NO20014225L - Nye sykliske tetrapeptid-derivater og anvendelse av dem som legemidler - Google Patents

Nye sykliske tetrapeptid-derivater og anvendelse av dem som legemidler

Info

Publication number
NO20014225L
NO20014225L NO20014225A NO20014225A NO20014225L NO 20014225 L NO20014225 L NO 20014225L NO 20014225 A NO20014225 A NO 20014225A NO 20014225 A NO20014225 A NO 20014225A NO 20014225 L NO20014225 L NO 20014225L
Authority
NO
Norway
Prior art keywords
cyclic tetrapeptide
drugs
optionally substituted
pharmaceutically acceptable
acceptable salt
Prior art date
Application number
NO20014225A
Other languages
English (en)
Other versions
NO20014225D0 (no
Inventor
Norikazu Nishino
Minoru Yoshida
Sueharu Horinouchi
Yasuhiko Komatsu
Original Assignee
Japan Energy Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Energy Corp filed Critical Japan Energy Corp
Publication of NO20014225D0 publication Critical patent/NO20014225D0/no
Publication of NO20014225L publication Critical patent/NO20014225L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/126—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Foreliggende oppfinnelse tilveiebringer et syklisk tetrapeptid-derivat repre- sentert ved den følgende generelle formel (I) eller et farmasøytisk akseptabelt salt derav: OH (D O hvor hver av R2i og R22, uavhengig, betyr hydrogen, en liineær Ci-C6-alkyl- gruppe som en ikke-aromatisk cykloalkylgruppe eller en eventuelt substituert aro- matisk ring kan være bundet til, eller en forgrenet C3-C6- alkylgruppe som en ikke- aromatisk cykloalkylgruppe eller en eventuelt substituert aromatisk ring kan være bundet til, og hver av R! og R3l uavhengig, betyr en d-C5-alkylengruppe som kan ha en Ci-C6-sidekjede, hvor sidekjeden kan danne en kondensert ringstruktur på alky- lenkjeden, Foreliggende oppfinnelse tilveiebringer også en histon-deacetylase- inhibitor, et MHC klasse-l-molekyl-ekspresjons-fremmende middel og et farma- søytisk preparat, idet hver av disse omfatter det sykliske tetrapeptid-derivat eller et farmasøytisk akseptabelt salt derav, som en aktiv ingrediens.
NO20014225A 1999-03-02 2001-08-31 Nye sykliske tetrapeptid-derivater og anvendelse av dem som legemidler NO20014225L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP05385199A JP4269041B2 (ja) 1999-03-02 1999-03-02 新規な環状テトラペプチド誘導体とその医薬用途
PCT/JP2000/001141 WO2000052033A1 (fr) 1999-03-02 2000-02-28 Nouveaux derives de tetrapeptides cycliques et leur utilisation comme medicaments

Publications (2)

Publication Number Publication Date
NO20014225D0 NO20014225D0 (no) 2001-08-31
NO20014225L true NO20014225L (no) 2001-10-17

Family

ID=12954285

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20014225A NO20014225L (no) 1999-03-02 2001-08-31 Nye sykliske tetrapeptid-derivater og anvendelse av dem som legemidler

Country Status (9)

Country Link
US (1) US6825317B2 (no)
EP (1) EP1174438A4 (no)
JP (1) JP4269041B2 (no)
AU (1) AU2694400A (no)
CA (1) CA2362817A1 (no)
NO (1) NO20014225L (no)
NZ (1) NZ513983A (no)
WO (1) WO2000052033A1 (no)
ZA (1) ZA200107320B (no)

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US6822267B1 (en) * 1997-08-20 2004-11-23 Advantest Corporation Signal transmission circuit, CMOS semiconductor device, and circuit board
US6718415B1 (en) * 1999-05-14 2004-04-06 Acqis Technology, Inc. Computer system and method including console housing multiple computer modules having independent processing units, mass storage devices, and graphics controllers
US6706686B2 (en) 2001-09-27 2004-03-16 The Regents Of The University Of Colorado Inhibition of histone deacetylase as a treatment for cardiac hypertrophy
US20040087657A1 (en) 2001-10-16 2004-05-06 Richon Victoria M. Treatment of neurodegenerative diseases and cancer of the brain using histone deacetylase inhibitors
CN1646558B (zh) * 2002-02-20 2010-05-12 国立大学法人九州工业大学 组蛋白脱乙酰酶抑制剂
AU2003211362A1 (en) * 2002-02-21 2003-09-09 Osaka Industrial Promotion Organization N-hydroxycarboxamide derivative
WO2003075856A2 (en) 2002-03-07 2003-09-18 University Of Delaware Methods, compositions, and kits for enhancing oligonucleotide-mediated nucleic acid sequence alteration using compositions comprising a histone deacetylase inhibitor, lambda phage beta protein, or hydroxyurea
DE10233412A1 (de) * 2002-07-23 2004-02-12 4Sc Ag Neue Verbindungen als Histondeacetylase-Inhibitoren
US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7250514B1 (en) 2002-10-21 2007-07-31 Takeda San Diego, Inc. Histone deacetylase inhibitors
US7169801B2 (en) 2003-03-17 2007-01-30 Takeda San Diego, Inc. Histone deacetylase inhibitors
JP4928261B2 (ja) 2003-06-18 2012-05-09 トランザイム・ファーマ・インコーポレイテッド モチリン受容体の大環状拮抗薬
EP1640380B1 (en) * 2003-06-20 2010-03-10 Riken Histone deacetylase inhibitor and process for producing the same
US8018930B2 (en) 2004-10-01 2011-09-13 Qualcomm Incorporated Apparatus and method for receiving packet data on a subset of carrier frequencies in a wireless communication system
US7642275B2 (en) 2004-12-16 2010-01-05 Takeda San Diego, Inc. Histone deacetylase inhibitors
WO2006094068A2 (en) * 2005-03-01 2006-09-08 The Regents Of The University Of Michigan Hdac inhibitors that promote brm expression and brm related diagnostics
US20100087328A1 (en) * 2005-03-01 2010-04-08 The Regents Of The University Of Michigan Brm expression and related diagnostics
EP1896436A2 (en) 2005-05-11 2008-03-12 Takeda San Diego, Inc. Histone deacetylase inhibitors
KR20080032188A (ko) 2005-07-14 2008-04-14 다케다 샌디에고, 인코포레이티드 히스톤 탈아세틸화 효소 억제제
EP1801115A1 (en) * 2005-12-23 2007-06-27 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Cyclic peptides and their use in treating advanced stage neuroblastoma
JP2007262058A (ja) * 2006-03-03 2007-10-11 Tokyo Univ Of Science 糸状菌の分化抑制剤
WO2008029565A1 (fr) 2006-09-05 2008-03-13 Kyushu Institute Of Technology Composé ayant une activité d'inhibition sur l'histone désacétylase et produit pharmaceutique comprenant le composé en tant qu'ingrédient actif
CA2574531C (en) * 2007-01-19 2016-10-25 The University Of British Columbia Hat acetylation promoters and uses of compositions thereof in promoting immunogenicity
KR100909867B1 (ko) 2007-04-16 2009-07-29 주식회사바이오러넥스 골대사성 질환의 예방 및 치료를 위한 조성물
CA2706750A1 (en) * 2007-11-27 2009-06-04 Ottawa Health Research Institute Amplification of cancer-specific oncolytic viral infection by histone deacetylase inhibitors
US10184933B2 (en) 2013-10-01 2019-01-22 The J. David Gladstone Industries Compositions, systems and methods for gene expression noise drug screening and uses thereof
ES2924903T3 (es) 2017-01-20 2022-10-11 Univ Kansas Péptidos macrocíclicos para uso en el tratamiento de un cáncer de próstata o mama
EP3461480A1 (en) 2017-09-27 2019-04-03 Onxeo Combination of a dna damage response cell cycle checkpoint inhibitors and belinostat for treating cancer
EP3461488A1 (en) 2017-09-27 2019-04-03 Onxeo Combination of a dbait molecule and a hdac inhibitor for treating cancer
EP3768297A4 (en) * 2018-03-23 2021-12-22 University of Kansas CYCLIC TETRAPEPTID ANALOGUES
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
WO2023041805A1 (en) 2021-09-20 2023-03-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for improving the efficacy of hdac inhibitor therapy and predicting the response to treatment with hdac inhibitor
WO2023194441A1 (en) 2022-04-05 2023-10-12 Istituto Nazionale Tumori Irccs - Fondazione G. Pascale Combination of hdac inhibitors and statins for use in the treatment of pancreatic cancer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU732299B2 (en) * 1997-09-02 2001-04-12 Japan Energy Corporation Novel cyclic tetrapeptide derivatives and pharmaceutical use thereof

Also Published As

Publication number Publication date
CA2362817A1 (en) 2000-09-08
JP4269041B2 (ja) 2009-05-27
AU2694400A (en) 2000-09-21
NZ513983A (en) 2001-09-28
US20020120099A1 (en) 2002-08-29
JP2000256397A (ja) 2000-09-19
WO2000052033A1 (fr) 2000-09-08
EP1174438A1 (en) 2002-01-23
ZA200107320B (en) 2002-09-04
US6825317B2 (en) 2004-11-30
NO20014225D0 (no) 2001-08-31
EP1174438A4 (en) 2003-01-22

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