NO163406C - Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazokinolinonderivater. - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazokinolinonderivater.

Info

Publication number
NO163406C
NO163406C NO861617A NO861617A NO163406C NO 163406 C NO163406 C NO 163406C NO 861617 A NO861617 A NO 861617A NO 861617 A NO861617 A NO 861617A NO 163406 C NO163406 C NO 163406C
Authority
NO
Norway
Prior art keywords
imidazokinolino
derivatives
preparation
therapeutic active
analogy procedure
Prior art date
Application number
NO861617A
Other languages
English (en)
Norwegian (no)
Other versions
NO861617L (no
NO163406B (no
Inventor
Nicholas A Meanwell
John J Wright
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO861617L publication Critical patent/NO861617L/no
Priority to NO893610A priority Critical patent/NO166081C/no
Priority to NO893611A priority patent/NO893611D0/no
Priority to NO893612A priority patent/NO166082C/no
Publication of NO163406B publication Critical patent/NO163406B/no
Publication of NO163406C publication Critical patent/NO163406C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO861617A 1985-04-25 1986-04-24 Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazokinolinonderivater. NO163406C (no)

Priority Applications (3)

Application Number Priority Date Filing Date Title
NO893610A NO166081C (no) 1985-04-25 1989-09-08 Mellomprodukter til bruk ved fremstilling av imidazokinolinderivater
NO893611A NO893611D0 (no) 1985-04-25 1989-09-08 Fremstilling av imidazokinolinonderivater.
NO893612A NO166082C (no) 1985-04-25 1989-09-08 Mellomprodukter til bruk ved fremstilling av imidazokinolinonderivater.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72686985A 1985-04-25 1985-04-25
US06/832,212 US4668686A (en) 1985-04-25 1986-02-26 Imidazoquinoline antithrombrogenic cardiotonic agents

Publications (3)

Publication Number Publication Date
NO861617L NO861617L (no) 1986-10-27
NO163406B NO163406B (no) 1990-02-12
NO163406C true NO163406C (no) 1990-05-23

Family

ID=27111398

Family Applications (1)

Application Number Title Priority Date Filing Date
NO861617A NO163406C (no) 1985-04-25 1986-04-24 Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazokinolinonderivater.

Country Status (32)

Country Link
US (1) US4668686A (de)
KR (1) KR940000828B1 (de)
CN (1) CN1016175B (de)
AT (1) AT390257B (de)
AU (1) AU592983B2 (de)
BE (1) BE904671A (de)
CA (1) CA1298836C (de)
CH (1) CH675722A5 (de)
CY (1) CY1641A (de)
DE (1) DE3614132A1 (de)
DK (3) DK164868C (de)
EG (1) EG18104A (de)
ES (3) ES8708229A1 (de)
FI (1) FI83316C (de)
FR (1) FR2581065B1 (de)
GB (1) GB2174987B (de)
GR (1) GR861086B (de)
HK (1) HK64492A (de)
HU (1) HU195813B (de)
IL (1) IL78581A0 (de)
IT (1) IT1215651B (de)
LU (1) LU86406A1 (de)
MY (1) MY102086A (de)
NL (1) NL8601053A (de)
NO (1) NO163406C (de)
NZ (1) NZ215885A (de)
OA (1) OA08242A (de)
PT (1) PT82460B (de)
SE (1) SE461468B (de)
SG (1) SG29092G (de)
SU (3) SU1450746A3 (de)
YU (1) YU46054B (de)

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US4775674A (en) * 1986-05-23 1988-10-04 Bristol-Myers Company Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) * 1986-07-08 1987-10-20 Bristol-Myers Company 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US4743607A (en) * 1987-05-29 1988-05-10 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic imidazolones
US4803210A (en) * 1987-05-29 1989-02-07 Merrell Dow Pharmaceuticals Inc. Cardiotonic tricyclic oxazolones
US4943573A (en) * 1989-11-01 1990-07-24 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
DE4035854C2 (de) * 1990-11-10 1996-10-02 Daimler Benz Ag Vorrichtung zum Fangen und Ableiten des von einem Fahrzeugrad hochgeschleuderten Spritzwassers
PH31245A (en) * 1991-10-30 1998-06-18 Janssen Pharmaceutica Nv 1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
US5208237A (en) * 1992-04-03 1993-05-04 Bristol-Meyers Squibb Company 7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
US5348960A (en) * 1992-04-03 1994-09-20 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
US5196428A (en) * 1992-04-03 1993-03-23 Bristol-Myers Squibb Company Imidazo[4,5-b]qinolinyl oxy alkyl ureas
US5158958A (en) * 1992-04-03 1992-10-27 Bristol-Myers Squibb Company Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
US5552267A (en) * 1992-04-03 1996-09-03 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
BRPI0413558A (pt) 2003-08-12 2006-10-17 3M Innovative Properties Co compostos contendo imidazo substituìdo por hidroxilamina
AU2004268625B2 (en) 2003-08-27 2011-03-31 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted imidazoquinolines
EP1660026A4 (de) 2003-09-05 2008-07-16 3M Innovative Properties Co Behandlung von cd5+ b-zell-lyphom
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
AR046046A1 (es) 2003-10-03 2005-11-23 3M Innovative Properties Co Imidazoquinolinas alcoxi sustituidas. composiciones farmaceuticas.
WO2005048945A2 (en) * 2003-11-14 2005-06-02 3M Innovative Properties Company Hydroxylamine substituted imidazo ring compounds
CN1906193A (zh) 2003-11-14 2007-01-31 3M创新有限公司 肟取代的咪唑环化合物
KR101130928B1 (ko) 2003-11-25 2012-04-12 쓰리엠 이노베이티브 프로퍼티즈 컴파니 치환된 이미다조 고리 시스템 및 방법
WO2005066170A1 (en) 2003-12-29 2005-07-21 3M Innovative Properties Company Arylalkenyl and arylalkynyl substituted imidazoquinolines
EP1699788A2 (de) 2003-12-30 2006-09-13 3M Innovative Properties Company Imidazochinolinyl-, imidazopyridinyl- und imidazonaphthyridinylsulfonamide
US8697873B2 (en) 2004-03-24 2014-04-15 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
WO2005123080A2 (en) 2004-06-15 2005-12-29 3M Innovative Properties Company Nitrogen-containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
US7915281B2 (en) 2004-06-18 2011-03-29 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and method
US7897609B2 (en) 2004-06-18 2011-03-01 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
US8026366B2 (en) 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
US7943609B2 (en) 2004-12-30 2011-05-17 3M Innovative Proprerties Company Chiral fused [1,2]imidazo[4,5-C] ring compounds
EP1831221B1 (de) 2004-12-30 2012-08-08 3M Innovative Properties Company Substituierte, chirale, fusionierte 1,2 imidazo-4,5-c-ringverbindungen
WO2006084251A2 (en) 2005-02-04 2006-08-10 Coley Pharmaceutical Group, Inc. Aqueous gel formulations containing immune reponse modifiers
US7968563B2 (en) 2005-02-11 2011-06-28 3M Innovative Properties Company Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
WO2006107853A2 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. Pyrazolopyridine-1,4-diamines and analogs thereof
US7943636B2 (en) 2005-04-01 2011-05-17 3M Innovative Properties Company 1-substituted pyrazolo (3,4-C) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
WO2008008432A2 (en) 2006-07-12 2008-01-17 Coley Pharmaceutical Group, Inc. Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods
US8227603B2 (en) 2006-08-01 2012-07-24 Cytokinetics, Inc. Modulating skeletal muscle
US8299248B2 (en) 2006-08-02 2012-10-30 Cytokinetics, Incorporated Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
EP2995619B1 (de) 2006-08-02 2019-09-25 Cytokinetics, Inc. Bestimmte chemische stoffe enthaltend imidazopyrimidine, zusammensetzungen und verfahren
US7851484B2 (en) 2007-03-30 2010-12-14 Cytokinetics, Inc. Certain chemical entities, compositions, and methods
KR101951220B1 (ko) 2011-07-13 2019-02-22 싸이토키네틱스, 인코포레이티드 조합 als 치료법

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932407A (en) * 1973-11-19 1976-01-13 Bristol-Myers Company Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones

Also Published As

Publication number Publication date
DK165248B (da) 1992-10-26
MY102086A (en) 1992-03-31
DK80291D0 (da) 1991-04-30
ATA112186A (de) 1989-09-15
CA1298836C (en) 1992-04-14
FR2581065A1 (fr) 1986-10-31
EG18104A (en) 1992-09-30
NZ215885A (en) 1989-04-26
CN86102747A (zh) 1987-02-04
IL78581A0 (en) 1986-08-31
GR861086B (en) 1986-09-01
SG29092G (en) 1992-05-15
KR860008177A (ko) 1986-11-12
ES557551A0 (es) 1988-02-16
DK165249C (da) 1993-03-22
FI83316C (fi) 1991-06-25
ES8802521A1 (es) 1988-07-16
AT390257B (de) 1990-04-10
DK165248C (da) 1993-03-22
DK81091A (da) 1991-05-01
DK81091D0 (da) 1991-05-01
FR2581065B1 (fr) 1990-02-02
DK190986D0 (da) 1986-04-24
DK80291A (da) 1991-04-30
DK190986A (da) 1986-10-26
NO861617L (no) 1986-10-27
YU116787A (en) 1988-04-30
FI861684A (fi) 1986-10-26
ES8801829A1 (es) 1988-02-16
CN1016175B (zh) 1992-04-08
GB8610037D0 (en) 1986-05-29
ES557552A0 (es) 1988-07-16
IT1215651B (it) 1990-02-22
SE461468B (sv) 1990-02-19
DK165249B (da) 1992-10-26
CY1641A (en) 1992-11-06
DK164868C (da) 1993-01-11
SU1470192A3 (ru) 1989-03-30
GB2174987B (en) 1989-08-02
ES554336A0 (es) 1987-10-01
ES8708229A1 (es) 1987-10-01
FI861684A0 (fi) 1986-04-22
IT8620206A0 (it) 1986-04-24
PT82460A (en) 1986-05-01
AU592983B2 (en) 1990-02-01
SU1560056A3 (ru) 1990-04-23
SU1450746A3 (ru) 1989-01-07
DE3614132A1 (de) 1986-11-27
LU86406A1 (fr) 1986-11-05
FI83316B (fi) 1991-03-15
SE8601907L (sv) 1986-10-26
GB2174987A (en) 1986-11-19
SE8601907D0 (sv) 1986-04-24
US4668686A (en) 1987-05-26
DK164868B (da) 1992-08-31
PT82460B (pt) 1988-11-30
AU5641386A (en) 1986-10-30
HK64492A (en) 1992-09-04
NL8601053A (nl) 1986-11-17
HUT42089A (en) 1987-06-29
BE904671A (fr) 1986-10-24
OA08242A (en) 1987-10-30
NO163406B (no) 1990-02-12
YU46054B (sh) 1992-12-21
KR940000828B1 (ko) 1994-02-02
HU195813B (en) 1988-07-28
CH675722A5 (de) 1990-10-31

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