NO20003565L - Sulfonylaminoderivater som hemmer matriks-nedbrytende metalloproteinaser - Google Patents
Sulfonylaminoderivater som hemmer matriks-nedbrytende metalloproteinaserInfo
- Publication number
- NO20003565L NO20003565L NO20003565A NO20003565A NO20003565L NO 20003565 L NO20003565 L NO 20003565L NO 20003565 A NO20003565 A NO 20003565A NO 20003565 A NO20003565 A NO 20003565A NO 20003565 L NO20003565 L NO 20003565L
- Authority
- NO
- Norway
- Prior art keywords
- inhibit matrix
- degrading metalloproteinases
- sulfonylamino derivatives
- sulfonylamino
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1881998A | 1998-02-04 | 1998-02-04 | |
PCT/EP1999/000646 WO1999042443A1 (en) | 1998-02-04 | 1999-02-02 | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20003565D0 NO20003565D0 (no) | 2000-07-11 |
NO20003565L true NO20003565L (no) | 2000-10-03 |
NO317977B1 NO317977B1 (no) | 2005-01-17 |
Family
ID=21789936
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20003565A NO317977B1 (no) | 1998-02-04 | 2000-07-11 | Sulfonylaminoderivater som hemmer matriks-nedbrytende metalloproteinaser |
Country Status (18)
Country | Link |
---|---|
US (1) | US6277987B1 (no) |
EP (2) | EP1053226A1 (no) |
JP (1) | JP4750272B2 (no) |
KR (1) | KR20010040698A (no) |
CN (1) | CN1195735C (no) |
AU (1) | AU747911B2 (no) |
BR (1) | BR9909322A (no) |
CA (1) | CA2318145C (no) |
HU (1) | HUP0101176A3 (no) |
ID (1) | ID24957A (no) |
IL (1) | IL137465A0 (no) |
NO (1) | NO317977B1 (no) |
NZ (1) | NZ505968A (no) |
PL (1) | PL342009A1 (no) |
RU (1) | RU2208609C2 (no) |
SK (1) | SK11692000A3 (no) |
TR (1) | TR200002224T2 (no) |
WO (1) | WO1999042443A1 (no) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999051572A1 (fr) * | 1998-04-03 | 1999-10-14 | Sankyo Company, Limited | Derives de sulfonamide |
PL350340A1 (en) * | 1999-03-03 | 2002-12-02 | Procter & Gamble | Alkenyl- and alkynyl-containing metalloprotease inhibitors |
NZ513830A (en) | 1999-03-03 | 2001-09-28 | Procter & Gamble | Dihetero-substituted metalloprotease inhibitors |
GB9918684D0 (en) | 1999-08-09 | 1999-10-13 | Novartis Ag | Organic compounds |
EP1088815A1 (en) | 1999-09-28 | 2001-04-04 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active sulfonyl amino acid derivatives |
AU7450300A (en) * | 1999-09-29 | 2001-04-30 | Sankyo Company Limited | Sulfonamide derivatives |
BR0109353A (pt) * | 2000-03-21 | 2003-04-08 | Procter & Gamble | Cadeia lateral heterocìclica contendo inibidores de metaloprotease |
CA2404131A1 (en) | 2000-03-21 | 2001-09-27 | The Procter & Gamble Company | Heterocyclic side chain containing, n-substituted metalloprotease inhibitors |
IL151250A0 (en) | 2000-03-21 | 2003-04-10 | Procter & Gamble | Difluorobutyric acid metalloprotease inhibitors |
AU2001248701A1 (en) * | 2000-03-24 | 2001-10-03 | Methylgene, Inc. | Inhibitors of histone deacetylase |
US6897237B2 (en) | 2000-04-28 | 2005-05-24 | Shionogi & Co. Ltd. | MMP-12 inhibitors |
EP1174129A1 (en) * | 2000-07-17 | 2002-01-23 | Zenner, Hans Peter, Prof. Dr. med. | Use of a matrix-metalloprotease inhibitor for the treatment of cancer |
GB0103303D0 (en) | 2001-02-09 | 2001-03-28 | Novartis Ag | Organic compounds |
SE0100903D0 (sv) * | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
SE0100902D0 (sv) | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
SE0103710D0 (sv) | 2001-11-07 | 2001-11-07 | Astrazeneca Ab | Compounds |
CA2473938C (en) | 2001-12-14 | 2013-10-08 | S. David Brown | Human adam-10 inhibitors |
TW200305396A (en) * | 2002-03-27 | 2003-11-01 | Shionogi & Co | Cartilage extracellular matrix degradation |
SI1511472T1 (sl) | 2002-05-29 | 2009-08-31 | Merck & Co Inc | Spojine uporabne pri zdravljenju antraksa in inhibiranju letalnega faktorja |
SE0202539D0 (sv) | 2002-08-27 | 2002-08-27 | Astrazeneca Ab | Compounds |
GB0221246D0 (en) * | 2002-09-13 | 2002-10-23 | Astrazeneca Ab | Compounds |
CN1950354A (zh) | 2004-05-11 | 2007-04-18 | 默克公司 | N-磺酰化-氨基酸衍生物的制备方法 |
GB0412553D0 (en) * | 2004-06-04 | 2004-07-07 | Univ Aberdeen | Therapeutic agents for the treatment of bone conditions |
US7648992B2 (en) | 2004-07-05 | 2010-01-19 | Astrazeneca Ab | Hydantoin derivatives for the treatment of obstructive airway diseases |
SE0401762D0 (sv) | 2004-07-05 | 2004-07-05 | Astrazeneca Ab | Novel compounds |
EP1802331A2 (en) * | 2004-09-08 | 2007-07-04 | Boys Town National Research Hospital | Treatment of glomerular basement membrane disease involving matrix metalloproteinase-12 |
US20100003276A1 (en) * | 2004-12-07 | 2010-01-07 | Hermes Jeffery D | Methods for treating anthrax and inhibiting lethal factor |
SE0403085D0 (sv) | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Novel componds |
SE0403086D0 (sv) | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Compounds |
US7576222B2 (en) * | 2004-12-28 | 2009-08-18 | Wyeth | Alkynyl-containing tryptophan derivative inhibitors of TACE/matrix metalloproteinase |
WO2007117451A2 (en) * | 2006-03-31 | 2007-10-18 | The Regents Of The University Of Michigan | A pericellular collagenase directs the 3-dimensional development of white adipose tissue |
TW200831488A (en) * | 2006-11-29 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
EP1972617A1 (en) * | 2007-03-19 | 2008-09-24 | Bracco Imaging, S.P.A. | Compounds having aryl-sulphonamidic structure useful as metalloproteases inhibitors |
GB0705400D0 (en) | 2007-03-21 | 2007-05-02 | Univ Aberdeen | Therapeutic compounds andm their use |
CN102036953B (zh) | 2008-03-24 | 2015-05-06 | 诺华股份有限公司 | 基于芳基磺酰胺的基质金属蛋白酶抑制剂 |
EP2149568A1 (en) | 2008-07-22 | 2010-02-03 | Bracco Imaging S.p.A | Aryl-sulphonamidic dimers as metalloproteases inhibitors |
EP2147684A1 (en) * | 2008-07-22 | 2010-01-27 | Bracco Imaging S.p.A | Diagnostic Agents Selective Against Metalloproteases |
GB0817207D0 (en) | 2008-09-19 | 2008-10-29 | Pimco 2664 Ltd | therapeutic apsac compounds and their use |
GB0817208D0 (en) | 2008-09-19 | 2008-10-29 | Pimco 2664 Ltd | Therapeutic apsap compounds and their use |
UA108193C2 (uk) * | 2008-12-04 | 2015-04-10 | Апоптозіндукуючий засіб для лікування раку і імунних і аутоімунних захворювань | |
US8557983B2 (en) | 2008-12-04 | 2013-10-15 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
US20100160322A1 (en) | 2008-12-04 | 2010-06-24 | Abbott Laboratories | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
US8563735B2 (en) | 2008-12-05 | 2013-10-22 | Abbvie Inc. | Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
US8586754B2 (en) | 2008-12-05 | 2013-11-19 | Abbvie Inc. | BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
EP3101019A1 (en) * | 2008-12-05 | 2016-12-07 | AbbVie Inc. | Sulfonamide derivatives as bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases |
ITTO20090648A1 (it) * | 2009-08-19 | 2011-02-20 | Istituto Naz Per La Ricerca Sul Cancro | Inibitori di adam17 atti a modulare il rilascio di alcam (cd166) solubile in cellule tumorali e loro uso nel trattamento terapeutico del carcinoma ovarico epiteliale (eoc) |
US9023318B2 (en) | 2011-06-08 | 2015-05-05 | Siemens Medical Solutions Usa, Inc. | Compounds with matrix-metalloproteinase inhibitory activity and imaging agents thereof |
GB201311361D0 (en) | 2013-06-26 | 2013-08-14 | Pimco 2664 Ltd | Compounds and their therapeutic use |
HUE057569T2 (hu) | 2014-12-17 | 2022-05-28 | Pimco 2664 Ltd | N-(4-hidroxi-4-metil-ciklohexil)-4-fenil-benzolszulfonamid és N-(4-hidroxi-4-metil-ciklohexil)-4-(2-piridil)-benzolszulfonamid vegyületek és terápiás alkalmazásuk |
CN110483437B (zh) * | 2018-05-14 | 2022-12-06 | 嘉兴维眸生物科技有限公司 | 一种含五元环的化合物及其制备和应用 |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1493664A1 (de) | 1964-07-16 | 1969-06-04 | Hoechst Ag | Verfahren zur Spaltung von aromatischen Sulfonsaeureamiden |
AU4267293A (en) | 1992-05-01 | 1993-11-29 | British Biotech Pharmaceuticals Limited | Use of MMP inhibitors |
US5646167A (en) * | 1993-01-06 | 1997-07-08 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamix acids |
US5506242A (en) * | 1993-01-06 | 1996-04-09 | Ciba-Geigy Corporation | Arylsufonamido-substituted hydroxamic acids |
US5552419A (en) * | 1993-01-06 | 1996-09-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
ATE191468T1 (de) | 1994-06-22 | 2000-04-15 | British Biotech Pharm | Metalloproteinase inhibitoren |
AU727569B2 (en) | 1995-11-17 | 2000-12-14 | Warner-Lambert Company | Sulfonamide inhibitors of matrix metalloproteinases |
US5753653A (en) | 1995-12-08 | 1998-05-19 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
IL138027A (en) | 1995-12-08 | 2004-08-31 | Agouron Pharma | Intermediates for the preparation and preparation of metalloproteinase inhibitors |
PL205341B1 (pl) * | 1996-01-23 | 2010-04-30 | Shionogi & Co | Pochodne sulfonowanych aminokwasów i zawierające je kompozycje farmaceutyczne inhibitujące metaloproteinazę |
IL126832A0 (en) * | 1996-05-17 | 1999-08-17 | Warner Lambert Co | Biphenylsulfonamide matrix metalloproteinase inhibitors |
JPH10265452A (ja) | 1996-05-24 | 1998-10-06 | Ono Pharmaceut Co Ltd | フェニルスルホンアミド誘導体 |
ATE227274T1 (de) | 1996-08-28 | 2002-11-15 | Procter & Gamble | 1,3-diheterozyklische metalloprotease inhibitoren |
CA2264044A1 (en) | 1996-08-28 | 1998-03-05 | Zhe Wang | Spirocyclic metalloprotease inhibitors |
JP3347331B2 (ja) | 1996-08-28 | 2002-11-20 | ザ プロクター アンド ギャンブル カンパニー | 複素環式メタロプロテアーゼ阻害剤 |
CZ62399A3 (cs) | 1996-08-28 | 1999-07-14 | The Procter & Gamble Company | 1,4-Heterocyklické metaloproteázové inhibitory |
DK0927161T3 (da) | 1996-08-28 | 2003-02-17 | Procter & Gamble | Substitueret cyklisk amin-metalloproteaseinhibitorer |
BR9712792A (pt) | 1996-08-28 | 1999-12-14 | Procter & Gamble | Inibidores de metaloprotease bidentada. |
PT946166E (pt) * | 1996-12-17 | 2004-06-30 | Warner Lambert Co | Utilizacao de inibidores das metaloproteinases da matriz para tratar disturbios neurologicos e promover a cicatrizacao de feridas |
AU720615B2 (en) * | 1997-01-17 | 2000-06-08 | Pharmacia & Upjohn Company | Bis-sulfonomides hydroxamic acids as MMP inhibitors |
US5985900A (en) * | 1997-04-01 | 1999-11-16 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
EP0973748A1 (en) | 1997-04-01 | 2000-01-26 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
US5756545A (en) * | 1997-04-21 | 1998-05-26 | Warner-Lambert Company | Biphenysulfonamide matrix metal alloproteinase inhibitors |
DE19719585A1 (de) | 1997-05-09 | 1998-11-12 | Hoechst Ag | Substituierte Diaminocarbonsäuren |
DE59802394D1 (de) * | 1997-05-09 | 2002-01-24 | Hoechst Ag | Substituierte Diaminocarbonsäuren |
DE19719428A1 (de) | 1997-05-12 | 1998-11-19 | Hoechst Ag | Substituierte Diaminocarbonsäuren |
WO1998050348A1 (en) | 1997-05-09 | 1998-11-12 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
DE19719621A1 (de) * | 1997-05-09 | 1998-11-12 | Hoechst Ag | Sulfonylaminocarbonsäuren |
BR9811521A (pt) | 1997-07-22 | 2000-08-22 | Shionogi & Co | Composição para tratar ou impedir a glomerulopatia |
HUP0004595A3 (en) * | 1997-07-31 | 2001-12-28 | Procter & Gamble | Acyclic metalloprotease inhibitors |
-
1999
- 1999-02-02 CN CNB998027154A patent/CN1195735C/zh not_active Expired - Fee Related
- 1999-02-02 RU RU2000123166/04A patent/RU2208609C2/ru not_active IP Right Cessation
- 1999-02-02 JP JP2000532395A patent/JP4750272B2/ja not_active Expired - Fee Related
- 1999-02-02 CA CA002318145A patent/CA2318145C/en not_active Expired - Fee Related
- 1999-02-02 EP EP99910174A patent/EP1053226A1/en not_active Ceased
- 1999-02-02 EP EP07120827A patent/EP1918278A1/en not_active Withdrawn
- 1999-02-02 PL PL99342009A patent/PL342009A1/xx not_active Application Discontinuation
- 1999-02-02 AU AU29235/99A patent/AU747911B2/en not_active Ceased
- 1999-02-02 KR KR1020007008576A patent/KR20010040698A/ko not_active Application Discontinuation
- 1999-02-02 ID IDW20001501A patent/ID24957A/id unknown
- 1999-02-02 TR TR2000/02224T patent/TR200002224T2/xx unknown
- 1999-02-02 HU HU0101176A patent/HUP0101176A3/hu unknown
- 1999-02-02 NZ NZ505968A patent/NZ505968A/xx unknown
- 1999-02-02 WO PCT/EP1999/000646 patent/WO1999042443A1/en not_active Application Discontinuation
- 1999-02-02 SK SK1169-2000A patent/SK11692000A3/sk unknown
- 1999-02-02 BR BR9909322-7A patent/BR9909322A/pt not_active IP Right Cessation
- 1999-02-02 IL IL13746599A patent/IL137465A0/xx unknown
- 1999-02-03 US US09/243,854 patent/US6277987B1/en not_active Expired - Fee Related
-
2000
- 2000-07-11 NO NO20003565A patent/NO317977B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US6277987B1 (en) | 2001-08-21 |
PL342009A1 (en) | 2001-05-07 |
CN1290250A (zh) | 2001-04-04 |
NO20003565D0 (no) | 2000-07-11 |
CA2318145A1 (en) | 1999-08-26 |
TR200002224T2 (tr) | 2000-12-21 |
RU2208609C2 (ru) | 2003-07-20 |
AU2923599A (en) | 1999-09-06 |
KR20010040698A (ko) | 2001-05-15 |
ID24957A (id) | 2000-08-31 |
SK11692000A3 (sk) | 2001-02-12 |
BR9909322A (pt) | 2000-12-05 |
JP4750272B2 (ja) | 2011-08-17 |
AU747911B2 (en) | 2002-05-30 |
JP2002503720A (ja) | 2002-02-05 |
HUP0101176A3 (en) | 2002-06-28 |
EP1918278A1 (en) | 2008-05-07 |
CA2318145C (en) | 2009-10-27 |
NZ505968A (en) | 2003-03-28 |
NO317977B1 (no) | 2005-01-17 |
HUP0101176A2 (hu) | 2001-09-28 |
WO1999042443A1 (en) | 1999-08-26 |
IL137465A0 (en) | 2001-07-24 |
EP1053226A1 (en) | 2000-11-22 |
CN1195735C (zh) | 2005-04-06 |
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