AU1406497A - Mutational variants of mammalian ob gene proteins - Google Patents

Mutational variants of mammalian ob gene proteins

Info

Publication number
AU1406497A
AU1406497A AU14064/97A AU1406497A AU1406497A AU 1406497 A AU1406497 A AU 1406497A AU 14064/97 A AU14064/97 A AU 14064/97A AU 1406497 A AU1406497 A AU 1406497A AU 1406497 A AU1406497 A AU 1406497A
Authority
AU
Australia
Prior art keywords
mammalian
gene proteins
mutational variants
mutational
variants
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU14064/97A
Inventor
Scott W. Altmann
J. Fernando Bazan
Robert A. Kastelein
Fernando Rock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of AU1406497A publication Critical patent/AU1406497A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Peptides Or Proteins (AREA)
AU14064/97A 1995-12-06 1996-12-03 Mutational variants of mammalian ob gene proteins Abandoned AU1406497A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56807795A 1995-12-06 1995-12-06
US568077 1995-12-06
PCT/US1996/018561 WO1997020933A2 (en) 1995-12-06 1996-12-03 MUTATIONAL VARIANTS OF MAMMALIAN Ob GENE PROTEINS

Publications (1)

Publication Number Publication Date
AU1406497A true AU1406497A (en) 1997-06-27

Family

ID=24269846

Family Applications (1)

Application Number Title Priority Date Filing Date
AU14064/97A Abandoned AU1406497A (en) 1995-12-06 1996-12-03 Mutational variants of mammalian ob gene proteins

Country Status (2)

Country Link
AU (1) AU1406497A (en)
WO (1) WO1997020933A2 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001968A (en) 1994-08-17 1999-12-14 The Rockefeller University OB polypeptides, modified forms and compositions
EP0741187A2 (en) * 1995-05-05 1996-11-06 F. Hoffmann-La Roche Ag Recombinant obese (Ob) proteins
JP2000505791A (en) * 1996-01-25 2000-05-16 イーライ・リリー・アンド・カンパニー Obesity protein analog compounds and formulations thereof
US6025324A (en) * 1996-05-15 2000-02-15 Hoffmann-La Roche Inc. Pegylated obese (ob) protein compositions
US6590088B1 (en) 1996-07-19 2003-07-08 Human Genome Sciences, Inc. CD33-like protein
WO1999025824A1 (en) * 1997-11-14 1999-05-27 Centre National De La Recherche Scientifique (Cnrs) cDNA SEQUENCE CODING FOR A MUTATED LEPTIN AND APPLICATIONS
EP1101112B1 (en) 1998-07-28 2004-10-06 Vlaams Interuniversitair Instituut voor Biotechnologie vzw. Leptin-mediated gene-induction
US6420339B1 (en) 1998-10-14 2002-07-16 Amgen Inc. Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
JP4841037B2 (en) * 1999-02-12 2011-12-21 アムジエン・インコーポレーテツド Glycosylated leptin compositions and related methods
CA2365040A1 (en) * 1999-04-02 2000-10-12 Eli Lilly And Company Hob-bp2h compositions, methods and uses thereof
WO2001066593A1 (en) * 2000-03-07 2001-09-13 Biomolecular Engineering Research Institute Structural coordinate of protein complex and utilization of the structural coordinate
EP1612221A3 (en) 2000-05-22 2008-07-23 Vlaams Interuniversitair Instituut voor Biotechnologie vzw. Receptor-based interaction trap
US7235629B2 (en) 2000-11-14 2007-06-26 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Functional fragment of the leptin receptor
DK2219031T3 (en) 2001-10-22 2013-06-17 Amgen Inc Use of leptin for the treatment of human lipoatrophy and method for determining predisposition to the treatment gene
ATE364630T1 (en) * 2003-08-21 2007-07-15 Vlaams Interuniv Inst Biotech NEW LEPTIN ANTAGONIST
US7423113B2 (en) 2004-08-25 2008-09-09 Vib Vzw Leptin antagonist
EP1812038A1 (en) 2004-11-18 2007-08-01 VIB vzw Fibronectin iii domain as leptin receptor antagonists
US7307142B2 (en) * 2004-11-26 2007-12-11 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Leptin antagonists
WO2010118384A2 (en) 2009-04-10 2010-10-14 Amylin Pharmaceuticals, Inc. Amylin agonist compounds for estrogen-deficient mammals
PT2621519T (en) 2010-09-28 2017-10-04 Aegerion Pharmaceuticals Inc Leptin-abd fusion polypeptides with enhanced duration of action
CN104829707B (en) * 2015-05-06 2017-12-19 广东省生物资源应用研究所 The leptin activity peptide and its encoding gene and application of one CD ring and E spiral region mutations
CN104829708B (en) * 2015-05-06 2017-11-28 广东省生物资源应用研究所 The leptin activity peptide of one D spiral region mutation and its encoding gene and application

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6309853B1 (en) * 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
EP0725079A1 (en) * 1995-01-31 1996-08-07 Eli Lilly And Company Anti-obesity proteins
AU4862396A (en) * 1995-02-06 1996-08-27 Eli Lilly And Company Human obesity gene
WO1996036644A1 (en) * 1995-05-19 1996-11-21 Eli Lilly And Company Obesity gene product
CA2221824A1 (en) * 1995-05-26 1996-11-28 Eli Lilly And Company Rhesus ob protein and dna

Also Published As

Publication number Publication date
WO1997020933A2 (en) 1997-06-12
WO1997020933A3 (en) 1997-10-02

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