GT200300199A - Indoles 2,7-sustituidos - Google Patents
Indoles 2,7-sustituidosInfo
- Publication number
- GT200300199A GT200300199A GT200300199A GT200300199A GT200300199A GT 200300199 A GT200300199 A GT 200300199A GT 200300199 A GT200300199 A GT 200300199A GT 200300199 A GT200300199 A GT 200300199A GT 200300199 A GT200300199 A GT 200300199A
- Authority
- GT
- Guatemala
- Prior art keywords
- indoles
- replaced
- receptors
- collesterol
- colesterol
- Prior art date
Links
- 150000002475 indoles Chemical class 0.000 title 1
- 108020005497 Nuclear hormone receptor Proteins 0.000 abstract 1
- 102000040945 Transcription factor Human genes 0.000 abstract 1
- 108091023040 Transcription factor Proteins 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 102000006255 nuclear receptors Human genes 0.000 abstract 1
- 108020004017 nuclear receptors Proteins 0.000 abstract 1
- 210000002824 peroxisome Anatomy 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
ESTOS COMPUESTOS ALTERAN LA ACTIVIDAD DE LOS RECEPTORES DE LA ACTIVACION DE PROLIFERADOR DE PEROXISOMAS (PPAR) QUE SON ELEMENTOS DE LA SUPERFAMILIA DE LOS RECEPTORES NUCLEARES DE FACTORES DE TRANSCRIPCION POR LO QUE SON DE UTILIDAD EN PACIENTES CON ALTOS NIVELES DE COLESTEROL Y LIPIDOS EN LA SANGRE.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41123902P | 2002-09-17 | 2002-09-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GT200300199A true GT200300199A (es) | 2006-08-22 |
Family
ID=32030655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GT200300199A GT200300199A (es) | 2002-09-17 | 2003-09-16 | Indoles 2,7-sustituidos |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US7247651B2 (es) |
| EP (1) | EP1587788B9 (es) |
| JP (1) | JP4327091B2 (es) |
| KR (1) | KR100686758B1 (es) |
| CN (1) | CN1314669C (es) |
| AR (1) | AR041255A1 (es) |
| AT (1) | ATE362469T1 (es) |
| AU (1) | AU2003273855B2 (es) |
| BR (1) | BR0314352A (es) |
| CA (1) | CA2496765A1 (es) |
| DE (1) | DE60313895T2 (es) |
| DK (1) | DK1587788T3 (es) |
| ES (1) | ES2287518T3 (es) |
| GT (1) | GT200300199A (es) |
| HK (1) | HK1083500A1 (es) |
| HR (1) | HRP20050229A2 (es) |
| MX (1) | MXPA05002696A (es) |
| MY (1) | MY138826A (es) |
| NO (1) | NO20050666L (es) |
| NZ (1) | NZ537982A (es) |
| PA (1) | PA8582201A1 (es) |
| PE (1) | PE20050054A1 (es) |
| PL (1) | PL376020A1 (es) |
| PT (1) | PT1587788E (es) |
| RU (1) | RU2327685C2 (es) |
| TW (1) | TWI249402B (es) |
| UY (1) | UY27980A1 (es) |
| WO (1) | WO2004026830A1 (es) |
| ZA (1) | ZA200501306B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60321558D1 (de) | 2002-03-27 | 2008-07-24 | Glaxo Group Ltd | Chinolinderivate und deren verwendung als 5-ht6 liganden |
| DE602004000260T2 (de) | 2003-07-22 | 2006-08-24 | Arena Pharmaceuticals, Inc., San Diego | Diaryl- und arylheteroarylharnstoffderivate als modulatoren des 5-ht2a-serotoninrezeptors, die sich zur prophylaxe und behandlung von damit im zusammenhang stehenden erkrankungen eignen |
| BRPI0417858B1 (pt) * | 2003-12-23 | 2017-10-10 | H. Lundbeck A/S | Derivative compounds of aniline and pharmaceutical composition that understand it |
| AR052308A1 (es) * | 2004-07-16 | 2007-03-14 | Lundbeck & Co As H | Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto |
| US7713954B2 (en) * | 2004-09-30 | 2010-05-11 | Roche Palo Alto Llc | Compositions and methods for treating cognitive disorders |
| CA2582273C (en) | 2004-09-30 | 2013-10-29 | Douglas William Bonhaus | Compositions and methods for treating cognitive disorders using serotonin receptor antagonists |
| WO2006062481A1 (en) * | 2004-12-09 | 2006-06-15 | Biovitrum Ab | New benzofuran derivatives and their use in the treatment of obesity, type ii diabetes and cns disorders . |
| AR054393A1 (es) * | 2005-06-17 | 2007-06-20 | Lundbeck & Co As H | Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos. |
| US7629473B2 (en) * | 2005-06-17 | 2009-12-08 | H. Lundbeck A/S | 2-(1H-indolylsulfanyl)-aryl amine derivatives |
| AU2007316736A1 (en) * | 2006-11-09 | 2008-05-15 | F. Hoffmann-La Roche Ag | Indole and benzofuran 2-carboxamide derivatives |
| WO2009074607A1 (en) | 2007-12-12 | 2009-06-18 | Glaxo Group Limited | Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline |
| WO2009123714A2 (en) | 2008-04-02 | 2009-10-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
| WO2010062321A1 (en) | 2008-10-28 | 2010-06-03 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto |
| CN103288707B (zh) * | 2013-05-28 | 2015-12-23 | 浙江大学 | 一种3-苯巯基吲哚衍生物的制备方法 |
| EP3083588B1 (en) | 2013-12-20 | 2020-12-09 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic compounds and their application in pharmaceuticals |
| US9974785B2 (en) | 2014-07-08 | 2018-05-22 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic derivatives and pharmaceutical applications thereof |
| CN109562085A (zh) | 2015-06-12 | 2019-04-02 | 阿速万科学有限责任公司 | 用于预防和治疗rem睡眠行为障碍的二芳基和芳基杂芳基脲衍生物 |
| BR112018000728A2 (pt) | 2015-07-15 | 2018-09-04 | Axovant Sciences Gmbh | resumo método para a profilaxia e/ou tratamento de alucinações visuais em um sujeito com necessidade do mesmo |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0773942A1 (en) | 1994-07-26 | 1997-05-21 | Pfizer Inc. | 4-indole derivatives as serotonin agonists and antagonists |
| US6114532A (en) | 1998-02-03 | 2000-09-05 | Boehringer Ingelheim Pharma Kg | Bicyclic heterocycles, the preparation thereof, and their use as pharmaceuticals |
| JP2002519323A (ja) | 1998-06-30 | 2002-07-02 | イーライ・リリー・アンド・カンパニー | セロトニン関連系に効果を及ぼすピペリジン誘導体 |
| FR2788772B1 (fr) * | 1999-01-26 | 2001-03-02 | Adir | Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| GB9912413D0 (en) | 1999-05-28 | 1999-07-28 | Pfizer Ltd | Compounds useful in therapy |
| ES2280546T3 (es) * | 2001-06-07 | 2007-09-16 | F. Hoffmann-La Roche Ag | Nuevos derivados de indol con afinidad por el receptor 5-ht6. |
| KR20040010709A (ko) * | 2001-06-15 | 2004-01-31 | 에프. 호프만-라 로슈 아게 | 5-ｈｔ6 수용체 친화력을 갖는 4-피페라지닐인돌 유도체 |
| JP2005527463A (ja) * | 2001-08-07 | 2005-09-15 | スミスクライン ビーチャム パブリック リミテッド カンパニー | Ｃｎｓ疾患を治療するための５−ｈｔ６受容体アフィニティーを有する３−アリールスルホニル−７−ピペラジニル−インドール、−ベンゾフランおよび−ベンゾチオフェン |
| US7943639B2 (en) | 2002-06-20 | 2011-05-17 | Proximagen Limited | Compounds |
-
2003
- 2003-09-11 DK DK03757820T patent/DK1587788T3/da active
- 2003-09-11 NZ NZ537982A patent/NZ537982A/en unknown
- 2003-09-11 PT PT03757820T patent/PT1587788E/pt unknown
- 2003-09-11 JP JP2004537044A patent/JP4327091B2/ja not_active Expired - Fee Related
- 2003-09-11 PL PL03376020A patent/PL376020A1/xx not_active Application Discontinuation
- 2003-09-11 RU RU2005111587/04A patent/RU2327685C2/ru not_active IP Right Cessation
- 2003-09-11 EP EP03757820A patent/EP1587788B9/en not_active Expired - Lifetime
- 2003-09-11 ES ES03757820T patent/ES2287518T3/es not_active Expired - Lifetime
- 2003-09-11 CN CNB03821590XA patent/CN1314669C/zh not_active Expired - Fee Related
- 2003-09-11 KR KR1020057004480A patent/KR100686758B1/ko not_active IP Right Cessation
- 2003-09-11 DE DE60313895T patent/DE60313895T2/de not_active Expired - Lifetime
- 2003-09-11 AT AT03757820T patent/ATE362469T1/de not_active IP Right Cessation
- 2003-09-11 WO PCT/EP2003/010101 patent/WO2004026830A1/en active IP Right Grant
- 2003-09-11 AU AU2003273855A patent/AU2003273855B2/en not_active Ceased
- 2003-09-11 CA CA002496765A patent/CA2496765A1/en not_active Abandoned
- 2003-09-11 BR BR0314352-0A patent/BR0314352A/pt not_active IP Right Cessation
- 2003-09-11 MX MXPA05002696A patent/MXPA05002696A/es active IP Right Grant
- 2003-09-12 PA PA20038582201A patent/PA8582201A1/es unknown
- 2003-09-12 TW TW092125197A patent/TWI249402B/zh not_active IP Right Cessation
- 2003-09-12 PE PE2003000929A patent/PE20050054A1/es not_active Application Discontinuation
- 2003-09-15 UY UY27980A patent/UY27980A1/es not_active Application Discontinuation
- 2003-09-15 AR ARP030103331A patent/AR041255A1/es unknown
- 2003-09-16 GT GT200300199A patent/GT200300199A/es unknown
- 2003-09-16 MY MYPI20033528A patent/MY138826A/en unknown
- 2003-09-16 US US10/663,314 patent/US7247651B2/en not_active Expired - Fee Related
-
2005
- 2005-02-08 NO NO20050666A patent/NO20050666L/no not_active Application Discontinuation
- 2005-02-14 ZA ZA200501306A patent/ZA200501306B/xx unknown
- 2005-03-09 HR HR20050229A patent/HRP20050229A2/hr not_active Application Discontinuation
-
2006
- 2006-03-20 HK HK06103482A patent/HK1083500A1/xx not_active IP Right Cessation
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