ES2185307T3 - Inhibidores de la farnesil transferasa que tienen una estructura piperidinica y procedimiento para su preparacion. - Google Patents
Inhibidores de la farnesil transferasa que tienen una estructura piperidinica y procedimiento para su preparacion.Info
- Publication number
- ES2185307T3 ES2185307T3 ES99901979T ES99901979T ES2185307T3 ES 2185307 T3 ES2185307 T3 ES 2185307T3 ES 99901979 T ES99901979 T ES 99901979T ES 99901979 T ES99901979 T ES 99901979T ES 2185307 T3 ES2185307 T3 ES 2185307T3
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- formula
- transferasa
- farnesil
- piperidinic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
Un derivado de piperidina representado por la siguiente fórmula (1) **(Fórmula)** en la que A representa hidrógeno, alquilo inferior o **(Fórmula)** en la que B representa CH2, C=O o SO2, y D representa un radical seleccionado del grupo siguiente: **(Fórmulas)** En la definición para el sustituyente D, m representa un número entero de 0 a 3, n representa un número entero de 1 a 3, X representa hidrógeno, fenilo, fenoxi, alquilo C1-C4, alcoxi C1-C4, halógeno, nitro, o amino que está opcionalmente sustituido con bencilo o alquilo C1-C4, R1 y R2 representan independientemente entre sí hidrógeno, alquilo C1-C4, cicloalquilo C3-C6, alquilo C1-C4 sustituido con cicloalquilo C3-C6, arilo o heteroarilo, E representa hidrógeno, fenilo, naftilo o **(Fórmula)** en la que R3 y R4 representan independientemente entre sí hidrógeno, alquilo C1-C4, arilo **(Fórmula)** (en la que Y representa O o S, n¿ representa un número entero de 2 a 4, y R5 representa alquilo C1-C4), G representa un radical seleccionadodel siguiente grupo: **(Fórmulas)** en la que Z representa O, S, SO2 o N-R6 (en la que R6 representa hidrógeno o alquilo C1-C4), R7 y R8 representan independientemente entre sí hidrógeno, alquilo C1-C4, alcoxi C1-C4, halógeno, ciano, hidroxicarbonilo, aminocarbonilo, aminotiocarbonilo, hidroxi, fenilo o fenoxi o una sal farmacéuticamente aceptable del mismo.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019980002777A KR100388789B1 (ko) | 1998-02-02 | 1998-02-02 | 피롤구조를갖는파네실전이효소억제제및그의제조방법 |
KR19980002776 | 1998-02-02 | ||
KR1019980028340A KR100388792B1 (ko) | 1998-02-02 | 1998-07-14 | 피페리딘구조를갖는파네실전이효소억제제및그의제조방법 |
KR10-1998-0032150A KR100388794B1 (ko) | 1998-08-07 | 1998-08-07 | 피페리딘구조를갖는파네실전이효소억제제및그의제조방법 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2185307T3 true ES2185307T3 (es) | 2003-04-16 |
Family
ID=27483262
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99901979T Expired - Lifetime ES2185307T3 (es) | 1998-02-02 | 1999-02-01 | Inhibidores de la farnesil transferasa que tienen una estructura piperidinica y procedimiento para su preparacion. |
Country Status (12)
Country | Link |
---|---|
US (1) | US6436960B1 (es) |
EP (1) | EP1058683B1 (es) |
JP (1) | JP3283032B2 (es) |
CN (1) | CN1158277C (es) |
AT (1) | ATE229017T1 (es) |
AU (1) | AU745855B2 (es) |
BR (1) | BR9908545A (es) |
CA (1) | CA2320233C (es) |
DE (1) | DE69904302T2 (es) |
ES (1) | ES2185307T3 (es) |
PT (1) | PT1058683E (es) |
WO (1) | WO1999038862A1 (es) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100388794B1 (ko) * | 1998-08-07 | 2003-10-10 | 주식회사 엘지생명과학 | 피페리딘구조를갖는파네실전이효소억제제및그의제조방법 |
KR100388792B1 (ko) * | 1998-02-02 | 2003-09-22 | 주식회사 엘지생명과학 | 피페리딘구조를갖는파네실전이효소억제제및그의제조방법 |
CN1151148C (zh) * | 1999-04-13 | 2004-05-26 | Lgci株式会社 | 具有吡咯结构的法尼转移酶抑制剂及其制备方法 |
KR20010063274A (ko) * | 1999-12-22 | 2001-07-09 | 성재갑 | 〔1-{〔1-(1,3-벤조디옥솔-5-일메틸-1h-이미다졸-5-일〕메틸}-4-(1-나프틸)-1h-피롤-3-일〕(4-메틸-1-피페라지닐)메타논의 약학적 조성물 |
US7035932B1 (en) * | 2000-10-27 | 2006-04-25 | Eric Morgan Dowling | Federated multiprotocol communication |
US7425618B2 (en) | 2002-06-14 | 2008-09-16 | Medimmune, Inc. | Stabilized anti-respiratory syncytial virus (RSV) antibody formulations |
US7132100B2 (en) | 2002-06-14 | 2006-11-07 | Medimmune, Inc. | Stabilized liquid anti-RSV antibody formulations |
US7563810B2 (en) | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
US8034831B2 (en) | 2002-11-06 | 2011-10-11 | Celgene Corporation | Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies |
KR100897642B1 (ko) | 2002-12-20 | 2009-05-14 | 글락소 그룹 리미티드 | 신경 장애 치료용 벤즈아제핀 유도체 |
US7354584B2 (en) | 2003-04-11 | 2008-04-08 | Medimmune, Inc. | Recombinant IL-9 antibodies |
EP2272566A3 (en) | 2003-08-18 | 2013-01-02 | MedImmune, LLC | Humanisation of antibodies |
JP4956191B2 (ja) * | 2003-10-17 | 2012-06-20 | インサイト コーポレーション | マトリックスメタロプロテイナーゼの阻害剤としての置換環状ヒドロキサメート |
AU2005299355A1 (en) | 2004-10-27 | 2006-05-04 | Medimmune, Llc | Modulation of antibody specificity by tailoring the affinity to cognate antigens |
CA2602035C (en) | 2005-03-18 | 2015-06-16 | Medimmune, Inc. | Framework-shuffling of antibodies |
US20070110757A1 (en) | 2005-06-23 | 2007-05-17 | Ziping Wei | Antibody formulations having optimized aggregation and fragmentation profiles |
BRPI0716088B8 (pt) | 2006-08-28 | 2021-05-25 | Kyowa Hakko Kirin Co Ltd | anticorpo isolado, composição, molécula de ácido nucléico isolada, vetor, método para produzir um anticorpo, hibridoma, e, kit |
CA2682170A1 (en) | 2007-03-30 | 2008-10-09 | Medimmune, Llc | Antibodies with decreased deamidation profiles |
US9540443B2 (en) | 2011-01-26 | 2017-01-10 | Kolltan Pharmaceuticals, Inc. | Anti-kit antibodies |
GB201107985D0 (en) | 2011-05-13 | 2011-06-29 | Astrazeneca Ab | Process |
BR112015001459B1 (pt) | 2012-07-25 | 2023-02-14 | Celldex Therapeutics, Inc | Anticorpo isolado ou fragmento do mesmo, conjugado, usos dos mesmos, composição farmacêutica, polinucleotídeo, vetor, célula hospedeira, célula isolada, kit, método in vitro para inibir atividade da kit, método para produzir um anticorpo |
CA2887129A1 (en) | 2012-10-09 | 2014-04-17 | Igenica, Inc. | Anti-c16orf54 antibodies and methods of use thereof |
CA2914369C (en) | 2013-06-06 | 2023-02-14 | Igenica Biotherapeutics, Inc. | Anti-c10orf54 antibodies and uses thereof |
WO2015053871A2 (en) | 2013-08-26 | 2015-04-16 | MabVax Therapeutics, Inc. | NUCLEIC ACIDS ENCODING HUMAN ANTIBODIES TO SIALYL-LEWISa |
GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
ES2863074T3 (es) | 2014-06-04 | 2021-10-08 | Biontech Res And Development Inc | Anticuerpos monoclonales humanos contra el gangliósido GD2 |
KR20170087500A (ko) | 2014-12-11 | 2017-07-28 | 피에르 파브르 메디카먼트 | 항-c10orf54 항체들 및 그들의 용도들 |
AU2016227493B2 (en) | 2015-03-03 | 2022-01-20 | Kymab Limited | Antibodies, uses & methods |
EP3383908A1 (en) | 2015-12-02 | 2018-10-10 | Stsciences, Inc. | Antibodies specific to glycosylated btla (b- and t- lymphocyte attenuator) |
US10875920B2 (en) | 2015-12-02 | 2020-12-29 | Stcube & Co., Inc. | Antibodies and molecules that immunospecifically bind to BTN1A1 and the therapeutic uses thereof |
WO2018083248A1 (en) | 2016-11-03 | 2018-05-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
KR20200024158A (ko) | 2017-05-31 | 2020-03-06 | 주식회사 에스티큐브앤컴퍼니 | Btn1a1에 면역특이적으로 결합하는 항체 및 분자를 사용하여 암을 치료하는 방법 |
EP3630835A1 (en) | 2017-05-31 | 2020-04-08 | STCube & Co., Inc. | Antibodies and molecules that immunospecifically bind to btn1a1 and the therapeutic uses thereof |
KR20200026209A (ko) | 2017-06-06 | 2020-03-10 | 주식회사 에스티큐브앤컴퍼니 | Btn1a1 또는 btn1a1-리간드에 결합하는 항체 및 분자를 사용하여 암을 치료하는 방법 |
JP7256796B2 (ja) | 2017-10-13 | 2023-04-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Thomsen-nouvelle(tn)抗原に対するヒト抗体 |
JP2021531007A (ja) | 2018-07-20 | 2021-11-18 | ピエール、ファーブル、メディカマン | Vistaに対する受容体 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE903957A1 (en) * | 1989-11-06 | 1991-05-08 | Sanofi Sa | Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present |
CZ229594A3 (en) * | 1992-03-25 | 1995-04-12 | Pfizer | Peptides, process of their preparation, their use and pharmaceutical compositions based thereon |
GB9312806D0 (en) * | 1993-06-22 | 1993-08-04 | Boots Co Plc | Therapeutic agents |
CA2249605A1 (en) * | 1996-04-03 | 1997-10-09 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
WO1997036900A1 (en) * | 1996-04-03 | 1997-10-09 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
EP0906099A4 (en) * | 1996-04-03 | 2001-02-07 | Merck & Co Inc | CANCER TREATMENT METHOD |
AU715202B2 (en) * | 1996-04-03 | 2000-01-20 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
AU716153B2 (en) * | 1996-04-03 | 2000-02-17 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
ES2193590T3 (es) * | 1997-11-28 | 2003-11-01 | Lg Chemical Ltd | Derivados de imidazol que tienen actividad inhibitoria frente a la farnesil transferasa y procedimiento para la preparacion de los mismos. |
-
1999
- 1999-02-01 CA CA002320233A patent/CA2320233C/en not_active Expired - Fee Related
- 1999-02-01 PT PT99901979T patent/PT1058683E/pt unknown
- 1999-02-01 DE DE69904302T patent/DE69904302T2/de not_active Expired - Fee Related
- 1999-02-01 EP EP99901979A patent/EP1058683B1/en not_active Expired - Lifetime
- 1999-02-01 JP JP2000529330A patent/JP3283032B2/ja not_active Expired - Fee Related
- 1999-02-01 WO PCT/KR1999/000051 patent/WO1999038862A1/en active IP Right Grant
- 1999-02-01 AT AT99901979T patent/ATE229017T1/de not_active IP Right Cessation
- 1999-02-01 US US09/601,426 patent/US6436960B1/en not_active Expired - Fee Related
- 1999-02-01 AU AU21886/99A patent/AU745855B2/en not_active Ceased
- 1999-02-01 ES ES99901979T patent/ES2185307T3/es not_active Expired - Lifetime
- 1999-02-01 CN CNB99802581XA patent/CN1158277C/zh not_active Expired - Fee Related
- 1999-02-01 BR BR9908545-3A patent/BR9908545A/pt not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN1158277C (zh) | 2004-07-21 |
AU745855B2 (en) | 2002-04-11 |
EP1058683B1 (en) | 2002-12-04 |
JP3283032B2 (ja) | 2002-05-20 |
US6436960B1 (en) | 2002-08-20 |
WO1999038862A1 (en) | 1999-08-05 |
CN1289331A (zh) | 2001-03-28 |
DE69904302T2 (de) | 2003-08-14 |
BR9908545A (pt) | 2001-10-02 |
CA2320233A1 (en) | 1999-08-05 |
JP2002501918A (ja) | 2002-01-22 |
ATE229017T1 (de) | 2002-12-15 |
EP1058683A1 (en) | 2000-12-13 |
PT1058683E (pt) | 2003-04-30 |
AU2188699A (en) | 1999-08-16 |
DE69904302D1 (de) | 2003-01-16 |
CA2320233C (en) | 2004-07-27 |
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