NO20024481D0 - Difluorbutyrsyre metalloproteaseinhibitorer - Google Patents
Difluorbutyrsyre metalloproteaseinhibitorerInfo
- Publication number
- NO20024481D0 NO20024481D0 NO20024481A NO20024481A NO20024481D0 NO 20024481 D0 NO20024481 D0 NO 20024481D0 NO 20024481 A NO20024481 A NO 20024481A NO 20024481 A NO20024481 A NO 20024481A NO 20024481 D0 NO20024481 D0 NO 20024481D0
- Authority
- NO
- Norway
- Prior art keywords
- metalloprotease inhibitors
- difluorobutyric acid
- acid metalloprotease
- difluorobutyric
- inhibitors
- Prior art date
Links
- SBSKRVZFWQPJID-UHFFFAOYSA-N 2,2-difluorobutanoic acid Chemical compound CCC(F)(F)C(O)=O SBSKRVZFWQPJID-UHFFFAOYSA-N 0.000 title 1
- 239000003475 metalloproteinase inhibitor Substances 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/44—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reduction and hydrolysis of nitriles
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- C—CHEMISTRY; METALLURGY
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
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- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
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- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
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- C07D277/70—Sulfur atoms
- C07D277/74—Sulfur atoms substituted by carbon atoms
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- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
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- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
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- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
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- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
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- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19129600P | 2000-03-21 | 2000-03-21 | |
PCT/US2001/008781 WO2001070693A2 (en) | 2000-03-21 | 2001-03-20 | Difluorobutyric acid derivatives and their use as metalloprotease inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20024481D0 true NO20024481D0 (no) | 2002-09-19 |
NO20024481L NO20024481L (no) | 2002-11-15 |
Family
ID=22704909
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20024481A NO20024481L (no) | 2000-03-21 | 2002-09-19 | Difluor smörsyre metalloproteaseinhibitorer |
Country Status (9)
Country | Link |
---|---|
US (1) | US6852751B2 (no) |
EP (1) | EP1265865A2 (no) |
JP (1) | JP2003528082A (no) |
AU (1) | AU2001245862A1 (no) |
CA (1) | CA2401728A1 (no) |
IL (1) | IL151250A0 (no) |
NO (1) | NO20024481L (no) |
PE (1) | PE20011136A1 (no) |
WO (1) | WO2001070693A2 (no) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2238860C (en) * | 1995-12-01 | 2009-01-13 | David R. Elmaleh | Stereoisomers of fatty acid analogs for diagnostic imaging |
WO2006038265A1 (ja) * | 2004-09-30 | 2006-04-13 | Yutaka Imauchi | 耳硬化症治療のための医薬組成物 |
US7576222B2 (en) | 2004-12-28 | 2009-08-18 | Wyeth | Alkynyl-containing tryptophan derivative inhibitors of TACE/matrix metalloproteinase |
US20100160322A1 (en) | 2008-12-04 | 2010-06-24 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
US8557983B2 (en) | 2008-12-04 | 2013-10-15 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
US8586754B2 (en) | 2008-12-05 | 2013-11-19 | Abbvie Inc. | BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
US8563735B2 (en) | 2008-12-05 | 2013-10-22 | Abbvie Inc. | Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
AU2011284397A1 (en) | 2010-07-30 | 2013-02-21 | Ranbaxy Laboratories Limited | Matrix metalloproteinase inhibitors |
US20140148459A1 (en) | 2010-09-24 | 2014-05-29 | Ranbaxy Laboratories Limited | Matrix metalloproteinase inhibitors |
CN107129476B (zh) * | 2017-05-16 | 2019-07-12 | 无锡捷化医药科技有限公司 | 一种4-氨基-2-(2-乙胺基)丁酸甲酯二盐酸盐的制备方法 |
Family Cites Families (67)
Publication number | Priority date | Publication date | Assignee | Title |
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US4743587A (en) | 1985-09-10 | 1988-05-10 | G. D. Searle & Co. | Hydroxamic acid based collagenase inhibitors |
US4771038A (en) | 1986-01-21 | 1988-09-13 | Ici Americas Inc. | Hydroxamic acids |
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-
2001
- 2001-03-20 IL IL15125001A patent/IL151250A0/xx unknown
- 2001-03-20 JP JP2001568905A patent/JP2003528082A/ja not_active Withdrawn
- 2001-03-20 WO PCT/US2001/008781 patent/WO2001070693A2/en not_active Application Discontinuation
- 2001-03-20 EP EP01918832A patent/EP1265865A2/en not_active Withdrawn
- 2001-03-20 CA CA002401728A patent/CA2401728A1/en not_active Abandoned
- 2001-03-20 AU AU2001245862A patent/AU2001245862A1/en not_active Abandoned
- 2001-03-21 PE PE2001000263A patent/PE20011136A1/es not_active Application Discontinuation
-
2002
- 2002-09-18 US US10/246,179 patent/US6852751B2/en not_active Expired - Fee Related
- 2002-09-19 NO NO20024481A patent/NO20024481L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO20024481L (no) | 2002-11-15 |
US6852751B2 (en) | 2005-02-08 |
WO2001070693A3 (en) | 2002-01-03 |
WO2001070693A2 (en) | 2001-09-27 |
AU2001245862A1 (en) | 2001-10-03 |
US20030139453A1 (en) | 2003-07-24 |
EP1265865A2 (en) | 2002-12-18 |
PE20011136A1 (es) | 2001-12-03 |
CA2401728A1 (en) | 2001-09-27 |
JP2003528082A (ja) | 2003-09-24 |
IL151250A0 (en) | 2003-04-10 |
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