NO20072918L - Heteroaromatiske quinolinforbindelser, og anvendelse av disse som inhibitorer av PDE10 - Google Patents

Heteroaromatiske quinolinforbindelser, og anvendelse av disse som inhibitorer av PDE10

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Publication number
NO20072918L
NO20072918L NO20072918A NO20072918A NO20072918L NO 20072918 L NO20072918 L NO 20072918L NO 20072918 A NO20072918 A NO 20072918A NO 20072918 A NO20072918 A NO 20072918A NO 20072918 L NO20072918 L NO 20072918L
Authority
NO
Norway
Prior art keywords
compounds
inhibitors
pde10
quinoline compounds
heteroaromatic
Prior art date
Application number
NO20072918A
Other languages
English (en)
Other versions
NO340476B1 (no
Inventor
Patrick Robert Verhoest
Christopher John Helal
Dennis Jay Hoover
John Michael Humphrey
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of NO20072918L publication Critical patent/NO20072918L/no
Publication of NO340476B1 publication Critical patent/NO340476B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/32—Alcohol-abuse
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/36—Opioid-abuse
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
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  • Pain & Pain Management (AREA)
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  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Det beskrives heteroaromatiske forbindelser som fungerer som effektive inhibitorer av fosfodiesterase (PDE). Nærmere bestemt vedrører oppfinnelsen nevnte forbindelser som er selektive inhibitorer av PDE 10. Oppfinnelsen vedrører også mellomprodukter for fremstilling av nevnte forbindelser, farmasøytiske sammensetninger omfattende nevnte forbindelser, og anvendelse av nevnte forbindelser i en fremgangsmåte for å behandle forstyrrelser av sentralnervesystemet (CNS) eller andre forstyrrelser.
NO20072918A 2005-01-07 2007-06-07 Heteroaromatiske quinolinforbindelser, og anvendelse av disse som inhibitorer av PDE10 NO340476B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64205805P 2005-01-07 2005-01-07
PCT/IB2005/003937 WO2006072828A2 (en) 2005-01-07 2005-12-22 Heteroaromatic quinoline compounds and their use as pde10 inhibitors

Publications (2)

Publication Number Publication Date
NO20072918L true NO20072918L (no) 2007-07-05
NO340476B1 NO340476B1 (no) 2017-05-02

Family

ID=36589327

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20072918A NO340476B1 (no) 2005-01-07 2007-06-07 Heteroaromatiske quinolinforbindelser, og anvendelse av disse som inhibitorer av PDE10

Country Status (44)

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US (2) US7429665B2 (no)
EP (1) EP1841757B1 (no)
JP (1) JP4302762B2 (no)
KR (1) KR100896380B1 (no)
CN (2) CN101098866A (no)
AP (1) AP2362A (no)
AR (1) AR052863A1 (no)
AT (1) ATE472543T1 (no)
AU (1) AU2005323794B2 (no)
BR (1) BRPI0518508A2 (no)
CA (1) CA2592986C (no)
CR (1) CR9180A (no)
CU (1) CU23780B7 (no)
CY (1) CY1110746T1 (no)
DE (1) DE602005022115D1 (no)
DK (1) DK1841757T3 (no)
EA (1) EA012211B1 (no)
EG (1) EG25993A (no)
ES (1) ES2346674T3 (no)
GE (1) GEP20094623B (no)
GT (1) GT200600002A (no)
HK (1) HK1167263A1 (no)
HN (1) HN2006000668A (no)
HR (1) HRP20100461T1 (no)
IL (1) IL183851A (no)
MA (1) MA29140B1 (no)
ME (1) ME01142B (no)
MX (1) MX2007008287A (no)
MY (1) MY142052A (no)
NL (1) NL1030863C2 (no)
NO (1) NO340476B1 (no)
NZ (1) NZ555737A (no)
PE (1) PE20060873A1 (no)
PL (1) PL1841757T3 (no)
PT (1) PT1841757E (no)
RS (1) RS51385B (no)
SI (1) SI1841757T1 (no)
SV (1) SV2008002365A (no)
TN (1) TNSN07258A1 (no)
TW (1) TWI312682B (no)
UA (1) UA86283C2 (no)
UY (1) UY29324A1 (no)
WO (1) WO2006072828A2 (no)
ZA (1) ZA200705427B (no)

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