ATA292885A - Verfahren zur herstellung von diphosphonsaeuren - Google Patents

Verfahren zur herstellung von diphosphonsaeuren

Info

Publication number
ATA292885A
ATA292885A AT852928A AT292885A ATA292885A AT A292885 A ATA292885 A AT A292885A AT 852928 A AT852928 A AT 852928A AT 292885 A AT292885 A AT 292885A AT A292885 A ATA292885 A AT A292885A
Authority
AT
Austria
Prior art keywords
producing
diphosphonic acids
diphosphonic
acids
producing diphosphonic
Prior art date
Application number
AT852928A
Other languages
English (en)
Other versions
AT391702B (de
Inventor
Giorgio Staibano
Original Assignee
Gentili Ist Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gentili Ist Spa filed Critical Gentili Ist Spa
Publication of ATA292885A publication Critical patent/ATA292885A/de
Application granted granted Critical
Publication of AT391702B publication Critical patent/AT391702B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT0292885A 1984-10-29 1985-10-10 Verfahren zur herstellung von diphosphonsaeuren AT391702B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT23362/84A IT1196315B (it) 1984-10-29 1984-10-29 Procedimento per la preparazione di acidi difosfonici

Publications (2)

Publication Number Publication Date
ATA292885A true ATA292885A (de) 1990-05-15
AT391702B AT391702B (de) 1990-11-26

Family

ID=11206414

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0292885A AT391702B (de) 1984-10-29 1985-10-10 Verfahren zur herstellung von diphosphonsaeuren

Country Status (13)

Country Link
US (1) US4705651A (de)
JP (1) JPS61109794A (de)
AT (1) AT391702B (de)
BE (1) BE903519A (de)
CH (1) CH663791A5 (de)
DE (1) DE3535404A1 (de)
FR (1) FR2572406B1 (de)
GB (1) GB2166741B (de)
HK (1) HK12891A (de)
IT (1) IT1196315B (de)
LU (1) LU86133A1 (de)
NL (1) NL193945C (de)
SE (1) SE464084B (de)

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DE3700772A1 (de) * 1987-01-13 1988-07-21 Inst Khim Kinetiki I Gorenija Verfahren zur herstellung von i-funktionellsubstituierten alkyliden-i,i-diphosphonsaeuren und deren gemischen
GB8825589D0 (en) * 1988-11-02 1988-12-07 Albright & Wilson Purification
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
IT1246992B (it) * 1991-01-08 1994-12-12 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici e loro sali
US5183815A (en) * 1991-01-22 1993-02-02 Merck & Co., Inc. Bone acting agents
DE4223940A1 (de) * 1992-07-21 1994-01-27 Boehringer Mannheim Gmbh Neue acyclische Amidingruppen-haltige Diphosphonsäurederivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
JPH0736804U (ja) * 1993-12-25 1995-07-11 松本 純子 指圧クッションシート
US5773429A (en) * 1996-12-11 1998-06-30 Fuisz Technologies Ltd. Drug combination for treating calcium loss
CA2197267C (en) * 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
PL346347A1 (en) * 1998-08-27 2002-02-11 Teva Pharma Novel hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
US6331533B1 (en) 1998-11-16 2001-12-18 Merck & Co., Inc. Method for inhibiting dental resorptive lesions
EA003861B1 (ru) * 1999-02-17 2003-10-30 Тева Фармасьютикал Индастриес Лтд. Новый способ получения алендроновой кислоты
US7205404B1 (en) * 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
ES2153794B1 (es) 1999-08-06 2001-10-16 Medichem Sa Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
US6410520B2 (en) 2000-02-01 2002-06-25 The Procter & Gamble Company Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate
US6562974B2 (en) 2000-02-01 2003-05-13 The Procter & Gamble Company Process for making geminal bisphosphonates
US7674480B2 (en) * 2000-06-23 2010-03-09 Teva Pharmaceutical Industries Ltd. Rapidly expanding composition for gastric retention and controlled release of therapeutic agents, and dosage forms including the composition
US6476006B2 (en) 2000-06-23 2002-11-05 Teva Pharmaceutical Industries, Ltd. Composition and dosage form for delayed gastric release of alendronate and/or other bis-phosphonates
US6881420B2 (en) * 2000-06-23 2005-04-19 Teva Pharmaceutical Industries Ltd. Compositions and dosage forms for gastric delivery of irinotecan and methods of treatment that use it to inhibit cancer cell proliferation
US6558702B2 (en) 2001-04-13 2003-05-06 Alkermes Controlled Therapeutics, Inc. Method of modifying the release profile of sustained release compositions
US20060269602A1 (en) * 2001-04-13 2006-11-30 Dasch James R Method of modifying the release profile of sustained release compositions
TR200101250A2 (tr) * 2001-05-10 2003-04-21 E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
WO2003008425A1 (fr) 2001-07-16 2003-01-30 Universite Paris 13 Nouveaux derives de bisphosphonates, leurs preparations et utilisations
CN100479823C (zh) * 2001-12-21 2009-04-22 宝洁公司 双膦酸盐在制造药物套盒中的用途以及用于增加骨质的套盒
ES2532393T3 (es) * 2002-05-10 2015-03-26 F. Hoffmann-La Roche Ag Acidos bisfosfónicos para tratamiento y prevención de osteoporosis
US7038083B2 (en) * 2002-05-17 2006-05-02 Teva Pharmaceutical Industries, Ltd. Process for making bisphosphonic acids using diluents other than halogenated hydrocarbons
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
NZ536273A (en) 2002-12-20 2007-08-31 Hoffmann La Roche High dose ibandronate formulation
CN1325506C (zh) * 2003-05-15 2007-07-11 中国科学院上海药物研究所 骨重吸收抑制剂阿伦膦酸及生理可接受的盐和它的制备
DE602004024545D1 (de) 2003-08-21 2010-01-21 Sun Pharmaceuticals Ind Ltd Indungen
US20050181043A1 (en) * 2004-02-12 2005-08-18 Indranil Nandi Alendronate salt tablet compositions
US7361761B2 (en) * 2004-09-28 2008-04-22 Orchid Chemicals & Pharmaceuticals Ltd. Process for the preparation of bisphosphonic acid
EP1832293A4 (de) * 2004-12-10 2009-01-07 Tmrc Co Ltd Mittel zur behandlung von krebsmetastasen und krebsmetastasenhemmer
CN1304401C (zh) * 2004-12-28 2007-03-14 浙江工业大学 一种阿伦膦酸的制备方法
EP2842559A3 (de) 2005-04-08 2015-03-18 Chimerix, Inc. Verbindungen, Zusammensetzungen und Verfahren zur Behandlung viraler Infektionen und anderer Erkrankungen
EP1868628B1 (de) 2005-04-08 2014-06-11 Chimerix, Inc. Verbindungen, zusammensetzungen und verfahren zur behandlung von pockenvirus-infektionen
US8003820B2 (en) * 2005-10-20 2011-08-23 Dr. Reddy's Laboratories Limited Process for preparing bisphosphonic acids
PT1803727E (pt) * 2005-12-27 2009-06-15 Ipca Lab Ltd Processo melhorado para o fabrico de ácido 4-amino-hidroxibutilideno-1,1 bisfosfónico e seus sais
WO2007083240A2 (en) 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids
CN105055432A (zh) * 2008-01-25 2015-11-18 奇默里克斯公司 治疗病毒感染的方法
US7964584B2 (en) * 2008-08-01 2011-06-21 Dong Wha Pharmaceutical Co., Ltd. Method of treating or preventing osteoporosis comprising administering to a patient in need thereof an effective amount of pharmaceutical composition comprising benzamidine derivatives or their salts, and alendronic acid or its salt
TR200900880A2 (tr) 2009-02-05 2010-08-23 Bi̇lgi̇ç Mahmut Tek bir dozaj formunda kombine edilen farmasötik bileşimler.
WO2011011519A1 (en) 2009-07-21 2011-01-27 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
WO2011017253A1 (en) 2009-08-03 2011-02-10 Chimerix, Inc. Composition and methods of treating viral infections and viral induced tumors
EP3216789A1 (de) 2010-02-12 2017-09-13 Chimerix, Inc. Verfahren zur behandlung von vireninfektionen
EP2563367A4 (de) 2010-04-26 2013-12-04 Chimerix Inc Verfahren zur behandlung von retroviren-infektionen und entsprechende dosierungspläne
WO2012093974A1 (en) 2011-01-06 2012-07-12 Mahmut Bilgic Improved bisphosphonate formulations
TR201100153A2 (tr) 2011-01-06 2012-07-23 Bi̇lgi̇ç Mahmut Efervesan bifosfonat formülasyonları.
WO2015123352A1 (en) 2014-02-13 2015-08-20 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
CN111788196A (zh) 2018-01-09 2020-10-16 配体药物公司 缩醛化合物及其治疗用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4060546A (en) * 1961-07-03 1977-11-29 Henkel Kommanditgesellschaft Auf Aktien Process for the manufacture of acylation products of phosphorous acid
US3366677A (en) * 1965-05-13 1968-01-30 Procter & Gamble Low temperature preparation of ethane-1-hydroxy-1, 1-diphosphonic acid
DE2130794C3 (de) * 1971-06-22 1974-07-11 Joh. A. Benckiser Gmbh, 6700 Ludwigshafen Verfahren zur Herstellung von l-Hydroxy-S-amino-propan-ljl-diphosphonsäure
DE2534391C2 (de) * 1975-08-01 1983-01-13 Henkel KGaA, 4000 Düsseldorf 1-Hydroxy-3-aminoalkan-1,1-diphosphonsäuren
DE2702631A1 (de) * 1977-01-22 1978-07-27 Henkel Kgaa Verfahren zur herstellung von 1-hydroxy-3-amino-propan-1,1-diphosphonsaeuren
DE2745083C2 (de) * 1977-10-07 1985-05-02 Henkel KGaA, 4000 Düsseldorf Hydroxydiphosphonsäuren und Verfahren zu deren Herstellung
DE2846835A1 (de) * 1978-10-27 1980-05-08 Benckiser Knapsack Gmbh Verfahren zur herstellung von carboxylalkan-aminoalkan-diphosphonsaeuren und -aminoarylalkan-diphosphonsaeuren
SU783300A1 (ru) * 1978-12-05 1980-11-30 Предприятие П/Я А-7346 Способ получени оксиэтилидендифосфоновой кислоты
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
GB2082585A (en) * 1980-08-27 1982-03-10 Vysoka Skola Chem Tech 6-amino-1-hydroxyhexylidene diphosphonic acid, salts thereof and a method of producing the acid and salts.
US4304734A (en) * 1980-10-16 1981-12-08 Vysoka Skola Chemicko-Technologicka 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof
DE3151038A1 (de) * 1981-12-23 1983-07-28 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von 3-amino-1-hydroxypropan-1,1-diphosphonsaeure

Also Published As

Publication number Publication date
US4705651A (en) 1987-11-10
IT8423362A1 (it) 1986-04-29
FR2572406B1 (fr) 1989-04-07
IT1196315B (it) 1988-11-16
NL193945B (nl) 2000-11-01
HK12891A (en) 1991-03-08
AT391702B (de) 1990-11-26
JPH0569110B2 (de) 1993-09-30
GB8524428D0 (en) 1985-11-06
BE903519A (nl) 1986-02-17
IT8423362A0 (it) 1984-10-29
FR2572406A1 (fr) 1986-05-02
SE464084B (sv) 1991-03-04
GB2166741B (en) 1988-07-20
DE3535404C2 (de) 1989-04-20
DE3535404A1 (de) 1986-04-30
NL193945C (nl) 2001-03-02
GB2166741A (en) 1986-05-14
SE8504687L (sv) 1986-04-30
CH663791A5 (it) 1988-01-15
LU86133A1 (fr) 1986-03-24
JPS61109794A (ja) 1986-05-28
SE8504687D0 (sv) 1985-10-09
NL8502949A (nl) 1986-05-16

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