MXPA02001754A - Sistema de ensayo in vitro de gama-secretasa. - Google Patents
Sistema de ensayo in vitro de gama-secretasa.Info
- Publication number
- MXPA02001754A MXPA02001754A MXPA02001754A MXPA02001754A MXPA02001754A MX PA02001754 A MXPA02001754 A MX PA02001754A MX PA02001754 A MXPA02001754 A MX PA02001754A MX PA02001754 A MXPA02001754 A MX PA02001754A MX PA02001754 A MXPA02001754 A MX PA02001754A
- Authority
- MX
- Mexico
- Prior art keywords
- secretase
- membranes
- substrate
- cells
- test kit
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96472—Aspartic endopeptidases (3.4.23)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE1999141039 DE19941039A1 (de) | 1999-08-28 | 1999-08-28 | gamma-Sekretase in vitro Testsystem |
PCT/EP2000/008340 WO2001016355A2 (de) | 1999-08-28 | 2000-08-25 | In-vitro-testsystem für gamma-sekretase aus angereicherten-membranen |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA02001754A true MXPA02001754A (es) | 2002-10-23 |
Family
ID=7920037
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA02001754A MXPA02001754A (es) | 1999-08-28 | 2000-08-25 | Sistema de ensayo in vitro de gama-secretasa. |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1212454A2 (de) |
JP (1) | JP2003508058A (de) |
CA (1) | CA2381952A1 (de) |
DE (1) | DE19941039A1 (de) |
MX (1) | MXPA02001754A (de) |
WO (1) | WO2001016355A2 (de) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10000161A1 (de) * | 2000-01-06 | 2001-07-19 | Boehringer Ingelheim Pharma | Verfahren zur Identifikation eines Proteaseinhibitors |
JP2004505608A (ja) | 2000-04-03 | 2004-02-26 | ブリストル−マイヤーズ スクイブ カンパニー | 機能的に活性なガンマ−セクレターゼタンパク質複合体の単離およびその活性およびインヒビターの検出法 |
DE60123074T3 (de) | 2000-05-11 | 2015-01-29 | Scios Inc. | Modulation von gamma-secretase aktivität |
DE10131899A1 (de) * | 2001-07-04 | 2003-02-27 | Boehringer Ingelheim Pharma | In vitro-Screening-Assay für gamma-Secretase |
WO2005031363A1 (en) * | 2003-09-24 | 2005-04-07 | University Of Chicago | Membrane preparation from pichia pastoris to assay ϝ-secretase activity |
CN1934251A (zh) * | 2004-01-29 | 2007-03-21 | 塞尔卓姆股份公司 | 使用atp7a-调控剂治疗神经变性疾病 |
DE602004011400T2 (de) * | 2004-01-29 | 2009-01-22 | Cellzome Ag | Behandlung von neurodegenerativen krankheiten mit gpr49 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996040885A2 (en) * | 1995-06-07 | 1996-12-19 | Athena Neurosciences, Inc. | β-SECRETASE, ANTIBODIES TO β-SECRETASE, AND ASSAYS FOR DETECTING β-SECRETASE INHIBITION |
CA2191924A1 (en) * | 1995-12-05 | 1997-06-06 | Kevin Felsenstein | 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of .beta.-amyloid protein production |
US6803188B1 (en) * | 1996-01-31 | 2004-10-12 | The Regents Of The University Of California | Tandem fluorescent protein constructs |
GB9608657D0 (en) * | 1996-04-26 | 1996-07-03 | Smithkline Beecham Plc | Novel treatment |
DE19641180A1 (de) * | 1996-09-24 | 1998-03-26 | Schering Ag | Verfahren zur Darstellung von APP-Sekretase Modulation und deren Verwendung als Mittel zur Behandlung der Alzheimer'schen Erkrankung |
AU4589297A (en) * | 1996-10-07 | 1998-05-05 | Scios Inc. | Method to identify direct inhibitors of the beta-amyloid forming enzyme gamma-secretase |
WO1998021589A1 (en) * | 1996-11-15 | 1998-05-22 | The Trustees Of The University Of Pennsylvania | Screening for modulators of amyloid processing |
-
1999
- 1999-08-28 DE DE1999141039 patent/DE19941039A1/de not_active Withdrawn
-
2000
- 2000-08-25 MX MXPA02001754A patent/MXPA02001754A/es unknown
- 2000-08-25 EP EP00962393A patent/EP1212454A2/de not_active Withdrawn
- 2000-08-25 CA CA002381952A patent/CA2381952A1/en not_active Abandoned
- 2000-08-25 JP JP2001520900A patent/JP2003508058A/ja active Pending
- 2000-08-25 WO PCT/EP2000/008340 patent/WO2001016355A2/de not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1212454A2 (de) | 2002-06-12 |
WO2001016355A2 (de) | 2001-03-08 |
CA2381952A1 (en) | 2001-03-08 |
WO2001016355A3 (de) | 2001-08-30 |
DE19941039A1 (de) | 2001-03-01 |
JP2003508058A (ja) | 2003-03-04 |
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