AU2003211362A1 - N-hydroxycarboxamide derivative - Google Patents
N-hydroxycarboxamide derivativeInfo
- Publication number
- AU2003211362A1 AU2003211362A1 AU2003211362A AU2003211362A AU2003211362A1 AU 2003211362 A1 AU2003211362 A1 AU 2003211362A1 AU 2003211362 A AU2003211362 A AU 2003211362A AU 2003211362 A AU2003211362 A AU 2003211362A AU 2003211362 A1 AU2003211362 A1 AU 2003211362A1
- Authority
- AU
- Australia
- Prior art keywords
- hydroxycarboxamide
- derivative
- hydroxycarboxamide derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/08—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002-45310 | 2002-02-21 | ||
JP2002045310 | 2002-02-21 | ||
JP2002-235912 | 2002-08-13 | ||
JP2002235912 | 2002-08-13 | ||
PCT/JP2003/001681 WO2003070691A1 (en) | 2002-02-21 | 2003-02-18 | N-hydroxycarboxamide derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2003211362A1 true AU2003211362A1 (en) | 2003-09-09 |
Family
ID=27759672
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2003211362A Abandoned AU2003211362A1 (en) | 2002-02-21 | 2003-02-18 | N-hydroxycarboxamide derivative |
Country Status (3)
Country | Link |
---|---|
JP (1) | JPWO2003070691A1 (en) |
AU (1) | AU2003211362A1 (en) |
WO (1) | WO2003070691A1 (en) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7598418B2 (en) * | 2002-04-18 | 2009-10-06 | Institute Of Medicinal Molecular Design, Inc. | Amide derivatives |
ITMI20030064A1 (en) | 2003-01-17 | 2004-07-18 | Italfarmaco Spa | USE OF HYDROXAMIC ACID DERIVATIVES FOR PREPARATION |
CA2520763A1 (en) | 2003-04-03 | 2004-10-21 | The Regents Of The University Of California | Improved inhibitors for the soluble epoxide hydrolase |
BRPI0409227C1 (en) | 2003-04-07 | 2021-05-25 | Axys Pharm Inc | compound, pharmaceutical composition, use of a compound and process for the preparation of a compound of formula (I) |
MXPA05011286A (en) | 2003-08-20 | 2006-01-24 | Axys Pharm Inc | Acetylene derivatives as inhibitors of histone deacetylase. |
JP5107579B2 (en) | 2003-12-02 | 2012-12-26 | ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション | Zn2 + chelate motif tethered short chain fatty acids as a novel class of histone deacetylase inhibitors |
US7326732B2 (en) * | 2004-02-12 | 2008-02-05 | Pharmagene Laboratories Limited | EP2 receptor agonists |
CA2559665A1 (en) | 2004-03-16 | 2005-09-29 | The Regents Of The University Of California | Reducing nephropathy with inhibitors of soluble epoxide hydrolase and epoxyeicosanoids |
ITMI20041347A1 (en) * | 2004-07-05 | 2004-10-05 | Italfarmaco Spa | ALPHA-AMINO ACID DERIVATIVES FOR ANTI-INFLAMMATORY ACTIVITIES |
NZ554555A (en) * | 2004-10-20 | 2011-09-30 | Univ California | Cyclohexyl-urea derivatives as improved inhibitors for the soluble epoxide hydrolase |
WO2007011626A2 (en) | 2005-07-14 | 2007-01-25 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
EP1984334B1 (en) * | 2006-02-15 | 2014-04-09 | Allergan, Inc. | Indole-3-carboxylic acid amide, ester, thioamide and thiol ester compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (s1p) receptor antagonist biological activity |
CN101460458A (en) | 2006-02-15 | 2009-06-17 | 阿勒根公司 | Indole-3-carboxylic acid amide, ester, thioamide and thiol ester compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (S1P) receptor antagonist biological activity |
CN101610996A (en) * | 2006-12-19 | 2009-12-23 | 梅特希尔基因公司 | Histone deacetylase inhibitor and prodrug thereof |
PT2099442E (en) | 2006-12-26 | 2015-02-10 | Pharmacyclics Inc | Method of using histone deacetylase inhibitors and monitoring biomarkers in combination therapy |
US8524917B2 (en) | 2007-01-11 | 2013-09-03 | Allergan, Inc. | 6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity |
JP2010515750A (en) * | 2007-01-11 | 2010-05-13 | アラーガン インコーポレイテッド | 6-Substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity |
CA2677000A1 (en) | 2007-01-30 | 2008-08-07 | Pharmacyclics, Inc. | Methods for determining cancer resistance to histone deacetylase inhibitors |
WO2008126731A1 (en) * | 2007-04-05 | 2008-10-23 | Daiichi Sankyo Company, Limited | Aryl derivatives |
US8293513B2 (en) | 2007-12-14 | 2012-10-23 | Georgetown University | Histone deacetylase inhibitors |
WO2010043953A2 (en) * | 2008-10-15 | 2010-04-22 | Orchid Research Laboratories Ltd. | Novel bridged cyclic compounds as histone deacetylase inhibitors |
US8603521B2 (en) | 2009-04-17 | 2013-12-10 | Pharmacyclics, Inc. | Formulations of histone deacetylase inhibitor and uses thereof |
US8546588B2 (en) | 2010-02-26 | 2013-10-01 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
WO2011106632A1 (en) * | 2010-02-26 | 2011-09-01 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
CN102775368B (en) * | 2011-05-10 | 2016-08-17 | 上海驺虞医药科技有限公司 | One class thiazole compound and its production and use |
SG2014014419A (en) | 2011-09-13 | 2014-07-30 | Pharmacyclics Inc | Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof |
US9409858B2 (en) | 2012-03-07 | 2016-08-09 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Selective histone deactylase 6 inhibitors |
AU2013230881A1 (en) * | 2012-03-07 | 2014-10-30 | Board Of Trustees Of The University Of Illinois | Selective histone deactylase 6 inhibitors |
AU2014260605B2 (en) | 2013-04-29 | 2016-07-14 | Chong Kun Dang Pharmaceutical Corp. | Novel compounds for selective histone deacetylase inhibitors, and pharmaceutical composition comprising the same |
WO2015017546A1 (en) | 2013-07-30 | 2015-02-05 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Selective histone deactylase 6 inhibitors |
JP6800750B2 (en) | 2013-08-02 | 2020-12-16 | ファーマサイクリックス エルエルシー | Treatment method for solid tumors |
EP3769757A3 (en) * | 2013-10-18 | 2021-10-06 | The General Hospital Corporation | Imaging histone deacetylases with a radiotracer using positron emission tomography |
TWI659949B (en) | 2016-05-16 | 2019-05-21 | 臺北醫學大學 | Histone deacetylase 6 inhibitors and use thereof |
CN107141244B (en) * | 2017-05-08 | 2019-11-19 | 潍坊医学院 | Indolebutyric acid class inhibitors of histone deacetylase and its preparation method and application |
CN113444038B (en) * | 2021-07-07 | 2022-09-27 | 新乡医学院 | 2-aryl isonicotinic acid amide LSD1/HDAC double-target inhibitor, and preparation method and application thereof |
CN113527195B (en) * | 2021-07-07 | 2022-09-20 | 新乡医学院 | 5-aryl nicotinamide LSD1/HDAC double-target inhibitor, preparation method and application thereof |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04217950A (en) * | 1990-03-28 | 1992-08-07 | Asahi Chem Ind Co Ltd | Hydroxamic acid derivative, enzyme inhibitor and antiulcer agent |
EP0855024A4 (en) * | 1995-09-20 | 2001-08-22 | Merck & Co Inc | Histone deacetylase as target for antiprotozoal agents |
IT1283637B1 (en) * | 1996-05-14 | 1998-04-23 | Italfarmaco Spa | COMPOUNDS WITH ANTI-INFLAMMATORY AND IMMUNOSOPPRESSIVE ACTIVITY |
JPH11335375A (en) * | 1998-05-20 | 1999-12-07 | Mitsui Chem Inc | Benzamide derivative having histone deacetylase inhibiting action |
JP4269041B2 (en) * | 1999-03-02 | 2009-05-27 | 国立大学法人九州工業大学 | Novel cyclic tetrapeptide derivatives and their pharmaceutical uses |
JP2001081031A (en) * | 1999-08-30 | 2001-03-27 | Schering Ag | Benzamide derivative-containing preparation having improved solubility and oral adsorption |
DK1233958T3 (en) * | 1999-11-23 | 2011-10-17 | Methylgene Inc | Inhibitors of histone deacetylase |
US20050119305A1 (en) * | 2001-03-21 | 2005-06-02 | Masao Naka | Il-6 production inhibitors |
ITMI20011733A1 (en) * | 2001-08-07 | 2003-02-07 | Italfarmaco Spa | HYDROXAMIC ACID DERIVATIVES HISTONE DEHYACETYLASE ENZYM INHIBITORS, WHICH NEW ANTI-INFLAMMATORY DRUGS INHIBIT CITOC SYNTHESIS |
-
2003
- 2003-02-18 WO PCT/JP2003/001681 patent/WO2003070691A1/en active Application Filing
- 2003-02-18 JP JP2003569600A patent/JPWO2003070691A1/en active Pending
- 2003-02-18 AU AU2003211362A patent/AU2003211362A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JPWO2003070691A1 (en) | 2005-06-09 |
WO2003070691A1 (en) | 2003-08-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK6 | Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase |