NO20082877L - Forloperforbindelse til radioaktiv halogenmerket organisk forbindelse - Google Patents

Forloperforbindelse til radioaktiv halogenmerket organisk forbindelse

Info

Publication number
NO20082877L
NO20082877L NO20082877A NO20082877A NO20082877L NO 20082877 L NO20082877 L NO 20082877L NO 20082877 A NO20082877 A NO 20082877A NO 20082877 A NO20082877 A NO 20082877A NO 20082877 L NO20082877 L NO 20082877L
Authority
NO
Norway
Prior art keywords
substituent
compound
amino acid
radioactive halogen
halogen
Prior art date
Application number
NO20082877A
Other languages
English (en)
Other versions
NO341981B1 (no
Inventor
Masahito Toyama
Fumie Kurosaki
Akio Hayashi
Osamu Ito
Toshiyuki Shinmura
Arinori Harano
Original Assignee
Nihon Mediphysics Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nihon Mediphysics Co Ltd filed Critical Nihon Mediphysics Co Ltd
Publication of NO20082877L publication Critical patent/NO20082877L/no
Publication of NO341981B1 publication Critical patent/NO341981B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/307—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Det beskrives en ny organisk aminosyreforbindelse som kan benyttes som merkeforløperforbindelse for radioaktivt halogen-merkede aminosyreforbindelser inkludert [18F]FACBC, og som forhindrer at metanol er tilbake i de radioaktivt halogen-merkede aminosyreforbindelser som fremstilles derfra. Den nye organiske aminosyreforbindelsen er en forbindelse representert ved formelen: der n er et helt tall 0 eller 1 til 4; R1 er en etyl-, 1-propyl- eller isopropylsubstituent; X er en halogen substituent eller en gruppe representert ved -OR2; R2 er en rettkjedet eller forgrenet haloalkylsulfonsyresubstituent med et til 10 karbonatomer, trialkylstannylsubstituent med 3 til 12 karbonatomer, fluorosulfonsyresubstituent eller aromatisk sulfonsyresubstituent; og R3 er en beskyttende gruppe.
NO20082877A 2005-11-29 2008-06-24 Forløperforbindelse til radioaktive, halogenmerkede organiske forbindelser NO341981B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005343653 2005-11-29
PCT/JP2006/323659 WO2007063824A1 (ja) 2005-11-29 2006-11-28 放射性ハロゲン標識有機化合物の前駆体化合物

Publications (2)

Publication Number Publication Date
NO20082877L true NO20082877L (no) 2008-08-25
NO341981B1 NO341981B1 (no) 2018-03-05

Family

ID=38092157

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20082877A NO341981B1 (no) 2005-11-29 2008-06-24 Forløperforbindelse til radioaktive, halogenmerkede organiske forbindelser
NO20180010A NO20180010A1 (no) 2005-11-29 2018-01-04 Forløperforbindelse for radioaktive, halogenmerkede organiske forbindelser

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20180010A NO20180010A1 (no) 2005-11-29 2018-01-04 Forløperforbindelse for radioaktive, halogenmerkede organiske forbindelser

Country Status (17)

Country Link
US (7) US8758724B2 (no)
EP (2) EP3354639B1 (no)
JP (2) JP5635225B2 (no)
KR (3) KR101643991B1 (no)
CN (1) CN101316812A (no)
AU (1) AU2006319987B2 (no)
BR (1) BRPI0619213B8 (no)
CA (1) CA2629227C (no)
ES (1) ES2663496T3 (no)
IL (2) IL191184A (no)
NO (2) NO341981B1 (no)
NZ (1) NZ568179A (no)
PL (1) PL1978015T3 (no)
PT (1) PT1978015T (no)
RU (1) RU2428415C2 (no)
TW (1) TW200800869A (no)
WO (1) WO2007063824A1 (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2128130B1 (en) * 2006-12-27 2018-10-10 Nihon Medi-Physics Co., Ltd. Process for production of precursor compound for radioactive halogen-labeled organic compound
JP2014501702A (ja) * 2010-10-28 2014-01-23 ジーイー・ヘルスケア・リミテッド 放射性医薬品前駆体の安定化
ES2643500T3 (es) 2010-11-29 2017-11-23 Blue Earth Diagnostics Limited Preparación de precursor de PET
GB201021530D0 (en) 2010-12-20 2011-02-02 Ge Healthcare Ltd Purification of precursor compound by crystallisation
GB201021523D0 (en) 2010-12-20 2011-02-02 Ge Healthcare Ltd Process simplification for precursor compound
US9061977B2 (en) 2010-12-20 2015-06-23 Ge Healthcare Limited Purification of precursor compound by crystallisation
CA2828975C (en) * 2011-03-08 2019-07-09 Ge Healthcare Limited Preparation of a 1-amino-3-hydroxy-cyclobutane-1-carboxylic acid derivative
WO2012171941A1 (en) 2011-06-14 2012-12-20 Ge Healthcare Limited Preparation of pet precursor
WO2013011115A1 (en) 2011-07-21 2013-01-24 Ge Healthcare Limited Precursor compounds and methods for making same
CN103998065A (zh) * 2011-12-21 2014-08-20 通用电气健康护理有限公司 在柠檬酸盐缓冲液中的18F-Fluciclovine组合物
GB201411569D0 (en) 2014-06-30 2014-08-13 Ge Healthcare Ltd Novel formulation and method of synthesis
US11534494B2 (en) 2011-12-21 2022-12-27 Ge Healthcare Limited Formulation and method of synthesis
BR112017026003A2 (pt) * 2015-06-04 2018-08-14 Nihon Mediphysics Co Ltd ?agente de imagem de diagnóstico para metástase óssea precoce de câncer?
WO2017139732A1 (en) * 2016-02-12 2017-08-17 Graphic Packaging International, Inc Carton with handle
CA3055417A1 (en) * 2017-03-07 2018-09-13 Nihon Medi-Physics Co., Ltd. Radioactive fluorine-labeling precursor compound and method for producing radioactive fluorine-labeled compound using same

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US5360928A (en) * 1989-10-23 1994-11-01 Research Corporation Technologies, Inc. Synthesis and use of amino acid fluorides as peptide coupling reagents
NZ262562A (en) 1993-02-23 1996-04-26 Warner Lambert Co Preparation of solvent free pharmaceutical compositions
US5808146A (en) 1995-11-09 1998-09-15 Emory University Amino acid analogs for tumor imaging
KR100660509B1 (ko) * 1998-05-15 2006-12-22 지이 헬쓰케어 리미티드 표지된 글루타민 및 라이신 유사체
EP1311482B1 (en) 2000-08-08 2007-02-21 Ortho-McNeil Pharmaceutical, Inc. Non-imidazole aryloxypiperidines as h3 receptor ligands
JP4275407B2 (ja) 2000-10-12 2009-06-10 中外製薬株式会社 新規な結晶構造を有するエリスロマイシン誘導体及びその製造方法
CA2455598A1 (en) 2001-07-27 2003-02-13 Targesome, Inc. Lipid constructs as therapeutic and imaging agents
GB0229695D0 (en) * 2002-12-20 2003-01-29 Amersham Plc Solid-phase preparation of 18F-labelled amino acids
EP1660137A4 (en) 2003-07-31 2008-11-12 Univ St Louis SIGMA 2 RECEPTOR RADIOACTIVE TRACTORS FOR IMAGING THE STATE OF PROLIFERATION OF SOLID TUMORS
US20070036258A1 (en) 2003-09-30 2007-02-15 Osamu Ito Process for producing radioactive fluorine compound
EP1768951A4 (en) * 2004-06-17 2011-06-15 Musc Found For Res Dev NON-NATURAL AMINO ACIDS
ES2364463T3 (es) * 2005-05-23 2011-09-02 Nihon Medi-Physics Co., Ltd. Nuevo compuesto orgánico, y método para producir un compuesto orgánico marcado con halógeno radioactivo que usa el mismo.
JP2009505947A (ja) * 2005-06-23 2009-02-12 エモリー・ユニバーシティ 画像化剤
WO2007001958A2 (en) 2005-06-23 2007-01-04 Emory University Stereoselective synthesis of amino acid analogs for tumor imaging
JP4550141B2 (ja) 2006-05-11 2010-09-22 日本メジフィジックス株式会社 放射性フッ素標識有機化合物の製造方法
CN101563107B (zh) 2006-12-21 2012-07-11 日本医事物理股份有限公司 放射性诊断显像剂
EP2128130B1 (en) 2006-12-27 2018-10-10 Nihon Medi-Physics Co., Ltd. Process for production of precursor compound for radioactive halogen-labeled organic compound
TWI406674B (zh) 2007-02-13 2013-09-01 Nihon Mediphysics Co Ltd Method for manufacturing diagnostic radiographic diagnostic agents
AU2008339435B2 (en) 2007-12-19 2012-08-16 Nihon Medi-Physics Co., Ltd. Process for production of radioactive-fluorine-labeled organic compound

Also Published As

Publication number Publication date
US20160082135A1 (en) 2016-03-24
EP1978015A4 (en) 2010-08-11
RU2008126277A (ru) 2010-01-10
ES2663496T3 (es) 2018-04-13
NO20180010A1 (no) 2008-08-25
US20180256760A1 (en) 2018-09-13
AU2006319987A1 (en) 2007-06-07
TW200800869A (en) 2008-01-01
CN101316812A (zh) 2008-12-03
US10953112B2 (en) 2021-03-23
KR20130101158A (ko) 2013-09-12
EP3354639B1 (en) 2024-02-21
BRPI0619213B1 (pt) 2018-12-26
KR101608755B1 (ko) 2016-04-04
PL1978015T3 (pl) 2018-07-31
BRPI0619213B8 (pt) 2021-07-27
US20210386873A1 (en) 2021-12-16
RU2428415C2 (ru) 2011-09-10
PT1978015T (pt) 2018-03-26
TWI371439B (no) 2012-09-01
US20200282082A1 (en) 2020-09-10
JP5635225B2 (ja) 2014-12-03
US9381259B2 (en) 2016-07-05
AU2006319987B2 (en) 2012-09-06
WO2007063824A1 (ja) 2007-06-07
US20140213817A1 (en) 2014-07-31
CA2629227A1 (en) 2007-06-07
EP3354639A1 (en) 2018-08-01
US20160000944A1 (en) 2016-01-07
NZ568179A (en) 2010-06-25
KR20080071146A (ko) 2008-08-01
US10010632B2 (en) 2018-07-03
IL191184A (en) 2015-07-30
KR20140108350A (ko) 2014-09-05
JP2013177468A (ja) 2013-09-09
US8758724B2 (en) 2014-06-24
US9387266B2 (en) 2016-07-12
US11083804B2 (en) 2021-08-10
EP1978015A1 (en) 2008-10-08
JPWO2007063824A1 (ja) 2009-05-07
CA2629227C (en) 2014-02-25
EP1978015B1 (en) 2018-03-07
NO341981B1 (no) 2018-03-05
JP5684333B2 (ja) 2015-03-11
KR101643991B1 (ko) 2016-07-29
IL235029A (en) 2016-02-29
BRPI0619213A2 (pt) 2011-09-20
US20080281121A1 (en) 2008-11-13

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Legal Events

Date Code Title Description
SPCF Filing of supplementary protection certificate

Free format text: PRODUCT NAME: (18F)FACBC ELLER FLUCIKLOVIN; REG. NO/DATE: EU/1/17/1186 20170531

Spc suppl protection certif: 2018027

Filing date: 20180827

SPCG Granted supplementary protection certificate

Free format text: PRODUCT NAME: (18F)FACBC ELLER FLUCIKLOVIN; REG. NO/DATE: EU/1/17/1186 20170531

Spc suppl protection certif: 2018027

Filing date: 20180827

Extension date: 20311128