NL193945B - Werkwijze voor het bereiden van 4-amino-1-hydroxy-butaan-1,1-difosfonzuur en 6-amino-1-hydroxy-hexaan-1,1-difosfonzuur. - Google Patents

Werkwijze voor het bereiden van 4-amino-1-hydroxy-butaan-1,1-difosfonzuur en 6-amino-1-hydroxy-hexaan-1,1-difosfonzuur.

Info

Publication number: NL193945B
Authority: NL; Netherlands
Prior art keywords: hydroxy; amino; diphosphonic acid; butane; hexane
Prior art date: 1984-10-29

Application number

NL8502949A

Other languages

English (en)

Other versions

NL8502949A (nl

NL193945C (nl

Original Assignee

Gentili Ist Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-10-29

Filing date

1985-10-29

Publication date

2000-11-01

1985-10-29 Application filed by Gentili Ist Spa filed Critical Gentili Ist Spa

1986-05-16 Publication of NL8502949A publication Critical patent/NL8502949A/nl

2000-11-01 Publication of NL193945B publication Critical patent/NL193945B/nl

2001-03-02 Application granted granted Critical

2001-03-02 Publication of NL193945C publication Critical patent/NL193945C/nl

Links

OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical compound NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
PUUSSSIBPPTKTP-UHFFFAOYSA-N neridronic acid Chemical compound NCCCCCC(O)(P(O)(O)=O)P(O)(O)=O PUUSSSIBPPTKTP-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

NL8502949A 1984-10-29 1985-10-29 Werkwijze voor het bereiden van 4-amino-1-hydroxy-butaan-1,1-difosfonzuur en 6-amino-1-hydroxy-hexaan-1,1-difosfonzuur. NL193945C (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2336284		1984-10-29
IT23362/84A IT1196315B (it)	1984-10-29	1984-10-29	Procedimento per la preparazione di acidi difosfonici

Publications (3)

Publication Number	Publication Date
NL8502949A NL8502949A (nl)	1986-05-16
NL193945B true NL193945B (nl)	2000-11-01
NL193945C NL193945C (nl)	2001-03-02

Family

ID=11206414

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8502949A NL193945C (nl)	1984-10-29	1985-10-29	Werkwijze voor het bereiden van 4-amino-1-hydroxy-butaan-1,1-difosfonzuur en 6-amino-1-hydroxy-hexaan-1,1-difosfonzuur.

Country Status (13)

Country	Link
US (1)	US4705651A (nl)
JP (1)	JPS61109794A (nl)
AT (1)	AT391702B (nl)
BE (1)	BE903519A (nl)
CH (1)	CH663791A5 (nl)
DE (1)	DE3535404A1 (nl)
FR (1)	FR2572406B1 (nl)
GB (1)	GB2166741B (nl)
HK (1)	HK12891A (nl)
IT (1)	IT1196315B (nl)
LU (1)	LU86133A1 (nl)
NL (1)	NL193945C (nl)
SE (1)	SE464084B (nl)

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ES2153794B1 (es)	1999-08-06	2001-10-16	Medichem Sa	Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
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US6881420B2 (en)	2000-06-23	2005-04-19	Teva Pharmaceutical Industries Ltd.	Compositions and dosage forms for gastric delivery of irinotecan and methods of treatment that use it to inhibit cancer cell proliferation
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TR200101250A2 (tr) *	2001-05-10	2003-04-21	E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�.	4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
DE60235085D1 (de)	2001-07-16	2010-03-04	Univ Paris Xiii	Herstellungsverfahren von derivate von bisphosphonaten
MXPA04006027A (es) *	2001-12-21	2004-09-27	Procter & Gamble	Metodo para el tratamiento de trastornos de los huesos.
KR20140021045A (ko) *	2002-05-10	2014-02-19	에프. 호프만-라 로슈 아게	골다공증 치료 및 예방용 비스포스폰산
ATE461205T1 (de) *	2002-05-17	2010-04-15	Teva Pharma	Verwendung von bestimmten lösungsmitteln zur herstellung von bisphosphonsäuren
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CN1325506C (zh) *	2003-05-15	2007-07-11	中国科学院上海药物研究所	骨重吸收抑制剂阿伦膦酸及生理可接受的盐和它的制备
US7411087B2 (en) *	2003-08-21	2008-08-12	Sun Pharmaceutical Industries Limited	Process for preparation of bisphosphonic acid compounds
US20050181043A1 (en) *	2004-02-12	2005-08-18	Indranil Nandi	Alendronate salt tablet compositions
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JPWO2006062072A1 (ja) *	2004-12-10	2008-08-07	テムリック株式会社	転移癌治療剤および癌転移抑制剤
CN1304401C (zh) *	2004-12-28	2007-03-14	浙江工业大学	一种阿伦膦酸的制备方法
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WO2006110655A2 (en)	2005-04-08	2006-10-19	Chimerix, Inc.	Compounds, compositions and methods for the treatment of poxvirus infections
US8003820B2 (en) *	2005-10-20	2011-08-23	Dr. Reddy's Laboratories Limited	Process for preparing bisphosphonic acids
PT1803727E (pt) *	2005-12-27	2009-06-15	Ipca Lab Ltd	Processo melhorado para o fabrico de ácido 4-amino-hidroxibutilideno-1,1 bisfosfónico e seus sais
WO2007083240A2 (en)	2006-01-20	2007-07-26	Aurobindo Pharma Limited	An improved process for the preparation of bisphosphonic acids
CA2713105C (en) *	2008-01-25	2016-06-07	Chimerix, Inc.	Methods of treating viral infections
US7964584B2 (en) *	2008-08-01	2011-06-21	Dong Wha Pharmaceutical Co., Ltd.	Method of treating or preventing osteoporosis comprising administering to a patient in need thereof an effective amount of pharmaceutical composition comprising benzamidine derivatives or their salts, and alendronic acid or its salt
TR200900880A2 (tr)	2009-02-05	2010-08-23	Bi̇lgi̇ç Mahmut	Tek bir dozaj formunda kombine edilen farmasötik bileşimler.
US8614200B2 (en)	2009-07-21	2013-12-24	Chimerix, Inc.	Compounds, compositions and methods for treating ocular conditions
CA2770282A1 (en)	2009-08-03	2011-02-10	Chimerix, Inc.	Composition and methods of treating viral infections and viral induced tumors
ES2629165T3 (es)	2010-02-12	2017-08-07	Chimerix, Inc.	Métodos de tratamiento de una infección vírica
EP2563367A4 (en)	2010-04-26	2013-12-04	Chimerix Inc	METHODS OF TREATING RETROVIRAL INFECTIONS AND ASSOCIATED DOSAGE REGIMES
TR201100153A2 (tr)	2011-01-06	2012-07-23	Bi̇lgi̇ç Mahmut	Efervesan bifosfonat formülasyonları.
WO2012093974A1 (en)	2011-01-06	2012-07-12	Mahmut Bilgic	Improved bisphosphonate formulations
CN106061984A (zh)	2014-02-13	2016-10-26	配体药物公司	前药化合物及其用途
EP3164136A4 (en)	2014-07-02	2018-04-04	Ligand Pharmaceuticals, Inc.	Prodrug compounds and uses therof
CA3087932A1 (en)	2018-01-09	2019-07-18	Ligand Pharmaceuticals, Inc.	Acetal compounds and therapeutic uses thereof

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US3366677A (en) *	1965-05-13	1968-01-30	Procter & Gamble	Low temperature preparation of ethane-1-hydroxy-1, 1-diphosphonic acid
DE2130794C3 (de) *	1971-06-22	1974-07-11	Joh. A. Benckiser Gmbh, 6700 Ludwigshafen	Verfahren zur Herstellung von l-Hydroxy-S-amino-propan-ljl-diphosphonsäure
DE2534391C2 (de) *	1975-08-01	1983-01-13	Henkel KGaA, 4000 Düsseldorf	1-Hydroxy-3-aminoalkan-1,1-diphosphonsäuren
DE2702631A1 (de) *	1977-01-22	1978-07-27	Henkel Kgaa	Verfahren zur herstellung von 1-hydroxy-3-amino-propan-1,1-diphosphonsaeuren
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DE2846835A1 (de) *	1978-10-27	1980-05-08	Benckiser Knapsack Gmbh	Verfahren zur herstellung von carboxylalkan-aminoalkan-diphosphonsaeuren und -aminoarylalkan-diphosphonsaeuren
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1984
- 1984-10-29 IT IT23362/84A patent/IT1196315B/it active
1985
- 1985-10-01 CH CH4239/85A patent/CH663791A5/it not_active IP Right Cessation
- 1985-10-03 DE DE19853535404 patent/DE3535404A1/de active Granted
- 1985-10-03 GB GB08524428A patent/GB2166741B/en not_active Expired
- 1985-10-09 SE SE8504687A patent/SE464084B/sv not_active IP Right Cessation
- 1985-10-10 AT AT0292885A patent/AT391702B/de not_active IP Right Cessation
- 1985-10-11 US US06/786,815 patent/US4705651A/en not_active Expired - Lifetime
- 1985-10-11 FR FR858515062A patent/FR2572406B1/fr not_active Expired
- 1985-10-17 JP JP60232271A patent/JPS61109794A/ja active Granted
- 1985-10-23 LU LU86133A patent/LU86133A1/fr unknown
- 1985-10-25 BE BE2/60826A patent/BE903519A/nl not_active IP Right Cessation
- 1985-10-29 NL NL8502949A patent/NL193945C/nl not_active IP Right Cessation
1991
- 1991-02-28 HK HK128/91A patent/HK12891A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
SE464084B (sv)	1991-03-04
FR2572406B1 (fr)	1989-04-07
ATA292885A (de)	1990-05-15
NL8502949A (nl)	1986-05-16
GB2166741B (en)	1988-07-20
LU86133A1 (fr)	1986-03-24
SE8504687L (sv)	1986-04-30
JPS61109794A (ja)	1986-05-28
DE3535404C2 (nl)	1989-04-20
US4705651A (en)	1987-11-10
DE3535404A1 (de)	1986-04-30
IT8423362A0 (it)	1984-10-29
HK12891A (en)	1991-03-08
AT391702B (de)	1990-11-26
NL193945C (nl)	2001-03-02
GB8524428D0 (en)	1985-11-06
FR2572406A1 (fr)	1986-05-02
JPH0569110B2 (nl)	1993-09-30
CH663791A5 (it)	1988-01-15
BE903519A (nl)	1986-02-17
IT1196315B (it)	1988-11-16
GB2166741A (en)	1986-05-14
SE8504687D0 (sv)	1985-10-09
IT8423362A1 (it)	1986-04-29

Legal Events

Date	Code	Title	Description
1992-11-02	BA	A request for search or an international-type search has been filed
1993-03-01	BB	A search report has been drawn up
1993-08-02	BC	A request for examination has been filed
2006-01-02	V4	Discontinued because of reaching the maximum lifetime of a patent	Effective date: 20051029

Publication	Publication Date	Title
NL193945B (nl)	2000-11-01	Werkwijze voor het bereiden van 4-amino-1-hydroxy-butaan-1,1-difosfonzuur en 6-amino-1-hydroxy-hexaan-1,1-difosfonzuur.
NL192986B (nl)	1998-03-02	Werkwijze voor het bereiden van 1,4-dihydro-4-oxo-naftyridinederivaten.
NL193538B (nl)	1999-09-01	Werkwijze voor het bereiden van tereftaalzuur.
NL186643C (nl)	1991-01-16	Werkwijze voor het veresteren van natuurhars.
NL189516C (nl)	1993-05-03	Werkwijze voor het bereiden van roet.
NL194042B (nl)	2001-01-02	Werkwijze voor de bereiding van 3-fenyl-4-cyaanpyrrolen.
NL7902521A (nl)	1979-10-02	Werkwijze voor het bereiden van 2,2,6,6-tetramethyl- -4-piperidon.
NL192108B (nl)	1996-10-01	Werkwijze voor het bereiden van halogeenalkyl-arylalkanoaten en van de overeenkomstige arylalkaanzuren.
NL191705C (nl)	1996-04-02	Werkwijze voor het bereiden van gezuiverd fosforzuur.
NL186258B (nl)	1990-05-16	Werkwijze voor de bereiding van cokes, in het bijzonder naaldcokes.
NL191943C (nl)	1996-11-04	Werkwijze voor het bereiden van een optisch actief beta-mercaptoalkaanzuur.
NL192187B (nl)	1996-11-01	Werkwijze voor de bereiding van caseïnaten.
NL7805438A (nl)	1979-11-21	Werkwijze voor het bereiden van p-hydroxyfenylazijnzuur.
NL189667B (nl)	1993-01-18	Sulfobetainen en werkwijze voor het bereiden daarvan.
NL193793B (nl)	2000-07-03	Werkwijze voor het vervaardigen van spaanplaten.
NL192457B (nl)	1997-04-01	Werkwijze voor het bereiden van dihydroxycyclobuteendion.
NL193190B (nl)	1998-10-01	Werkwijze voor het bereiden van methaansulfonylchloride.
NL8600136A (nl)	1986-08-18	Werkwijze voor het bereiden van 4,4-dialkyl-2-azetidinonen.
NL189317C (nl)	1993-03-01	Werkwijze voor het vervaardigen van staafvormig materiaal.
NL194001B (nl)	2000-12-01	Werkwijze voor bereiden van gesubstitueerd benzaldehyde.
NL187013C (nl)	1991-05-01	Werkwijze voor het bereiden van isobutyrylfluoride.
NL187689C (nl)	1991-12-16	Werkwijze voor het vervaardigen respectievelijk vormgeven van voortbrengselen.
NL193407B (nl)	1999-05-03	Werkwijze voor de bereiding van 3-exomethyleencefamderivaten.
NL192117B (nl)	1996-10-01	Werkwijze voor het bereiden van L-serine.
NL193866B (nl)	2000-09-01	Werkwijze voor het bereiden van isobuteen.