NO20084832L - Pyrimidinderivater som P13K-inhibitorer - Google Patents
Pyrimidinderivater som P13K-inhibitorerInfo
- Publication number
- NO20084832L NO20084832L NO20084832A NO20084832A NO20084832L NO 20084832 L NO20084832 L NO 20084832L NO 20084832 A NO20084832 A NO 20084832A NO 20084832 A NO20084832 A NO 20084832A NO 20084832 L NO20084832 L NO 20084832L
- Authority
- NO
- Norway
- Prior art keywords
- group
- alk
- unsubstituted
- alkyl
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0608264A GB0608264D0 (en) | 2006-04-26 | 2006-04-26 | Pharmaceutical compounds |
GB0608397A GB0608397D0 (en) | 2006-04-27 | 2006-04-27 | Pharmaceutical compounds |
PCT/GB2007/001504 WO2007122410A1 (fr) | 2006-04-26 | 2007-04-25 | Dérivés pyrimidiniques utilisés comme inhibiteurs de la pi3k |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20084832L true NO20084832L (no) | 2008-11-18 |
Family
ID=38110021
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20084832A NO20084832L (no) | 2006-04-26 | 2008-11-18 | Pyrimidinderivater som P13K-inhibitorer |
Country Status (15)
Country | Link |
---|---|
US (2) | US8252792B2 (fr) |
EP (1) | EP2032582A1 (fr) |
JP (1) | JP5302186B2 (fr) |
KR (1) | KR20090021155A (fr) |
AU (1) | AU2007242594A1 (fr) |
BR (1) | BRPI0710866A2 (fr) |
CA (1) | CA2650196A1 (fr) |
CR (1) | CR10369A (fr) |
EC (1) | ECSP088867A (fr) |
IL (1) | IL194755A0 (fr) |
MA (1) | MA30360B1 (fr) |
MX (1) | MX2008013582A (fr) |
NO (1) | NO20084832L (fr) |
RU (1) | RU2008141356A (fr) |
WO (1) | WO2007122410A1 (fr) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CL2007001167A1 (es) * | 2006-04-26 | 2008-01-25 | Genentech Inc | Compuestos derivados de pirimidina condensada, inhibidores de p13-quinasa; procesos para preparar los compuestos; composicion farmaceutica que los comprende; uso de los compuestos en la preparacion de medicamentos; proceso para preparar la composicion farmaceutica; y kit que incluye a la composicionfarmaceutica. |
KR101460816B1 (ko) | 2006-12-07 | 2014-11-12 | 에프. 호프만-라 로슈 아게 | 포스포이노시타이드 3-키나제 억제제 화합물 및 그의 사용 방법 |
KR101507182B1 (ko) | 2006-12-07 | 2015-03-30 | 제넨테크, 인크. | 포스포이노시타이드 3-키나제 억제제 화합물 및 그의 사용 방법 |
WO2008152390A1 (fr) * | 2007-06-12 | 2008-12-18 | F.Hoffmann-La Roche Ag | Thiazolopyrimidines et leur utilisation comme inhibiteurs de la phosphatidylinositol-3 kinase (pi3k) |
PE20140100A1 (es) | 2007-09-12 | 2014-02-12 | Genentech Inc | Combinaciones de compuestos inhibidores de fosfoinositida 3-quinasa y agentes quimioterapeuticos |
ES2399774T3 (es) | 2007-09-24 | 2013-04-03 | Genentech, Inc. | Compuestos de tiazolopirimidina inhibidores de PI3K y métodos de uso |
US8354528B2 (en) | 2007-10-25 | 2013-01-15 | Genentech, Inc. | Process for making thienopyrimidine compounds |
GB0721095D0 (en) * | 2007-10-26 | 2007-12-05 | Piramed Ltd | Pharmaceutical compounds |
KR20110046514A (ko) | 2008-07-31 | 2011-05-04 | 제넨테크, 인크. | 피리미딘 화합물, 조성물 및 사용 방법 |
EP2617414A3 (fr) | 2008-10-01 | 2013-11-06 | Novartis AG | Antagonisme lissé pour le traitement de troubles liés à la voie Hedgehog |
TWI378933B (en) | 2008-10-14 | 2012-12-11 | Daiichi Sankyo Co Ltd | Morpholinopurine derivatives |
PT2385832E (pt) | 2009-01-08 | 2015-11-02 | Curis Inc | Inibidores de fosfoinoritide 3-quinase com uma fração de ligação ao zinco |
US8158625B2 (en) | 2009-05-27 | 2012-04-17 | Genentech, Inc. | Bicyclic indole-pyrimidine PI3K inhibitor compounds selective for P110 delta, and methods of use |
CA2761445A1 (fr) | 2009-05-27 | 2010-12-02 | Genentech, Inc. | Composes pyrimidines bicycliques inhibiteurs de pi3k selectifs pour p110 delta, et procedes d'utilisation |
PE20120508A1 (es) * | 2009-06-17 | 2012-05-09 | Vertex Pharma | Inhibidores de la replicacion de los virus de la gripe |
AR077405A1 (es) | 2009-07-10 | 2011-08-24 | Sanofi Aventis | Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer |
PL2467387T3 (pl) | 2009-08-20 | 2015-08-31 | Karus Therapeutics Ltd | Tricykliczne związki heterocykliczne jako inhibitory kinazy 3-fosfoinozytydu |
CN102711766B (zh) | 2009-11-12 | 2014-06-04 | 霍夫曼-拉罗奇有限公司 | N-9-取代的嘌呤化合物、组合物和使用方法 |
JP5572715B2 (ja) | 2009-11-12 | 2014-08-13 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | N−7置換プリン及びピラゾロピリミジン化合物、組成物及び使用方法 |
NZ609448A (en) | 2010-12-16 | 2015-07-31 | Hoffmann La Roche | Tricyclic pi3k inhibitor compounds and methods of use |
UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
GB201204125D0 (en) | 2012-03-08 | 2012-04-25 | Karus Therapeutics Ltd | Compounds |
KR20160027217A (ko) | 2012-05-23 | 2016-03-09 | 에프. 호프만-라 로슈 아게 | 내배엽 및 간세포를 수득하고 사용하는 조성물 및 방법 |
US20150258127A1 (en) | 2012-10-31 | 2015-09-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for preventing antiphospholipid syndrome (aps) |
NZ707366A (en) | 2012-11-07 | 2018-11-30 | Karus Therapeutics Ltd | Novel histone deacetylase inhibitors and their use in therapy |
AU2014264370B2 (en) | 2013-05-10 | 2017-12-14 | Karus Therapeutics Ltd | Novel histone deacetylase inhibitors |
US9296727B2 (en) | 2013-10-07 | 2016-03-29 | Vertex Pharmaceuticals Incorporated | Methods of regioselective synthesis of 2,4-disubstituted pyrimidines |
SG10201804021TA (en) | 2013-11-13 | 2018-07-30 | Vertex Pharma | Methods of preparing inhibitors of influenza viruses replication |
EP3068776B1 (fr) | 2013-11-13 | 2019-05-29 | Vertex Pharmaceuticals Incorporated | Inhibiteurs de la réplication des virus de la grippe |
GB201402431D0 (en) | 2014-02-12 | 2014-03-26 | Karus Therapeutics Ltd | Compounds |
GB201419264D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
GB201419228D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
WO2016092556A1 (fr) * | 2014-12-11 | 2016-06-16 | Natco Pharma Limited | Dérivés de 7-(morpholinyl)-2-(n-pipérazinyl)méthylthiéno[2, 3-c]pyridine en tant que médicaments anticancéreux |
WO2016147543A1 (fr) | 2015-03-13 | 2016-09-22 | Ricoh Company, Ltd. | Composé électrochromique, composition électrochromique, élément électrochromique et élément d'obscurcissement électrochromique |
WO2016183116A1 (fr) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Procédés de préparation d'inhibiteurs de réplication des virus de la grippe |
JP6857617B2 (ja) | 2015-05-13 | 2021-04-14 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | インフルエンザウイルスの複製の阻害剤 |
GB201514751D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds |
GB201514754D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds |
GB201514758D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Formulation |
GB201514760D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds and method of use |
BR112018073699A2 (pt) * | 2016-05-16 | 2019-05-07 | The Board Of Regents Of The University Of Texas System | amino lipídios de sulfonamida catiônica e amino lipídios zwiteriônico anfifílicos |
EP4326276A1 (fr) * | 2021-04-21 | 2024-02-28 | Natco Pharma Ltd | Procédé amélioré pour la préparation de dérivés de 7-(morpholinyl)-2-(n-pipérazinyl)méthylthiéno[2, 3-c]pyridine |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1067123B1 (fr) | 1998-03-31 | 2011-01-19 | Kyowa Hakko Kirin Co., Ltd. | Composes heterocycliques azotes |
US6232320B1 (en) * | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
WO2001083456A1 (fr) | 2000-04-27 | 2001-11-08 | Yamanouchi Pharmaceutical Co., Ltd. | Derives d'heteroaryle condenses |
AU2003255845A1 (en) | 2002-08-22 | 2004-03-11 | Piramed Limited | Phosphadidylinositol 3,5-biphosphate inhibitors as anti-viral agents |
GB0423653D0 (en) * | 2004-10-25 | 2004-11-24 | Piramed Ltd | Pharmaceutical compounds |
CL2007001167A1 (es) * | 2006-04-26 | 2008-01-25 | Genentech Inc | Compuestos derivados de pirimidina condensada, inhibidores de p13-quinasa; procesos para preparar los compuestos; composicion farmaceutica que los comprende; uso de los compuestos en la preparacion de medicamentos; proceso para preparar la composicion farmaceutica; y kit que incluye a la composicionfarmaceutica. |
-
2007
- 2007-04-25 BR BRPI0710866-4A patent/BRPI0710866A2/pt not_active Application Discontinuation
- 2007-04-25 EP EP07732542A patent/EP2032582A1/fr not_active Withdrawn
- 2007-04-25 JP JP2009507152A patent/JP5302186B2/ja not_active Expired - Fee Related
- 2007-04-25 WO PCT/GB2007/001504 patent/WO2007122410A1/fr active Application Filing
- 2007-04-25 RU RU2008141356/04A patent/RU2008141356A/ru not_active Application Discontinuation
- 2007-04-25 KR KR1020087028890A patent/KR20090021155A/ko not_active Application Discontinuation
- 2007-04-25 CA CA002650196A patent/CA2650196A1/fr not_active Abandoned
- 2007-04-25 US US12/298,507 patent/US8252792B2/en not_active Expired - Fee Related
- 2007-04-25 AU AU2007242594A patent/AU2007242594A1/en not_active Abandoned
- 2007-04-25 MX MX2008013582A patent/MX2008013582A/es not_active Application Discontinuation
-
2008
- 2008-10-15 CR CR10369A patent/CR10369A/es not_active Application Discontinuation
- 2008-10-22 IL IL194755A patent/IL194755A0/en unknown
- 2008-10-27 MA MA31338A patent/MA30360B1/fr unknown
- 2008-11-05 EC EC2008008867A patent/ECSP088867A/es unknown
- 2008-11-18 NO NO20084832A patent/NO20084832L/no not_active Application Discontinuation
-
2012
- 2012-07-19 US US13/553,650 patent/US8697693B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ECSP088867A (es) | 2008-12-30 |
IL194755A0 (en) | 2009-08-03 |
AU2007242594A1 (en) | 2007-11-01 |
US8252792B2 (en) | 2012-08-28 |
US20100016306A1 (en) | 2010-01-21 |
MX2008013582A (es) | 2009-01-19 |
JP2009534453A (ja) | 2009-09-24 |
CR10369A (es) | 2009-01-09 |
RU2008141356A (ru) | 2010-06-10 |
EP2032582A1 (fr) | 2009-03-11 |
MA30360B1 (fr) | 2009-04-01 |
US20120283257A1 (en) | 2012-11-08 |
KR20090021155A (ko) | 2009-02-27 |
CA2650196A1 (fr) | 2007-11-01 |
WO2007122410A1 (fr) | 2007-11-01 |
US8697693B2 (en) | 2014-04-15 |
JP5302186B2 (ja) | 2013-10-02 |
BRPI0710866A2 (pt) | 2012-08-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |