SI1637527T1 - Modulator kanabinoidnega receptorja - Google Patents

Modulator kanabinoidnega receptorja

Info

Publication number
SI1637527T1
SI1637527T1 SI200432037T SI200432037T SI1637527T1 SI 1637527 T1 SI1637527 T1 SI 1637527T1 SI 200432037 T SI200432037 T SI 200432037T SI 200432037 T SI200432037 T SI 200432037T SI 1637527 T1 SI1637527 T1 SI 1637527T1
Authority
SI
Slovenia
Prior art keywords
receptor modulator
cannabinoid receptor
cannabinoid
modulator
receptor
Prior art date
Application number
SI200432037T
Other languages
English (en)
Inventor
Shigenori Ohkawa
Tetsuya Tsukamoto
Yoshihiro Kiyota
Mika Goto
Shouzou Yamamoto
Masato Shimojou
Masaki Setou
Original Assignee
Takeda Pharmaceutical Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Company Limited filed Critical Takeda Pharmaceutical Company Limited
Publication of SI1637527T1 publication Critical patent/SI1637527T1/sl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
SI200432037T 2003-06-26 2004-06-25 Modulator kanabinoidnega receptorja SI1637527T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003182039 2003-06-26
PCT/JP2004/009355 WO2005000829A1 (ja) 2003-06-26 2004-06-25 カンナビノイド受容体調節剤
EP04746824.4A EP1637527B1 (en) 2003-06-26 2004-06-25 Cannabinoid receptor modulator

Publications (1)

Publication Number Publication Date
SI1637527T1 true SI1637527T1 (sl) 2013-07-31

Family

ID=33549544

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200432037T SI1637527T1 (sl) 2003-06-26 2004-06-25 Modulator kanabinoidnega receptorja

Country Status (24)

Country Link
US (4) US7465815B2 (sl)
EP (1) EP1637527B1 (sl)
KR (1) KR101138673B1 (sl)
CN (1) CN1816536B (sl)
AU (1) AU2004252005B2 (sl)
BR (1) BRPI0411740A (sl)
CA (1) CA2531020C (sl)
CO (1) CO5650243A2 (sl)
CR (1) CR8152A (sl)
CY (1) CY1114472T1 (sl)
DK (1) DK1637527T3 (sl)
ES (1) ES2420932T3 (sl)
HK (1) HK1088305A1 (sl)
HR (1) HRP20130638T1 (sl)
IL (1) IL172577A0 (sl)
MX (1) MXPA05013652A (sl)
NO (1) NO335769B1 (sl)
NZ (1) NZ544298A (sl)
PL (1) PL1637527T3 (sl)
PT (1) PT1637527E (sl)
SI (1) SI1637527T1 (sl)
TW (1) TWI329013B (sl)
WO (1) WO2005000829A1 (sl)
ZA (1) ZA200510304B (sl)

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ES2420932T3 (es) * 2003-06-26 2013-08-27 Takeda Pharmaceutical Company Limited Modulador del receptor de cannabinoides
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US9079854B2 (en) 2007-07-13 2015-07-14 The Cleveland Clinic Foundation Hydrazone modulators of cannabinoid receptors
US8440832B2 (en) * 2007-07-13 2013-05-14 Board Of Regents, The University Of Texas System Heterocyclic modulators of cannabinoid receptors
US8309595B2 (en) * 2007-07-13 2012-11-13 Board Of Regents, The University Of Texas System Hydrazone modulators of cannabinoid receptors
US9394267B2 (en) 2007-07-13 2016-07-19 The Cleveland Clinic Foundation Heterocyclic modulators of cannabinoid receptors
ES2716407T3 (es) 2007-11-30 2019-06-12 Zynerba Pharmaceuticals Inc Profármacos de tetrahidrocannabinol, composiciones que comprenden profármacos de tetrahidrocannabinol y métodos para uso de los mismos
PL2406243T3 (pl) 2009-03-10 2014-10-31 Takeda Pharmaceuticals Co Pochodne benzofuranu
US20130059890A1 (en) * 2009-12-18 2013-03-07 Sydney West Area Health Service Antiviral agents
CN103748085A (zh) 2011-06-09 2014-04-23 诺华股份有限公司 杂环磺酰胺衍生物
WO2013025984A2 (en) * 2011-08-18 2013-02-21 Temple University Cannabinoid receptor treatments
CN104936596A (zh) 2012-07-13 2015-09-23 克利夫兰临床基金会 神经保护性cb2受体激动剂
CN105878251B (zh) * 2016-04-22 2019-04-09 上海市同济医院 帕金森病动物模型的制备方法及其用途
CN107935981B (zh) * 2016-10-12 2020-10-09 中国科学院上海药物研究所 3,4-二氢-1-苯并氧杂卓类衍生物、其制备方法和用途
CN109503533B (zh) * 2019-01-04 2022-06-24 湖南大学 一种苯并呋喃酮类化合物及其高效催化合成方法
CN111072613B (zh) * 2019-11-29 2023-03-24 五邑大学 一类松萝酸类衍生物及其制备方法和在制备抗老年痴呆药物中的应用
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US20070099990A1 (en) 2007-05-03
MXPA05013652A (es) 2006-02-24
TWI329013B (en) 2010-08-21
WO2005000829A1 (ja) 2005-01-06
NO20060426L (no) 2006-02-07
KR20060066677A (ko) 2006-06-16
NO335769B1 (no) 2015-02-09
DK1637527T3 (da) 2013-07-01
US20090023800A1 (en) 2009-01-22
CO5650243A2 (es) 2006-06-30
US7465815B2 (en) 2008-12-16
CA2531020C (en) 2014-03-25
HK1088305A1 (en) 2006-11-03
US20080021087A1 (en) 2008-01-24
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BRPI0411740A (pt) 2006-05-23
AU2004252005A1 (en) 2005-01-06
CR8152A (es) 2007-08-28
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ZA200510304B (en) 2007-04-25
EP1637527B1 (en) 2013-04-17
PT1637527E (pt) 2013-06-28
CA2531020A1 (en) 2005-01-06
HRP20130638T1 (en) 2013-08-31
CN1816536A (zh) 2006-08-09
AU2004252005B2 (en) 2010-02-18
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PL1637527T3 (pl) 2013-09-30
EP1637527A4 (en) 2008-09-10

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