NO148377B - 3-CHLORO-7-ALFA-AMINO-ACYLCEPHALOSPORINE COMPOUNDS FOR USE AS INTERMEDIATES IN THE PREPARATION OF THERAPEUTICALLY EFFECTIVE CEPHALOSPORINE DERIVATIVES - Google Patents

3-CHLORO-7-ALFA-AMINO-ACYLCEPHALOSPORINE COMPOUNDS FOR USE AS INTERMEDIATES IN THE PREPARATION OF THERAPEUTICALLY EFFECTIVE CEPHALOSPORINE DERIVATIVES

Info

Publication number
NO148377B
NO148377B NO792681A NO792681A NO148377B NO 148377 B NO148377 B NO 148377B NO 792681 A NO792681 A NO 792681A NO 792681 A NO792681 A NO 792681A NO 148377 B NO148377 B NO 148377B
Authority
NO
Norway
Prior art keywords
drill
intermediates
chloro
compounds
preparation
Prior art date
Application number
NO792681A
Other languages
Norwegian (no)
Other versions
NO792681L (en
NO148377C (en
Inventor
Robert Raymond Chauvette
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of NO792681L publication Critical patent/NO792681L/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO148377B publication Critical patent/NO148377B/en
Publication of NO148377C publication Critical patent/NO148377C/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/207-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02Preparation
    • C07D501/04Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D501/00Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/59Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

3-klor-7-a-aminoacylcefalosporinforbindeIser for anvendelse som mellomprodukter ved fremstilling av terapeutisk virksomme cefalosporinderivater.3-Chloro-7-α-aminoacylcephalosporin compounds for use as intermediates in the preparation of therapeutically active cephalosporin derivatives.

Description

Anordning til å fastholde en bormeisel som tjener til fremstilling av plugghull i betong, murverk o. 1., og sikre den mot dreining i en verktøyholder. Device for holding a drill bit used for making dowel holes in concrete, masonry etc., and securing it against turning in a tool holder.

Oppfinnelsen angår en anordning til å The invention relates to a device to

fastholde en bormeisel som tjener til fremstilling av plugghull i betong, murverk o. 1., maintain a drill bit that is used for making dowel holes in concrete, masonry etc. 1.,

i en verktøyholder og sikre den mot dreining i denne. Anordningen er særlig be-stemt for slike bormeisler som er utstanset in a tool holder and secure it against turning in this. The device is particularly intended for drill bits of this type that have been punched out

i rett vinkel fra en plate og deretter delvis at right angles from a plate and then partially

innrullet slik at der gjenstår et ribbelignende fremspring ved den bakre ende av rolled in so that a rib-like projection remains at the rear end of

meiselen. the chisel.

Ved kjente verktøy av denne art har In known tools of this kind have

bormeiselen vært holdt og sikret mot dreining i en verktøyholder som borskaftet the drill bit has been held and secured against turning in a tool holder like the drill shank

stikkes inn i, ved hj elp av særskilte organer inserted into, with the help of special organs

som er anordnet på verktøyholderen som f. which is arranged on the tool holder such as

eks. kiler eller koniske ringer, eller ved en e.g. wedges or conical rings, or by a

oppdeling av borskaftet i bajonettformig division of the drill shaft into bayonet-shaped

forbundne deler eller ved hjelp av låse-stifter innsatt på tvers gjennom borhol-deren. connected parts or by means of locking pins inserted transversely through the drill holder.

I motsetning til disse verktøy, som er In contrast to these tools, which are

kostbare og fremstilt av metall, blir der expensive and made of metal, stays there

ifølge oppfinnelsen foreslått en verktøyhol-der som har form av et vinkelformet plasthåndtak, hvis frie ben har boringer som according to the invention, a tool holder is proposed which has the shape of an angular plastic handle, whose free legs have bores that

tjener til å oppta bormeisler med forskjellige diametre og som er utformet med en serves to accommodate drill bits of different diameters and which are designed with a

sliss som et ribbelignende fremspring ved slit as a rib-like projection at

den bakre ende av bormeiselen er innrettet the rear end of the drill is aligned

til å gripe inn i for å hindre meiselen i å to engage in to prevent the chisel from

dreie seg i holderen. turn in the holder.

Por å sikre bormeiselen mot aksialfor-skyvnihg i boringen er vidden av den med To secure the drill bit against axial displacement in the borehole, the width of the bit is included

boringen forbundne sliss mindre enn godstykkelsen av det ribbelignende fremspring, the bore connected slots smaller than the thickness of the rib-like projection,

så der oppnås en fjærende fastklemming. so a resilient clamping is achieved.

En slik dreie- og holdesikring av bormeiselen har den fordel at det på en enkel måte sørges for at der kan anvendes bormeisler med forskjellige diametre, samtidig som et ben av verktøyet stadig tjener som håndtak. Festeanordningen har dessuten den fordel at den kan fremstilles billig ved at der anvendes plast. Such a turning and holding protection of the drill bit has the advantage that it is ensured in a simple way that drill bits with different diameters can be used, while one leg of the tool still serves as a handle. The fastening device also has the advantage that it can be produced cheaply by using plastic.

På tegningen er der vist et utførelses-eksempel på anordningen ifølge oppfinnelsen. The drawing shows an embodiment of the device according to the invention.

Fig. 1 er et lengdesnitt av anordningen, Fig. 1 is a longitudinal section of the device,

tatt langs linjen I—I på fig. 2. taken along the line I—I in fig. 2.

Fig. 2 er et perspektivriss av anordningen. Fig. 2 is a perspective view of the device.

Verktøyholderen består av et vinkelformet håndtak som danner to frie ben 1 og 2. Som materiale for dette håndtak anvendes en plast som tåler hammerslag uten å gå i stykker, f. eks. nylon. The tool holder consists of an angular handle that forms two free legs 1 and 2. The material used for this handle is a plastic that can withstand hammer blows without breaking, e.g. nylon.

Ved de frie ender av benene har håndtaket boringer 3 og 4 med forskjellige diametre, slik at der i disse boringer kan set-tes inn bormeisler med forskjellige diametre. Ved sin bakre ende er bormeiselen 5 forsynt med et ribbelignende fremspring At the free ends of the legs, the handle has bores 3 and 4 of different diameters, so that drill bits of different diameters can be inserted into these bores. At its rear end, the drill bit 5 is provided with a rib-like projection

6 til å sikre den mot dreining. 6 to secure it against rotation.

Slike bormeisler dannes som kjent ved at de utstanses i rett vinkel fra en plate, samtidig som skjæreeggen dannes, og idet der levnes et ribbelignende fremspring. As is known, such drill bits are formed by punching them out at a right angle from a plate, at the same time as the cutting edge is formed, leaving a rib-like projection.

Som det fremgår av tegningen, er bo-ringene 3 og 4 utformet med hver sin sliss 3a resp. 4a som er tilpasset det ribbelignende fremspring som tjener til dreiesik-ring. For samtidig å sikre bormeislene mot å trekkes ut fra håndtaket 1, 2 eller for-skyves aksialt i boringen 4, resp. 3, er slis-sen 4a, resp. 3a, utført med en noe mindre vidde enn godstykkelsen av det ribbelignende fremspring 6. Dermed oppnås en fjærende fastklemming av bormeiselen 5. As can be seen from the drawing, the bore rings 3 and 4 are each designed with a slot 3a or 4a which is adapted to the rib-like projection which serves as a rotation lock. In order at the same time to secure the drill bits against being pulled out from the handle 1, 2 or pushed axially in the bore 4, resp. 3, is the slot 4a, resp. 3a, made with a slightly smaller width than the thickness of the rib-like projection 6. Thus, a resilient clamping of the drill bit 5 is achieved.

Etterat bormeiselen 5 med sitt fremspring 6 er innsatt i boringen 4 i benet 2, kan det annet, frie ben 1, som ikke opptar noen bormeisel, tjene som håndtak for meislingen. For å gi boret 5 godt hold i verktøyholderen må boret bankes inn i håndtaket 1, 2. Til dette formål blir håndtaket lagt på et fast underlag, hvorpå boret slås inn i boringen 3 eller 4 i håndtaket 1, 2 med en hammer. Selvfølgelig kan den be-skrevne dreie- og holdesikring også anvendes for bor av massivt gods. After the drill bit 5 with its projection 6 has been inserted into the bore 4 in the leg 2, the other, free leg 1, which does not accommodate a drill bit, can serve as a handle for the chisel. To give the drill 5 a good hold in the tool holder, the drill must be tapped into the handle 1, 2. For this purpose, the handle is placed on a firm surface, after which the drill is driven into the bore 3 or 4 in the handle 1, 2 with a hammer. Of course, the described turning and holding device can also be used for drilling solid goods.

Alt etter lengden av de frie ben 1 og 2 vil det la seg gjøre å anordne ytterligere boringer for bormeisler med andre diametre. Depending on the length of the free legs 1 and 2, it will be possible to arrange additional holes for drill bits with other diameters.

Claims (1)

Anordning til å fastholde en bormeisel, fortrinsvis av den art som er utstanset i rett vinkel fra en plate og deretter delvis innrullet slik at der gjenstår et ribbelignende fremspring ved den bakre ende av meiselen, som tjener til fremstilling av plugghull i betong, murverk o. 1., og sikre den mot dreining i en verktøyholder, karakterisert ved at holderen har form av et vinkelformet plasthåndtak, hvis frie ben (1, 2) har boringer (3, 4) som tjener til å oppta bormeisler med forskjellige diametre og hver er utformet med en sliss (3a, 4a) som det ribbelignende fremspring (6) ved den bakre ende av bormeiselen (5) er innrettet til å gripe inn i for å hindre meiselen i å dreie seg i holderen.Device for holding a drill bit, preferably of the kind that is punched out at right angles from a plate and then partially rolled in so that there remains a rib-like projection at the rear end of the bit, which serves to make dowel holes in concrete, masonry etc. 1., and securing it against turning in a tool holder, characterized in that the holder has the form of an angular plastic handle, whose free legs (1, 2) have bores (3, 4) which serve to accommodate drill bits of different diameters and each is formed with a slot (3a, 4a) into which the rib-like projection (6) at the rear end of the drill bit (5) is adapted to engage to prevent the bit from rotating in the holder.
NO792681A 1973-02-23 1979-08-16 3-CHLORO-7-ALFA-AMINO-ACYLCEPHALOSPORINE COMPOUNDS FOR USE AS INTERMEDIATES IN THE PREPARATION OF THERAPEUTICALLY EFFECTIVE CEPHALOSPORINE DERIVATIVES NO148377C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33538173A 1973-02-23 1973-02-23

Publications (3)

Publication Number Publication Date
NO792681L NO792681L (en) 1974-08-26
NO148377B true NO148377B (en) 1983-06-20
NO148377C NO148377C (en) 1983-09-28

Family

ID=23311540

Family Applications (2)

Application Number Title Priority Date Filing Date
NO740606A NO148375C (en) 1973-02-23 1974-02-22 ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVITY 3-CHLORO-7-ALFA-AMINO-ACYLCEPHALOSPORINE
NO792681A NO148377C (en) 1973-02-23 1979-08-16 3-CHLORO-7-ALFA-AMINO-ACYLCEPHALOSPORINE COMPOUNDS FOR USE AS INTERMEDIATES IN THE PREPARATION OF THERAPEUTICALLY EFFECTIVE CEPHALOSPORINE DERIVATIVES

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO740606A NO148375C (en) 1973-02-23 1974-02-22 ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVITY 3-CHLORO-7-ALFA-AMINO-ACYLCEPHALOSPORINE

Country Status (37)

Country Link
JP (4) JPS6139313B2 (en)
AR (1) AR199510A1 (en)
AT (1) AT333953B (en)
BE (1) BE811495A (en)
BR (1) BR7401384D0 (en)
CA (1) CA1016537A (en)
CH (1) CH593988A5 (en)
CS (1) CS187409B2 (en)
CY (1) CY1043A (en)
DD (1) DD110278A5 (en)
DE (1) DE2408698C2 (en)
DK (1) DK153157C (en)
EG (1) EG11104A (en)
ES (1) ES423531A1 (en)
FI (1) FI63035C (en)
FR (1) FR2218877B1 (en)
GB (1) GB1461323A (en)
GT (1) GT197432133A (en)
HK (1) HK20080A (en)
HU (1) HU166849B (en)
IE (1) IE39046B1 (en)
IL (1) IL44262A (en)
IN (1) IN139620B (en)
KE (1) KE3027A (en)
MW (1) MW674A1 (en)
MY (1) MY8100024A (en)
NL (1) NL179057C (en)
NO (2) NO148375C (en)
OA (1) OA04809A (en)
PH (1) PH9616A (en)
PL (1) PL88702B1 (en)
RO (1) RO64663A (en)
SE (1) SE411212B (en)
SU (1) SU676166A3 (en)
YU (1) YU36970B (en)
ZA (1) ZA741191B (en)
ZM (1) ZM3574A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT342197B (en) * 1975-02-20 1978-03-28 Ciba Geigy Ag NEW PROCESS FOR PRODUCING 3-CEPHEM CONNECTIONS
CH619233A5 (en) * 1975-07-31 1980-09-15 Ciba Geigy Ag
CH622802A5 (en) * 1975-08-20 1981-04-30 Ciba Geigy Ag
IE45158B1 (en) * 1976-08-16 1982-06-30 Lilly Co Eli 3-chloro-cephem synthesis
DE3508258A1 (en) * 1985-03-08 1986-09-18 Bayer Ag, 5090 Leverkusen SS LACTAMANTIBIOTICS, METHOD FOR THE PRODUCTION AND THEIR USE AS AND IN MEDICINAL PRODUCTS
DE3509618A1 (en) * 1985-03-16 1986-09-18 Bayer Ag, 5090 Leverkusen SS LACTAM ANTIBIOTICS, METHOD FOR THE PRODUCTION AND THEIR USE AS A MEDICINAL PRODUCT
JPS6436445U (en) * 1987-08-28 1989-03-06
DE3803169A1 (en) 1988-02-03 1989-08-17 Bayer Ag SS LACTAM ANTIBIOTICS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS AND IN MEDICINAL PRODUCTS
ES2010075A6 (en) * 1989-01-10 1989-10-16 Antibioticos Sa Process for the preparation of 3-chloro-cefem compounds.
JP2539459Y2 (en) * 1991-12-18 1997-06-25 三重ホーロー株式会社 Assembled garbage incinerator
IT1255458B (en) * 1992-05-11 1995-11-02 Col Marco Da PROCEDURE FOR THE PREPARATION OF HALOGENATED BETA-LACTAMIC DERIVATIVES
ES2079327B1 (en) 1994-12-13 1996-08-01 Lilly Sa PHARMACEUTICAL FORMULATIONS OF CEFACLOR.
CN101805357B (en) * 2010-04-28 2012-01-11 陶灵刚 Cefaclor compound and novel preparation method thereof
CN103588790A (en) * 2013-11-29 2014-02-19 中国科学院长春应用化学研究所 Preparation method of 7-amino-3-chloro-3-cephem-4-carboxylic acid-p-nitrobenzyl ester
CN106632400A (en) * 2016-12-16 2017-05-10 石家庄柏奇化工有限公司 Method for preparing 7-ACCA by removing 4-nitrobenzyl through catalytic hydrogenation of Pd-C

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3641021A (en) * 1969-04-18 1972-02-08 Lilly Co Eli 3 7-(ring-substituted) cephalosporin compounds
DE2265798C2 (en) * 1971-06-24 1985-09-26 Fujisawa Pharmaceutical Co., Ltd., Osaka Process for the preparation of oxoazetidine derivatives
AR206201A1 (en) * 1972-06-29 1976-07-07 Ciba Geigy Ag PROCEDURE FOR OBTAINING ACID COMPOUNDS 7BETA-AMINO-3-CEFEM-3-01-4-CARBOXILICO0-SUBSTITUIDOS

Also Published As

Publication number Publication date
HU166849B (en) 1975-06-28
NL7402489A (en) 1974-08-27
AU6591674A (en) 1975-08-28
SE411212B (en) 1979-12-10
MY8100024A (en) 1981-12-31
CH593988A5 (en) 1977-12-30
AR199510A1 (en) 1974-09-09
IL44262A (en) 1977-08-31
CY1043A (en) 1980-08-01
GT197432133A (en) 1975-08-16
JPS56138191A (en) 1981-10-28
SU676166A3 (en) 1979-07-25
IN139620B (en) 1976-07-10
MW674A1 (en) 1975-04-09
ES423531A1 (en) 1976-05-16
IE39046L (en) 1974-08-23
IL44262A0 (en) 1974-05-16
BE811495A (en) 1974-08-22
JPS49110689A (en) 1974-10-22
NO148375B (en) 1983-06-20
NL179057B (en) 1986-02-03
OA04809A (en) 1980-08-31
JPS6139313B2 (en) 1986-09-03
IE39046B1 (en) 1978-07-19
PH9616A (en) 1976-01-20
DE2408698A1 (en) 1974-09-05
YU36970B (en) 1984-08-31
KE3027A (en) 1980-03-14
FR2218877A1 (en) 1974-09-20
AT333953B (en) 1976-12-27
ATA142574A (en) 1976-04-15
NO740606L (en) 1974-08-26
RO64663A (en) 1979-02-15
PL88702B1 (en) 1976-09-30
YU39974A (en) 1982-06-18
NO148375C (en) 1983-09-28
ZM3574A1 (en) 1975-11-21
ZA741191B (en) 1975-10-29
JPS6140235B2 (en) 1986-09-08
DK153157B (en) 1988-06-20
JPS56138192A (en) 1981-10-28
DK153157C (en) 1988-10-31
FI63035B (en) 1982-12-31
HK20080A (en) 1980-04-25
NO792681L (en) 1974-08-26
FR2218877B1 (en) 1977-03-11
CS187409B2 (en) 1979-01-31
GB1461323A (en) 1977-01-13
BR7401384D0 (en) 1974-11-05
JPS56138190A (en) 1981-10-28
FI63035C (en) 1983-04-11
DE2408698C2 (en) 1983-11-10
DD110278A5 (en) 1974-12-12
NL179057C (en) 1986-07-01
EG11104A (en) 1976-12-31
JPS6140236B2 (en) 1986-09-08
NO148377C (en) 1983-09-28
JPS6140237B2 (en) 1986-09-08
CA1016537A (en) 1977-08-30

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