PL1745075T3 - Peptydy wiążące poli-N-acetyloglukozaminę (PNAG/DPNAG) i sposoby ich zastosowania - Google Patents

Peptydy wiążące poli-N-acetyloglukozaminę (PNAG/DPNAG) i sposoby ich zastosowania

Info

Publication number
PL1745075T3
PL1745075T3 PL05770709T PL05770709T PL1745075T3 PL 1745075 T3 PL1745075 T3 PL 1745075T3 PL 05770709 T PL05770709 T PL 05770709T PL 05770709 T PL05770709 T PL 05770709T PL 1745075 T3 PL1745075 T3 PL 1745075T3
Authority
PL
Poland
Prior art keywords
dpnag
pnag
poly
methods
binding peptides
Prior art date
Application number
PL05770709T
Other languages
English (en)
Inventor
Gerald B Pier
Casie Anne Kelly-Quintos
Lisa Cavacini
Marshall R Posner
Original Assignee
Brigham & Womens Hospital Inc
Beth Israel Deaconess Medical Ct Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham & Womens Hospital Inc, Beth Israel Deaconess Medical Ct Inc filed Critical Brigham & Womens Hospital Inc
Publication of PL1745075T3 publication Critical patent/PL1745075T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PL05770709T 2004-04-21 2005-04-21 Peptydy wiążące poli-N-acetyloglukozaminę (PNAG/DPNAG) i sposoby ich zastosowania PL1745075T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56410504P 2004-04-21 2004-04-21
PCT/US2005/013694 WO2005103084A2 (en) 2004-04-21 2005-04-21 Poly-n-acetyl glucosamine (pnag/dpnag)-binding peptides and methods of use thereof
EP05770709A EP1745075B1 (en) 2004-04-21 2005-04-21 Poly-n-acetyl glucosamine (pnag/dpnag)-binding peptides and methods of use thereof

Publications (1)

Publication Number Publication Date
PL1745075T3 true PL1745075T3 (pl) 2013-09-30

Family

ID=35197541

Family Applications (1)

Application Number Title Priority Date Filing Date
PL05770709T PL1745075T3 (pl) 2004-04-21 2005-04-21 Peptydy wiążące poli-N-acetyloglukozaminę (PNAG/DPNAG) i sposoby ich zastosowania

Country Status (13)

Country Link
US (13) US7786255B2 (pl)
EP (6) EP2439213B1 (pl)
JP (2) JP5080243B2 (pl)
CN (1) CN101001874B (pl)
AU (1) AU2005236068C1 (pl)
CA (1) CA2567748A1 (pl)
DK (1) DK1745075T3 (pl)
ES (2) ES2415358T3 (pl)
HK (1) HK1100369A1 (pl)
PL (1) PL1745075T3 (pl)
PT (1) PT1745075E (pl)
SI (1) SI1745075T1 (pl)
WO (1) WO2005103084A2 (pl)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7252828B2 (en) 1998-07-15 2007-08-07 The Brigham And Women's Hospital, Inc. Polysaccharide vaccine for staphylococcal infections
US7047058B1 (en) 2001-02-06 2006-05-16 Medrad, Inc. Apparatuses, systems and methods for extravasation detection
AU2003290867A1 (en) * 2002-11-12 2004-06-03 The Brigham And Women's Hospital, Inc. Methods and products for treating staphylococcal infections
CN100351260C (zh) 2002-11-12 2007-11-28 布赖汉姆妇女医院 葡萄球菌感染的多糖疫苗
EP2439213B1 (en) 2004-04-21 2018-12-12 The Brigham and Women's Hospital, Inc. Poly-N-acetyl glucosamine (PNAG/DPNAG)-binding antibodies and methods of use thereof
CN103351435B (zh) * 2006-06-06 2015-08-19 克鲁塞尔荷兰公司 具有杀灭葡萄球菌活性的人结合分子及其应用
JP5586952B2 (ja) 2006-06-06 2014-09-10 クルセル ホランド ベー ヴェー 腸球菌に対する殺活性を有するヒトの結合分子及びその使用方法
AU2012268821B2 (en) * 2006-06-06 2016-06-02 Janssen Vaccines & Prevention B.V. Human binding molecules having killing activity against staphylococci and uses thereof
US8455623B2 (en) 2008-05-21 2013-06-04 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
BRPI0916365A2 (pt) 2008-07-21 2018-05-02 Brigham & Womens Hospital Inc métodos e composições relacionados aos oligossacarídeos de glicosina beta-1,6 sintéticos
CN103906535B (zh) 2011-08-15 2017-07-14 芝加哥大学 与葡萄球菌蛋白a的抗体相关的组合物和方法
WO2013033162A1 (en) 2011-09-02 2013-03-07 Battelle Memorial Institute Distributed extravasation detection system
WO2013075740A1 (en) * 2011-11-23 2013-05-30 Sanofi Antibody purification method
JP2015517496A (ja) * 2012-05-07 2015-06-22 サノフイ バイオフィルム形成を防止する方法
CA2879592A1 (en) * 2012-05-30 2013-12-05 The Brigham And Women's Hospital, Inc. Polysaccharide compositions and methods of use
WO2014031822A1 (en) 2012-08-24 2014-02-27 Sanofi Anti-poly-n-acetyl glucosamine (pnag) monoclonal antibody and uses thereof for the prevention or treatment of pnag expressing bacterial infection
WO2014050518A1 (ja) 2012-09-28 2014-04-03 日本電気株式会社 情報処理装置、情報処理方法および情報処理プログラム
EP2912058A1 (en) 2012-10-23 2015-09-02 The Board of Regents of The University of Texas System Antibodies with engineered igg fc domains
US9809645B2 (en) 2013-03-12 2017-11-07 Zenyaku Kogyo Kabushikikaisha Anti-Staphylococcus antibody, method for manufacturing same, and usage of same
KR102272851B1 (ko) 2013-05-06 2021-07-02 사노피 항체를 정제하기 위한 연속 다단계 공정
EP2889311B1 (en) 2013-12-30 2018-03-21 Albert-Ludwigs-Universität Freiburg Opsonic and protective monoclonal antibodies against gram-positive pathogens
AU2017316604A1 (en) 2016-08-24 2019-04-11 Teneobio, Inc. Transgenic non-human animals producing modified heavy chain-only antibodies
CN110891596A (zh) * 2017-05-04 2020-03-17 希望之城 抗体可变结构域及抗体构建体
JP2022519631A (ja) 2019-02-12 2022-03-24 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 補体および標的抗原に結合する二重特異性抗体を使用するための組成物および方法
CN110184231B (zh) * 2019-05-31 2021-02-12 杭州丰海生物科技有限公司 一种胞外分泌pnag多糖的重组枯草芽孢杆菌及其应用
US11173199B2 (en) 2019-11-13 2021-11-16 Alopexx Inc. Low contaminant compositions
JP2023502276A (ja) * 2019-11-22 2023-01-23 アロペックス・インコーポレイテッド Ｐｎａｇを含む微生物に対する持続的治療を提供するための方法
US10828360B1 (en) 2020-02-04 2020-11-10 OneBioPharma, Inc. Methods for inhibiting biofilm formation
WO2023173020A1 (en) * 2022-03-11 2023-09-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Antibody materials and methods targeting microbial polysaccharides

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US213668A (en) 1879-03-25 Improvement in ice-making apparatus
US3854480A (en) 1969-04-01 1974-12-17 Alza Corp Drug-delivery system
JPS5452794A (en) 1977-09-30 1979-04-25 Kousaku Yoshida Extracting of polysacchride from capusle containing epidermis staphylococus
US4285936A (en) 1979-12-10 1981-08-25 The United States Of America As Represented By The Secretary Of The Army Method for producing a vaccine against bacterial infections caused by pseudomonas aeruginosa
US4355023A (en) 1980-09-30 1982-10-19 The Massachusetts General Hospital Antibody fragment compositions and process
US4675189A (en) 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
US4443549A (en) 1981-10-19 1984-04-17 Molecular Genetics, Inc. Production of monoclonal antibodies against bacterial adhesins
US4470925A (en) 1982-05-05 1984-09-11 E. I. Du Pont De Nemours And Company Immunoglobulin half-molecules and process for producing hybrid antibodies
US4462334A (en) 1982-08-19 1984-07-31 Kim Ho K Solar animal structure
US4465776A (en) * 1982-09-27 1984-08-14 Research Corporation Monoclonal antibodies to vitamin B6 and immunoassay method
US4652448A (en) 1982-10-07 1987-03-24 Molecular Genetics, Inc. Use of monoclonal antibodies against bacterial adhesins
US4452775A (en) 1982-12-03 1984-06-05 Syntex (U.S.A.) Inc. Cholesterol matrix delivery system for sustained release of macromolecules
US4578458A (en) 1983-03-23 1986-03-25 Brigham And Women's Hospital Mucoid exopolysaccharide vaccine against Pseudomonas aeruginosa
DK219084D0 (da) 1984-05-02 1984-05-02 Frederik Carl Peter Lindberg Antigen
JPS6191131A (ja) 1984-10-09 1986-05-09 Chugai Pharmaceut Co Ltd 医薬品の吸着防止方法および組成物
GB8426463D0 (en) 1984-10-19 1984-11-28 Technology Licence Co Ltd Monoclonal antibodies
NZ214503A (en) 1984-12-20 1990-02-26 Merck & Co Inc Covalently-modified neutral bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins, and methods of preparing such polysaccharides and conjugates
FR2581877B1 (fr) 1985-05-14 1987-12-18 Louvain Universite Catholique Conjugue constitue d'une adhesine de paroi de s. mutans, de nature proteique et d'un polysaccharide de s. mutans, sa preparation et son utilisation notamment dans des vaccins anti-caries
US4786592A (en) 1986-06-18 1988-11-22 Scripps Clinic And Research Foundation Neisseria gonorrhoeae lectin useful as a vaccine and diagnostic marker and means for producing this lectin
US5589591A (en) 1986-07-03 1996-12-31 Advanced Magnetics, Inc. Endotoxin-free polysaccharides
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
GB8621910D0 (en) 1986-09-11 1986-10-15 Technology Licence Co Ltd Monoclonal antibodies
US5075109A (en) 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
FR2619122B1 (fr) 1987-08-03 1990-03-09 Pasteur Institut Procede d'obtention de polyosides capsulaires de staphylocoques, polyosides obtenus, applications de ces polyosides et souches pour la mise en oeuvre du procede
US4859449A (en) 1987-09-14 1989-08-22 Center For Molecular Medicine And Immunology Modified antibodies for enhanced hepatocyte clearance
CA1340506C (en) 1987-11-24 1999-04-20 Nicholas H. Carbonetti Production of gonorrheal pi proteins and vaccines
US5055455A (en) 1988-09-28 1991-10-08 Brigham And Women's Hospital Capsular polysaccharide adhesin antigen, preparation, purification and use
US5211657A (en) 1988-11-07 1993-05-18 The United States Government As Represented By The Secretary Of The Department Of Health And Human Services Laminin a chain deduced amino acid sequence, expression vectors and active synthetic peptides
FR2640628A1 (fr) 1988-12-16 1990-06-22 Commissariat Energie Atomique Oligosaccharides lies (beta)-(1 -> 6) en particulier des 2-acetamido-2-desoxy-glucoses ou - galactoses et leur preparation
AU640118B2 (en) 1988-12-19 1993-08-19 De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezonheid En Cultuur Meningococcal class 1 outer-membrane protein vaccine
US5133974A (en) 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US5571511A (en) 1990-10-22 1996-11-05 The U.S. Government Broadly reactive opsonic antibodies that react with common staphylococcal antigens
WO1993001276A1 (en) 1991-07-12 1993-01-21 Smithkline Beecham Corporation Continuous cell line and vaccine against avian coccidia
EP0648127B1 (en) 1991-11-22 2003-04-16 Univax Biologics Incorporated Type i surface antigens associated with staphylococcus epidermidis
US5407686A (en) 1991-11-27 1995-04-18 Sidmak Laboratories, Inc. Sustained release composition for oral administration of active ingredient
US5872215A (en) * 1991-12-02 1999-02-16 Medical Research Council Specific binding members, materials and methods
ATE156368T1 (de) 1991-12-06 1997-08-15 North Shore Univ Hospital Verfahren zum vermindern von durch medizinische vorrichtungen bedingten infektionen
PT635132E (pt) 1992-03-19 2001-03-30 Henry M Jackson Found Advanc M Anticorpos opsonicos amplamente reactivos que reagem com antigenios de estafilococos comuns
US5688516A (en) 1992-11-12 1997-11-18 Board Of Regents, The University Of Texas System Non-glycopeptide antimicrobial agents in combination with an anticoagulant, an antithrombotic or a chelating agent, and their uses in, for example, the preparation of medical devices
US5362754A (en) 1992-11-12 1994-11-08 Univ. Of Tx Md Anderson Cancer Center M-EDTA pharmaceutical preparations and uses thereof
CA2153661A1 (en) 1993-01-12 1994-07-21 Anthony George Gristina Methods and compositions for the direct concentrated delivery of passive immunity
US5718694A (en) 1993-11-09 1998-02-17 The Board Of Regents Of The University Of Nebraska Inhibition of adherence of microorganisms to biomaterial surfaces by treatment with carbohydrates
US5858350A (en) 1993-12-01 1999-01-12 Marine Polymer Technologies Methods and compositions for poly-β-1→4-N-acetylglucosamine cell therapy system
AU710504B2 (en) 1994-03-15 1999-09-23 Brown University Research Foundation Polymeric gene delivery system
CZ292061B6 (cs) * 1994-03-17 2003-07-16 Merck Patent Gmbh Jednořetězcové fragmenty protilátek a protilátky proti receptoru epidermálního růstového faktoru, způsob jejich přípravy a farmaceutický prostředek, který je obsahuje
US5945311A (en) 1994-06-03 1999-08-31 GSF--Forschungszentrumfur Umweltund Gesundheit Method for producing heterologous bi-specific antibodies
JPH0840932A (ja) 1994-07-29 1996-02-13 Kitasato Inst:The スタフイロコッカス属菌感染症の予防ワクチン及び治療用抗体並びにそれの製造法
US5736152A (en) 1995-10-27 1998-04-07 Atrix Laboratories, Inc. Non-polymeric sustained release delivery system
US5830539A (en) 1995-11-17 1998-11-03 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Methods for functionalizing and coating substrates and devices made according to the methods
US6245735B1 (en) 1996-07-29 2001-06-12 The Brigham And Women's Hospital, Inc. Methods and products for treating pseudomonas infection
EP0826696B1 (de) 1996-09-03 2002-05-29 GSF-Forschungszentrum für Umwelt und Gesundheit GmbH Verwendung bi-und trispezifischer Antikörper zur Induktion einer Tumorimmunität
RU2198220C2 (ru) * 1996-09-26 2003-02-10 Чугаи Сейяку Кабусики Кайся Антитело против белка, родственного паращитовидному гормону человека, днк, вектор, способ получения и использование антитела
US6235883B1 (en) * 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
TW586934B (en) 1997-05-19 2004-05-11 Sumitomo Pharma Immunopotentiating composition
WO1999008705A1 (en) 1997-08-20 1999-02-25 Brigham And Women's Hospital Capsular polysaccharides from enterococci
IT1298539B1 (it) 1998-02-03 2000-01-12 Bracco Spa Metodo per la determinazione di infezioni da protesi
EP1068312A2 (en) * 1998-04-09 2001-01-17 Genset 5' ests and encoded human proteins
AU4919699A (en) 1998-07-11 2000-02-01 Mhm Holdings Limited Vehicle seat, vehicle seat table and vehicle communication system
US7252828B2 (en) 1998-07-15 2007-08-07 The Brigham And Women's Hospital, Inc. Polysaccharide vaccine for staphylococcal infections
AU771563C (en) * 1998-07-15 2004-10-28 Brigham And Women's Hospital Polysaccharide vaccine for staphylococcal infections
EP1140229B1 (en) 1998-12-16 2010-10-06 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Acidic superabsorbent polysaccharides
AU2002309567A1 (en) * 2001-05-16 2002-12-03 The Children's Hospital Of Philadelphia Dna-antibody complexes to enhance gene transfer
AU2002303832A1 (en) 2001-05-21 2002-12-03 Beth Israel Deaconess Medical Center, Inc. P.aeruginosa mucoid exopolysaccharide specific binding peptides
US7119172B2 (en) 2001-05-21 2006-10-10 The Brigham And Women's Hospital, Inc. P. aeruginosa mucoid exopolysaccharide specific binding peptides
EP1461082A4 (en) 2001-12-03 2006-06-28 Abgenix Inc ANTIBODIES AGAINST THE TUMOR ANTIGEN OF CARBON IX ANHYDRASE (CA IX)
JP2005532415A (ja) 2001-12-11 2005-10-27 メルク　エンド　カムパニー　インコーポレーテッド スタフィロコッカス・アウレウスエキソポリサッカライド及び方法
CA2471849A1 (en) * 2001-12-28 2003-07-17 Abgenix, Inc. Antibodies against the muc18 antigen
KR100708398B1 (ko) 2002-03-22 2007-04-18 (주) 에이프로젠 인간화 항체 및 이의 제조방법
AU2003218456A1 (en) * 2002-04-01 2003-10-20 Human Genome Sciences, Inc. Antibodies that specifically bind to gmad
DE10228103A1 (de) 2002-06-24 2004-01-15 Bayer Cropscience Ag Fungizide Wirkstoffkombinationen
WO2004042407A1 (en) 2002-11-04 2004-05-21 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g-protein coupled receptor 73a (gpr73a)
AU2003290867A1 (en) * 2002-11-12 2004-06-03 The Brigham And Women's Hospital, Inc. Methods and products for treating staphylococcal infections
CN100351260C (zh) 2002-11-12 2007-11-28 布赖汉姆妇女医院 葡萄球菌感染的多糖疫苗
US7563748B2 (en) 2003-06-23 2009-07-21 Cognis Ip Management Gmbh Alcohol alkoxylate carriers for pesticide active ingredients
EP2439213B1 (en) 2004-04-21 2018-12-12 The Brigham and Women's Hospital, Inc. Poly-N-acetyl glucosamine (PNAG/DPNAG)-binding antibodies and methods of use thereof
US8510225B2 (en) 2004-09-01 2013-08-13 Research In Motion Limited Split channel authenticity queries in multi-party dialog
EP2410043A3 (en) 2004-12-29 2013-01-23 Hadasit Medical Research Services And Development Ltd. Stem cells culture systems
AR060188A1 (es) 2006-03-30 2008-05-28 Glaxosmithkline Biolog Sa Procedimiento de conjugacion
BRPI0916365A2 (pt) 2008-07-21 2018-05-02 Brigham & Womens Hospital Inc métodos e composições relacionados aos oligossacarídeos de glicosina beta-1,6 sintéticos
JP4951150B2 (ja) 2009-02-20 2012-06-13 有限会社メイショウ 免疫増強組成物及びそれを製造する方法
US20120189700A1 (en) 2011-01-19 2012-07-26 Zoraida Aguilar Nanoparticle Based Immunological Stimulation
CA2879592A1 (en) 2012-05-30 2013-12-05 The Brigham And Women's Hospital, Inc. Polysaccharide compositions and methods of use
US9759721B2 (en) 2013-01-22 2017-09-12 Imicroq, S.L. Rapid method for detection of pathogen

Also Published As

Publication number Publication date
US20120201833A1 (en) 2012-08-09
EP1745075A2 (en) 2007-01-24
EP2455400A1 (en) 2012-05-23
US20110274700A1 (en) 2011-11-10
CA2567748A1 (en) 2005-11-03
AU2005236068A1 (en) 2005-11-03
US20120196359A1 (en) 2012-08-02
ES2738112T3 (es) 2020-01-20
DK1745075T3 (da) 2013-06-24
EP2455401A1 (en) 2012-05-23
JP5717582B2 (ja) 2015-05-13
SI1745075T1 (sl) 2013-07-31
US20060115486A1 (en) 2006-06-01
JP2008501317A (ja) 2008-01-24
US7786255B2 (en) 2010-08-31
US8084595B2 (en) 2011-12-27
CN101001874B (zh) 2012-12-19
US8252894B2 (en) 2012-08-28
US8912314B2 (en) 2014-12-16
US20210363228A1 (en) 2021-11-25
US20190127448A1 (en) 2019-05-02
US8410249B2 (en) 2013-04-02
US10906962B2 (en) 2021-02-02
CN101001874A (zh) 2007-07-18
US20130243806A1 (en) 2013-09-19
EP1745075B1 (en) 2013-04-03
US9458227B2 (en) 2016-10-04
US8350017B2 (en) 2013-01-08
AU2005236068C1 (en) 2012-08-30
JP5080243B2 (ja) 2012-11-21
US20120201834A1 (en) 2012-08-09
US20150329620A1 (en) 2015-11-19
WO2005103084A2 (en) 2005-11-03
US20120208270A1 (en) 2012-08-16
WO2005103084A3 (en) 2006-02-16
US8461319B2 (en) 2013-06-11
EP2455400B1 (en) 2019-03-20
US20230382980A1 (en) 2023-11-30
EP2455401B1 (en) 2018-01-24
EP2455402A1 (en) 2012-05-23
JP2011224023A (ja) 2011-11-10
ES2415358T3 (es) 2013-07-25
AU2005236068B2 (en) 2012-04-26
US10017563B2 (en) 2018-07-10
EP2468769A1 (en) 2012-06-27
EP2439213A1 (en) 2012-04-11
US8435515B2 (en) 2013-05-07
PT1745075E (pt) 2013-06-17
HK1100369A1 (en) 2007-09-21
US20170226194A1 (en) 2017-08-10
EP2439213B1 (en) 2018-12-12
US20110002932A1 (en) 2011-01-06

Similar Documents

Publication Publication Date Title
HK1100369A1 (en) Poly-n-acetyl glucosamine (pnag/dpnag)-binding peptides and methods of use thereof
EP1838331A4 (en) ANTIMICROBIAL PEPTIDES AND METHODS OF USE THEREOF
GB2412589B (en) Hyperbaric dressing
ZA200600716B (en) Improvements in and to processes
IL190332A0 (en) Human antibodies against il13 and therapeutic uses
HK1092315A1 (en) Improvements in or relating to distributed radio units
IL179300A0 (en) Novel-antigen-binding polypeptides and their uses
EP1757658A4 (en) RUBBER COMPOSITION AND USE THEREOF
HK1097859A1 (en) Anti-cd38 human antibodies and uses therefor -cd38
ZA200703313B (en) Recombinant human T2 RNase and uses thereof
EP1794589A4 (en) PROTEIN ARRAYS AND METHOD OF USE THEREOF
IL178181A0 (en) Fungicidal mixtures and novel triazolopyrimidines
IL183400A0 (en) New peptides useful as dual caspase-2/-6 inhibitors and their biological applications
EP1960523A4 (en) MODIFIED POREN FORMING PROTEIN TOXINS AND USE THEREOF
TWI340752B (en) Elastomer composition and molded body
PL2215908T3 (pl) 2-alkilo-cykloalk(en)ylo-karboksamidy i ich zastosowanie jako fungicydów
EP1717272A4 (en) POLYURETHANE COMPOSITION AND MOLDED ARTICLE MADE THEREFROM
ZA200606216B (en) Modified human interferon polypeptides and their uses
GB0426161D0 (en) Protein isolation and purification
SK50812005A3 (sk) Zmesi polyuretánu a gumy
EP1931368A4 (en) ANTIMYCOTIC PEPTIDES AND METHOD OF USE THEREOF
EP1687330A4 (en) PEPTIDES WITH ANTIBODY EFFECT AND OTHER RELATED APPLICATIONS
GB0401182D0 (en) Improvements in and relating to conveyors
EP1811985A4 (en) NUTRIENT SUPPLEMENT AND USE OF SUCH SUPPLEMENT
EP1813671A4 (en) SOLUBLE PROTEIN AND USE THEREOF