NO312973B1 - Lipase-katalysert forestring av marine oljer - Google Patents

Lipase-katalysert forestring av marine oljer Download PDF

Info

Publication number: NO312973B1
Authority: NO; Norway
Prior art keywords: dha; lipase; epa; fatty acids; esterification
Prior art date: 1999-02-17

Application number

NO19990739A

Other languages

English (en)

Norwegian (no)

Other versions

NO990739D0 (no

NO990739L (no

Inventor

Gudmundur G Haraldsson

Olav Thorstad

Bjoern Kristinsson

Original Assignee

Norsk Hydro As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-02-17

Filing date

1999-02-17

Publication date

2002-07-22

1999-02-17 Application filed by Norsk Hydro As filed Critical Norsk Hydro As

1999-02-17 Priority to NO19990739A priority Critical patent/NO312973B1/no

1999-02-17 Publication of NO990739D0 publication Critical patent/NO990739D0/no

2000-02-16 Priority to DE60032337T priority patent/DE60032337T2/de

2000-02-16 Priority to ES00906778T priority patent/ES2276669T3/es

2000-02-16 Priority to EP00906778A priority patent/EP1153114B1/en

2000-02-16 Priority to AU28338/00A priority patent/AU757203B2/en

2000-02-16 Priority to JP2000599845A priority patent/JP2002537442A/ja

2000-02-16 Priority to AT00906778T priority patent/ATE348140T1/de

2000-02-16 Priority to PCT/NO2000/000056 priority patent/WO2000049117A1/en

2000-02-16 Priority to NZ513574A priority patent/NZ513574A/xx

2000-02-16 Priority to CA002362212A priority patent/CA2362212C/en

2000-02-16 Priority to US09/913,585 priority patent/US6518049B1/en

2000-08-18 Publication of NO990739L publication Critical patent/NO990739L/no

2001-08-17 Priority to ZA200106813A priority patent/ZA200106813B/en

2002-07-22 Publication of NO312973B1 publication Critical patent/NO312973B1/no

Links

238000005886 esterification reaction Methods 0.000 title claims description 36
230000032050 esterification Effects 0.000 title claims description 20
239000003921 oil Substances 0.000 title description 29
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 102
108090001060 Lipase Proteins 0.000 claims description 68
102000004882 Lipase Human genes 0.000 claims description 68
239000004367 Lipase Substances 0.000 claims description 67
235000019421 lipase Nutrition 0.000 claims description 67
238000000034 method Methods 0.000 claims description 46
235000021588 free fatty acids Nutrition 0.000 claims description 39
239000000203 mixture Substances 0.000 claims description 33
230000008569 process Effects 0.000 claims description 29
150000004665 fatty acids Chemical class 0.000 claims description 25
235000014113 dietary fatty acids Nutrition 0.000 claims description 23
229930195729 fatty acid Natural products 0.000 claims description 23
239000000194 fatty acid Substances 0.000 claims description 23
125000005456 glyceride group Chemical group 0.000 claims description 22
239000003054 catalyst Substances 0.000 claims description 13
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
150000002148 esters Chemical class 0.000 claims description 5
230000007062 hydrolysis Effects 0.000 claims description 5
238000006460 hydrolysis reaction Methods 0.000 claims description 5
238000000199 molecular distillation Methods 0.000 claims description 5
241000235402 Rhizomucor Species 0.000 claims description 2
230000008859 change Effects 0.000 claims description 2
MBMBGCFOFBJSGT-KUBAVDMBSA-N docosahexaenoic acid Natural products CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 description 74
235000020669 docosahexaenoic acid Nutrition 0.000 description 73
JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 description 68
235000020673 eicosapentaenoic acid Nutrition 0.000 description 68
235000019198 oils Nutrition 0.000 description 28
238000006243 chemical reaction Methods 0.000 description 22
239000000047 product Substances 0.000 description 17
239000012141 concentrate Substances 0.000 description 14
235000021323 fish oil Nutrition 0.000 description 14
230000000694 effects Effects 0.000 description 12
238000002474 experimental method Methods 0.000 description 9
235000020777 polyunsaturated fatty acids Nutrition 0.000 description 9
239000002253 acid Substances 0.000 description 8
239000007858 starting material Substances 0.000 description 8
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
125000004494 ethyl ester group Chemical group 0.000 description 7
241001125048 Sardina Species 0.000 description 6
235000019512 sardine Nutrition 0.000 description 6
238000000926 separation method Methods 0.000 description 6
230000008901 benefit Effects 0.000 description 5
229940013317 fish oils Drugs 0.000 description 5
230000007306 turnover Effects 0.000 description 5
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
101001003495 Pseudomonas fluorescens Lipase Proteins 0.000 description 4
101001064559 Pseudomonas fluorescens Lipase Proteins 0.000 description 4
230000000052 comparative effect Effects 0.000 description 4
230000002349 favourable effect Effects 0.000 description 4
239000003960 organic solvent Substances 0.000 description 4
238000011084 recovery Methods 0.000 description 4
235000003441 saturated fatty acids Nutrition 0.000 description 4
241000252203 Clupea harengus Species 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
241000589774 Pseudomonas sp. Species 0.000 description 3
241000235403 Rhizomucor miehei Species 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
150000007513 acids Chemical class 0.000 description 3
235000019514 herring Nutrition 0.000 description 3
125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
239000002994 raw material Substances 0.000 description 3
150000004671 saturated fatty acids Chemical class 0.000 description 3
239000000758 substrate Substances 0.000 description 3
150000003626 triacylglycerols Chemical class 0.000 description 3
LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 2
241000228245 Aspergillus niger Species 0.000 description 2
241000222175 Diutina rugosa Species 0.000 description 2
102000004190 Enzymes Human genes 0.000 description 2
108090000790 Enzymes Proteins 0.000 description 2
108010048733 Lipozyme Proteins 0.000 description 2
241001661345 Moesziomyces antarcticus Species 0.000 description 2
241000498617 Mucor javanicus Species 0.000 description 2
101000968489 Rhizomucor miehei Lipase Proteins 0.000 description 2
101000966371 Rhizopus niveus Lipase Proteins 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
239000000061 acid fraction Substances 0.000 description 2
150000001298 alcohols Chemical class 0.000 description 2
238000004458 analytical method Methods 0.000 description 2
230000009286 beneficial effect Effects 0.000 description 2
238000005194 fractionation Methods 0.000 description 2
235000019626 lipase activity Nutrition 0.000 description 2
FCCDDURTIIUXBY-UHFFFAOYSA-N lipoamide Chemical compound NC(=O)CCCCC1CCSS1 FCCDDURTIIUXBY-UHFFFAOYSA-N 0.000 description 2
239000007788 liquid Substances 0.000 description 2
229910052757 nitrogen Inorganic materials 0.000 description 2
235000020660 omega-3 fatty acid Nutrition 0.000 description 2
238000012746 preparative thin layer chromatography Methods 0.000 description 2
230000035484 reaction time Effects 0.000 description 2
238000007670 refining Methods 0.000 description 2
238000011160 research Methods 0.000 description 2
229920006395 saturated elastomer Polymers 0.000 description 2
239000002904 solvent Substances 0.000 description 2
238000010561 standard procedure Methods 0.000 description 2
238000003756 stirring Methods 0.000 description 2
238000004448 titration Methods 0.000 description 2
238000005809 transesterification reaction Methods 0.000 description 2
235000021122 unsaturated fatty acids Nutrition 0.000 description 2
150000004670 unsaturated fatty acids Chemical class 0.000 description 2
241000589540 Pseudomonas fluorescens Species 0.000 description 1
240000005384 Rhizopus oryzae Species 0.000 description 1
235000013752 Rhizopus oryzae Nutrition 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
238000004140 cleaning Methods 0.000 description 1
230000000593 degrading effect Effects 0.000 description 1
230000006866 deterioration Effects 0.000 description 1
229940090949 docosahexaenoic acid Drugs 0.000 description 1
229960005135 eicosapentaenoic acid Drugs 0.000 description 1
JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 description 1
238000001914 filtration Methods 0.000 description 1
239000012467 final product Substances 0.000 description 1
235000013305 food Nutrition 0.000 description 1
235000013350 formula milk Nutrition 0.000 description 1
238000009472 formulation Methods 0.000 description 1
239000011521 glass Substances 0.000 description 1
230000036541 health Effects 0.000 description 1
150000002632 lipids Chemical class 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
230000011987 methylation Effects 0.000 description 1
238000007069 methylation reaction Methods 0.000 description 1
235000021281 monounsaturated fatty acids Nutrition 0.000 description 1
239000012299 nitrogen atmosphere Substances 0.000 description 1
230000020477 pH reduction Effects 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
238000012545 processing Methods 0.000 description 1
BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
238000004064 recycling Methods 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
238000007127 saponification reaction Methods 0.000 description 1
239000004460 silage Substances 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
150000003509 tertiary alcohols Chemical class 0.000 description 1
108010072641 thermostable lipase Proteins 0.000 description 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
210000002268 wool Anatomy 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6434—Docosahexenoic acids [DHA]
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
- C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
- C11C3/02—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fatty acids with glycerol
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6432—Eicosapentaenoic acids [EPA]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6458—Glycerides by transesterification, e.g. interesterification, ester interchange, alcoholysis or acidolysis
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Wood Science & Technology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Oil, Petroleum & Natural Gas (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Fats And Perfumes (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO19990739A 1999-02-17 1999-02-17 Lipase-katalysert forestring av marine oljer NO312973B1 (no)

Priority Applications (12)

Application Number	Priority Date	Filing Date	Title
NO19990739A NO312973B1 (no)	1999-02-17	1999-02-17	Lipase-katalysert forestring av marine oljer
US09/913,585 US6518049B1 (en)	1999-02-17	2000-02-16	Lipase-catalysed esterification of marine oil
AT00906778T ATE348140T1 (de)	1999-02-17	2000-02-16	Lipasekatalysierte veresterung von fischoel
ES00906778T ES2276669T3 (es)	1999-02-17	2000-02-16	Esterificacion de aceite marino catalizada por lipasa.
EP00906778A EP1153114B1 (en)	1999-02-17	2000-02-16	Lipase-catalysed esterification of marine oil
AU28338/00A AU757203B2 (en)	1999-02-17	2000-02-16	Lipase-catalysed esterification of marine oil
JP2000599845A JP2002537442A (ja)	1999-02-17	2000-02-16	海産油のリパーゼ触媒したエステル化
DE60032337T DE60032337T2 (de)	1999-02-17	2000-02-16	Lipasekatalysierte veresterung von fischoelen
PCT/NO2000/000056 WO2000049117A1 (en)	1999-02-17	2000-02-16	Lipase-catalysed esterification of marine oil
NZ513574A NZ513574A (en)	1999-02-17	2000-02-16	Lipase-catalysed esterification of marine oil
CA002362212A CA2362212C (en)	1999-02-17	2000-02-16	Lipase-catalysed esterification of marine oil
ZA200106813A ZA200106813B (en)	1999-02-17	2001-08-17	Lipase-catalysed esterification of marine oil.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
NO19990739A NO312973B1 (no)	1999-02-17	1999-02-17	Lipase-katalysert forestring av marine oljer

Publications (3)

Publication Number	Publication Date
NO990739D0 NO990739D0 (no)	1999-02-17
NO990739L NO990739L (no)	2000-08-18
NO312973B1 true NO312973B1 (no)	2002-07-22

Family

ID=19902972

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19990739A NO312973B1 (no)	1999-02-17	1999-02-17	Lipase-katalysert forestring av marine oljer

Country Status (12)

Country	Link
US (1)	US6518049B1 (es)
EP (1)	EP1153114B1 (es)
JP (1)	JP2002537442A (es)
AT (1)	ATE348140T1 (es)
AU (1)	AU757203B2 (es)
CA (1)	CA2362212C (es)
DE (1)	DE60032337T2 (es)
ES (1)	ES2276669T3 (es)
NO (1)	NO312973B1 (es)
NZ (1)	NZ513574A (es)
WO (1)	WO2000049117A1 (es)
ZA (1)	ZA200106813B (es)

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JP2002293774A (ja) *	2001-03-29	2002-10-09	Kuraray Co Ltd	５−（メタ）アクリロイルオキシ−２，６−ノルボルナンカルボラクトンの製造方法
EP2295529B2 (en) *	2002-07-11	2022-05-18	Basf As	Use of a volatile environmental pollutants-decreasing working fluid for decreasing the amount of pollutants in a fat for alimentary or cosmetic use
SE0202188D0 (sv) *	2002-07-11	2002-07-11	Pronova Biocare As	A process for decreasing environmental pollutants in an oil or a fat, a volatile fat or oil environmental pollutants decreasing working fluid, a health supplement, and an animal feed product
NO319194B1 (no) *	2002-11-14	2005-06-27	Pronova Biocare As	Lipase-katalysert forestringsfremgangsmate av marine oljer
WO2005084129A2 (en) *	2004-03-04	2005-09-15	Htl High-Tech Lipids Ltd.	Structured triglycerides and emulsions comprising same
DE102004015781A1 (de) *	2004-03-31	2005-10-20	Cognis Ip Man Gmbh	Verfahren zur enzymatischen Synthese von Triglyceriden ungesättigter Fettsäuren
US20060135610A1 (en) *	2004-12-22	2006-06-22	Bortz Jonathan D	Cardiovascular compositions
CA2609341C (en) *	2005-05-23	2011-10-04	Natural Asa	Concentration of fatty acid alkyl esters by enzymatic reactions with glycerol
ES2559959T3 (es) *	2005-06-16	2016-02-16	Dsm Nutritional Products Ag	Enzimas inmovilizadas y métodos para usar las mismas
ES2292341B1 (es) *	2006-03-13	2009-03-16	Universidad De Almeria	"procedimiento para la purificacion de acido eicosapentaenoico (epa)".
EP1978102B1 (de) *	2007-04-02	2010-07-07	Cognis IP Management GmbH	Ein Gemisch enthaltend Fettsäureglyceride
EP1978101A1 (de)	2007-04-02	2008-10-08	Cognis IP Management GmbH	Verfahren zur Anreicherung mehrfach ungesättigter Fettsäuren
JP2008278781A (ja) *	2007-05-09	2008-11-20	Osaka City	２位よりも１，３位のｄｈａ含有率が高いトリアシルグリセロールの製造方法
CL2008002020A1 (es)	2007-07-12	2008-11-14	Ocean Nutrition Canada Ltd	Metodo de modificacion de un aceite, que comprende hidrolizar gliceridos con una solucion de lipasa thermomyces lanuginosus, separar la fraccion de acido graso saturado de la fraccion de glicerido hidrolizado y esterificar los gliceridos hidrolizados en la presencia de candida antarctica lipasa b; y composicion de aceite.
KR101357298B1 (ko) *	2008-06-20	2014-01-28	에이케이 앤 엠엔 바이오팜 주식회사	오메가-3계 고도불포화 지방산의 고순도 정제방법
DK2349250T3 (en)	2008-10-31	2017-07-03	Lipid Pharmaceuticals Ehf	Fatty acids for use as a medicament
US8362080B2 (en)	2008-12-18	2013-01-29	Baylor College Of Medicine	Increasing glutathione levels for therapy
WO2011067666A1 (en)	2009-12-03	2011-06-09	Blt Berg Lipidtech As	Processes to generate compositions of enriched fatty acids
ES2862980T3 (es)	2009-12-30	2021-10-08	Basf Pharma Callanish Ltd	Composiciones de ácido graso poliinsaturado obtenibles mediante un proceso de separación cromatográfica en lecho móvil simulado
WO2012095749A1 (en)	2011-01-14	2012-07-19	Pharma Marine As	Removal of monoglycerides from fatty acid concentrates
GB201111595D0 (en)	2011-07-06	2011-08-24	Equateq Ltd	Improved process
GB201111594D0 (en)	2011-07-06	2011-08-24	Equateq Ltd	New improved process
GB201111591D0 (en)	2011-07-06	2011-08-24	Equateq Ltd	Further new process
GB201111589D0 (en)	2011-07-06	2011-08-24	Equateq Ltd	New modified process
GB201111601D0 (en)	2011-07-06	2011-08-24	Equateq Ltd	New process
WO2013035113A1 (en)	2011-09-06	2013-03-14	Lipid Pharmaceuticals Ehf.	Coated suppositories
SI2800563T1 (sl)	2012-01-06	2018-11-30	Omthera Pharmaceuticals Inc.	Z DPA obogateni sestavki omega-3 polinenasičenih maščobnih kislin v obliki proste kisline
EP2846779A4 (en)	2012-05-07	2015-12-16	Omthera Pharmaceuticals Inc	STATIN AND OMEGA-3 FATTY ACID COMPOSITIONS
GB201300354D0 (en)	2013-01-09	2013-02-20	Basf Pharma Callanish Ltd	Multi-step separation process
US8802880B1 (en)	2013-05-07	2014-08-12	Group Novasep	Chromatographic process for the production of highly purified polyunsaturated fatty acids
US9428711B2 (en)	2013-05-07	2016-08-30	Groupe Novasep	Chromatographic process for the production of highly purified polyunsaturated fatty acids
EP3118186B1 (fr)	2013-12-11	2022-02-09	Novasep Process	Installation chromatographique de production d acides gras polyinsatures
US10975031B2 (en)	2014-01-07	2021-04-13	Novasep Process	Method for purifying aromatic amino acids
US10722542B2 (en)	2016-06-16	2020-07-28	Ambo Innovations, Llc	Non-winterized, standardized marine source oil products and methods of making thereof

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JPH02303492A (ja)	1989-05-19	1990-12-17	Nippon Oil & Fats Co Ltd	長鎖高度不飽和脂肪酸グリセリドの濃縮法
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JPH07203979A (ja)	1994-01-25	1995-08-08	Maruha Corp	高度不飽和脂肪酸グリセリドの製造方法
GB9404483D0 (en) *	1994-03-08	1994-04-20	Norsk Hydro As	Refining marine oil compositions
WO1996037586A1 (en) *	1995-05-24	1996-11-28	Loders Croklaan B.V.	Production method for fats with long chain polyunsaturated fatty acids
AU6610996A (en) *	1995-05-24	1996-12-11	Loders Croklaan B.V.	Production of materials high in long chain polyunsaturated f atty acids
WO1998018952A1 (fr)	1996-10-30	1998-05-07	Nippon Suisan Kaisha, Ltd.	Procede de production de matieres grasses contenant des acides gras hautement insatures contenant eux-memes un acide docosahexaenoique a concentration selective

1999
- 1999-02-17 NO NO19990739A patent/NO312973B1/no not_active IP Right Cessation
2000
- 2000-02-16 AT AT00906778T patent/ATE348140T1/de not_active IP Right Cessation
- 2000-02-16 EP EP00906778A patent/EP1153114B1/en not_active Expired - Lifetime
- 2000-02-16 DE DE60032337T patent/DE60032337T2/de not_active Expired - Lifetime
- 2000-02-16 CA CA002362212A patent/CA2362212C/en not_active Expired - Lifetime
- 2000-02-16 WO PCT/NO2000/000056 patent/WO2000049117A1/en active IP Right Grant
- 2000-02-16 AU AU28338/00A patent/AU757203B2/en not_active Ceased
- 2000-02-16 ES ES00906778T patent/ES2276669T3/es not_active Expired - Lifetime
- 2000-02-16 JP JP2000599845A patent/JP2002537442A/ja active Pending
- 2000-02-16 US US09/913,585 patent/US6518049B1/en not_active Expired - Lifetime
- 2000-02-16 NZ NZ513574A patent/NZ513574A/xx unknown
2001
- 2001-08-17 ZA ZA200106813A patent/ZA200106813B/en unknown

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Publication number	Publication date
JP2002537442A (ja)	2002-11-05
ES2276669T3 (es)	2007-07-01
NZ513574A (en)	2002-12-20
EP1153114B1 (en)	2006-12-13
CA2362212A1 (en)	2000-08-24
AU757203B2 (en)	2003-02-06
NO990739D0 (no)	1999-02-17
EP1153114A1 (en)	2001-11-14
NO990739L (no)	2000-08-18
CA2362212C (en)	2009-10-27
DE60032337T2 (de)	2007-07-12
ATE348140T1 (de)	2007-01-15
DE60032337D1 (de)	2007-01-25
AU2833800A (en)	2000-09-04
WO2000049117A1 (en)	2000-08-24
US6518049B1 (en)	2003-02-11
ZA200106813B (en)	2002-08-19

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