MX9707636A - Ascomicinas. - Google Patents

Ascomicinas.

Info

Publication number
MX9707636A
MX9707636A MX9707636A MX9707636A MX9707636A MX 9707636 A MX9707636 A MX 9707636A MX 9707636 A MX9707636 A MX 9707636A MX 9707636 A MX9707636 A MX 9707636A MX 9707636 A MX9707636 A MX 9707636A
Authority
MX
Mexico
Prior art keywords
compounds
ascomycins
moieties
dermatitis
asthma
Prior art date
Application number
MX9707636A
Other languages
English (en)
Inventor
Rene Hersperger
Reto Naef
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9507128.8A external-priority patent/GB9507128D0/en
Priority claimed from GBGB9526049.3A external-priority patent/GB9526049D0/en
Priority claimed from GBGB9526050.1A external-priority patent/GB9526050D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX9707636A publication Critical patent/MX9707636A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La invencion proporciona ascomicinas que llevan una o más fracciones de oxicarbonilo o fracciones de carboxi fisiologicamente hidrolizables y aceptables, encontrándose que estos compuestos son utiles como productos farmacéuticos, especialmente en el tratamiento de asma y dermatitis. También se proporciona métodos para producir los compuestos y las composiciones farmacéuticas que comprenden a los compuestos.
MX9707636A 1995-04-06 1997-10-03 Ascomicinas. MX9707636A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9507128.8A GB9507128D0 (en) 1995-04-06 1995-04-06 Organic compounds
GBGB9526049.3A GB9526049D0 (en) 1995-12-20 1995-12-20 Organic compounds
GBGB9526050.1A GB9526050D0 (en) 1995-12-20 1995-12-20 Organic compounds

Publications (1)

Publication Number Publication Date
MX9707636A true MX9707636A (es) 1998-06-30

Family

ID=27267660

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9707636A MX9707636A (es) 1995-04-06 1997-10-03 Ascomicinas.

Country Status (21)

Country Link
US (1) US5925649A (es)
EP (1) EP0819130A1 (es)
JP (1) JP2000505044A (es)
KR (1) KR19980703583A (es)
CN (1) CN1088068C (es)
AR (1) AR004480A1 (es)
AU (1) AU703523B2 (es)
BR (1) BR9604808A (es)
CA (1) CA2216562A1 (es)
CO (1) CO4750668A1 (es)
CZ (1) CZ312397A3 (es)
FI (1) FI973529A (es)
HU (1) HUP9801993A3 (es)
IL (1) IL117815A (es)
MX (1) MX9707636A (es)
NO (1) NO309273B1 (es)
NZ (1) NZ307170A (es)
PL (1) PL322553A1 (es)
SK (1) SK133997A3 (es)
TR (1) TR199700999T1 (es)
WO (1) WO1996031514A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100505464B1 (ko) 1998-03-26 2005-08-04 후지사와 야꾸힝 고교 가부시키가이샤 서방성 제제
GB9826656D0 (en) * 1998-12-03 1999-01-27 Novartis Ag Organic compounds
US6121257A (en) * 1999-03-31 2000-09-19 Abbott Laboratories Sulfamate containing macrocyclic immunomodulators
US7063857B1 (en) 1999-04-30 2006-06-20 Sucampo Ag Use of macrolide compounds for the treatment of dry eye
ES2232439T3 (es) * 1999-04-30 2005-06-01 Sucampo Ag Uso de compuestos macrolidos para el tratamiento de los ojos secos.
US6593292B1 (en) 1999-08-24 2003-07-15 Cellgate, Inc. Compositions and methods for enhancing drug delivery across and into epithelial tissues
AR033151A1 (es) * 2001-04-12 2003-12-03 Sucampo Pharmaceuticals Inc Agente para el tratamiento oftalmico topico de las enfermedades inflamatorias oculares
WO2002089796A2 (en) * 2001-05-09 2002-11-14 Novartis Ag Methods for selective immunomodulation using pimecrolimus
KR20050086648A (ko) * 2002-11-15 2005-08-30 노파르티스 아게 약물 전달 시스템
US20060115522A1 (en) * 2003-02-17 2006-06-01 Cipla Ltd Pharmaceutical composition
TWI324604B (en) 2003-06-18 2010-05-11 Novartis Ag New use of staurosporine derivatives
US7780973B2 (en) * 2003-12-15 2010-08-24 Ethicon Endo-Surgery, Inc. Method and device for minimally invasive implantation of biomaterial
US20050142161A1 (en) * 2003-12-30 2005-06-30 Freeman Lynetta J. Collagen matrix for soft tissue augmentation
JP2007516951A (ja) * 2003-12-30 2007-06-28 アステラス製薬株式会社 気道閉塞症の治療または予防のためのマクロライドの使用
WO2006082588A2 (en) * 2005-02-07 2006-08-10 Pharmalight Inc. Method and device for ophthalmic administration of active pharmaceutical ingredients
JPWO2016068208A1 (ja) 2014-10-28 2017-08-10 晃史 山口 妊娠状態を改善するための薬剤及びその利用
WO2020032252A1 (ja) 2018-08-10 2020-02-13 晃史 山口 母体と胎児との関係における液性免疫関連疾患の治療薬
WO2020129348A1 (ja) 2018-12-18 2020-06-25 晃史 山口 不妊・不育症または妊娠状態を改善するための薬剤

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3244592A (en) * 1962-06-09 1966-04-05 Arai Tadashi Ascomycin and process for its production
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
JPS6317884A (ja) * 1986-05-30 1988-01-25 Fujisawa Pharmaceut Co Ltd トリシクロ化合物
JPH01125394A (ja) * 1987-11-10 1989-05-17 Mect Corp シアロシルグリセロリピッド類及びその製造方法
ATE120466T1 (de) * 1987-12-09 1995-04-15 Fisons Plc Makrozyklische verbindungen.
AU6286690A (en) * 1989-08-18 1991-04-03 Fisons Plc Macrocyclic compounds
KR0159766B1 (ko) * 1989-10-16 1998-12-01 후지사와 토모키치로 양모제 조성물
ATE126803T1 (de) * 1989-11-09 1995-09-15 Sandoz Ag Heteroatome enthaltende tricyclische verbindungen.
JPH05504956A (ja) * 1990-03-12 1993-07-29 藤沢薬品工業株式会社 トリシクロ化合物
WO1991019495A1 (en) * 1990-06-11 1991-12-26 Fujisawa Pharmaceutical Co., Ltd. Use of a macrolide compound such as fk 506 for manufacturing a medicament for treating idiopathic thrombocytopenic purpura and basedow's disease
MY110418A (en) * 1990-07-02 1998-05-30 Novartis Ag Heteroatoms-containing tricyclic compounds.
ATE150304T1 (de) * 1990-09-04 1997-04-15 Fujisawa Pharmaceutical Co Tricyclische verbindungen enthaltende salben
CA2054983A1 (en) * 1990-11-08 1992-05-09 Sotoo Asakura Suspendible composition and process for preparing the same
US5208241A (en) * 1991-09-09 1993-05-04 Merck & Co., Inc. N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity
US5247076A (en) * 1991-09-09 1993-09-21 Merck & Co., Inc. Imidazolidyl macrolides having immunosuppressive activity
US5252732A (en) * 1991-09-09 1993-10-12 Merck & Co., Inc. D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity
US5457194A (en) * 1993-03-17 1995-10-10 Abbott Laboratories Substituted aliphatic amine-containing macrocyclic immunomodulators
CN1089233C (zh) * 1994-10-26 2002-08-21 诺瓦蒂斯有限公司 药物组合物

Also Published As

Publication number Publication date
HUP9801993A2 (hu) 1998-12-28
NO974536D0 (no) 1997-10-01
JP2000505044A (ja) 2000-04-25
EP0819130A1 (en) 1998-01-21
AU5645396A (en) 1996-10-23
WO1996031514A1 (en) 1996-10-10
KR19980703583A (ko) 1998-11-05
AR004480A1 (es) 1998-12-16
NO974536L (no) 1997-10-01
CA2216562A1 (en) 1996-10-10
SK133997A3 (en) 1998-05-06
IL117815A (en) 2000-07-16
IL117815A0 (en) 1996-08-04
CZ312397A3 (cs) 1998-01-14
US5925649A (en) 1999-07-20
BR9604808A (pt) 1998-06-09
NZ307170A (en) 1999-03-29
CN1088068C (zh) 2002-07-24
NO309273B1 (no) 2001-01-08
AU703523B2 (en) 1999-03-25
TR199700999T1 (xx) 1998-01-21
FI973529A (fi) 1997-11-25
HUP9801993A3 (en) 2000-04-28
FI973529A0 (fi) 1997-08-27
PL322553A1 (en) 1998-02-02
CO4750668A1 (es) 1999-03-31
CN1180359A (zh) 1998-04-29

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Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees