NO20071245L - Kinazolinonderivater og deres anvendelse som b-RAF-inhibitorer. - Google Patents

Kinazolinonderivater og deres anvendelse som b-RAF-inhibitorer.

Info

Publication number
NO20071245L
NO20071245L NO20071245A NO20071245A NO20071245L NO 20071245 L NO20071245 L NO 20071245L NO 20071245 A NO20071245 A NO 20071245A NO 20071245 A NO20071245 A NO 20071245A NO 20071245 L NO20071245 L NO 20071245L
Authority
NO
Norway
Prior art keywords
raf inhibitors
quinazolinone derivatives
marrow
chemical compounds
relates
Prior art date
Application number
NO20071245A
Other languages
English (en)
Inventor
Paul Dermot Lyne
Brian Aquila
Timothy Pontz
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20071245L publication Critical patent/NO20071245L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Oppfinnelsen angår kjemiske forbindelser med formel (I): eller farmasøytisk akseptable salter derav, som har B-Raf-hemmende aktivitet og følgelig er anvendelige for deres anti-kreft-aktivitet og således ved metoder for behandling av mermeske- eller dyrekroppen. Oppfirmelsen angår også fremgangsmåter for fremstilling av nevnte kjemiske forbindelser, farmasøytiske preparater irmeholdende dem og anvendelse av dem ved fremstilling av medikamenter anvendelige for produksjon av en anti-kreft-efifekt hos et varmblodig dyr så som mermesker.
NO20071245A 2004-09-01 2007-03-07 Kinazolinonderivater og deres anvendelse som b-RAF-inhibitorer. NO20071245L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60653504P 2004-09-01 2004-09-01
PCT/GB2005/003336 WO2006024836A1 (en) 2004-09-01 2005-08-26 Quinazolinone derivatives and their use as b-raf inhibitors

Publications (1)

Publication Number Publication Date
NO20071245L true NO20071245L (no) 2007-05-24

Family

ID=35149373

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20071245A NO20071245L (no) 2004-09-01 2007-03-07 Kinazolinonderivater og deres anvendelse som b-RAF-inhibitorer.

Country Status (16)

Country Link
US (1) US20090054469A1 (no)
EP (1) EP1789400A1 (no)
JP (1) JP2008511600A (no)
KR (1) KR20070055575A (no)
CN (1) CN101010303A (no)
AR (1) AR050545A1 (no)
AU (1) AU2005278961A1 (no)
BR (1) BRPI0514679A (no)
CA (1) CA2577278A1 (no)
IL (1) IL181213A0 (no)
MX (1) MX2007002433A (no)
NO (1) NO20071245L (no)
TW (1) TW200621259A (no)
UY (1) UY29092A1 (no)
WO (1) WO2006024836A1 (no)
ZA (1) ZA200701366B (no)

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* Cited by examiner, † Cited by third party
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US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
DK1957461T3 (en) * 2005-11-14 2016-12-19 Genentech Inc Bisamidhæmmere the hedgehog-signalling
JP2009532450A (ja) * 2006-04-05 2009-09-10 アストラゼネカ アクチボラグ 化合物
CN101421253A (zh) * 2006-04-18 2009-04-29 阿斯利康(瑞典)有限公司 喹唑啉-4-酮衍生物、其制备方法及含有它们的药用组合物
WO2008020203A1 (en) * 2006-08-17 2008-02-21 Astrazeneca Ab Pyridinylquinaz0linamine derivatives and their use as b-raf inhibitors
MX2009003793A (es) 2006-10-09 2009-12-14 Takeda Pharmaceutical Inhibidores de cinasa.
WO2009111277A1 (en) * 2008-02-29 2009-09-11 Array Biopharma Inc. Imdizo [4. 5-b] pyridine derivatives used as raf inhibitors
JP2011513332A (ja) * 2008-02-29 2011-04-28 アレイ バイオファーマ、インコーポレイテッド 癌の治療のためのｒａｆ阻害剤としてのｎ−（６−アミノピリジン−３−イル）−３−（スルホンアミド）ベンズアミド誘導体
KR20100122505A (ko) * 2008-02-29 2010-11-22 어레이 바이오파마 인크. Ｒａｆ 저해물질 화합물 및 이들의 이용 방법
TW200940539A (en) * 2008-02-29 2009-10-01 Array Biopharma Inc RAF inhibitor compounds and methods of use thereof
US9084781B2 (en) 2008-12-10 2015-07-21 Novartis Ag MEK mutations conferring resistance to MEK inhibitors
ES2714875T3 (es) 2010-03-09 2019-05-30 Dana Farber Cancer Inst Inc Métodos de diagnóstico y tratamiento del cáncer en pacientes que presentan o desarrollan resistencia a una primera terapia del cáncer
WO2011147764A1 (en) 2010-05-28 2011-12-01 N.V. Organon Thieno (2, 3b) pyrazine compounds as b - raf inhibitors
AU2011264833B2 (en) 2010-06-09 2014-07-03 Dana-Farber Cancer Institute, Inc. A MEK 1 mutation conferring resistance to RAF and MEK inhibitors
WO2013109142A1 (en) 2012-01-16 2013-07-25 Stichting Het Nederlands Kanker Instituut Combined pdk and mapk/erk pathway inhibition in neoplasia
WO2013169858A1 (en) 2012-05-08 2013-11-14 The Broad Institute, Inc. Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy
ES2774549T3 (es) * 2013-03-13 2020-07-21 Bioasis Technologies Inc Fragmentos de P97 y usos de los mismos
WO2015041534A1 (en) 2013-09-20 2015-03-26 Stichting Het Nederlands Kanker Instituut P90rsk in combination with raf/erk/mek
US9629851B2 (en) 2013-09-20 2017-04-25 Stitching Het Nederlands Kanker Institut—Antoni Van Leeuwenhoek Ziekenhuis ROCK in combination with MAPK pathway
JP6038212B2 (ja) * 2015-03-18 2016-12-07 ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ 甲状腺刺激ホルモン受容体（ｔｓｈｒ）の低分子量アゴニスト
BR112021018168B1 (pt) 2019-03-21 2023-11-28 Onxeo Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2444606A (en) * 1945-12-15 1948-07-06 Gen Aniline & Film Corp Stabilizers for photographic emulsions
GB9623833D0 (en) * 1996-11-16 1997-01-08 Zeneca Ltd Chemical compound
CN1142912C (zh) * 1998-08-04 2004-03-24 阿斯特拉曾尼卡有限公司 用作细胞因子产生的抑制剂的酰胺衍生物
GB0005357D0 (en) * 2000-03-06 2000-04-26 Smithkline Beecham Plc Compounds
CA2480638C (en) * 2002-03-29 2013-02-12 Chiron Corporation Substituted benzazoles and use thereof as raf kinase inhibitors

Also Published As

Publication number Publication date
UY29092A1 (es) 2006-04-28
EP1789400A1 (en) 2007-05-30
US20090054469A1 (en) 2009-02-26
ZA200701366B (en) 2008-09-25
MX2007002433A (es) 2007-05-04
AU2005278961A1 (en) 2006-03-09
CA2577278A1 (en) 2006-03-09
AR050545A1 (es) 2006-11-01
JP2008511600A (ja) 2008-04-17
WO2006024836A1 (en) 2006-03-09
BRPI0514679A (pt) 2008-06-17
TW200621259A (en) 2006-07-01
CN101010303A (zh) 2007-08-01
KR20070055575A (ko) 2007-05-30
IL181213A0 (en) 2007-07-04

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