MXPA05013652A - Modulador del receptor canabinoide. - Google Patents

Modulador del receptor canabinoide.

Info

Publication number
MXPA05013652A
MXPA05013652A MXPA05013652A MXPA05013652A MXPA05013652A MX PA05013652 A MXPA05013652 A MX PA05013652A MX PA05013652 A MXPA05013652 A MX PA05013652A MX PA05013652 A MXPA05013652 A MX PA05013652A MX PA05013652 A MXPA05013652 A MX PA05013652A
Authority
MX
Mexico
Prior art keywords
receptor modulator
cannabinoid receptor
ring
optionally substituted
compound
Prior art date
Application number
MXPA05013652A
Other languages
English (en)
Inventor
Masaki Setou
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of MXPA05013652A publication Critical patent/MXPA05013652A/es

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    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
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    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
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Abstract

Se describe un modulador del receptor canabinoide, que contiene un compuesto representado por la formula (I0) (ver formula) en donde, X es un atomo de oxigeno, etc., R0 es un grupo acilamino opcionalmente substituido, el anillo A0 es un anillo de benceno el cual puede ademas tener un substituyente ademas de R0, y el anillo B es un heterociclo de 5 miembros opcionalmente substituido, o una sal del mismo o un profarmaco del mismo.
MXPA05013652A 2003-06-26 2004-06-25 Modulador del receptor canabinoide. MXPA05013652A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003182039 2003-06-26
PCT/JP2004/009355 WO2005000829A1 (ja) 2003-06-26 2004-06-25 カンナビノイド受容体調節剤

Publications (1)

Publication Number Publication Date
MXPA05013652A true MXPA05013652A (es) 2006-02-24

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MXPA05013652A MXPA05013652A (es) 2003-06-26 2004-06-25 Modulador del receptor canabinoide.

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US (4) US7465815B2 (es)
EP (1) EP1637527B1 (es)
KR (1) KR101138673B1 (es)
CN (1) CN1816536B (es)
AU (1) AU2004252005B2 (es)
BR (1) BRPI0411740A (es)
CA (1) CA2531020C (es)
CO (1) CO5650243A2 (es)
CR (1) CR8152A (es)
CY (1) CY1114472T1 (es)
DK (1) DK1637527T3 (es)
ES (1) ES2420932T3 (es)
HK (1) HK1088305A1 (es)
HR (1) HRP20130638T1 (es)
IL (1) IL172577A0 (es)
MX (1) MXPA05013652A (es)
NO (1) NO335769B1 (es)
NZ (1) NZ544298A (es)
PL (1) PL1637527T3 (es)
PT (1) PT1637527E (es)
SI (1) SI1637527T1 (es)
TW (1) TWI329013B (es)
WO (1) WO2005000829A1 (es)
ZA (1) ZA200510304B (es)

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PL2406243T3 (pl) 2009-03-10 2014-10-31 Takeda Pharmaceuticals Co Pochodne benzofuranu
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CN104936596A (zh) 2012-07-13 2015-09-23 克利夫兰临床基金会 神经保护性cb2受体激动剂
CN105878251B (zh) * 2016-04-22 2019-04-09 上海市同济医院 帕金森病动物模型的制备方法及其用途
CN107935981B (zh) * 2016-10-12 2020-10-09 中国科学院上海药物研究所 3,4-二氢-1-苯并氧杂卓类衍生物、其制备方法和用途
CN109503533B (zh) * 2019-01-04 2022-06-24 湖南大学 一种苯并呋喃酮类化合物及其高效催化合成方法
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CN1816536B (zh) 2012-12-26
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US20070099990A1 (en) 2007-05-03
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NO20060426L (no) 2006-02-07
KR20060066677A (ko) 2006-06-16
NO335769B1 (no) 2015-02-09
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US20090023800A1 (en) 2009-01-22
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CA2531020C (en) 2014-03-25
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US20080021087A1 (en) 2008-01-24
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CA2531020A1 (en) 2005-01-06
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AU2004252005B2 (en) 2010-02-18
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