Antibodies to EGF receptor and their antitumour effect

Also Published As

Publication number Publication date
EP0699237B1 (en) 2003-02-19
MX9504802A (es) 1997-05-31
KR100376038B1 (ko) 2003-06-09
UA41929C2 (uk) 2001-10-15
NO954626D0 (no) 1995-11-16
NO954626L (no) 1995-11-16
US5844093A (en) 1998-12-01
AU2071695A (en) 1995-10-03
DE69529649D1 (de) 2003-03-27
PL181342B1 (pl) 2001-07-31
CZ301495A3 (en) 1996-02-14
SK283889B6 (sk) 2004-04-06
HUT73461A (en) 1996-08-28
EP0699237A1 (en) 1996-03-06
ATE232902T1 (de) 2003-03-15
DE69529649T2 (de) 2003-12-18
PT699237E (pt) 2003-07-31
WO1995025167A1 (en) 1995-09-21
PL311661A1 (en) 1996-03-04
JP2006025794A (ja) 2006-02-02
CZ292061B6 (cs) 2003-07-16
SK143095A3 (en) 1996-11-06
CA2163012A1 (en) 1995-09-21
CA2163012C (en) 2009-12-08
HU221001B1 (hu) 2002-07-29
HU9503285D0 (en) 1996-02-28
ES2191702T3 (es) 2003-09-16
JPH08510922A (ja) 1996-11-19
RU2170257C2 (ru) 2001-07-10
DK0699237T3 (da) 2003-05-26

Similar Documents

Publication Publication Date Title
NO322252B1 (no) Anti-EGFR-enkeltkjede-Fv-er, DNA-molekyl som koder for denne, fremgangsmate for fremstilling av denne, kimert anti-EGFR-antistoff, fremgangsmate for fremstilling av helt kimert anti-EGFR-antistoff, farmasoytisk preparat som omfatter disse og anvendelse av disse for fremstilling av legemiddel mot tumorer.
Shalaby et al. Development of humanized bispecific antibodies reactive with cytotoxic lymphocytes and tumor cells overexpressing the HER2 protooncogene.
US11713348B2 (en) ScFv amino acid sequence, chimeric antigen receptor containing same and application thereof
US20180155452A1 (en) Bispecific heterodimeric diabodies and uses thereof
Ahmad et al. scFv antibody: principles and clinical application
JP7399852B2 (ja) 多重特異性抗体とその作製及び使用方法
WO2004111233A1 (ja) 抗体の製造方法
JPH06510671A (ja) キメラ抗体の製造−組合せアプローチ
CN112500485B (zh) 一种抗b7-h3抗体及其应用
US20230090014A1 (en) Anti-cd47/anti-pd-l1 antibody and applications thereof
CN112830969A (zh) 一种特异性结合人Claudin18.2的单克隆抗体及包含其的药物和试剂盒
Clark et al. Isolation of human anti‐c‐erbB‐2 Fabs from a lymph node‐derived phage display library
US20220348665A1 (en) BISPECIFIC ANTIBODY AGAINST Alpha-SYN/IGF1R AND USE THEREOF
KR102624213B1 (ko) 항-her2 어피바디 및 이를 스위치 분자로 이용하는 스위처블 키메라 항원 수용체
WO2022100694A1 (zh) 抗体及其制备方法
Zuhaida et al. Construction of single-chain variable fragment antibodies against MCF-7 breast cancer cells
WO2024094151A1 (en) Multi-specific antibody and medical use thereof
JPH10155489A (ja) 組換え抗体及びそれをコードする核酸
CN114685655B (zh) Pd-1结合分子及其应用
AU724562B2 (en) Anti-EGFR single-chain Fvs and anti-EGFR antibodies
CN114249827A (zh) 抗tigit抗体及双抗体和它们的应用

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees