EA201070818A1 - ПРОИЗВОДНЫЕ N-ГЕТЕРОЦИКЛИЧЕСКИХ-6-ГЕТЕРОЦИКЛИЧЕСКИХ-ИМИДАЗО[1,2a]ПИРИДИН-2-КАРБОКСАМИДОВ, ИХ ПОЛУЧЕНИЕ И ИХ ПРИМЕНЕНИЕ В ТЕРАПИИ - Google Patents
ПРОИЗВОДНЫЕ N-ГЕТЕРОЦИКЛИЧЕСКИХ-6-ГЕТЕРОЦИКЛИЧЕСКИХ-ИМИДАЗО[1,2a]ПИРИДИН-2-КАРБОКСАМИДОВ, ИХ ПОЛУЧЕНИЕ И ИХ ПРИМЕНЕНИЕ В ТЕРАПИИInfo
- Publication number
- EA201070818A1 EA201070818A1 EA201070818A EA201070818A EA201070818A1 EA 201070818 A1 EA201070818 A1 EA 201070818A1 EA 201070818 A EA201070818 A EA 201070818A EA 201070818 A EA201070818 A EA 201070818A EA 201070818 A1 EA201070818 A1 EA 201070818A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- heterocyclic
- therapy
- group
- carboxamides
- imidazo
- Prior art date
Links
- 238000002560 therapeutic procedure Methods 0.000 title abstract 2
- IBBMAWULFFBRKK-UHFFFAOYSA-N picolinamide Chemical class NC(=O)C1=CC=CC=N1 IBBMAWULFFBRKK-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 229910003827 NRaRb Inorganic materials 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/22—Tin compounds
- C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Addiction (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Соединения формулы (I)где Х означает гетероциклическую группу, в случае необходимости замещенную; Rозначает атом водорода, атом галогена, (C-С)алкосигруппу, (C-С)алкилгруппу, аминогруппу или NRaRb; Rозначает гетероциклическую или гетероароматическую группу, в случае необходимости замещенную; Rозначает атом водорода; (C-C)алкилгруппу, (C-C)алкосигруппу или атом галогена; Rозначает атом водорода, (C-С)алкилгруппу, (C-С)алкоксигруппу или атом фтора, в виде основания или соли присоединения с кислотой. Применение в терапии.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0800006A FR2925904B1 (fr) | 2008-01-02 | 2008-01-02 | DERIVES DE N-HETEROCYCLIQUE-6-HETEROCYCLIQUE-IMIDAZO°1,2-a! PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
PCT/FR2008/001838 WO2009106751A2 (fr) | 2008-01-02 | 2008-12-31 | Dérivés de n-heterocyclique-6-heterocyclique-imidazo[1,2- a]pyridiνe-2-carb0xamides, leur préparation et leur application en thérapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201070818A1 true EA201070818A1 (ru) | 2011-02-28 |
Family
ID=39768560
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201070818A EA201070818A1 (ru) | 2008-01-02 | 2008-12-31 | ПРОИЗВОДНЫЕ N-ГЕТЕРОЦИКЛИЧЕСКИХ-6-ГЕТЕРОЦИКЛИЧЕСКИХ-ИМИДАЗО[1,2a]ПИРИДИН-2-КАРБОКСАМИДОВ, ИХ ПОЛУЧЕНИЕ И ИХ ПРИМЕНЕНИЕ В ТЕРАПИИ |
Country Status (23)
Country | Link |
---|---|
US (1) | US20100317686A1 (ru) |
EP (1) | EP2225243B1 (ru) |
JP (1) | JP2011508762A (ru) |
KR (1) | KR20100103660A (ru) |
CN (1) | CN101959885A (ru) |
AR (1) | AR070075A1 (ru) |
AT (1) | ATE533767T1 (ru) |
AU (1) | AU2008351929A1 (ru) |
BR (1) | BRPI0821823A2 (ru) |
CA (1) | CA2710794A1 (ru) |
CL (1) | CL2008003929A1 (ru) |
CO (1) | CO6331311A2 (ru) |
EA (1) | EA201070818A1 (ru) |
FR (1) | FR2925904B1 (ru) |
IL (1) | IL206672A0 (ru) |
MA (1) | MA32058B1 (ru) |
MX (1) | MX2010007352A (ru) |
PA (1) | PA8810201A1 (ru) |
PE (1) | PE20091531A1 (ru) |
TW (1) | TW200936133A (ru) |
UY (1) | UY31590A1 (ru) |
WO (1) | WO2009106751A2 (ru) |
ZA (1) | ZA201004646B (ru) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2925907B1 (fr) * | 2008-01-02 | 2010-10-15 | Sanofi Aventis | DERIVES DE 2-HETEROAROYL-IMIDAZO°1,2-a!PYRIDINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
WO2012147890A1 (ja) * | 2011-04-27 | 2012-11-01 | 持田製薬株式会社 | 新規アゾール誘導体 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004103991A1 (fr) * | 2003-05-20 | 2004-12-02 | 'chemical Diversity Research Institute', Ltd. | Piperidines 2-substituees, bibliotheque focalisee et composition pharmaceutique |
US7544803B2 (en) * | 2004-01-23 | 2009-06-09 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
JPWO2006088246A1 (ja) * | 2005-02-18 | 2008-07-10 | 武田薬品工業株式会社 | Gpr34受容体機能調節剤 |
BRPI0608581A2 (pt) * | 2005-03-14 | 2010-01-19 | Transtech Pharma Inc | derivados de benzazol, composiÇÕes e mÉtodos de uso como inibidores de b-secretase |
TW200800997A (en) * | 2006-03-22 | 2008-01-01 | Astrazeneca Ab | Chemical compounds |
-
2008
- 2008-01-02 FR FR0800006A patent/FR2925904B1/fr not_active Expired - Fee Related
- 2008-12-23 PA PA20088810201A patent/PA8810201A1/es unknown
- 2008-12-30 CL CL2008003929A patent/CL2008003929A1/es unknown
- 2008-12-30 PE PE2008002194A patent/PE20091531A1/es not_active Application Discontinuation
- 2008-12-30 AR ARP080105780A patent/AR070075A1/es unknown
- 2008-12-30 UY UY31590A patent/UY31590A1/es not_active Application Discontinuation
- 2008-12-31 KR KR1020107017145A patent/KR20100103660A/ko not_active Application Discontinuation
- 2008-12-31 JP JP2010541087A patent/JP2011508762A/ja not_active Withdrawn
- 2008-12-31 BR BRPI0821823-4A patent/BRPI0821823A2/pt not_active IP Right Cessation
- 2008-12-31 AU AU2008351929A patent/AU2008351929A1/en not_active Abandoned
- 2008-12-31 MX MX2010007352A patent/MX2010007352A/es active IP Right Grant
- 2008-12-31 CN CN2008801277673A patent/CN101959885A/zh active Pending
- 2008-12-31 TW TW097151696A patent/TW200936133A/zh unknown
- 2008-12-31 WO PCT/FR2008/001838 patent/WO2009106751A2/fr active Application Filing
- 2008-12-31 CA CA2710794A patent/CA2710794A1/fr not_active Abandoned
- 2008-12-31 AT AT08872982T patent/ATE533767T1/de active
- 2008-12-31 EA EA201070818A patent/EA201070818A1/ru unknown
- 2008-12-31 EP EP08872982A patent/EP2225243B1/fr active Active
-
2010
- 2010-06-28 IL IL206672A patent/IL206672A0/en unknown
- 2010-07-01 US US12/828,376 patent/US20100317686A1/en not_active Abandoned
- 2010-07-01 ZA ZA2010/04646A patent/ZA201004646B/en unknown
- 2010-07-02 CO CO10080869A patent/CO6331311A2/es not_active Application Discontinuation
- 2010-08-02 MA MA33056A patent/MA32058B1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
US20100317686A1 (en) | 2010-12-16 |
CO6331311A2 (es) | 2011-10-20 |
MX2010007352A (es) | 2010-08-18 |
WO2009106751A3 (fr) | 2010-02-25 |
ZA201004646B (en) | 2011-09-28 |
IL206672A0 (en) | 2010-12-30 |
KR20100103660A (ko) | 2010-09-27 |
EP2225243A2 (fr) | 2010-09-08 |
ATE533767T1 (de) | 2011-12-15 |
EP2225243B1 (fr) | 2011-11-16 |
JP2011508762A (ja) | 2011-03-17 |
UY31590A1 (es) | 2009-08-03 |
MA32058B1 (fr) | 2011-02-01 |
FR2925904A1 (fr) | 2009-07-03 |
AU2008351929A1 (en) | 2009-09-03 |
BRPI0821823A2 (pt) | 2015-06-16 |
CA2710794A1 (fr) | 2009-09-03 |
FR2925904B1 (fr) | 2010-01-01 |
PE20091531A1 (es) | 2009-10-29 |
AR070075A1 (es) | 2010-03-10 |
CL2008003929A1 (es) | 2010-01-22 |
WO2009106751A2 (fr) | 2009-09-03 |
CN101959885A (zh) | 2011-01-26 |
TW200936133A (en) | 2009-09-01 |
PA8810201A1 (es) | 2009-08-26 |
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