MXPA04003773A - Uso de leptina para tratar lipoatrofia humana y metodo para determinar la predisposicion a dicho tratamiento. - Google Patents

Uso de leptina para tratar lipoatrofia humana y metodo para determinar la predisposicion a dicho tratamiento.

Info

Publication number
MXPA04003773A
MXPA04003773A MXPA04003773A MXPA04003773A MXPA04003773A MX PA04003773 A MXPA04003773 A MX PA04003773A MX PA04003773 A MXPA04003773 A MX PA04003773A MX PA04003773 A MXPA04003773 A MX PA04003773A MX PA04003773 A MXPA04003773 A MX PA04003773A
Authority
MX
Mexico
Prior art keywords
leptin
treatment
treating human
determining predisposition
lipodystrophy
Prior art date
Application number
MXPA04003773A
Other languages
English (en)
Inventor
Alex M Depaoli
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MXPA04003773A publication Critical patent/MXPA04003773A/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2264—Obesity-gene products, e.g. leptin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Emergency Medicine (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)

Abstract

La leptina, analodos de leptina, y derivados de leptina se utilizan para tratar pacientes con lipodistrofia; la leptina es efectiva contra las condiciones de lipodistrofia para formas geneticas y adquiridas de la enfermedad; una cantidad terapeuticamente efectiva de leptina puede administrarse en una variedad de formas, incluyendo un vector que comprende secuencias de acido nucleico que codifican para la leptina; los metodos de la presente invencion contemplan la administracion de leptina, analogos de leptina, y derivados de leptina a pacientes que tienen aproximadamente 4ng/ml o menos antes del tratamiento.
MXPA04003773A 2001-10-22 2002-10-22 Uso de leptina para tratar lipoatrofia humana y metodo para determinar la predisposicion a dicho tratamiento. MXPA04003773A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33639401P 2001-10-22 2001-10-22
PCT/US2002/033875 WO2003034996A2 (en) 2001-10-22 2002-10-22 Use of leptin for treating human lipoatrophy and method of determining predisposition to said treatment

Publications (1)

Publication Number Publication Date
MXPA04003773A true MXPA04003773A (es) 2004-07-30

Family

ID=23315890

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04003773A MXPA04003773A (es) 2001-10-22 2002-10-22 Uso de leptina para tratar lipoatrofia humana y metodo para determinar la predisposicion a dicho tratamiento.

Country Status (14)

Country Link
US (7) US7183254B2 (es)
EP (2) EP2219031B1 (es)
JP (7) JP2005506994A (es)
AT (1) ATE475094T1 (es)
AU (1) AU2002359288B2 (es)
CA (1) CA2464277C (es)
DE (1) DE60237100D1 (es)
DK (2) DK2219031T3 (es)
ES (2) ES2350924T3 (es)
MX (1) MXPA04003773A (es)
PL (1) PL214862B1 (es)
PT (1) PT2219031E (es)
SI (1) SI2219031T1 (es)
WO (1) WO2003034996A2 (es)

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Also Published As

Publication number Publication date
PL214862B1 (pl) 2013-09-30
DE60237100D1 (de) 2010-09-02
US20200268853A1 (en) 2020-08-27
US20170095535A1 (en) 2017-04-06
ATE475094T1 (de) 2010-08-15
WO2003034996B1 (en) 2004-02-12
ES2350924T3 (es) 2011-01-28
JP2014224142A (ja) 2014-12-04
WO2003034996A2 (en) 2003-05-01
US20190321447A1 (en) 2019-10-24
EP1444516A2 (en) 2004-08-11
PT2219031E (pt) 2013-05-17
PL374301A1 (en) 2005-10-03
JP6764906B2 (ja) 2020-10-07
EP1444516A4 (en) 2006-05-10
EP2219031A1 (en) 2010-08-18
EP2219031B1 (en) 2013-04-24
JP2005506994A (ja) 2005-03-10
JP2016190855A (ja) 2016-11-10
ES2418954T3 (es) 2013-08-19
JP2018203744A (ja) 2018-12-27
US20110306540A1 (en) 2011-12-15
DK1444516T3 (da) 2010-11-15
US20130190225A1 (en) 2013-07-25
US20050020496A1 (en) 2005-01-27
US8318666B2 (en) 2012-11-27
SI2219031T1 (sl) 2013-11-29
JP2016190872A (ja) 2016-11-10
US20070099836A1 (en) 2007-05-03
DK2219031T3 (da) 2013-06-17
EP1444516B1 (en) 2010-07-21
JP2020055868A (ja) 2020-04-09
AU2002359288B2 (en) 2008-07-31
CA2464277C (en) 2013-02-05
WO2003034996A3 (en) 2003-12-11
CA2464277A1 (en) 2003-05-01
US7183254B2 (en) 2007-02-27
JP2010209114A (ja) 2010-09-24

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