NO20055333L - Indazolderivater - Google Patents
IndazolderivaterInfo
- Publication number
- NO20055333L NO20055333L NO20055333A NO20055333A NO20055333L NO 20055333 L NO20055333 L NO 20055333L NO 20055333 A NO20055333 A NO 20055333A NO 20055333 A NO20055333 A NO 20055333A NO 20055333 L NO20055333 L NO 20055333L
- Authority
- NO
- Norway
- Prior art keywords
- substituted
- unsubstituted
- heterocyclic group
- hydrogen atom
- ararkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Det beskrives indazolderivater som representeres ved den generelle formel (I) eller farmakologisk akseptable salter derav: lb derR'erCONRlaR1D,der Rla og Rlb hver uavhengig er hydrogen, lavere alkyl, aryl, aralkyl eller en heterosyklisk gruppe, eller Rla og Rlb sammen med nabo-nitrogenatomet kan danne en heterosyklisk gruppe, eller lignende; og R2 er hydrogen, CONR2aR2b der, R2a og R2b er som definert for Rla og Rlb, NR2cR2d der R2c og R2d hver uavhengig er hydrogen, lavere alkyl, lavere alkanoyl, aroyl, heteroaryl, aralkyl, alkylsulfonyl eller arylsulfonyl, eller lignende.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003203508 | 2003-07-30 | ||
PCT/JP2004/011287 WO2005012257A1 (ja) | 2003-07-30 | 2004-07-30 | インダゾール誘導体 |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20055333L true NO20055333L (no) | 2005-11-11 |
Family
ID=34113614
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20055333A NO20055333L (no) | 2003-07-30 | 2005-11-11 | Indazolderivater |
Country Status (15)
Country | Link |
---|---|
US (2) | US7470717B2 (no) |
EP (1) | EP1652842B1 (no) |
JP (1) | JP4335212B2 (no) |
KR (1) | KR20060119705A (no) |
CN (1) | CN100390149C (no) |
AT (1) | ATE553092T1 (no) |
AU (1) | AU2004260756B2 (no) |
BR (1) | BRPI0408876A (no) |
CA (1) | CA2518950A1 (no) |
EA (1) | EA010165B1 (no) |
ES (1) | ES2384568T3 (no) |
MX (1) | MXPA05011420A (no) |
NO (1) | NO20055333L (no) |
WO (1) | WO2005012257A1 (no) |
ZA (1) | ZA200509952B (no) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003212335B8 (en) | 2002-03-13 | 2009-04-23 | Janssen Pharmaceutica N.V. | Aminocarbonyl-derivatives as novel inhibitors of histone deacetylase |
DK1485354T3 (da) | 2002-03-13 | 2008-09-01 | Janssen Pharmaceutica Nv | Sulfonylamino-derivater som nye inhibitorer af histandeacetylase |
BR0307606A (pt) | 2002-03-13 | 2004-12-21 | Janssen Pharmaceutica Nv | Derivados de piperazinila, piperidinila e morfolinila como inibidores de histona desacetilase |
NZ534831A (en) | 2002-03-13 | 2007-01-26 | Janssen Pharmaceutica Nv | Carbonylamino-derivatives having histone deacetylase (HDAC) inhibiting enzymatic activity |
JP4335212B2 (ja) * | 2003-07-30 | 2009-09-30 | 協和発酵キリン株式会社 | インダゾール誘導体 |
WO2006010750A1 (en) | 2004-07-28 | 2006-02-02 | Janssen Pharmaceutica N.V. | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase |
ES2426482T3 (es) * | 2005-01-27 | 2013-10-23 | Kyowa Hakko Kirin Co., Ltd. | Inhibidor de IGF-1R |
WO2006118257A1 (ja) * | 2005-04-28 | 2006-11-09 | Kyowa Hakko Kogyo Co., Ltd. | インダゾール-3-イルメチルホスホニウム塩の製造法 |
EP1885710B1 (en) | 2005-05-18 | 2015-08-19 | Janssen Pharmaceutica N.V. | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase |
EP1943232B1 (en) | 2005-10-27 | 2011-05-18 | Janssen Pharmaceutica NV | Squaric acid derivatives as inhibitors of histone deacetylase |
AU2007206942B2 (en) | 2006-01-19 | 2012-08-23 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
SI1981874T1 (sl) | 2006-01-19 | 2009-10-31 | Janssen Pharmaceutica Nv | Aminofenilni derivati kot novi inhibitorji histon deacetilaze |
JP5137849B2 (ja) | 2006-01-19 | 2013-02-06 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ヒストンデアセチラーゼのインヒビターとしての置換インドリル−アルキル−アミノ−誘導体 |
AU2007206944B2 (en) | 2006-01-19 | 2012-08-23 | Janssen Pharmaceutica N.V. | Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase |
CN101484427A (zh) | 2006-06-30 | 2009-07-15 | 协和发酵麒麟株式会社 | Abl激酶抑制剂 |
EP2036894A4 (en) * | 2006-06-30 | 2011-01-12 | Kyowa Hakko Kirin Co Ltd | AURORA INHIBITOR |
JPWO2008020606A1 (ja) * | 2006-08-16 | 2010-01-07 | 協和発酵キリン株式会社 | 血管新生阻害剤 |
GB0619325D0 (en) | 2006-09-30 | 2006-11-08 | Univ Strathclyde | New compounds |
CA2680161A1 (en) | 2007-03-05 | 2008-09-12 | Kyowa Hakko Kirin Co., Ltd. | Pharmaceutical composition |
JPWO2008111441A1 (ja) | 2007-03-05 | 2010-06-24 | 協和発酵キリン株式会社 | 医薬組成物 |
WO2008114812A1 (ja) * | 2007-03-19 | 2008-09-25 | Kyowa Hakko Kirin Co., Ltd. | Jak阻害剤 |
WO2009143404A1 (en) * | 2008-05-23 | 2009-11-26 | Wyeth | Piperazine metabotropic glutamate receptor 5 (mglur5) negative allosteric modulators for anxiety/depression |
CN103804382A (zh) * | 2012-11-05 | 2014-05-21 | 韩文毅 | 一类治疗湿疹的化合物及其用途 |
CN103804306A (zh) * | 2012-11-12 | 2014-05-21 | 韩文毅 | 一类治疗糖尿病的化合物及其用途 |
GB201511382D0 (en) | 2015-06-29 | 2015-08-12 | Imp Innovations Ltd | Novel compounds and their use in therapy |
MX2018003462A (es) | 2015-09-22 | 2018-09-06 | Graybug Vision Inc | Compuestos y composiciones para el tratamiento de trastornos oculares. |
JP7217022B2 (ja) | 2017-03-23 | 2023-02-02 | グレイバグ ビジョン インコーポレイテッド | 眼障害の治療のための薬物及び組成物 |
EP3621654A4 (en) | 2017-05-10 | 2021-02-17 | Graybug Vision, Inc. | PROLONGED-RELEASE MICROPARTICLES AND SUSPENSIONS OF THESE INTENDED FOR MEDICAL THERAPY |
US11629139B2 (en) | 2017-09-08 | 2023-04-18 | President And Fellows Of Harvard College | Small molecule inhibitors of Ebola and Lassa fever viruses and methods of use |
US11566004B2 (en) * | 2018-07-23 | 2023-01-31 | Celgene Quanticel Research, Inc. | Process for the preparation of bromodomain inhibitor |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0232059A (ja) * | 1988-07-18 | 1990-02-01 | Kyowa Hakko Kogyo Co Ltd | インダゾール誘導体 |
PE20010306A1 (es) * | 1999-07-02 | 2001-03-29 | Agouron Pharma | Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa |
TWI262914B (en) * | 1999-07-02 | 2006-10-01 | Agouron Pharma | Compounds and pharmaceutical compositions for inhibiting protein kinases |
US6632815B2 (en) * | 1999-09-17 | 2003-10-14 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
YU54202A (sh) * | 2000-01-18 | 2006-01-16 | Agouron Pharmaceuticals Inc. | Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije |
US7238853B2 (en) * | 2000-07-14 | 2007-07-03 | Unicrop Ltd | Molecular mechanisms for gene containment in plants |
US20050009876A1 (en) * | 2000-07-31 | 2005-01-13 | Bhagwat Shripad S. | Indazole compounds, compositions thereof and methods of treatment therewith |
US7211594B2 (en) * | 2000-07-31 | 2007-05-01 | Signal Pharmaceuticals, Llc | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith |
US6897231B2 (en) * | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
ATE449763T1 (de) * | 2001-04-16 | 2009-12-15 | Eisai R&D Man Co Ltd | 1h-indazolverbindungen die jnk hemmen |
EP1510516A4 (en) * | 2002-05-31 | 2005-11-02 | Eisai Co Ltd | PYRAZOL COMPOUND AND MEDICAL COMPOSITION CONTAINING THEM |
CA2508319A1 (en) * | 2002-12-03 | 2004-06-17 | Kyowa Hakko Kogyo Co., Ltd. | Jnk inhibitors |
JP4335212B2 (ja) * | 2003-07-30 | 2009-09-30 | 協和発酵キリン株式会社 | インダゾール誘導体 |
-
2004
- 2004-07-30 JP JP2005512586A patent/JP4335212B2/ja not_active Expired - Fee Related
- 2004-07-30 CN CNB2004800104880A patent/CN100390149C/zh not_active Expired - Fee Related
- 2004-07-30 AU AU2004260756A patent/AU2004260756B2/en not_active Ceased
- 2004-07-30 EA EA200600333A patent/EA010165B1/ru not_active IP Right Cessation
- 2004-07-30 EP EP04771301A patent/EP1652842B1/en not_active Not-in-force
- 2004-07-30 KR KR1020057018013A patent/KR20060119705A/ko active IP Right Grant
- 2004-07-30 CA CA002518950A patent/CA2518950A1/en not_active Abandoned
- 2004-07-30 US US10/548,475 patent/US7470717B2/en not_active Expired - Fee Related
- 2004-07-30 ES ES04771301T patent/ES2384568T3/es active Active
- 2004-07-30 WO PCT/JP2004/011287 patent/WO2005012257A1/ja active Application Filing
- 2004-07-30 MX MXPA05011420A patent/MXPA05011420A/es active IP Right Grant
- 2004-07-30 BR BRPI0408876-0A patent/BRPI0408876A/pt not_active IP Right Cessation
- 2004-07-30 AT AT04771301T patent/ATE553092T1/de active
-
2005
- 2005-11-11 NO NO20055333A patent/NO20055333L/no unknown
- 2005-12-07 ZA ZA200509952A patent/ZA200509952B/en unknown
-
2008
- 2008-11-21 US US12/275,614 patent/US7919517B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
BRPI0408876A (pt) | 2006-04-11 |
US20070117856A1 (en) | 2007-05-24 |
AU2004260756B2 (en) | 2010-03-25 |
ES2384568T3 (es) | 2012-07-09 |
CN100390149C (zh) | 2008-05-28 |
CN1777590A (zh) | 2006-05-24 |
WO2005012257A1 (ja) | 2005-02-10 |
JP4335212B2 (ja) | 2009-09-30 |
US7919517B2 (en) | 2011-04-05 |
US20090082348A1 (en) | 2009-03-26 |
ATE553092T1 (de) | 2012-04-15 |
ZA200509952B (en) | 2006-09-27 |
EA200600333A1 (ru) | 2006-06-30 |
KR20060119705A (ko) | 2006-11-24 |
CA2518950A1 (en) | 2005-02-10 |
EA010165B1 (ru) | 2008-06-30 |
EP1652842B1 (en) | 2012-04-11 |
AU2004260756A1 (en) | 2005-02-10 |
EP1652842A4 (en) | 2008-10-01 |
JPWO2005012257A1 (ja) | 2006-09-14 |
EP1652842A1 (en) | 2006-05-03 |
MXPA05011420A (es) | 2005-12-12 |
US7470717B2 (en) | 2008-12-30 |
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