DK165248C - 1,3,9,9a-tetrahydro-imidazooe4,5-baaquinolin-2-oner samt fremgangsmaade til fremstilling deraf - Google Patents

1,3,9,9a-tetrahydro-imidazooe4,5-baaquinolin-2-oner samt fremgangsmaade til fremstilling deraf

Info

Publication number: DK165248C
Authority: DK; Denmark
Prior art keywords: imidazooe4; baaquinolin; oner; tetrahydro; preparing
Prior art date: 1985-04-25

Application number

DK080291A

Other languages

English (en)

Other versions

DK165248B (da

DK80291A (da

DK80291D0 (da

Inventor

Nicholas A Meanwell

John J Wright

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-04-25

Filing date

1991-04-30

Publication date

1993-03-22

1991-04-30 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

1991-04-30 Publication of DK80291A publication Critical patent/DK80291A/da

1991-04-30 Publication of DK80291D0 publication Critical patent/DK80291D0/da

1992-10-26 Publication of DK165248B publication Critical patent/DK165248B/da

1993-03-22 Application granted granted Critical

1993-03-22 Publication of DK165248C publication Critical patent/DK165248C/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK080291A 1985-04-25 1991-04-30 1,3,9,9a-tetrahydro-imidazooe4,5-baaquinolin-2-oner samt fremgangsmaade til fremstilling deraf DK165248C (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US72686985A	1985-04-25	1985-04-25
US72686985		1985-04-25
US06/832,212 US4668686A (en)	1985-04-25	1986-02-26	Imidazoquinoline antithrombrogenic cardiotonic agents
US83221286		1986-02-26

Publications (4)

Publication Number	Publication Date
DK80291A DK80291A (da)	1991-04-30
DK80291D0 DK80291D0 (da)	1991-04-30
DK165248B DK165248B (da)	1992-10-26
DK165248C true DK165248C (da)	1993-03-22

Family

ID=27111398

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK190986A DK164868C (da)	1985-04-25	1986-04-24	Imidazooe4,5-baaquinolin-2-on-derivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse
DK080291A DK165248C (da)	1985-04-25	1991-04-30	1,3,9,9a-tetrahydro-imidazooe4,5-baaquinolin-2-oner samt fremgangsmaade til fremstilling deraf
DK081091A DK165249C (da)	1985-04-25	1991-05-01	Imidazooe4,5-baaquinolin-2-thionderivater samt fremgangsmaade til fremstilling deraf

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK190986A DK164868C (da)	1985-04-25	1986-04-24	Imidazooe4,5-baaquinolin-2-on-derivater, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende disse

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK081091A DK165249C (da)	1985-04-25	1991-05-01	Imidazooe4,5-baaquinolin-2-thionderivater samt fremgangsmaade til fremstilling deraf

Country Status (32)

Country	Link
US (1)	US4668686A (da)
KR (1)	KR940000828B1 (da)
CN (1)	CN1016175B (da)
AT (1)	AT390257B (da)
AU (1)	AU592983B2 (da)
BE (1)	BE904671A (da)
CA (1)	CA1298836C (da)
CH (1)	CH675722A5 (da)
CY (1)	CY1641A (da)
DE (1)	DE3614132A1 (da)
DK (3)	DK164868C (da)
EG (1)	EG18104A (da)
ES (3)	ES8708229A1 (da)
FI (1)	FI83316C (da)
FR (1)	FR2581065B1 (da)
GB (1)	GB2174987B (da)
GR (1)	GR861086B (da)
HK (1)	HK64492A (da)
HU (1)	HU195813B (da)
IL (1)	IL78581A0 (da)
IT (1)	IT1215651B (da)
LU (1)	LU86406A1 (da)
MY (1)	MY102086A (da)
NL (1)	NL8601053A (da)
NO (1)	NO163406C (da)
NZ (1)	NZ215885A (da)
OA (1)	OA08242A (da)
PT (1)	PT82460B (da)
SE (1)	SE461468B (da)
SG (1)	SG29092G (da)
SU (3)	SU1450746A3 (da)
YU (1)	YU46054B (da)

Families Citing this family (39)

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US4775674A (en) *	1986-05-23	1988-10-04	Bristol-Myers Company	Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) *	1986-07-08	1987-10-20	Bristol-Myers Company	7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US4743607A (en) *	1987-05-29	1988-05-10	Merrell Dow Pharmaceuticals Inc.	Cardiotonic tricyclic imidazolones
US4803210A (en) *	1987-05-29	1989-02-07	Merrell Dow Pharmaceuticals Inc.	Cardiotonic tricyclic oxazolones
US4943573A (en) *	1989-11-01	1990-07-24	Bristol-Myers Squibb Company	Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
DE4035854C2 (de) *	1990-11-10	1996-10-02	Daimler Benz Ag	Vorrichtung zum Fangen und Ableiten des von einem Fahrzeugrad hochgeschleuderten Spritzwassers
PH31245A (en) *	1991-10-30	1998-06-18	Janssen Pharmaceutica Nv	1,3-Dihydro-2H-imidazoÄ4,5-BÜ-quinolin-2-one derivatives.
US5158958A (en) *	1992-04-03	1992-10-27	Bristol-Myers Squibb Company	Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
US5552267A (en) *	1992-04-03	1996-09-03	The Trustees Of Columbia University In The City Of New York	Solution for prolonged organ preservation
US5348960A (en) *	1992-04-03	1994-09-20	Bristol-Myers Squibb Company	Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
US5208237A (en) *	1992-04-03	1993-05-04	Bristol-Meyers Squibb Company	7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
US5196428A (en) *	1992-04-03	1993-03-23	Bristol-Myers Squibb Company	Imidazo[4,5-b]qinolinyl oxy alkyl ureas
JP2007502293A (ja)	2003-08-12	2007-02-08	スリーエムイノベイティブプロパティズカンパニー	ヒドロキシルアミン置換イミダゾ含有化合物
RU2006105101A (ru)	2003-08-27	2007-10-10	3М Инновейтив Пропертиз Компани (US)	Арилокси и арилалкиленокси замещенные имидазохинолины
CA2537763A1 (en)	2003-09-05	2005-03-17	3M Innovative Properties Company	Treatment for cd5+ b cell lymphoma
US7544697B2 (en)	2003-10-03	2009-06-09	Coley Pharmaceutical Group, Inc.	Pyrazolopyridines and analogs thereof
AU2004278014B2 (en)	2003-10-03	2011-04-28	3M Innovative Properties Company	Alkoxy substituted imidazoquinolines
JP2007511527A (ja)	2003-11-14	2007-05-10	スリーエムイノベイティブプロパティズカンパニー	オキシム置換イミダゾ環化合物
US8598192B2 (en) *	2003-11-14	2013-12-03	3M Innovative Properties Company	Hydroxylamine substituted imidazoquinolines
WO2005051317A2 (en)	2003-11-25	2005-06-09	3M Innovative Properties Company	Substituted imidazo ring systems and methods
WO2005066170A1 (en)	2003-12-29	2005-07-21	3M Innovative Properties Company	Arylalkenyl and arylalkynyl substituted imidazoquinolines
CA2551399A1 (en)	2003-12-30	2005-07-21	3M Innovative Properties Company	Imidazoquinolinyl, imidazopyridinyl, and imidazonaphthyridinyl sulfonamides
US8697873B2 (en)	2004-03-24	2014-04-15	3M Innovative Properties Company	Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
US8017779B2 (en)	2004-06-15	2011-09-13	3M Innovative Properties Company	Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
US8026366B2 (en)	2004-06-18	2011-09-27	3M Innovative Properties Company	Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
US7915281B2 (en)	2004-06-18	2011-03-29	3M Innovative Properties Company	Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and method
US7897609B2 (en)	2004-06-18	2011-03-01	3M Innovative Properties Company	Aryl substituted imidazonaphthyridines
JP5313502B2 (ja)	2004-12-30	2013-10-09	スリーエムイノベイティブプロパティズカンパニー	置換キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物
JP5543068B2 (ja)	2004-12-30	2014-07-09	スリーエムイノベイティブプロパティズカンパニー	キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物
JP2008530022A (ja)	2005-02-04	2008-08-07	コーリーファーマシューティカルグループ，インコーポレイテッド	免疫反応調節物質を含む水性ゲル処方物
AU2006213746A1 (en)	2005-02-11	2006-08-17	Coley Pharmaceutical Group, Inc.	Oxime and hydroxylamine substituted imidazo(4,5-c) ring compounds and methods
AU2006232375A1 (en)	2005-04-01	2006-10-12	Coley Pharmaceutical Group, Inc.	1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
WO2006107853A2 (en)	2005-04-01	2006-10-12	Coley Pharmaceutical Group, Inc.	Pyrazolopyridine-1,4-diamines and analogs thereof
WO2008008432A2 (en)	2006-07-12	2008-01-17	Coley Pharmaceutical Group, Inc.	Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods
US8227603B2 (en)	2006-08-01	2012-07-24	Cytokinetics, Inc.	Modulating skeletal muscle
US8299248B2 (en)	2006-08-02	2012-10-30	Cytokinetics, Incorporated	Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
ES2558517T3 (es)	2006-08-02	2016-02-04	Cytokinetics, Inc.	Ciertas entidades químicas, composiciones y métodos que comprenden imidazopirimidinas
EP2139478A4 (en) *	2007-03-30	2010-05-05	Cytokinetics Inc	CHEMICAL ENTITIES, COMPOSITIONS AND METHODS
IN2014DN00200A (da)	2011-07-13	2015-06-05	Cytokinetics Inc

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3932407A (en) *	1973-11-19	1976-01-13	Bristol-Myers Company	Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones

1986
- 1986-02-26 US US06/832,212 patent/US4668686A/en not_active Expired - Fee Related
- 1986-03-26 CA CA000505136A patent/CA1298836C/en not_active Expired - Fee Related
- 1986-04-18 NZ NZ215885A patent/NZ215885A/xx unknown
- 1986-04-21 AU AU56413/86A patent/AU592983B2/en not_active Ceased
- 1986-04-22 FI FI861684A patent/FI83316C/fi not_active IP Right Cessation
- 1986-04-22 IL IL78581A patent/IL78581A0/xx not_active IP Right Cessation
- 1986-04-23 EG EG237/86A patent/EG18104A/xx active
- 1986-04-23 CN CN86102747A patent/CN1016175B/zh not_active Expired
- 1986-04-24 BE BE0/216585A patent/BE904671A/fr not_active IP Right Cessation
- 1986-04-24 DK DK190986A patent/DK164868C/da not_active IP Right Cessation
- 1986-04-24 NO NO861617A patent/NO163406C/no unknown
- 1986-04-24 CH CH1679/86A patent/CH675722A5/de not_active IP Right Cessation
- 1986-04-24 GR GR861086A patent/GR861086B/el unknown
- 1986-04-24 GB GB8610037A patent/GB2174987B/en not_active Expired
- 1986-04-24 FR FR868605966A patent/FR2581065B1/fr not_active Expired - Fee Related
- 1986-04-24 SE SE8601907A patent/SE461468B/sv not_active IP Right Cessation
- 1986-04-24 SU SU864027355A patent/SU1450746A3/ru active
- 1986-04-24 IT IT8620206A patent/IT1215651B/it active
- 1986-04-24 NL NL8601053A patent/NL8601053A/xx not_active Application Discontinuation
- 1986-04-24 PT PT82460A patent/PT82460B/pt not_active IP Right Cessation
- 1986-04-24 ES ES554336A patent/ES8708229A1/es not_active Expired
- 1986-04-24 LU LU86406A patent/LU86406A1/fr unknown
- 1986-04-25 AT AT0112186A patent/AT390257B/de not_active IP Right Cessation
- 1986-04-25 KR KR1019860003204A patent/KR940000828B1/ko active IP Right Grant
- 1986-04-25 HU HU861723A patent/HU195813B/hu not_active IP Right Cessation
- 1986-04-25 OA OA58845A patent/OA08242A/xx unknown
- 1986-04-25 DE DE19863614132 patent/DE3614132A1/de not_active Ceased
1987
- 1987-02-27 SU SU874202071A patent/SU1470192A3/ru active
- 1987-05-14 ES ES557552A patent/ES8802521A1/es not_active Expired
- 1987-05-14 ES ES557551A patent/ES8801829A1/es not_active Expired
- 1987-06-23 YU YU116787A patent/YU46054B/sh unknown
- 1987-09-25 SU SU874203391A patent/SU1560056A3/ru active
- 1987-09-29 MY MYPI87002266A patent/MY102086A/en unknown
1991
- 1991-04-30 DK DK080291A patent/DK165248C/da not_active IP Right Cessation
- 1991-05-01 DK DK081091A patent/DK165249C/da not_active IP Right Cessation
1992
- 1992-03-10 SG SG290/92A patent/SG29092G/en unknown
- 1992-08-27 HK HK644/92A patent/HK64492A/xx unknown
- 1992-11-06 CY CY1641A patent/CY1641A/xx unknown

Also Published As

Publication number	Publication date
SU1450746A3 (ru)	1989-01-07
SE8601907L (sv)	1986-10-26
ATA112186A (de)	1989-09-15
DK165248B (da)	1992-10-26
OA08242A (en)	1987-10-30
CH675722A5 (da)	1990-10-31
CA1298836C (en)	1992-04-14
ES8708229A1 (es)	1987-10-01
DK164868B (da)	1992-08-31
CN1016175B (zh)	1992-04-08
IT8620206A0 (it)	1986-04-24
US4668686A (en)	1987-05-26
PT82460A (en)	1986-05-01
SU1560056A3 (ru)	1990-04-23
CN86102747A (zh)	1987-02-04
FI83316C (fi)	1991-06-25
DK81091D0 (da)	1991-05-01
NO163406B (no)	1990-02-12
HK64492A (en)	1992-09-04
DK81091A (da)	1991-05-01
DK165249C (da)	1993-03-22
ES554336A0 (es)	1987-10-01
NL8601053A (nl)	1986-11-17
DK80291A (da)	1991-04-30
DE3614132A1 (de)	1986-11-27
DK165249B (da)	1992-10-26
GB2174987B (en)	1989-08-02
DK190986D0 (da)	1986-04-24
HU195813B (en)	1988-07-28
IL78581A0 (en)	1986-08-31
HUT42089A (en)	1987-06-29
SG29092G (en)	1992-05-15
FR2581065A1 (fr)	1986-10-31
ES8802521A1 (es)	1988-07-16
PT82460B (pt)	1988-11-30
SU1470192A3 (ru)	1989-03-30
IT1215651B (it)	1990-02-22
ES557552A0 (es)	1988-07-16
AT390257B (de)	1990-04-10
YU46054B (sh)	1992-12-21
DK190986A (da)	1986-10-26
DK164868C (da)	1993-01-11
KR860008177A (ko)	1986-11-12
SE461468B (sv)	1990-02-19
NZ215885A (en)	1989-04-26
EG18104A (en)	1992-09-30
NO163406C (no)	1990-05-23
BE904671A (fr)	1986-10-24
YU116787A (en)	1988-04-30
FI861684A0 (fi)	1986-04-22
SE8601907D0 (sv)	1986-04-24
FR2581065B1 (fr)	1990-02-02
FI83316B (fi)	1991-03-15
AU592983B2 (en)	1990-02-01
GR861086B (en)	1986-09-01
ES557551A0 (es)	1988-02-16
ES8801829A1 (es)	1988-02-16
GB8610037D0 (en)	1986-05-29
AU5641386A (en)	1986-10-30
MY102086A (en)	1992-03-31
GB2174987A (en)	1986-11-19
LU86406A1 (fr)	1986-11-05
KR940000828B1 (ko)	1994-02-02
DK80291D0 (da)	1991-04-30
NO861617L (no)	1986-10-27
FI861684A (fi)	1986-10-26
CY1641A (en)	1992-11-06

Legal Events

Date	Code	Title	Description
1994-12-27	PBP	Patent lapsed

Publication	Publication Date	Title
DK165248C (da)	1993-03-22	1,3,9,9a-tetrahydro-imidazooe4,5-baaquinolin-2-oner samt fremgangsmaade til fremstilling deraf
DK273587A (da)	1987-11-30	1,5-diaryl-3-substituerede pyrazoler samt fremgangsmaade til fremstilling deraf
NO171364C (no)	1993-03-03	N-aryl-3-aryl-4,5-dihydro-1h-pyrazol-1-karboksamider og fremgangsmaate til fremstilling derav, samt insektmiddel sominneholder karboksamidet
DK74087D0 (da)	1987-02-13	Indolizinderivater og fremgangsmaade til fremstilling deraf samt midler indeholdende derivaterne
DK594587D0 (da)	1987-11-12	Soedemiddel samt fremgangsmaade til fremstilling deraf
DK355485D0 (da)	1985-08-05	Dinatrium-3-amino-l-hydroxy-propan-1,1-diphosphonat samt fremgangsmaade til fremstilling deraf
NO167034C (no)	1991-09-25	Fremgangsmaate for fremstilling av 1,6-diklor-1,6-dideoksy-beta-d-fruktofuranosyl-4-kloro-4-dioksy-alfa-galactopyranosid
NO852264L (no)	1985-12-09	Fremgangsmaate for fremstilling av mikrolateks, samt anvendelse av en slik lateks
DK418985D0 (da)	1985-09-16	Indkapslede pyrethroider samt fremgangsmaade til fremstilling deraf oganvendelse som insecticid
NO863131D0 (no)	1986-08-04	Isolasjonsmateriale, samt fremgangsmaate for fremstilling av slikt.
DK437286A (da)	1987-03-14	2,5-diaryl-tetrahydrothiophenforbindelse og fremgangsmaade til fremstilling deraf
DK346889A (da)	1990-01-14	Heteropolysaccharid bm07, fremgangsmaade til fremstilling deraf samt anvendelse deraf
NO161402C (no)	1989-08-09	Prosjektildannende innlegg samt framgangsmaate for framstilling av dette.
DK115685A (da)	1985-09-15	Prespap samt fremgangsmaade til fremstilling deraf
DK113591D0 (da)	1991-06-13	3-oe2-chlorethylaaquinazolin-2,4-dioner samt fremgangsmaade til fremstilling deraf
DK548086D0 (da)	1986-11-17	Nitroanthracycliner, fremgangsmaade til deres fremstilling samt deres anvendelse
DK593985A (da)	1986-06-21	Olieadjuveret vaccine samt fremgangsmaade til fremstilling deraf
DK504786A (da)	1987-04-24	Peptidforbindelser samt fremgangsmaade til fremstilling heraf
DK51785D0 (da)	1985-02-05	1,4-aminoalkylamino-9h-thioxanthen-9-oner, laegemidler indeholdende disse samt fremgangsmaade til fremstilling deraf
DK404587A (da)	1988-02-05	5-deoxy-5-flourkanamycin b-derivater samt fremgangsmaader til fremstilling deraf
DK401786A (da)	1987-02-24	Substituerede cyclohexanalkansyrer samt fremgangsmaade til fremstilling deraf
DK519086A (da)	1987-05-01	Substituerede 1,1,2-triphenylbut-1-ener, fremgangsmaade til deres fremstilling samt deres anvendelse
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