NO20050668L - 7,8,9,10-tetrahydro-6H-azepino6,7,8,9-tetrahydro-pyrido og 2,3-dihydro-2H-pyrrolo [2,1-B]-kinazolinon-derivater - Google Patents

7,8,9,10-tetrahydro-6H-azepino6,7,8,9-tetrahydro-pyrido og 2,3-dihydro-2H-pyrrolo [2,1-B]-kinazolinon-derivater

Info

Publication number
NO20050668L
NO20050668L NO20050668A NO20050668A NO20050668L NO 20050668 L NO20050668 L NO 20050668L NO 20050668 A NO20050668 A NO 20050668A NO 20050668 A NO20050668 A NO 20050668A NO 20050668 L NO20050668 L NO 20050668L
Authority
NO
Norway
Prior art keywords
tetrahydro
pyrido
pyrrolo
dihydro
azepino6
Prior art date
Application number
NO20050668A
Other languages
English (en)
Norwegian (no)
Inventor
Ralf Koberstein
Thomas Weller
Walter Fischli
Thierry Sifferlen
Martine Clozel
Hamed Aissaoui
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of NO20050668L publication Critical patent/NO20050668L/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO20050668A 2002-07-09 2005-02-08 7,8,9,10-tetrahydro-6H-azepino6,7,8,9-tetrahydro-pyrido og 2,3-dihydro-2H-pyrrolo [2,1-B]-kinazolinon-derivater NO20050668L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP0207608 2002-07-09
PCT/EP2003/007297 WO2004004733A1 (fr) 2002-07-09 2003-07-08 Derives de 7,8,9,10-tetrahydro-6h-azepino, 6,7,8,9-tetrahydro-pyrido et 2,3-dihydro-2h-pyrrolo[2,1-b]-quinazolinone

Publications (1)

Publication Number Publication Date
NO20050668L true NO20050668L (no) 2005-04-05

Family

ID=30011039

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20050668A NO20050668L (no) 2002-07-09 2005-02-08 7,8,9,10-tetrahydro-6H-azepino6,7,8,9-tetrahydro-pyrido og 2,3-dihydro-2H-pyrrolo [2,1-B]-kinazolinon-derivater

Country Status (16)

Country Link
US (1) US7067519B2 (fr)
EP (1) EP1521583B1 (fr)
JP (1) JP4498922B2 (fr)
CN (1) CN1556705B (fr)
AU (1) AU2003246657A1 (fr)
CA (1) CA2460051A1 (fr)
DE (1) DE60311101T2 (fr)
ES (1) ES2278197T3 (fr)
IL (1) IL166100A0 (fr)
MX (1) MXPA04002269A (fr)
NO (1) NO20050668L (fr)
NZ (1) NZ538029A (fr)
PL (1) PL373223A1 (fr)
RU (1) RU2005103398A (fr)
WO (1) WO2004004733A1 (fr)
ZA (1) ZA200500026B (fr)

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PE20081229A1 (es) 2006-12-01 2008-08-28 Merck & Co Inc Antagonistas de receptor de orexina de diazepam sustituido
EP2125823B1 (fr) 2006-12-22 2012-02-15 Actelion Pharmaceuticals Ltd. Dérivés de 5,6,7,8-tétrahydro-imidazo[1,5-a]pyrazine
US8263586B2 (en) 2007-05-18 2012-09-11 Merck Sharp & Dohme Corp. OXO bridged diazepan orexin receptor antagonists
EP2150115B1 (fr) 2007-05-23 2013-09-18 Merck Sharp & Dohme Corp. Antagonistes du récepteur de la cyclopropylpyrrolidine orexine
RS52200B (en) 2007-05-23 2012-10-31 Merck Sharp & Dohme Corp. PIRIDIL PIPERIDIN ORREXIN ANTAGONIST RECEPTORA
EP2161266A1 (fr) 2008-08-22 2010-03-10 EVOTEC Neurosciences GmbH Dérivés de benzofurane en tant qu'antagonistes du récepteur de l'orexine
MX2011004258A (es) 2008-10-22 2011-06-01 Merck Sharp & Dohme Derivados de bencimidazol ciclicos novedosos utiles como agentes anti-diabeticos.
JP5557845B2 (ja) 2008-10-31 2014-07-23 メルク・シャープ・アンド・ドーム・コーポレーション 糖尿病用剤として有用な新規環状ベンゾイミダゾール誘導体
ES2735411T3 (es) 2009-10-23 2019-12-18 Janssen Pharmaceutica Nv Octahidropirrolo[3,4-c]pirroles disustituidos como moduladores del receptor de orexina
EP2491034B1 (fr) 2009-10-23 2013-12-18 Janssen Pharmaceutica, N.V. Composés hétérocycliques condensés en tant que modulateurs de récepteur d'orexine
EP2491031B1 (fr) 2009-10-23 2013-08-07 Janssen Pharmaceutica N.V. Composés hétérocycliques condensés en tant que modulateurs de récepteur d'orexine
AU2011218830B2 (en) 2010-02-25 2014-07-24 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
WO2011138265A2 (fr) 2010-05-03 2011-11-10 Evotec Ag Dérivés d'indole et d'indazole utilisés comme antagonistes du récepteur de l'orexine
WO2011138266A1 (fr) 2010-05-03 2011-11-10 Evotec Ag Dérivés d'indolizine et d'imidazopyridine comme antagonistes de récepteurs d'orexine
EP3243385B1 (fr) 2011-02-25 2021-01-13 Merck Sharp & Dohme Corp. Nouveaux dérivés d'azabenzimidazole cyclique utiles en tant qu'agents antidiabétiques
WO2012145581A1 (fr) 2011-04-20 2012-10-26 Janssen Pharmaceutica Nv Octahydropyrrolo [3,4-c] pyrroles disubstitués utilisés comme modulateurs du récepteur de l'orexine
EP2733144B1 (fr) * 2011-07-13 2016-01-06 Santen Pharmaceutical Co., Ltd Nouveau composé ayant une activité d'inhibition de parp
AR088352A1 (es) 2011-10-19 2014-05-28 Merck Sharp & Dohme Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
EP2811997B1 (fr) 2012-02-07 2018-04-11 Eolas Therapeutics Inc. Pipéridines/prolines substituées en tant qu'antagonistes du récepteur de l'orexine
AU2013296470B2 (en) 2012-08-02 2016-03-17 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
EP2958562A4 (fr) 2013-02-22 2016-08-10 Merck Sharp & Dohme Composés bicycliques antidiabétiques
US9650375B2 (en) 2013-03-14 2017-05-16 Merck Sharp & Dohme Corp. Indole derivatives useful as anti-diabetic agents
WO2015051496A1 (fr) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Composés tricycliques antidiabétiques
WO2016025669A1 (fr) 2014-08-13 2016-02-18 Eolas Therapeutics, Inc. Difluoropyrrolidines en tant que modulateurs des récepteurs de l'orexine
CA3013927C (fr) 2016-02-12 2024-02-13 Astrazeneca Ab Piperidines halosubstituees en tant que modulateurs de recepteur des orexines
MA43468B1 (fr) 2016-03-10 2020-08-31 Janssen Pharmaceutica Nv Méthodes de traitement de la dépression à l'aide d'antagonistes de récepteurs de l'orexine-2
US20190151304A1 (en) 2016-05-10 2019-05-23 Inserm (Institut National De La Santé Et De La Rechercjae Médicale Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory
EP3551176A4 (fr) 2016-12-06 2020-06-24 Merck Sharp & Dohme Corp. Composés hétérocycliques antidiabétiques
US10968232B2 (en) 2016-12-20 2021-04-06 Merck Sharp & Dohme Corp. Antidiabetic spirochroman compounds
CN111032039B (zh) 2017-08-03 2024-03-26 卡莱克汀科学有限责任公司 用于预防和治疗医学障碍的化合物及其用途
JP7379374B2 (ja) 2018-12-12 2023-11-14 武田薬品工業株式会社 複素環化合物

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Also Published As

Publication number Publication date
EP1521583A1 (fr) 2005-04-13
ZA200500026B (en) 2005-10-20
AU2003246657A1 (en) 2004-01-23
JP2005532381A (ja) 2005-10-27
CN1556705A (zh) 2004-12-22
RU2005103398A (ru) 2006-06-27
MXPA04002269A (es) 2004-06-29
US7067519B2 (en) 2006-06-27
ES2278197T3 (es) 2007-08-01
NZ538029A (en) 2006-08-31
CA2460051A1 (fr) 2004-01-15
IL166100A0 (en) 2006-01-15
DE60311101D1 (de) 2007-02-22
JP4498922B2 (ja) 2010-07-07
DE60311101T2 (de) 2007-06-21
PL373223A1 (en) 2005-08-22
CN1556705B (zh) 2010-04-28
US20050009852A1 (en) 2005-01-13
EP1521583B1 (fr) 2007-01-10
WO2004004733A1 (fr) 2004-01-15

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