NO20091562L - 2-aryl-6-fenylimidazol{1,2-alpha}pyridin derivater, femstilling derav samt terapeutisk anvendelse derav - Google Patents

2-aryl-6-fenylimidazol{1,2-alpha}pyridin derivater, femstilling derav samt terapeutisk anvendelse derav

Info

Publication number
NO20091562L
NO20091562L NO20091562A NO20091562A NO20091562L NO 20091562 L NO20091562 L NO 20091562L NO 20091562 A NO20091562 A NO 20091562A NO 20091562 A NO20091562 A NO 20091562A NO 20091562 L NO20091562 L NO 20091562L
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NO
Norway
Prior art keywords
optionally substituted
aryl
cycloalkyl
phenylimidazole
alpha
Prior art date
Application number
NO20091562A
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English (en)
Inventor
Antonio Garcia Almario
Patrick A C Lardenois
Anne Olivier
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Sanofi Aventis
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Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of NO20091562L publication Critical patent/NO20091562L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Det beskrives derivater med den generelle formel (I) der R1 er en fenylgruppe eller en naftylgruppe og der disse to grupper eventuelt kan være substituert; R1 og R3 uavhengig, av hverandre er et hydrogenatom, en (C1-C6)alkyl, (C3-C7)sykloalkyl eller, (C3-C7)sykloalkyl, (C1-C3)alkylengruppe, som eventuelt er substituert; en eventuelt substituert arylgruppe, R4 er et hydrogenatom, en (C1-C6)alkyl, (C3-C7)sykloalkyl, eller, (C3-C7)sykloalkyl, (C1-C3)alkylengruppe, som eventuelt er substituert; en arylgruppe som eventuelt er substituert med en eller flere substituenter i form av en base eller et addisjonssalt med syre.
NO20091562A 2006-09-22 2009-04-20 2-aryl-6-fenylimidazol{1,2-alpha}pyridin derivater, femstilling derav samt terapeutisk anvendelse derav NO20091562L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0608350A FR2906250B1 (fr) 2006-09-22 2006-09-22 Derives de 2-aryl-6phenyl-imidazo(1,2-a) pyridines, leur preparation et leur application en therapeutique
PCT/FR2007/001517 WO2008034974A1 (fr) 2006-09-22 2007-09-19 DERIVES DE 2-ARYL-6-PHENYL-IMIDAZO[1,2-α]PYRIDINES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Publications (1)

Publication Number Publication Date
NO20091562L true NO20091562L (no) 2009-04-20

Family

ID=37841968

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20091562A NO20091562L (no) 2006-09-22 2009-04-20 2-aryl-6-fenylimidazol{1,2-alpha}pyridin derivater, femstilling derav samt terapeutisk anvendelse derav

Country Status (44)

Country Link
US (1) US7915284B2 (no)
EP (1) EP2069342B1 (no)
JP (1) JP5336378B2 (no)
KR (1) KR101470039B1 (no)
CN (1) CN101516881B (no)
AR (1) AR062897A1 (no)
AT (1) ATE467633T1 (no)
AU (1) AU2007298856B2 (no)
BR (1) BRPI0718517A2 (no)
CA (1) CA2662848C (no)
CL (1) CL2007002733A1 (no)
CO (1) CO6160308A2 (no)
CR (1) CR10643A (no)
CY (1) CY1110232T1 (no)
DE (1) DE602007006525D1 (no)
DK (1) DK2069342T3 (no)
EA (1) EA017442B1 (no)
ES (1) ES2345016T3 (no)
FR (1) FR2906250B1 (no)
GT (1) GT200900049A (no)
HK (1) HK1135388A1 (no)
HN (1) HN2009000502A (no)
HR (1) HRP20100408T1 (no)
IL (1) IL197352A (no)
JO (1) JO2643B1 (no)
MA (1) MA30792B1 (no)
ME (1) ME00615B (no)
MX (1) MX2009002802A (no)
MY (1) MY145603A (no)
NI (1) NI200900037A (no)
NO (1) NO20091562L (no)
NZ (1) NZ575337A (no)
PE (1) PE20080671A1 (no)
PL (1) PL2069342T3 (no)
PT (1) PT2069342E (no)
RS (1) RS51412B (no)
SI (1) SI2069342T1 (no)
SV (1) SV2009003193A (no)
TN (1) TN2009000081A1 (no)
TW (1) TWI381837B (no)
UA (1) UA95976C2 (no)
UY (1) UY30603A1 (no)
WO (1) WO2008034974A1 (no)
ZA (1) ZA200901551B (no)

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FR2928923B1 (fr) 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 2-heteroaryl-6-phenyl-imidazo °1,2-a!pyridines, leur preparation et leur application en therapeutiques
FR2928922B1 (fr) 2008-03-21 2010-04-23 Sanofi Aventis Derives de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines polysubstitues, leur preparation et leur application en therapeutique
FR2928921B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines, leur preparation et leur application en therapeutique
FR2928924B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique
FR2933609B1 (fr) 2008-07-10 2010-08-27 Fournier Lab Sa Utilisation de derives d'indole comme activateurs de nurr-1, pour le traitement de la maladie de parkinson.
FR2950345B1 (fr) * 2009-09-18 2011-09-23 Sanofi Aventis Derives acetyleniques de 5-phenyl-pyrazolopyridine, leur preparation et leur application en therapeutique
FR2950344B1 (fr) * 2009-09-18 2011-11-25 Sanofi Aventis Derives de 5-phenyl-pyrazolopyridine, leur preparation et leur aplication en therapeutique.
FR2953520B1 (fr) 2009-12-04 2011-11-25 Sanofi Aventis Derives de diphenyl-pyrazolopyridines, leur preparation et leur application en therapeutique
MX2015006513A (es) * 2012-11-29 2015-08-14 Hoffmann La Roche Derivados de imidazopiridina.
TWI644899B (zh) 2013-02-04 2018-12-21 健生藥品公司 Ｆｌａｐ調節劑
EP3495359A1 (en) 2013-02-04 2019-06-12 Janssen Pharmaceutica NV Flap modulators
EP3027615B1 (en) * 2013-08-02 2021-07-21 Institut Pasteur Korea Anti-infective compounds
KR20170137165A (ko) 2015-04-10 2017-12-12 베이진 엘티디 인돌아민 및/또는 트립토판 2,3-디옥시게나아제로서 신규한 5 또는 8-치환된 이미다조[1,5-a]피리딘
TW201718581A (zh) 2015-10-19 2017-06-01 英塞特公司 作為免疫調節劑之雜環化合物
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PE20230731A1 (es) 2015-12-22 2023-05-03 Incyte Corp Compuestos heterociclicos como inmunomoduladores
TW201808950A (zh) 2016-05-06 2018-03-16 英塞特公司 作為免疫調節劑之雜環化合物
ES2905980T3 (es) 2016-05-26 2022-04-12 Incyte Corp Compuestos heterocíclicos como inmunomoduladores
PT3472167T (pt) 2016-06-20 2022-11-11 Incyte Corp Compostos heterocíclicos como imunomoduladores
EP3484866B1 (en) 2016-07-14 2022-09-07 Incyte Corporation Heterocyclic compounds as immunomodulators
EP3504198B1 (en) 2016-08-29 2023-01-25 Incyte Corporation Heterocyclic compounds as immunomodulators
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KR102641030B1 (ko) 2016-12-22 2024-02-29 인사이트 코포레이션 Pd-l1 내재화 유도제로서의 테트라하이드로 이미다조[4,5-c]피리딘 유도체
US20180179179A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Heterocyclic compounds as immunomodulators
WO2018119236A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Triazolo[1,5-a]pyridine derivatives as immunomodulators
CA3047986A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Benzooxazole derivatives as immunomodulators
US11472788B2 (en) 2017-11-25 2022-10-18 Beigene, Ltd. Benzoimidazoles as selective inhibitors of indoleamine 2,3-dioxygenases
FI3774791T3 (fi) 2018-03-30 2023-03-21 Incyte Corp Heterosyklisiä yhdisteitä immunomodulaattoreina
EP3790877B1 (en) 2018-05-11 2023-03-01 Incyte Corporation Tetrahydro-imidazo[4,5-c]pyridine derivatives as pd-l1 immunomodulators
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BR112022005826A2 (pt) 2019-09-30 2022-06-21 Incyte Corp Compostos de pirido[3,2-d]pirimidina como imunomoduladores
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Also Published As

Publication number Publication date
AU2007298856B2 (en) 2012-08-09
BRPI0718517A2 (pt) 2013-11-19
HN2009000502A (es) 2011-07-11
RS51412B (en) 2011-02-28
SI2069342T1 (sl) 2010-09-30
MEP10709A (en) 2011-12-20
NI200900037A (es) 2014-02-20
CN101516881B (zh) 2012-07-18
JO2643B1 (en) 2012-06-17
HRP20100408T1 (hr) 2010-09-30
CR10643A (es) 2009-04-29
IL197352A (en) 2014-11-30
CN101516881A (zh) 2009-08-26
FR2906250A1 (fr) 2008-03-28
CA2662848C (fr) 2014-12-23
US7915284B2 (en) 2011-03-29
ES2345016T3 (es) 2010-09-13
DK2069342T3 (da) 2010-08-23
MX2009002802A (es) 2009-04-01
DE602007006525D1 (de) 2010-06-24
HK1135388A1 (no) 2010-06-04
CY1110232T1 (el) 2015-01-14
CO6160308A2 (es) 2010-05-20
TN2009000081A1 (en) 2010-08-19
JP5336378B2 (ja) 2013-11-06
ATE467633T1 (de) 2010-05-15
UA95976C2 (en) 2011-09-26
SV2009003193A (es) 2010-02-01
MY145603A (en) 2012-03-15
PE20080671A1 (es) 2008-07-14
PT2069342E (pt) 2010-07-19
ME00615B (me) 2011-12-20
KR101470039B1 (ko) 2014-12-05
IL197352A0 (en) 2009-12-24
CA2662848A1 (fr) 2008-03-27
NZ575337A (en) 2011-12-22
MA30792B1 (fr) 2009-10-01
KR20090054449A (ko) 2009-05-29
TW200833329A (en) 2008-08-16
ZA200901551B (en) 2010-06-30
AU2007298856A1 (en) 2008-03-27
EP2069342A1 (fr) 2009-06-17
EA017442B1 (ru) 2012-12-28
EP2069342B1 (fr) 2010-05-12
CL2007002733A1 (es) 2008-04-11
EA200970311A1 (ru) 2009-08-28
JP2010504309A (ja) 2010-02-12
FR2906250B1 (fr) 2008-10-31
AR062897A1 (es) 2008-12-10
WO2008034974A1 (fr) 2008-03-27
US20090253735A1 (en) 2009-10-08
PL2069342T3 (pl) 2010-10-29
GT200900049A (es) 2010-03-04
TWI381837B (zh) 2013-01-11
UY30603A1 (es) 2008-05-02

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