NO20074666L - Imidazo(1,2-A)pyridinforbindelser som VEGF-R2-inhibitorer - Google Patents

Imidazo(1,2-A)pyridinforbindelser som VEGF-R2-inhibitorer

Info

Publication number
NO20074666L
NO20074666L NO20074666A NO20074666A NO20074666L NO 20074666 L NO20074666 L NO 20074666L NO 20074666 A NO20074666 A NO 20074666A NO 20074666 A NO20074666 A NO 20074666A NO 20074666 L NO20074666 L NO 20074666L
Authority
NO
Norway
Prior art keywords
vegf
inhibitors
imidazo
pyridine compounds
compounds
Prior art date
Application number
NO20074666A
Other languages
English (en)
Inventor
Yvonne Yee Mai Yip
David Anthony Barda
Timothy Paul Burkholder
Joshua Ryan Clayton
Yan Hao
Perry Clark Heath
James Robert Henry
John Monte Knobeloch
David Mendel
Johnathan Alexander Mclean
David Michael Remick
Mark Edward Rempala
Zhao-Qing Wang
Boyu Zhong
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO20074666L publication Critical patent/NO20074666L/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Foreliggende oppfinnelse tilveiebringer forbindelser som er inhibitorer av VEGF-R2 med formel (I) og fremgangsmåter for anvendelse av disse forbindelsene.
NO20074666A 2005-02-24 2007-09-13 Imidazo(1,2-A)pyridinforbindelser som VEGF-R2-inhibitorer NO20074666L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65598105P 2005-02-24 2005-02-24
PCT/US2006/006283 WO2006091671A1 (en) 2005-02-24 2006-02-23 Imidazo (1, 2-a) pyridine compounds as vegf-r2 inhibitors

Publications (1)

Publication Number Publication Date
NO20074666L true NO20074666L (no) 2007-11-09

Family

ID=36587138

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20074666A NO20074666L (no) 2005-02-24 2007-09-13 Imidazo(1,2-A)pyridinforbindelser som VEGF-R2-inhibitorer

Country Status (34)

Country Link
US (1) US7666879B2 (no)
EP (1) EP1904494B1 (no)
JP (1) JP5055136B2 (no)
KR (1) KR100904938B1 (no)
CN (1) CN101128461B (no)
AR (1) AR056186A1 (no)
AT (1) ATE490254T1 (no)
AU (1) AU2006216710B2 (no)
BR (1) BRPI0609047A2 (no)
CA (1) CA2599124C (no)
CR (1) CR9331A (no)
CY (1) CY1111154T1 (no)
DE (1) DE602006018615D1 (no)
DK (1) DK1904494T3 (no)
DO (1) DOP2006000051A (no)
EA (1) EA011691B1 (no)
ES (1) ES2354716T3 (no)
HK (1) HK1118284A1 (no)
HR (1) HRP20100677T1 (no)
IL (1) IL184717A (no)
MA (1) MA29433B1 (no)
MX (1) MX2007010326A (no)
NO (1) NO20074666L (no)
NZ (2) NZ560402A (no)
PE (1) PE20061098A1 (no)
PL (1) PL1904494T3 (no)
PT (1) PT1904494E (no)
RS (1) RS51590B (no)
SI (1) SI1904494T1 (no)
TN (1) TNSN07323A1 (no)
TW (1) TW200640924A (no)
UA (1) UA91535C2 (no)
WO (1) WO2006091671A1 (no)
ZA (1) ZA200707136B (no)

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US8131527B1 (en) 2006-12-22 2012-03-06 Astex Therapeutics Ltd. FGFR pharmacophore compounds
CN101669030B (zh) 2007-03-08 2016-01-13 小利兰·斯坦福大学托管委员会 线粒体醛脱氢酶2调节剂和其使用方法
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GB0810902D0 (en) 2008-06-13 2008-07-23 Astex Therapeutics Ltd New compounds
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US8389522B2 (en) 2008-10-28 2013-03-05 The Board Of Trustees Of The Leland Stanford Junior University Modulators of aldehyde dehydrogenase and methods of use thereof
JO3265B1 (ar) 2008-12-09 2018-09-16 Novartis Ag مثبطات بيريديلوكسى اندولات vegf-r2 واستخدامها لعلاج المرض
US8278302B2 (en) 2009-04-08 2012-10-02 Boehringer Ingelheim International Gmbh Substituted piperidines as CCR3 antagonists
GB0906470D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
GB0906472D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
TW201124391A (en) 2009-10-20 2011-07-16 Lundbeck & Co As H 2-substituted-ethynylthiazole derivatives and uses of same
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UA109290C2 (uk) 2010-10-07 2015-08-10 Спільні кристали і солі інгібіторів ccr3
US10457659B2 (en) 2011-04-29 2019-10-29 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for increasing proliferation of adult salivary stem cells
AR090566A1 (es) * 2012-04-02 2014-11-19 Boehringer Ingelheim Int Proceso para la produccion de inhibidores de crr
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US9738636B2 (en) 2012-09-28 2017-08-22 Vanderbilt University Fused heterocyclic compounds as selective BMP inhibitors
KR101735975B1 (ko) * 2012-11-29 2017-05-15 에프. 호프만-라 로슈 아게 이미다조피리딘 유도체
JP6410790B2 (ja) 2013-03-14 2018-10-24 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー ミトコンドリアアルデヒドデヒドロゲナーゼ−２調節因子およびその使用方法
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CN103772308B (zh) * 2013-12-31 2015-11-18 北京颖泰嘉和生物科技股份有限公司 5-氨基-3-(1-乙基-1-甲基丙基)异噁唑中间体的制备方法和异噁草胺的制备方法
US9988371B2 (en) 2014-06-03 2018-06-05 The Arizona Board Of Regents On Behalf Of The University Of Arizona Benzimidazole analogues and related methods
KR102485100B1 (ko) 2014-07-17 2023-01-04 선샤인 레이크 파르마 컴퍼니 리미티드 치환된 우레아 유도체 및 이의 약제학적 용도
CN104163790B (zh) * 2014-08-19 2016-02-10 贵州威顿晶磷电子材料股份有限公司 一种2-氨基-4-甲基-5溴吡啶的制备工艺
US10829484B2 (en) 2015-07-28 2020-11-10 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
JP2018526452A (ja) * 2015-09-03 2018-09-13 アリゾナ ボード オブ リージェンツ オン ビハーフ オブ ザ ユニバーシティー オブ アリゾナ Ｄｙｒｋ１ａの小分子抑制剤およびその使用
WO2017161045A1 (en) * 2016-03-16 2017-09-21 Plexxikon Inc. Compounds and methods for kinase modulation and indications therefore
WO2019178383A1 (en) 2018-03-14 2019-09-19 Vanderbilt University Inhibition of bmp signaling, compounds, compositions and uses thereof
US10239885B1 (en) 2018-06-18 2019-03-26 Avista Pharma Solutions, Inc. Compound 1-[2-[4-(2-ethyl-6,8-dimethylimidazo[1,2-α]pyrazin-3-yl)phenyl]ethyl]-3-(p-tolylsulfonyl)urea as a prostaglandin EP4 receptor antagonist
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Also Published As

Publication number Publication date
MA29433B1 (fr) 2008-05-02
IL184717A (en) 2011-11-30
MX2007010326A (es) 2007-10-16
EP1904494A1 (en) 2008-04-02
CY1111154T1 (el) 2015-06-11
AR056186A1 (es) 2007-09-26
SI1904494T1 (sl) 2011-02-28
CN101128461B (zh) 2010-12-22
US20090227622A1 (en) 2009-09-10
HK1118284A1 (en) 2009-02-06
EA011691B1 (ru) 2009-04-28
BRPI0609047A2 (pt) 2010-11-16
KR100904938B1 (ko) 2009-06-29
PE20061098A1 (es) 2006-10-20
NZ584753A (en) 2011-06-30
TNSN07323A1 (en) 2008-12-31
CA2599124A1 (en) 2006-08-31
EA200701802A1 (ru) 2008-02-28
CN101128461A (zh) 2008-02-20
HRP20100677T1 (hr) 2011-01-31
KR20070099029A (ko) 2007-10-08
EP1904494B1 (en) 2010-12-01
JP5055136B2 (ja) 2012-10-24
AU2006216710A1 (en) 2006-08-31
DOP2006000051A (es) 2006-08-31
TW200640924A (en) 2006-12-01
ZA200707136B (en) 2008-11-26
ES2354716T3 (es) 2011-03-17
IL184717A0 (en) 2007-12-03
WO2006091671A1 (en) 2006-08-31
PL1904494T3 (pl) 2011-04-29
US7666879B2 (en) 2010-02-23
CR9331A (es) 2008-03-31
AU2006216710B2 (en) 2011-08-11
ATE490254T1 (de) 2010-12-15
UA91535C2 (en) 2010-08-10
DK1904494T3 (da) 2011-02-21
JP2008531574A (ja) 2008-08-14
RS51590B (en) 2011-08-31
PT1904494E (pt) 2010-12-23
NZ560402A (en) 2010-06-25
CA2599124C (en) 2013-08-06
DE602006018615D1 (de) 2011-01-13

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