NO20180010A1 - Forløperforbindelse for radioaktive, halogenmerkede organiske forbindelser - Google Patents

Forløperforbindelse for radioaktive, halogenmerkede organiske forbindelser

Info

Publication number
NO20180010A1
NO20180010A1 NO20180010A NO20180010A NO20180010A1 NO 20180010 A1 NO20180010 A1 NO 20180010A1 NO 20180010 A NO20180010 A NO 20180010A NO 20180010 A NO20180010 A NO 20180010A NO 20180010 A1 NO20180010 A1 NO 20180010A1
Authority
NO
Norway
Prior art keywords
substituent
halogen
amino acid
compound
precursor compound
Prior art date
Application number
NO20180010A
Other languages
English (en)
Inventor
Masahito Toyama
Fumie Kurosaki
Akio Hayashi
Osamu Ito
Toshiyuki Shinmura
Arinori Harano
Original Assignee
Nihon Mediphysics Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of NO20180010A1 publication Critical patent/NO20180010A1/no
Application filed by Nihon Mediphysics Co Ltd filed Critical Nihon Mediphysics Co Ltd

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/307—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Det beskrives en ny organisk aminosyreforbindelse som kan benyttes som merkeforløperforbindelse for radioaktivt halogen-merkede aminosyreforbindelser inkludert [18F]FACBC, og som forhindrer at metanol er tilbake i de radioaktivt halogenmerkede aminosyreforbindelser som fremstilles derfra. Den nye organiske aminosyreforbindelsen er en forbindelse representert ved formelen: (I)der n er et helt tall O eller l til 4; Ri er en etyl-, 1-propyl- eller isopropylsubstituent; X er en halogen substituent eller en gruppe representert ved -OR2; R2 er en rettkjedet eller forgrenet haloalkylsulfonsyresubstituent med et til 10 karbonatomer, trialkylstannylsubstituent med 3 til 12 karbonatomer, fluorosulfonsyresubstituent eller aromatisk sulfonsyresubstituent; og R3 er en beskyttende gruppe.
NO20180010A 2005-11-29 2018-01-04 Forløperforbindelse for radioaktive, halogenmerkede organiske forbindelser NO20180010A1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005343653 2005-11-29
PCT/JP2006/323659 WO2007063824A1 (ja) 2005-11-29 2006-11-28 放射性ハロゲン標識有機化合物の前駆体化合物

Publications (1)

Publication Number Publication Date
NO20180010A1 true NO20180010A1 (no) 2008-08-25

Family

ID=38092157

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20082877A NO341981B1 (no) 2005-11-29 2008-06-24 Forløperforbindelse til radioaktive, halogenmerkede organiske forbindelser
NO20180010A NO20180010A1 (no) 2005-11-29 2018-01-04 Forløperforbindelse for radioaktive, halogenmerkede organiske forbindelser

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20082877A NO341981B1 (no) 2005-11-29 2008-06-24 Forløperforbindelse til radioaktive, halogenmerkede organiske forbindelser

Country Status (17)

Country Link
US (7) US8758724B2 (no)
EP (2) EP3354639B1 (no)
JP (2) JP5635225B2 (no)
KR (3) KR101643991B1 (no)
CN (1) CN101316812A (no)
AU (1) AU2006319987B2 (no)
BR (1) BRPI0619213B8 (no)
CA (1) CA2629227C (no)
ES (1) ES2663496T3 (no)
IL (2) IL191184A (no)
NO (2) NO341981B1 (no)
NZ (1) NZ568179A (no)
PL (1) PL1978015T3 (no)
PT (1) PT1978015T (no)
RU (1) RU2428415C2 (no)
TW (1) TW200800869A (no)
WO (1) WO2007063824A1 (no)

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EP2128130B1 (en) * 2006-12-27 2018-10-10 Nihon Medi-Physics Co., Ltd. Process for production of precursor compound for radioactive halogen-labeled organic compound
JP2014501702A (ja) * 2010-10-28 2014-01-23 ジーイー・ヘルスケア・リミテッド 放射性医薬品前駆体の安定化
ES2643500T3 (es) 2010-11-29 2017-11-23 Blue Earth Diagnostics Limited Preparación de precursor de PET
GB201021530D0 (en) 2010-12-20 2011-02-02 Ge Healthcare Ltd Purification of precursor compound by crystallisation
GB201021523D0 (en) 2010-12-20 2011-02-02 Ge Healthcare Ltd Process simplification for precursor compound
US9061977B2 (en) 2010-12-20 2015-06-23 Ge Healthcare Limited Purification of precursor compound by crystallisation
CA2828975C (en) * 2011-03-08 2019-07-09 Ge Healthcare Limited Preparation of a 1-amino-3-hydroxy-cyclobutane-1-carboxylic acid derivative
WO2012171941A1 (en) 2011-06-14 2012-12-20 Ge Healthcare Limited Preparation of pet precursor
WO2013011115A1 (en) 2011-07-21 2013-01-24 Ge Healthcare Limited Precursor compounds and methods for making same
CN103998065A (zh) * 2011-12-21 2014-08-20 通用电气健康护理有限公司 在柠檬酸盐缓冲液中的18F-Fluciclovine组合物
GB201411569D0 (en) 2014-06-30 2014-08-13 Ge Healthcare Ltd Novel formulation and method of synthesis
US11534494B2 (en) 2011-12-21 2022-12-27 Ge Healthcare Limited Formulation and method of synthesis
BR112017026003A2 (pt) * 2015-06-04 2018-08-14 Nihon Mediphysics Co Ltd ?agente de imagem de diagnóstico para metástase óssea precoce de câncer?
WO2017139732A1 (en) * 2016-02-12 2017-08-17 Graphic Packaging International, Inc Carton with handle
CA3055417A1 (en) * 2017-03-07 2018-09-13 Nihon Medi-Physics Co., Ltd. Radioactive fluorine-labeling precursor compound and method for producing radioactive fluorine-labeled compound using same

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Also Published As

Publication number Publication date
US20160082135A1 (en) 2016-03-24
EP1978015A4 (en) 2010-08-11
RU2008126277A (ru) 2010-01-10
ES2663496T3 (es) 2018-04-13
US20180256760A1 (en) 2018-09-13
AU2006319987A1 (en) 2007-06-07
TW200800869A (en) 2008-01-01
CN101316812A (zh) 2008-12-03
US10953112B2 (en) 2021-03-23
KR20130101158A (ko) 2013-09-12
EP3354639B1 (en) 2024-02-21
BRPI0619213B1 (pt) 2018-12-26
KR101608755B1 (ko) 2016-04-04
PL1978015T3 (pl) 2018-07-31
BRPI0619213B8 (pt) 2021-07-27
US20210386873A1 (en) 2021-12-16
RU2428415C2 (ru) 2011-09-10
PT1978015T (pt) 2018-03-26
TWI371439B (no) 2012-09-01
US20200282082A1 (en) 2020-09-10
JP5635225B2 (ja) 2014-12-03
US9381259B2 (en) 2016-07-05
AU2006319987B2 (en) 2012-09-06
WO2007063824A1 (ja) 2007-06-07
US20140213817A1 (en) 2014-07-31
CA2629227A1 (en) 2007-06-07
EP3354639A1 (en) 2018-08-01
US20160000944A1 (en) 2016-01-07
NZ568179A (en) 2010-06-25
KR20080071146A (ko) 2008-08-01
US10010632B2 (en) 2018-07-03
IL191184A (en) 2015-07-30
NO20082877L (no) 2008-08-25
KR20140108350A (ko) 2014-09-05
JP2013177468A (ja) 2013-09-09
US8758724B2 (en) 2014-06-24
US9387266B2 (en) 2016-07-12
US11083804B2 (en) 2021-08-10
EP1978015A1 (en) 2008-10-08
JPWO2007063824A1 (ja) 2009-05-07
CA2629227C (en) 2014-02-25
EP1978015B1 (en) 2018-03-07
NO341981B1 (no) 2018-03-05
JP5684333B2 (ja) 2015-03-11
KR101643991B1 (ko) 2016-07-29
IL235029A (en) 2016-02-29
BRPI0619213A2 (pt) 2011-09-20
US20080281121A1 (en) 2008-11-13

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