ID27589A - Pirimidina bisiklik dan dihidropirimidina bisiklik 3,4 sebagai penghambat proliferasi selular - Google Patents
Pirimidina bisiklik dan dihidropirimidina bisiklik 3,4 sebagai penghambat proliferasi selularInfo
- Publication number
- ID27589A ID27589A IDW20002452A ID20002452A ID27589A ID 27589 A ID27589 A ID 27589A ID W20002452 A IDW20002452 A ID W20002452A ID 20002452 A ID20002452 A ID 20002452A ID 27589 A ID27589 A ID 27589A
- Authority
- ID
- Indonesia
- Prior art keywords
- bicyclic
- pyyrimine
- dihydropirymidine
- proliferation
- mobile
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8670898P | 1998-05-26 | 1998-05-26 | |
US12615899P | 1999-03-25 | 1999-03-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
ID27589A true ID27589A (id) | 2001-04-12 |
Family
ID=26775058
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IDW20002452A ID27589A (id) | 1998-05-26 | 1999-05-10 | Pirimidina bisiklik dan dihidropirimidina bisiklik 3,4 sebagai penghambat proliferasi selular |
Country Status (29)
Country | Link |
---|---|
US (1) | US7501425B1 (id) |
EP (1) | EP1080092B1 (id) |
JP (1) | JP2002516327A (id) |
KR (1) | KR20010043829A (id) |
CN (1) | CN1138778C (id) |
AP (1) | AP2000001964A0 (id) |
AT (1) | ATE402177T1 (id) |
AU (1) | AU763839B2 (id) |
BG (1) | BG104960A (id) |
BR (1) | BR9911590A (id) |
CA (1) | CA2329703C (id) |
DE (1) | DE69939168D1 (id) |
EA (1) | EA003640B1 (id) |
EE (1) | EE200000706A (id) |
ES (1) | ES2310039T3 (id) |
GE (1) | GEP20033093B (id) |
HK (1) | HK1039483A1 (id) |
HR (1) | HRP20000799A2 (id) |
HU (1) | HUP0102514A3 (id) |
ID (1) | ID27589A (id) |
IL (1) | IL139599A0 (id) |
IS (1) | IS5687A (id) |
NO (1) | NO20005928L (id) |
NZ (1) | NZ508268A (id) |
PL (1) | PL344248A1 (id) |
SK (1) | SK17532000A3 (id) |
TR (1) | TR200003429T2 (id) |
WO (1) | WO1999061444A2 (id) |
YU (1) | YU73300A (id) |
Families Citing this family (102)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL344248A1 (en) | 1998-05-26 | 2001-10-22 | Warner Lambert Co | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation |
HUP0104199A3 (en) * | 1998-10-23 | 2002-12-28 | Hoffmann La Roche | Substituted pyrimido pyrimidinone derivatives, pharmaceutical compositions containing the same, process for the preparation thereof and intermediates |
IL149230A0 (en) * | 1999-10-21 | 2002-11-10 | Hoffmann La Roche | Alkylamino substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase |
ES2280247T3 (es) | 1999-10-21 | 2007-09-16 | F. Hoffmann-La Roche Ag | Heterociclos de nitrogeno biciclicos heteroalquilamino sustituidos como inhibidores de proteinas de quinasa p38. |
EA005585B1 (ru) | 2000-01-24 | 2005-04-28 | Уорнер-Ламберт Компани | 3-аминохиназолин-2,4-дионовые антибактериальные агенты |
KR20020065939A (ko) * | 2000-01-25 | 2002-08-14 | 워너-램버트 캄파니 | 피리도[2,3-d]피리미딘-2,7-디아민 카이나제 억제제 |
US7053070B2 (en) | 2000-01-25 | 2006-05-30 | Warner-Lambert Company | Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors |
AR030053A1 (es) * | 2000-03-02 | 2003-08-13 | Smithkline Beecham Corp | 1h-pirimido [4,5-d] pirimidin-2-onas y sales, composiciones farmaceuticas, uso para la fabricacion de un medicamento y procedimiento para producirlas |
US7235551B2 (en) | 2000-03-02 | 2007-06-26 | Smithkline Beecham Corporation | 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases |
AP2002002643A0 (en) * | 2000-03-06 | 2002-12-31 | Warner Lambert Co | 5-alkylpyrido[2,3-d]pyrimidines tyrosine kinase inhibitors |
US6506749B2 (en) | 2000-08-31 | 2003-01-14 | Syntex (U.S.A.) Llc | 7-oxo-pyridopyrimidines (I) |
WO2002018380A1 (en) * | 2000-08-31 | 2002-03-07 | F. Hoffmann-La Roche Ag | 7-oxo pyridopyrimidines as inhibitors of a cellular proliferation |
NZ524806A (en) | 2000-10-23 | 2006-03-31 | Smithkline Beecham Corp | Tri-substituted 8H-pyrido[2,3-d]pyrimidin-7-one compounds |
GB0029015D0 (en) | 2000-11-28 | 2001-01-10 | Univ London | Medical device |
AU2002251788A1 (en) | 2001-01-19 | 2002-08-12 | Smithkline Beecham Corporation | Novel compounds and uses thereof |
DK1361880T3 (da) | 2001-02-12 | 2006-01-23 | Hoffmann La Roche | 6-substituerede pyrido-pyrimidiner |
US7105667B2 (en) | 2001-05-01 | 2006-09-12 | Bristol-Myers Squibb Co. | Fused heterocyclic compounds and use thereof |
MXPA03010799A (es) | 2001-05-30 | 2005-07-25 | Warner Lambert Co | Agentes antibacterianos. |
KR20060111716A (ko) * | 2002-01-22 | 2006-10-27 | 워너-램버트 캄파니 엘엘씨 | 2-(피리딘-2-일아미노)-피리도[2,3-d]피리미딘-7-온 |
US7176310B1 (en) | 2002-04-09 | 2007-02-13 | Ucb Sa | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents |
RU2004133811A (ru) | 2002-04-19 | 2005-04-20 | Смитклайн Бичам Корпорейшн (US) | Новые соединения |
US7196090B2 (en) * | 2002-07-25 | 2007-03-27 | Warner-Lambert Company | Kinase inhibitors |
ATE374201T1 (de) | 2002-08-06 | 2007-10-15 | Hoffmann La Roche | 6-alkoxypyridopyrimidine als inhibitoren der p-38-map-kinase |
US7084270B2 (en) * | 2002-08-14 | 2006-08-01 | Hoffman-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
US7112676B2 (en) * | 2002-11-04 | 2006-09-26 | Hoffmann-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
TW200413381A (en) | 2002-11-04 | 2004-08-01 | Hoffmann La Roche | Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents |
DE602004021558D1 (de) * | 2003-01-17 | 2009-07-30 | Warner Lambert Co | 2-aminopyridin-substituierteheterocyclen als inhibitoren der zellulären proliferation |
KR20050111636A (ko) * | 2003-04-10 | 2005-11-25 | 에프. 호프만-라 로슈 아게 | 피리미도 화합물 |
DE10325133A1 (de) * | 2003-06-04 | 2004-12-23 | Bayer Cropscience Ag | Triazolopyrimidine |
EP1651648A4 (en) * | 2003-07-29 | 2009-09-02 | Irm Llc | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS |
DK1685131T3 (da) | 2003-11-13 | 2007-07-09 | Hoffmann La Roche | Hydroxyalkylsubstituerede pyrido-7-pyrimidin-7-oner |
CA2566531A1 (en) * | 2004-05-18 | 2005-12-15 | Rigel Pharmaceuticals, Inc. | Cycloalkyl substituted pyrimidinediamine compounds and their uses |
CA2576924A1 (en) * | 2004-08-31 | 2006-03-09 | F. Hoffmann-La Roche Ag | Amide derivatives of 7-amino-3-phenyl-dihydropyrimido [4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents |
CN1980933B (zh) | 2004-08-31 | 2010-07-14 | 霍夫曼-拉罗奇有限公司 | 3-苯基-二氢嘧啶并[4,5-d]嘧啶酮的酰胺衍生物,它们的制备和用作药剂的用途 |
CA2590294A1 (en) | 2004-12-13 | 2006-06-22 | Sunesis Pharmaceuticals, Inc. | Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as raf kinase inhibitors |
JP2008535822A (ja) | 2005-03-25 | 2008-09-04 | グラクソ グループ リミテッド | 新規化合物 |
UY29440A1 (es) | 2005-03-25 | 2006-10-02 | Glaxo Group Ltd | Nuevos compuestos |
PE20061193A1 (es) | 2005-03-25 | 2006-12-02 | Glaxo Group Ltd | DERIVADOS DE 3,4-DIHIDROPIRIMIDO[4,5-d]PIRIMIDIN-2-[1H]-0NA COMO INHIBIDORES DE QUINASA p38 |
WO2006104917A2 (en) | 2005-03-25 | 2006-10-05 | Glaxo Group Limited | Process for preparing pyrido[2,3-d]pyrimidin-7-one and 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one derivatives |
EP1981886B1 (en) | 2006-01-31 | 2009-08-12 | F.Hoffmann-La Roche Ag | 7h-pyrido[3,4-d]pyrimidin-8-ones, their manufacture and use as protein kinase inhibitors |
CA2689429C (en) * | 2007-06-15 | 2012-08-21 | Banyu Pharmaceutical Co., Ltd. | Bicycloaniline derivatives |
US8071766B2 (en) | 2008-02-01 | 2011-12-06 | Takeda Pharmaceutical Company Limited | HSP90 inhibitors |
CA2745959A1 (en) * | 2008-12-12 | 2010-06-17 | Msd K.K. | Dihydropyrimidopyrimidine derivatives |
EP2376493B1 (en) | 2008-12-12 | 2016-10-05 | Msd K.K. | Dihydropyrimidopyrimidine derivative |
JP5908728B2 (ja) * | 2009-01-06 | 2016-04-26 | ダナ ファーバー キャンサー インスティテュート インコーポレイテッド | ピリミド−ジアゼピノンキナーゼ骨格化合物及び疾患を治療する方法 |
CA2750716A1 (en) * | 2009-02-25 | 2010-09-02 | Msd K.K. | Pyrimidopyrimidoindazole derivative |
SA111320200B1 (ar) | 2010-02-17 | 2014-02-16 | ديبيوفارم اس ايه | مركبات ثنائية الحلقة واستخداماتها كمثبطات c-src/jak مزدوجة |
CN103200822B (zh) * | 2010-08-05 | 2014-12-24 | 天普大学-联邦高等教育体系 | 2-取代-8-烷基-7-氧代-7,8-二氢吡啶并[2,3-d]嘧啶-6-腈和其应用 |
WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
CN105001165B (zh) | 2011-04-22 | 2020-06-23 | 西格诺药品有限公司 | 取代的二氨基嘧啶其组合物,和用其治疗的方法 |
CN103987697B (zh) | 2011-10-14 | 2017-04-26 | 百时美施贵宝公司 | 作为因子xia抑制剂的取代的四氢异喹啉化合物 |
PE20141825A1 (es) | 2011-10-14 | 2014-11-29 | Bristol Myers Squibb Co | Compuestos de tetrahidroisoquinolina sustituidos como inhibidores del factor xia |
JP6033318B2 (ja) | 2011-10-14 | 2016-11-30 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 第XIa因子阻害剤としての置換テトラヒドロイソキノリン化合物 |
SG11201408238WA (en) | 2012-06-13 | 2015-01-29 | Incyte Corp | Substituted tricyclic compounds as fgfr inhibitors |
NZ703495A (en) * | 2012-07-11 | 2018-02-23 | Blueprint Medicines Corp | Inhibitors of the fibroblast growth factor receptor |
US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
US9403774B2 (en) | 2012-10-12 | 2016-08-02 | Bristol-Myers Squibb Company | Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
EA032092B1 (ru) | 2012-10-12 | 2019-04-30 | Бристол-Майерс Сквибб Компани | Кристаллические формы ингибитора фактора xia |
WO2014059202A1 (en) | 2012-10-12 | 2014-04-17 | Bristol-Myers Squibb Company | Guanidine substituted tetrahydroisoquinoline compounds as factor xia inhibitors |
US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
JP6576325B2 (ja) | 2013-03-15 | 2019-09-18 | セルジーン シーエーアール エルエルシー | ヘテロアリール化合物およびそれらの使用 |
NZ711376A (en) | 2013-03-15 | 2020-01-31 | Sanofi Sa | Heteroaryl compounds and uses thereof |
US9321786B2 (en) | 2013-03-15 | 2016-04-26 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
WO2014160668A1 (en) | 2013-03-25 | 2014-10-02 | Bristol-Myers Squibb Company | Tetrahydroisoquinolines containing substituted azoles as factor xia inhibitors |
EA035095B1 (ru) * | 2013-04-19 | 2020-04-27 | Инсайт Холдингс Корпорейшн | Бициклические гетероциклы в качестве ингибиторов fgfr |
US9783504B2 (en) * | 2013-07-09 | 2017-10-10 | Dana-Farber Cancer Institute, Inc. | Kinase inhibitors for the treatment of disease |
UA116920C2 (uk) | 2013-10-18 | 2018-05-25 | ЕЙСАЙ Ар ЕНД Ді МЕНЕДЖМЕНТ КО., ЛТД. | Інгібітори fgfr4 |
WO2015061572A1 (en) | 2013-10-25 | 2015-04-30 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor |
ES2812605T3 (es) | 2013-12-20 | 2021-03-17 | Signal Pharm Llc | Compuestos de diaminopirimidilo sustituidos, composiciones de los mismos y procedimientos de tratamiento con ellos |
NO2760821T3 (id) | 2014-01-31 | 2018-03-10 | ||
EP3988549A1 (en) | 2014-01-31 | 2022-04-27 | Bristol-Myers Squibb Company | Macrocycles with heterocyclic p2' groups as factor xia inhibitors |
CN103880861B (zh) * | 2014-02-21 | 2016-02-03 | 温州医科大学 | 一种作用于FGF受体的4,6-二甲基-噁唑并[5,4-d]嘧啶-5,7(4H,6H)-二酮衍生物 |
WO2016036893A1 (en) | 2014-09-04 | 2016-03-10 | Bristol-Myers Squibb Company | Diamide macrocycles that are fxia inhibitors |
US9453018B2 (en) | 2014-10-01 | 2016-09-27 | Bristol-Myers Squibb Company | Pyrimidinones as factor XIa inhibitors |
US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
CR20170390A (es) | 2015-02-20 | 2017-10-23 | Incyte Holdings Corp | Heterociclos biciclicos como inhibidores de fgfr |
MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
MX2017013248A (es) | 2015-04-14 | 2018-07-06 | Eisai R&D Man Co Ltd | Compuesto del inhibidor fgfr4 cristalino y usos del mismo. |
EP3454898B1 (en) | 2016-05-10 | 2021-11-10 | Eisai R&D Management Co., Ltd. | Drug combinations for reducing cell viability and/or cell proliferation |
CN107459519A (zh) * | 2016-06-06 | 2017-12-12 | 上海艾力斯医药科技有限公司 | 稠合嘧啶哌啶环衍生物及其制备方法和应用 |
CN110225914A (zh) * | 2016-07-05 | 2019-09-10 | 布罗德研究所股份有限公司 | 双环脲激酶抑制剂及其用途 |
TWI808958B (zh) | 2017-01-25 | 2023-07-21 | 美商特普醫葯公司 | 涉及二芳基巨環化合物之組合療法 |
KR20190120331A (ko) | 2017-02-28 | 2019-10-23 | 더 제너럴 하스피탈 코포레이션 | Sik 억제제로서의 피리미도피리미디논의 용도 |
AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
WO2019213506A1 (en) | 2018-05-04 | 2019-11-07 | Incyte Corporation | Salts of an fgfr inhibitor |
SG11202010636VA (en) | 2018-05-04 | 2020-11-27 | Incyte Corp | Solid forms of an fgfr inhibitor and processes for preparing the same |
US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
CR20220169A (es) | 2019-10-14 | 2022-10-27 | Incyte Corp | Heterociclos bicíclicos como inhibidores de fgfr |
WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
JP2023505258A (ja) | 2019-12-04 | 2023-02-08 | インサイト・コーポレイション | Fgfr阻害剤としての三環式複素環 |
CA3162010A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Derivatives of an fgfr inhibitor |
US12012409B2 (en) | 2020-01-15 | 2024-06-18 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
WO2021257863A1 (en) | 2020-06-19 | 2021-12-23 | Incyte Corporation | Pyrrolotriazine compounds as jak2 v617f inhibitors |
US11691971B2 (en) | 2020-06-19 | 2023-07-04 | Incyte Corporation | Naphthyridinone compounds as JAK2 V617F inhibitors |
WO2022006456A1 (en) | 2020-07-02 | 2022-01-06 | Incyte Corporation | Tricyclic pyridone compounds as jak2 v617f inhibitors |
WO2022006457A1 (en) | 2020-07-02 | 2022-01-06 | Incyte Corporation | Tricyclic urea compounds as jak2 v617f inhibitors |
WO2022046989A1 (en) | 2020-08-27 | 2022-03-03 | Incyte Corporation | Tricyclic urea compounds as jak2 v617f inhibitors |
US11919908B2 (en) | 2020-12-21 | 2024-03-05 | Incyte Corporation | Substituted pyrrolo[2,3-d]pyrimidine compounds as JAK2 V617F inhibitors |
US11958861B2 (en) | 2021-02-25 | 2024-04-16 | Incyte Corporation | Spirocyclic lactams as JAK2 V617F inhibitors |
CA3220274A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2949466A (en) | 1958-03-04 | 1960-08-16 | Parke Davis & Co | Pyrimidine compounds and means of producing the same |
NL6704601A (id) | 1966-04-06 | 1967-10-09 | ||
US3912723A (en) | 1971-03-29 | 1975-10-14 | Pfizer | 2-Phenyl-as-triazine-3,5(2H,4H)diones |
CA1132137A (en) | 1979-06-14 | 1982-09-21 | David S. Duch | Alkoxybenzylpyridopyrimidines, methods for their preparation, formulations thereof and their use in medicine |
US4425346A (en) | 1980-08-01 | 1984-01-10 | Smith And Nephew Associated Companies Limited | Pharmaceutical compositions |
JPS60226882A (ja) | 1984-04-24 | 1985-11-12 | Nippon Zoki Pharmaceut Co Ltd | 新規ピリミドピリミジン誘導体 |
AU598093B2 (en) | 1987-02-07 | 1990-06-14 | Wellcome Foundation Limited, The | Pyridopyrimidines, methods for their preparation and pharmaceutical formulations thereof |
AU658646B2 (en) | 1991-05-10 | 1995-04-27 | Rhone-Poulenc Rorer International (Holdings) Inc. | Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
US5654307A (en) | 1994-01-25 | 1997-08-05 | Warner-Lambert Company | Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
IL112249A (en) | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
CA2200468A1 (en) | 1994-10-27 | 1996-05-09 | Wayne J. Thompson | Muscarine antagonists |
ES2146782T3 (es) * | 1994-11-14 | 2000-08-16 | Warner Lambert Co | 6-aril-pirido(2,3-d)pirimidinas y naftiridinas para la inhibicion de la proliferacion celular inducida por la proteina tirosina quinasa. |
IL117923A (en) | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
EP0892789B2 (en) * | 1996-04-12 | 2009-11-18 | Warner-Lambert Company LLC | Irreversible inhibitors of tyrosine kinases |
AU749750B2 (en) * | 1997-02-05 | 2002-07-04 | Warner-Lambert Company | Pyrido {2,3-d} pyrimidines and 4-aminopyrimidines as inhibitors of cellular proliferation |
ZA986732B (en) * | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
ES2235353T3 (es) * | 1997-08-20 | 2005-07-01 | Warner-Lambert Company Llc | Naftridonas para inhibir la proteina tirasina quinasa y proliferacion celular mediada por la quinasa del ciclo celular. |
JP4038624B2 (ja) | 1997-11-29 | 2008-01-30 | 日本農薬株式会社 | 縮合複素環誘導体及びその中間体並びに有害生物防除剤 |
PL344248A1 (en) | 1998-05-26 | 2001-10-22 | Warner Lambert Co | Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation |
HUP0104199A3 (en) * | 1998-10-23 | 2002-12-28 | Hoffmann La Roche | Substituted pyrimido pyrimidinone derivatives, pharmaceutical compositions containing the same, process for the preparation thereof and intermediates |
ES2280247T3 (es) | 1999-10-21 | 2007-09-16 | F. Hoffmann-La Roche Ag | Heterociclos de nitrogeno biciclicos heteroalquilamino sustituidos como inhibidores de proteinas de quinasa p38. |
IL149230A0 (en) | 1999-10-21 | 2002-11-10 | Hoffmann La Roche | Alkylamino substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase |
AR030053A1 (es) | 2000-03-02 | 2003-08-13 | Smithkline Beecham Corp | 1h-pirimido [4,5-d] pirimidin-2-onas y sales, composiciones farmaceuticas, uso para la fabricacion de un medicamento y procedimiento para producirlas |
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1999
- 1999-05-10 PL PL99344248A patent/PL344248A1/xx not_active Application Discontinuation
- 1999-05-10 ID IDW20002452A patent/ID27589A/id unknown
- 1999-05-10 US US09/623,737 patent/US7501425B1/en not_active Expired - Fee Related
- 1999-05-10 ES ES99924165T patent/ES2310039T3/es not_active Expired - Lifetime
- 1999-05-10 EE EEP200000706A patent/EE200000706A/xx unknown
- 1999-05-10 YU YU73300A patent/YU73300A/sh unknown
- 1999-05-10 HU HU0102514A patent/HUP0102514A3/hu unknown
- 1999-05-10 TR TR2000/03429T patent/TR200003429T2/xx unknown
- 1999-05-10 AT AT99924165T patent/ATE402177T1/de not_active IP Right Cessation
- 1999-05-10 NZ NZ508268A patent/NZ508268A/xx unknown
- 1999-05-10 AU AU40734/99A patent/AU763839B2/en not_active Ceased
- 1999-05-10 EA EA200001171A patent/EA003640B1/ru not_active IP Right Cessation
- 1999-05-10 CN CNB998065587A patent/CN1138778C/zh not_active Expired - Fee Related
- 1999-05-10 GE GEAP19995700A patent/GEP20033093B/en unknown
- 1999-05-10 EP EP99924165A patent/EP1080092B1/en not_active Expired - Lifetime
- 1999-05-10 CA CA002329703A patent/CA2329703C/en not_active Expired - Fee Related
- 1999-05-10 SK SK1753-2000A patent/SK17532000A3/sk unknown
- 1999-05-10 BR BR9911590-5A patent/BR9911590A/pt not_active Application Discontinuation
- 1999-05-10 IL IL13959999A patent/IL139599A0/xx unknown
- 1999-05-10 KR KR1020007013279A patent/KR20010043829A/ko not_active Application Discontinuation
- 1999-05-10 JP JP2000550849A patent/JP2002516327A/ja not_active Abandoned
- 1999-05-10 AP APAP/P/2000/001964A patent/AP2000001964A0/en unknown
- 1999-05-10 DE DE69939168T patent/DE69939168D1/de not_active Expired - Fee Related
- 1999-05-10 WO PCT/US1999/010187 patent/WO1999061444A2/en not_active Application Discontinuation
-
2000
- 2000-10-27 IS IS5687A patent/IS5687A/is unknown
- 2000-11-17 BG BG104960A patent/BG104960A/xx unknown
- 2000-11-20 HR HR20000799A patent/HRP20000799A2/hr not_active Application Discontinuation
- 2000-11-23 NO NO20005928A patent/NO20005928L/no not_active Application Discontinuation
-
2001
- 2001-11-08 HK HK01107828A patent/HK1039483A1/xx not_active IP Right Cessation
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