ATE126803T1 - Heteroatome enthaltende tricyclische verbindungen. - Google Patents

Heteroatome enthaltende tricyclische verbindungen.

Info

Publication number
ATE126803T1
ATE126803T1 AT90810854T AT90810854T ATE126803T1 AT E126803 T1 ATE126803 T1 AT E126803T1 AT 90810854 T AT90810854 T AT 90810854T AT 90810854 T AT90810854 T AT 90810854T AT E126803 T1 ATE126803 T1 AT E126803T1
Authority
AT
Austria
Prior art keywords
treatment
compounds containing
containing heteroatoms
tricyclic compounds
epimerizing
Prior art date
Application number
AT90810854T
Other languages
English (en)
Inventor
Karl Baumann
Gerhard Emmer
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Application granted granted Critical
Publication of ATE126803T1 publication Critical patent/ATE126803T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)
  • Steroid Compounds (AREA)
AT90810854T 1989-11-09 1990-11-07 Heteroatome enthaltende tricyclische verbindungen. ATE126803T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE3937336 1989-11-09
DE3938132 1989-11-16
DE3942831 1989-12-23
DE3942833 1989-12-23
DE4006819 1990-03-05

Publications (1)

Publication Number Publication Date
ATE126803T1 true ATE126803T1 (de) 1995-09-15

Family

ID=27511355

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90810854T ATE126803T1 (de) 1989-11-09 1990-11-07 Heteroatome enthaltende tricyclische verbindungen.

Country Status (18)

Country Link
EP (1) EP0427680B1 (de)
JP (1) JP2750302B2 (de)
KR (1) KR0166074B1 (de)
AT (1) ATE126803T1 (de)
AU (1) AU640963B2 (de)
CA (1) CA2029694C (de)
DE (2) DE69021833T2 (de)
DK (1) DK0427680T3 (de)
ES (1) ES2077663T3 (de)
GR (1) GR3017858T3 (de)
HK (1) HK30096A (de)
HU (1) HU210900A9 (de)
IE (1) IE69974B1 (de)
LU (1) LU91021I2 (de)
LV (1) LV11621B (de)
MY (1) MY111430A (de)
NL (1) NL300134I2 (de)
NZ (1) NZ235991A (de)

Families Citing this family (60)

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Publication number Priority date Publication date Assignee Title
EP0356399A3 (de) * 1988-08-26 1991-03-20 Sandoz Ag Substituierte 4-Azatricyclo (22.3.1.04.9) octacos-18-en-Derivate, Verfahren zu ihrer Herstellung und die sie enthaltenden pharmazeutischen Zusammensetzungen
EP0402931A1 (de) * 1989-06-14 1990-12-19 Sandoz Ltd. Heteroatome enthaltende tricyclische Verbindungen
US5208228A (en) * 1989-11-13 1993-05-04 Merck & Co., Inc. Aminomacrolides and derivatives having immunosuppressive activity
MY110418A (en) * 1990-07-02 1998-05-30 Novartis Ag Heteroatoms-containing tricyclic compounds.
EP0480623A1 (de) * 1990-10-11 1992-04-15 Merck & Co. Inc. Halomakrolide und Derivate mit immunosuppressiver Wirkung
US5143918A (en) * 1990-10-11 1992-09-01 Merck & Co., Inc. Halomacrolides and derivatives having immunosuppressive activity
US5162334A (en) * 1991-05-13 1992-11-10 Merck & Co., Inc. Amino O-alkyl, O-alkenyl and O-alkynlmacrolides having immunosuppressive activity
WO1992020688A1 (en) * 1991-05-13 1992-11-26 Merck & Co., Inc. Amino o-aryl, o-alkyl, o-alkenyl and o-alkynyl macrolides
US5565560A (en) * 1991-05-13 1996-10-15 Merck & Co., Inc. O-Aryl,O-alkyl,O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
US5250678A (en) * 1991-05-13 1993-10-05 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
US5189042A (en) * 1991-08-22 1993-02-23 Merck & Co. Inc. Fluoromacrolides having immunosuppressive activity
US5708002A (en) * 1991-09-05 1998-01-13 Abbott Laboratories Macrocyclic immunomodulators
CA2103453A1 (en) * 1991-09-05 1993-03-06 Jay R. Luly Macrocyclic immunomodulators
US5208241A (en) * 1991-09-09 1993-05-04 Merck & Co., Inc. N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity
ES2108261T3 (es) * 1992-03-02 1997-12-16 Pfizer Derivados 2-aminoazucar de macrolidos.
CA2091194A1 (en) * 1992-04-08 1993-10-09 Richard D. Connell 2-oxo-ethyl derivatives as immunosuppressants
US5284877A (en) * 1992-06-12 1994-02-08 Merck & Co., Inc. Alkyl and alkenyl macrolides having immunosuppressive activity
US5284840A (en) * 1992-06-12 1994-02-08 Merck & Co., Inc. Alkylidene macrolides having immunosuppressive activity
CH686761A5 (de) 1993-05-27 1996-06-28 Sandoz Ag Galenische Formulierungen.
WO1995015328A1 (en) * 1993-11-30 1995-06-08 Abbott Laboratories Macrocyclic immunomodulators with novel cyclohexyl ring replacements
US5612350A (en) * 1993-11-30 1997-03-18 Abbott Laboratories Macrocyclic immunomodulators with novel cyclohexyl ring replacements
US5880280A (en) * 1994-06-15 1999-03-09 Merck & Co., Inc. Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppressive activity
US5550233A (en) * 1994-06-21 1996-08-27 Merck & Co., Inc. Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppressive activity
US5693648A (en) * 1994-09-30 1997-12-02 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides having immunosuppressive activity
US5545734A (en) * 1994-10-25 1996-08-13 Merck & Co., Inc. Aryl and heteroaryl macrolides having immunosuppressive activity
IL129547A (en) 1994-10-26 2001-01-11 Novartis Ag Pharmaceutical compositions comprising a macrolide and an acid
EP0786986B1 (de) * 1994-10-26 2002-03-20 Novartis AG Verwendung eines ungesättigten Fettalkohols
GB9618952D0 (en) * 1996-09-11 1996-10-23 Sandoz Ltd Process
AR004480A1 (es) * 1995-04-06 1998-12-16 Amico Derin C D Compuestos de ascomicina que poseen actividad antiinflamatoria, pro cedimiento para prepararlos, uso de dichos compuestos para preparar agentesfarmaceuticos y composiciones farmaceuticas que los incluyen
JP3282945B2 (ja) * 1995-06-07 2002-05-20 松下電器産業株式会社 スピンドルモータ
FR2736550B1 (fr) 1995-07-14 1998-07-24 Sandoz Sa Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule
GB9601120D0 (en) * 1996-01-19 1996-03-20 Sandoz Ltd Organic compounds
GB9713730D0 (en) 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds
ATE464900T1 (de) 1998-03-26 2010-05-15 Astellas Pharma Inc Retardpräparat mit makroliden wie tacrolimus
GB9826656D0 (en) 1998-12-03 1999-01-27 Novartis Ag Organic compounds
US7063857B1 (en) 1999-04-30 2006-06-20 Sucampo Ag Use of macrolide compounds for the treatment of dry eye
GB0003932D0 (en) * 2000-02-18 2000-04-12 Novartis Ag Pharmaceutical compositions
GB0008785D0 (en) 2000-04-10 2000-05-31 Novartis Ag Organic compounds
GB0012383D0 (en) 2000-05-22 2000-07-12 Novartis Ag Organic compounds
AR033151A1 (es) * 2001-04-12 2003-12-03 Sucampo Pharmaceuticals Inc Agente para el tratamiento oftalmico topico de las enfermedades inflamatorias oculares
GB0125443D0 (en) * 2001-10-23 2001-12-12 Novartis Ag Organic Compounds
WO2004009056A1 (en) 2002-07-23 2004-01-29 Novartis Ag Ophtalmic ointment composition comprising a drug, an ointment base and a solubiling/dispersing agent
US20060035879A1 (en) * 2002-11-15 2006-02-16 Prescott Margaret F Organic Compounds
CA2513731A1 (en) * 2003-02-10 2004-08-19 Novartis Ag Pharmaceutical combinations comprising corticoids and immunosuppressants for treating corticoid- and/or calcineurin inhibitors-resistant diseases
AR043504A1 (es) * 2003-03-17 2005-08-03 Novartis Ag Composiciones farmaceuticas que comprenden rapamicina para el tratamiento de enfermedades inflamatorias
JP5138362B2 (ja) 2004-03-23 2013-02-06 ノバルティス アーゲー 医薬組成物
GT200500282A (es) * 2004-10-12 2006-05-04 Heteroatomos conteniendo compuestos triciclicos.
EP1817314A1 (de) 2004-12-01 2007-08-15 Teva Gyógyszergyár Zártköruen Muködo Részvenytarsaság Nichthygroskopisches und pulverförmiges amorphes pimecrolimus
WO2008057511A2 (en) * 2006-11-06 2008-05-15 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Ascomycin and pimecrolimus having reduced levels of desmethylascomycin and 32-deoxy-32-epichloro-desmethylascomycin respectively, and methods for preparation thereof
US20100087550A1 (en) 2008-10-06 2010-04-08 Zora Marlowe Formulations with a Tertiary Amine Oxide
US20100106128A1 (en) 2008-10-23 2010-04-29 Shane Mao Contact lens cases for delivery of ophthalmic agents
IT1394309B1 (it) 2009-05-22 2012-06-06 Poli Ind Chimica Spa Nuovo approccio chimico-enzimatico alla sintesi del pimecrolimus
GB0914589D0 (en) * 2009-08-20 2009-09-30 Biotica Tech Ltd Novel compounds and methods for their production
EP3246036B1 (de) 2014-10-28 2021-10-13 Koushi Yamaguchi Mittel zur verbesserung schwangerschaftsinduzierten bluthochdruck
EP3178824A1 (de) 2015-12-08 2017-06-14 Medichem, S.A. Verfahren zur herstellung von pimecrolimus
CN106074367A (zh) * 2016-07-20 2016-11-09 中山大学中山眼科中心 含fk506类化合物/fkbp蛋白二聚体的药物组合物及其制备方法
KR102592374B1 (ko) 2017-05-01 2023-10-25 메다 파마 게엠베하 운트 코. 카게 조질의 아스코마이신을 정제된 피메크롤리무스로 전환하는 방법
AU2019318035A1 (en) 2018-08-10 2021-03-04 Koushi Yamaguchi Therapeutic agent for humoral immunity-related diseases in materno-fetal relationship
EP3900729A4 (de) 2018-12-18 2022-09-07 Koushi Yamaguchi Mittel zur verbesserung von unfruchtbarkeit, wiederholten fehlgeburten und schwangerschaftszuständen
EP3741367A1 (de) 2019-05-21 2020-11-25 Premark Pharma GmbH Behandlung von augenerkrankungen

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
US4650803A (en) * 1985-12-06 1987-03-17 University Of Kansas Prodrugs of rapamycin
DE3853477T2 (de) * 1987-12-09 1995-11-09 Fisons Plc Makrozyklische verbindungen.
EP0402931A1 (de) * 1989-06-14 1990-12-19 Sandoz Ltd. Heteroatome enthaltende tricyclische Verbindungen
PT98990A (pt) * 1990-09-19 1992-08-31 American Home Prod Processo para a preparacao de esteres de acidos carboxilicos de rapamicina

Also Published As

Publication number Publication date
NL300134I1 (nl) 2003-11-03
GR3017858T3 (en) 1996-01-31
MY111430A (en) 2000-05-31
EP0427680B1 (de) 1995-08-23
CA2029694C (en) 2001-05-08
KR910009711A (ko) 1991-06-28
LU91021I2 (fr) 2003-06-24
IE69974B1 (en) 1996-10-16
JPH03223291A (ja) 1991-10-02
DE10299040I1 (de) 2003-02-20
JP2750302B2 (ja) 1998-05-13
NL300134I2 (nl) 2004-05-03
HU210900A9 (en) 1995-09-28
DE69021833T2 (de) 1996-03-21
LV11621B (en) 1997-04-20
DE69021833D1 (de) 1995-09-28
AU640963B2 (en) 1993-09-09
DE10299040I2 (de) 2006-08-24
KR0166074B1 (ko) 1999-01-15
IE904023A1 (en) 1991-05-22
EP0427680A1 (de) 1991-05-15
AU6584390A (en) 1991-05-23
LV11621A (lv) 1996-12-20
HK30096A (en) 1996-02-23
DK0427680T3 (da) 1995-12-18
ES2077663T3 (es) 1995-12-01
NZ235991A (en) 1993-05-26
CA2029694A1 (en) 1991-05-10

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