ATE227274T1 - 1,3-diheterozyklische metalloprotease inhibitoren - Google Patents
1,3-diheterozyklische metalloprotease inhibitorenInfo
- Publication number
- ATE227274T1 ATE227274T1 AT97937317T AT97937317T ATE227274T1 AT E227274 T1 ATE227274 T1 AT E227274T1 AT 97937317 T AT97937317 T AT 97937317T AT 97937317 T AT97937317 T AT 97937317T AT E227274 T1 ATE227274 T1 AT E227274T1
- Authority
- AT
- Austria
- Prior art keywords
- diheterocyclic
- metalloprotease inhibitors
- metalloprotease
- inhibitors
- diheterocyclic metalloprotease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/10—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/04—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
- C07D279/06—1,3-Thiazines; Hydrogenated 1,3-thiazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2483096P | 1996-08-28 | 1996-08-28 | |
PCT/US1997/014550 WO1998008822A1 (en) | 1996-08-28 | 1997-08-22 | 1,3-diheterocyclic metalloprotease inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE227274T1 true ATE227274T1 (de) | 2002-11-15 |
Family
ID=21822602
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97937317T ATE227274T1 (de) | 1996-08-28 | 1997-08-22 | 1,3-diheterozyklische metalloprotease inhibitoren |
Country Status (25)
Country | Link |
---|---|
US (4) | US6150370A (de) |
EP (1) | EP0927168B1 (de) |
JP (1) | JP3347330B2 (de) |
KR (1) | KR20000035918A (de) |
CN (1) | CN1228771A (de) |
AR (1) | AR009455A1 (de) |
AT (1) | ATE227274T1 (de) |
AU (1) | AU727820B2 (de) |
BR (1) | BR9713186A (de) |
CA (1) | CA2264266A1 (de) |
CO (1) | CO4900035A1 (de) |
CZ (1) | CZ62899A3 (de) |
DE (1) | DE69716934T2 (de) |
DK (1) | DK0927168T3 (de) |
HU (1) | HUP0000130A2 (de) |
ID (1) | ID18141A (de) |
IL (1) | IL128661A (de) |
NO (1) | NO315158B1 (de) |
NZ (1) | NZ334251A (de) |
PE (1) | PE107898A1 (de) |
PL (1) | PL331838A1 (de) |
SK (1) | SK24999A3 (de) |
TR (1) | TR199900383T2 (de) |
WO (1) | WO1998008822A1 (de) |
ZA (1) | ZA977693B (de) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0927168B1 (de) * | 1996-08-28 | 2002-11-06 | The Procter & Gamble Company | 1,3-diheterozyklische metalloprotease inhibitoren |
WO1999006340A2 (en) | 1997-07-31 | 1999-02-11 | The Procter & Gamble Company | Sulfonylamino substituted hydroxamic acid derivatives as metalloprotease inhibitors |
US6410580B1 (en) | 1998-02-04 | 2002-06-25 | Novartis Ag | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases |
BR9909322A (pt) | 1998-02-04 | 2000-12-05 | Novartis Ag | Derivados de sulfonilamino que inibem metaloproteinases de degradação de matriz |
US6846478B1 (en) | 1998-02-27 | 2005-01-25 | The Procter & Gamble Company | Promoting whole body health |
US6200996B1 (en) | 1999-01-27 | 2001-03-13 | American Cyanamid Company | Heteroaryl acetylenic sulfonamide and phosphinic acid amide hydroxamic acid tace inhibitors |
US6762178B2 (en) | 1999-01-27 | 2004-07-13 | Wyeth Holdings Corporation | Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors |
US6277885B1 (en) | 1999-01-27 | 2001-08-21 | American Cyanamid Company | Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors |
US6340691B1 (en) | 1999-01-27 | 2002-01-22 | American Cyanamid Company | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors |
US6225311B1 (en) | 1999-01-27 | 2001-05-01 | American Cyanamid Company | Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors |
US6326516B1 (en) | 1999-01-27 | 2001-12-04 | American Cyanamid Company | Acetylenic β-sulfonamido and phosphinic acid amide hydroxamic acid TACE inhibitors |
US6544984B1 (en) | 1999-01-27 | 2003-04-08 | American Cyanamid Company | 2,3,4,5-tetrahydro-1H-(1,4)benzodiazepine-3-hydroxamic acids |
US6753337B2 (en) | 1999-01-27 | 2004-06-22 | Wyeth Holdings Corporation | Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors |
AR022423A1 (es) * | 1999-01-27 | 2002-09-04 | American Cyanamid Co | Compuestos derivados de acidos 2,3,4,5-tetrahidro-1h-[1,4]benzodiazepina-3-hidroxamicos, composicion farmaceutica que los comprenden, y el uso de losmismos para la manufactura de un medicamento |
US6946473B2 (en) | 1999-01-27 | 2005-09-20 | Wyeth Holdings Corporation | Preparation and use of acetylenic ortho-sulfonamido and phosphinic acid amido bicyclic heteroaryl hydroxamic acids as TACE inhibitors |
BR0007784A (pt) | 1999-01-27 | 2002-02-05 | American Cyanamid Co | Composto, método para inibir mudanças patológicas mediadas pela enzima que converte o tnf-alfa (tace) em um mamìfero, composição farmacêutica, e, processo para preparar um composto |
US6313123B1 (en) | 1999-01-27 | 2001-11-06 | American Cyanamid Company | Acetylenic sulfonamide thiol tace inhibitors |
KR20010102486A (ko) | 1999-03-03 | 2001-11-15 | 데이비드 엠 모이어 | 알케닐- 및 알키닐-함유 메탈로프로테아제 저해제 |
HUP0201714A3 (en) | 1999-03-03 | 2003-05-28 | Procter & Gamble | Substituted heterocyclic compounds and pharmaceutical compositions containing them |
ATE383873T1 (de) * | 1999-10-22 | 2008-02-15 | Biogen Idec Inc | Verwendung eines cd40:cd154 bindungs- unterbrechers zur behandlung immunologischer komplikationen des auges |
GB0011409D0 (en) * | 2000-05-11 | 2000-06-28 | Smithkline Beecham Plc | Novel compounds |
US8283135B2 (en) | 2000-06-30 | 2012-10-09 | The Procter & Gamble Company | Oral care compositions containing combinations of anti-bacterial and host-response modulating agents |
WO2002002096A2 (en) | 2000-06-30 | 2002-01-10 | The Procter & Gamble Company | Oral compositions comprising host-response modulating agent |
MXPA01013326A (es) | 2001-02-14 | 2002-08-26 | Warner Lambert Co | Bifenil sulfonamidas utiles como inhibisdores de metaloproteinasa de matriz. |
WO2002096420A2 (en) * | 2001-05-29 | 2002-12-05 | Guilford Pharmaceuticals Inc. | Method for treating nerve injury caused by surgery |
WO2003037852A1 (en) | 2001-11-01 | 2003-05-08 | Wyeth Holdings Corporation | Allenic aryl sulfonamide hydroxamic acids as matrix metalloproteinase and tace inhibitors |
CN100484524C (zh) | 2002-03-28 | 2009-05-06 | 雪兰诺实验室有限公司 | 用作***素受体调节剂的噻唑烷甲酰胺衍生物 |
EP2266993B1 (de) * | 2002-10-30 | 2017-06-14 | Bridgestone Corporation | Verwendung von schwefelhaltigen initiatoren zur anionischen polymerisation von monomeren |
US7199155B2 (en) | 2002-12-23 | 2007-04-03 | Wyeth Holdings Corporation | Acetylenic aryl sulfonate hydroxamic acid TACE and matrix metalloproteinase inhibitors |
US8394858B2 (en) | 2009-12-03 | 2013-03-12 | Novartis Ag | Cyclohexane derivatives and uses thereof |
JP6037396B2 (ja) | 2012-01-27 | 2016-12-07 | 国立大学法人富山大学 | セリンラセマーゼ阻害剤 |
WO2017006271A1 (en) | 2015-07-08 | 2017-01-12 | University Of Southern California | Deoxyuridine triphosphatase inhibitors containing amino sulfonyl linkage |
US10577321B2 (en) | 2015-07-08 | 2020-03-03 | University Of Southern California | Deoxyuridine triphosphatase inhibitors |
US10544105B2 (en) | 2015-07-08 | 2020-01-28 | Cv6 Therapeutics (Ni) Limited | Deoxyuridine triphosphatase inhibitors containing cyclopropano linkage |
WO2017006282A1 (en) | 2015-07-08 | 2017-01-12 | Cv6 Therapeutics (Ni) Limited | Hydantoin containing deoxyuridine triphosphatase inhibitors |
WO2018098208A1 (en) | 2016-11-23 | 2018-05-31 | Cv6 Therapeutics (Ni) Limited | Nitrogen ring linked deoxyuridine triphosphatase inhibitors |
WO2018098209A1 (en) | 2016-11-23 | 2018-05-31 | Cv6 Therapeutics (Ni) Limited | Amino sulfonyl compounds |
WO2018098204A1 (en) | 2016-11-23 | 2018-05-31 | Cv6 Therapeutics (Ni) Limited | 6-membered uracil isosteres |
WO2018128720A1 (en) | 2017-01-05 | 2018-07-12 | Cv6 Therapeutics (Ni) Limited | Uracil containing compounds |
RU2717246C1 (ru) * | 2019-06-17 | 2020-03-19 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермская государственная фармацевтическая академия" Министерства здравоохранения Российской Федерации (ПГФА) | Этил 4-(5-бензоил-6-(4-(диэтиламино)фенил)-4-гидрокси-2-тиоксогексагидропиримидин-4-карбоксамино)бензоат, проявляющий анальгетическое и противовоспалительное действие |
CN114981241A (zh) * | 2020-01-17 | 2022-08-30 | 大邱庆北尖端医疗产业振兴财团 | 新型化合物及其制备方法和用途 |
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NZ288299A (en) * | 1994-06-22 | 1998-06-26 | British Biotech Pharm | Substituted (hetero)aryl-sulphonylaminomethyl-hydroxamic acid and medicaments |
CZ292942B6 (cs) * | 1995-12-08 | 2004-01-14 | Agouron Pharmaceuticals, Inc. | Derivát (N-hydroxykarbamoyl)-1-(4-fenoxy)benzensulfonylu |
US5753653A (en) * | 1995-12-08 | 1998-05-19 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
EP0927168B1 (de) * | 1996-08-28 | 2002-11-06 | The Procter & Gamble Company | 1,3-diheterozyklische metalloprotease inhibitoren |
HUP0000210A3 (en) * | 1996-08-28 | 2001-07-30 | Procter And Gamble Co Cincinna | Heterocyclic compounds as metalloprotease inhibitors and use of them for producing pharmaceutical compisitions |
-
1997
- 1997-08-22 EP EP97937317A patent/EP0927168B1/de not_active Expired - Lifetime
- 1997-08-22 TR TR1999/00383T patent/TR199900383T2/xx unknown
- 1997-08-22 CZ CZ99628A patent/CZ62899A3/cs unknown
- 1997-08-22 NZ NZ334251A patent/NZ334251A/xx unknown
- 1997-08-22 WO PCT/US1997/014550 patent/WO1998008822A1/en not_active Application Discontinuation
- 1997-08-22 CA CA002264266A patent/CA2264266A1/en not_active Abandoned
- 1997-08-22 IL IL12866197A patent/IL128661A/en not_active IP Right Cessation
- 1997-08-22 SK SK249-99A patent/SK24999A3/sk unknown
- 1997-08-22 HU HU0000130A patent/HUP0000130A2/hu unknown
- 1997-08-22 AT AT97937317T patent/ATE227274T1/de not_active IP Right Cessation
- 1997-08-22 PL PL97331838A patent/PL331838A1/xx unknown
- 1997-08-22 KR KR1019997001654A patent/KR20000035918A/ko not_active Application Discontinuation
- 1997-08-22 BR BR9713186-5A patent/BR9713186A/pt unknown
- 1997-08-22 JP JP51171098A patent/JP3347330B2/ja not_active Expired - Fee Related
- 1997-08-22 DE DE69716934T patent/DE69716934T2/de not_active Expired - Fee Related
- 1997-08-22 CN CN97197545A patent/CN1228771A/zh active Pending
- 1997-08-22 DK DK97937317T patent/DK0927168T3/da active
- 1997-08-22 AU AU39858/97A patent/AU727820B2/en not_active Ceased
- 1997-08-26 US US08/918,419 patent/US6150370A/en not_active Expired - Fee Related
- 1997-08-27 AR ARP970103900A patent/AR009455A1/es unknown
- 1997-08-27 ZA ZA9707693A patent/ZA977693B/xx unknown
- 1997-08-27 CO CO97049507A patent/CO4900035A1/es unknown
- 1997-08-28 ID IDP972991A patent/ID18141A/id unknown
- 1997-08-28 PE PE1997000771A patent/PE107898A1/es not_active Application Discontinuation
-
1999
- 1999-02-22 NO NO19990838A patent/NO315158B1/no not_active IP Right Cessation
-
2000
- 2000-08-29 US US09/649,826 patent/US6469000B1/en not_active Expired - Fee Related
- 2000-08-29 US US09/652,114 patent/US6465474B1/en not_active Expired - Fee Related
-
2002
- 2002-08-27 US US10/228,490 patent/US20030130271A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0927168B1 (de) | 2002-11-06 |
ZA977693B (en) | 1998-02-23 |
DK0927168T3 (da) | 2003-03-10 |
US6465474B1 (en) | 2002-10-15 |
ID18141A (id) | 1998-03-05 |
PL331838A1 (en) | 1999-08-02 |
DE69716934D1 (de) | 2002-12-12 |
AU727820B2 (en) | 2000-12-21 |
CZ62899A3 (cs) | 1999-07-14 |
JP3347330B2 (ja) | 2002-11-20 |
NO990838L (no) | 1999-04-28 |
AR009455A1 (es) | 2000-04-26 |
SK24999A3 (en) | 2000-02-14 |
CA2264266A1 (en) | 1998-03-05 |
TR199900383T2 (xx) | 1999-05-21 |
EP0927168A1 (de) | 1999-07-07 |
NZ334251A (en) | 2000-11-24 |
NO990838D0 (no) | 1999-02-22 |
HUP0000130A2 (hu) | 2000-06-28 |
PE107898A1 (es) | 1999-02-19 |
CO4900035A1 (es) | 2000-03-27 |
AU3985897A (en) | 1998-03-19 |
BR9713186A (pt) | 1999-11-03 |
US20030130271A1 (en) | 2003-07-10 |
IL128661A0 (en) | 2000-01-31 |
IL128661A (en) | 2001-10-31 |
WO1998008822A1 (en) | 1998-03-05 |
KR20000035918A (ko) | 2000-06-26 |
NO315158B1 (no) | 2003-07-21 |
JP2000516251A (ja) | 2000-12-05 |
US6469000B1 (en) | 2002-10-22 |
US6150370A (en) | 2000-11-21 |
CN1228771A (zh) | 1999-09-15 |
DE69716934T2 (de) | 2003-07-31 |
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Legal Events
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |