NO20041379L - Enzymatiske prosesser for fremstilling av 4-substituerte 3-hydroksysmorsyrederivater - Google Patents

Enzymatiske prosesser for fremstilling av 4-substituerte 3-hydroksysmorsyrederivater

Info

Publication number
NO20041379L
NO20041379L NO20041379A NO20041379A NO20041379L NO 20041379 L NO20041379 L NO 20041379L NO 20041379 A NO20041379 A NO 20041379A NO 20041379 A NO20041379 A NO 20041379A NO 20041379 L NO20041379 L NO 20041379L
Authority
NO
Norway
Prior art keywords
acid derivatives
hydroxybutyric acid
substituted
preparation
enzymatic processes
Prior art date
Application number
NO20041379A
Other languages
English (en)
Inventor
Christopher S Davis
John H Grate
David R Gray
John M Gruber
Gjalr W Huisman
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of NO20041379L publication Critical patent/NO20041379L/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/002—Nitriles (-CN)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
NO20041379A 2002-08-09 2004-04-02 Enzymatiske prosesser for fremstilling av 4-substituerte 3-hydroksysmorsyrederivater NO20041379L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40243602P 2002-08-09 2002-08-09
PCT/US2003/025263 WO2004015132A2 (en) 2002-08-09 2003-08-11 Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives
US10/639,159 US7125693B2 (en) 2002-08-09 2003-08-11 Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives

Publications (1)

Publication Number Publication Date
NO20041379L true NO20041379L (no) 2004-06-01

Family

ID=31715856

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20041379A NO20041379L (no) 2002-08-09 2004-04-02 Enzymatiske prosesser for fremstilling av 4-substituerte 3-hydroksysmorsyrederivater

Country Status (12)

Country Link
US (1) US7125693B2 (no)
EP (1) EP1537222B1 (no)
JP (2) JP4578240B2 (no)
AT (1) ATE501264T1 (no)
AU (1) AU2003258187A1 (no)
BR (1) BR0305767A (no)
CA (1) CA2493941A1 (no)
DE (1) DE60336324D1 (no)
HK (1) HK1074059A1 (no)
MX (1) MXPA05001537A (no)
NO (1) NO20041379L (no)
WO (1) WO2004015132A2 (no)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7132267B2 (en) 2002-08-09 2006-11-07 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters
MXPA05001537A (es) 2002-08-09 2005-11-17 Codexis Inc Procesos enzimaticos para la produccion de derivados de acido 4-sustituido 3-hidroxibutirico.
US7588928B2 (en) 2003-08-11 2009-09-15 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
US7541171B2 (en) 2003-08-11 2009-06-02 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
JP2007502124A (ja) * 2003-08-11 2007-02-08 コデクシス， インコーポレイテッド 改良ケトレダクターゼポリペプチドおよび関連ポリヌクレオチド
SG148180A1 (en) 2003-08-11 2008-12-31 Codexis Inc Improved halohydrin dehalogenases and related polynucleotides
WO2005045016A2 (en) * 2003-08-11 2005-05-19 Codexis, Inc. Improved glucose dehydrogenase polypeptides and related polynucleotides
JP2008537477A (ja) * 2005-02-23 2008-09-18 コデクシス， インコーポレイテッド 改良されたハロヒドリンデハロゲナーゼおよび関連のポリヌクレオチド
ITMI20051971A1 (it) * 2005-10-18 2007-04-19 Dipharma Spa Procedimento per la preparazione di - modafinil
WO2008115840A2 (en) 2007-03-16 2008-09-25 Genomatica, Inc. Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors
US7947483B2 (en) 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
WO2010030711A2 (en) 2008-09-10 2010-03-18 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol
SG172231A1 (en) * 2008-12-18 2011-07-28 Codexis Inc Recombinant halohydrin dehalogenase polypeptides
MY187676A (en) 2009-06-04 2021-10-08 Genomatica Inc Microorganisms for the production of 1,4-butanediol and related methods
CN102459138A (zh) 2009-06-04 2012-05-16 基因组股份公司 分离发酵液成分的方法
CN102482648B (zh) 2009-06-22 2014-12-10 科德克希思公司 酮还原酶介导的产生α氯代醇的立体选择性途径
CA2777459A1 (en) * 2009-10-13 2011-04-21 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-coa, putrescine and related compounds, and methods related thereto
WO2011066076A1 (en) 2009-11-25 2011-06-03 Genomatica, Inc. Microorganisms and methods for the coproduction of 1,4-butanediol and gamma-butyrolactone
US9080192B2 (en) 2010-02-10 2015-07-14 Codexis, Inc. Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system
US8048661B2 (en) 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
US8445244B2 (en) 2010-02-23 2013-05-21 Genomatica, Inc. Methods for increasing product yields
WO2012003299A2 (en) 2010-06-30 2012-01-05 Codexis, Inc. Highly stable beta-class carbonic anhydrases useful in carbon capture systems
CN102168117B (zh) * 2011-01-12 2014-05-07 江苏阿尔法药业有限公司 一种制备(r)-4-氰基-3-羟基丁酸乙酯的方法
JP5705580B2 (ja) 2011-02-21 2015-04-22 公益財団法人微生物化学研究会 チオアミド化合物、チオアミド化合物の製造方法、［（４ｒ，６ｒ）−６−アミノエチル−１，３−ジオキサン−４−イル］アセテート誘導体の製造方法、及びアトルバスタチンの製造方法
CN102676597A (zh) * 2011-03-16 2012-09-19 苏州国镝医药科技有限公司 生物酶手性合成立普妥中间体ats-5
TW201410865A (zh) 2012-06-04 2014-03-16 Genomatica Inc 製造４－羥基丁酸酯、１，４－丁二醇及相關化合物之微生物及方法
CN103695486A (zh) * 2014-01-03 2014-04-02 黄冈华阳药业有限公司 一种(3r,5r)-6-氰基-3,5-二羟基己酸叔丁酯的生物制备方法
CN105368886A (zh) * 2015-12-11 2016-03-02 江苏万年长药业有限公司 一种树脂固定卤醇脱卤酶催化合成(r)-4-氰基-3-羟基丁酸乙酯的工艺
CN109439700A (zh) * 2018-11-09 2019-03-08 浙江宏元药业股份有限公司 一种脱卤酶高效催化合成他汀类药物中间体的方法
CN111876448A (zh) * 2020-08-03 2020-11-03 连云港宏业化工有限公司 4-氰基-3-羟基丁酸乙酯合成方法

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3019450A1 (de) * 1980-05-21 1981-11-26 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur gewinnung von glucosedehydrogenase und hierfuer geeigneter mikroorganismus
IE56322B1 (en) * 1982-12-06 1991-06-19 Sigma Tau Ind Farmaceuti Process for preparing l-carnitine and chemical intermediates employed therein
US4542098A (en) * 1983-05-06 1985-09-17 Institut Francais Du Petrole Production of glucose dehydrogenase and use of the resultant enzyme in the enzymatic synthesis of L-carnitine
US4710468A (en) * 1983-10-24 1987-12-01 Sigma-Tau Industrie Pharmaceutiche Riunite S.P.A. Process for preparing L-carnitine and chemical intermediates employed therein
US4877733A (en) * 1986-05-02 1989-10-31 Toyo Jozo Kabushiki Kaisha Glucose dehydrogenase and its production
DE3711881A1 (de) * 1987-04-08 1988-10-27 Merck Patent Gmbh Verfahren zur herstellung von glucosedehydrogenase aus bacillus megaterium
US5250415A (en) * 1987-04-08 1993-10-05 Merck Patent Gesellschaft Mit Beschrankter Haftung Process for the preparation of glucose dehydrogenase from Bacillus megaterium
JPH0286779A (ja) * 1988-09-22 1990-03-27 Amano Pharmaceut Co Ltd 改良型組換えｄｎａ、それを含む形質転換体及びそれを用いた耐熱性グルコースデヒドロゲナーゼの製造法
JP2742281B2 (ja) * 1988-12-29 1998-04-22 旭化成工業株式会社 グルコース―６―リン酸デヒドロゲナーゼ遺伝子
US5210031A (en) * 1989-07-20 1993-05-11 Nitto Chemical Industry Co., Ltd. Process for the production of R(-)-4-halo-3-hydroxybutyronitrile
JP2840722B2 (ja) * 1989-07-20 1998-12-24 日東化学工業株式会社 ４‐ハロ‐３‐ヒドロキシブチロニトリルの製造法
JP2850515B2 (ja) * 1990-09-25 1999-01-27 東洋紡績株式会社 グルコースデヒドロゲナーゼおよびその製造法
US5244796A (en) * 1990-10-12 1993-09-14 Syracuse University Cloned leuconostoc mesenteroides glucose-6-phosphate dehydrogenase genes and method of making glucose-6-phospate dehydrogenase
US5155251A (en) * 1991-10-11 1992-10-13 Warner-Lambert Company Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate
US5385833A (en) * 1992-02-26 1995-01-31 The Scripps Research Institute Pseudomonas sp. ATCC No. 49794 alcohol dehydrogenase
WO1993018138A1 (de) * 1992-03-13 1993-09-16 Forschungszentrum Jülich GmbH Neue ketoester-reduktase, deren herstellung und verwendung für enzymatische redoxreaktionen
US5413921A (en) * 1992-05-28 1995-05-09 Ajinomoto Co., Ltd. Method of the production of (s)-gamma-halogenated-γ-hydroxybutyric acid esters
JP3171931B2 (ja) * 1992-06-02 2001-06-04 高砂香料工業株式会社 （Ｒ）−（−）−４−シアノ−３−ヒドロキシ酪酸ｔ−ブチルエステル及びその製造方法
JP3155107B2 (ja) * 1993-01-12 2001-04-09 ダイセル化学工業株式会社 光学活性４−ハロ−３−ヒドロキシ酪酸エステルの製造方法
JPH08336393A (ja) * 1995-04-13 1996-12-24 Mitsubishi Chem Corp 光学活性なγ−置換−β−ヒドロキシ酪酸エステルの製造法
GB9512837D0 (en) * 1995-06-23 1995-08-23 Zeneca Ltd reduction of ketone groups
US5891685A (en) * 1996-06-03 1999-04-06 Mitsubishi Chemical Corporation Method for producing ester of (S)-γ-halogenated-β-hydroxybutyric acid
US5908953A (en) * 1996-12-18 1999-06-01 Mitsubishi Chemical Corporation Method for producing (R)-4-cyano-3-hydroxybutyric acid lower alkyl ester
KR100506134B1 (ko) * 1997-02-07 2005-08-08 카네카 코포레이션 신규한 카르보닐 환원효소 및 이것을 코딩하는 유전자 및 이러한 환원효소 및 유전자 이용방법
US6531308B2 (en) * 1997-11-04 2003-03-11 Eli Lilly And Company Ketoreductase gene and protein from yeast
JPH11171850A (ja) 1997-12-12 1999-06-29 Kanegafuchi Chem Ind Co Ltd 酪酸エステル誘導体の製造方法
ATE360608T1 (de) * 1997-12-19 2007-05-15 Pfizer Ireland Pharmaceuticals Verfahren zur herstellung von 1,3-diolen
JPH11187869A (ja) * 1997-12-25 1999-07-13 Daicel Chem Ind Ltd 新規な４−ハロアセト酢酸エステル還元酵素、該酵素の製造方法、及び該酵素を利用したアルコールの製造方法
JP4012299B2 (ja) * 1998-02-25 2007-11-21 ダイセル化学工業株式会社 ハロゲン置換を含む光学活性アルコールの製造方法
HUP0103659A3 (en) * 1998-04-30 2003-01-28 Kaneka Corp Process for producing 6-cyanomethyl-1,3-dioxane-4-acetic acid derivatives
DE69917204T2 (de) * 1998-08-05 2005-06-23 Kaneka Corp. Verfahren zur herstellung optisch aktiver 2-(6-(hydroxymethyl)-1,3-dioxan-4-yl) -essigsäure-derivate
JP2000236883A (ja) * 1998-12-21 2000-09-05 Daicel Chem Ind Ltd 新規なカルボニル還元酵素、該酵素の製造方法、該酵素をコードするｄｎａおよびこれを利用したアルコールの製造方法
KR100313668B1 (ko) * 1999-02-03 2001-11-26 박영구 (ｒ)-4-시아노-3-히드록시부티르산 에스테르의 제조방법
EP1194582A1 (de) * 1999-07-09 2002-04-10 Forschungszentrum Jülich Gmbh Verfahren zur reduktion von keto-carbonsäuren und deren estern
CZ20012792A3 (cs) * 1999-12-03 2002-03-13 Kaneka Corporation Polypeptid, polynukleotid kódující polypeptid, expresní vektor, transformant a způsob přípravy
EP1158054A1 (en) 2000-05-25 2001-11-28 Rijksuniversiteit te Groningen Enzymatic conversion of epoxides
JP2001335554A (ja) * 2000-05-30 2001-12-04 Mitsubishi Chemicals Corp （ｒ）−４−シアノ−３−ヒドロキシ酪酸低級アルキルエステルの製造方法
JP2002201169A (ja) * 2000-10-31 2002-07-16 Sumitomo Chem Co Ltd ４−シアノ−３−オキソブタン酸エステルの製造法
EP1201647B1 (en) * 2000-10-31 2004-09-22 Sumitomo Chemical Company, Limited Process for producing 4-cyano-4oxobutanoate and 4-cyano-3-hydroxybutanoate
JP4603171B2 (ja) * 2001-01-22 2010-12-22 ダイセル化学工業株式会社 （ｓ）−４−ハロ−３−ヒドロキシ酪酸エステルの製造に有用な酵素をコードする遺伝子、その取得方法、およびこれを利用した光学活性アルコールの製造方法
WO2003004653A1 (fr) 2001-07-02 2003-01-16 Kaneka Corporation Methode permettant de modifier un enzyme et
US7132267B2 (en) 2002-08-09 2006-11-07 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters
MXPA05001537A (es) 2002-08-09 2005-11-17 Codexis Inc Procesos enzimaticos para la produccion de derivados de acido 4-sustituido 3-hidroxibutirico.
US7541171B2 (en) * 2003-08-11 2009-06-02 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
JP2007502124A (ja) 2003-08-11 2007-02-08 コデクシス， インコーポレイテッド 改良ケトレダクターゼポリペプチドおよび関連ポリヌクレオチド
WO2005045016A2 (en) 2003-08-11 2005-05-19 Codexis, Inc. Improved glucose dehydrogenase polypeptides and related polynucleotides
SG148180A1 (en) 2003-08-11 2008-12-31 Codexis Inc Improved halohydrin dehalogenases and related polynucleotides

Also Published As

Publication number Publication date
JP2005535330A (ja) 2005-11-24
CA2493941A1 (en) 2004-02-19
EP1537222A2 (en) 2005-06-08
EP1537222B1 (en) 2011-03-09
EP1537222A4 (en) 2008-10-01
US20040137585A1 (en) 2004-07-15
US7125693B2 (en) 2006-10-24
WO2004015132A3 (en) 2005-04-14
AU2003258187A8 (en) 2004-02-25
JP4578240B2 (ja) 2010-11-10
DE60336324D1 (de) 2011-04-21
MXPA05001537A (es) 2005-11-17
BR0305767A (pt) 2005-05-24
AU2003258187A1 (en) 2004-02-25
JP2010172348A (ja) 2010-08-12
WO2004015132A2 (en) 2004-02-19
ATE501264T1 (de) 2011-03-15
HK1074059A1 (en) 2005-10-28

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