ATE120466T1 - Makrozyklische verbindungen. - Google Patents

Makrozyklische verbindungen.

Info

Publication number
ATE120466T1
ATE120466T1 AT89900628T AT89900628T ATE120466T1 AT E120466 T1 ATE120466 T1 AT E120466T1 AT 89900628 T AT89900628 T AT 89900628T AT 89900628 T AT89900628 T AT 89900628T AT E120466 T1 ATE120466 T1 AT E120466T1
Authority
AT
Austria
Prior art keywords
represent
alkyl
groups including
compounds
carbon
Prior art date
Application number
AT89900628T
Other languages
English (en)
Inventor
Martin Edward Cooper
David Keith Donald
David Norman Hardern
Bonnington
Original Assignee
Fisons Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878728820A external-priority patent/GB8728820D0/en
Priority claimed from GB878728821A external-priority patent/GB8728821D0/en
Priority claimed from GB888803374A external-priority patent/GB8803374D0/en
Priority claimed from GB888803373A external-priority patent/GB8803373D0/en
Priority claimed from GB888803370A external-priority patent/GB8803370D0/en
Priority claimed from GB888803377A external-priority patent/GB8803377D0/en
Priority claimed from GB888803371A external-priority patent/GB8803371D0/en
Priority claimed from GB888803372A external-priority patent/GB8803372D0/en
Priority claimed from GB888803375A external-priority patent/GB8803375D0/en
Priority claimed from GB888809174A external-priority patent/GB8809174D0/en
Priority claimed from GB888817624A external-priority patent/GB8817624D0/en
Priority claimed from GB888818426A external-priority patent/GB8818426D0/en
Application filed by Fisons Plc filed Critical Fisons Plc
Publication of ATE120466T1 publication Critical patent/ATE120466T1/de
Application granted granted Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18Bridged systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
AT89900628T 1987-12-09 1988-12-02 Makrozyklische verbindungen. ATE120466T1 (de)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
GB878728820A GB8728820D0 (en) 1987-12-09 1987-12-09 Compounds
GB878728821A GB8728821D0 (en) 1987-12-09 1987-12-09 Compounds
GB888803373A GB8803373D0 (en) 1988-02-13 1988-02-13 Compound
GB888803374A GB8803374D0 (en) 1988-02-13 1988-02-13 Compound
GB888803370A GB8803370D0 (en) 1988-02-13 1988-02-13 Compound
GB888803377A GB8803377D0 (en) 1988-02-13 1988-02-13 Compound
GB888803371A GB8803371D0 (en) 1988-02-13 1988-02-13 Compound
GB888803372A GB8803372D0 (en) 1988-02-13 1988-02-13 Compound
GB888803375A GB8803375D0 (en) 1988-02-13 1988-02-13 Compound
GB888809174A GB8809174D0 (en) 1988-04-19 1988-04-19 Compounds
GB888817624A GB8817624D0 (en) 1988-07-23 1988-07-23 Compounds
GB888818426A GB8818426D0 (en) 1988-08-03 1988-08-03 Compounds

Publications (1)

Publication Number Publication Date
ATE120466T1 true ATE120466T1 (de) 1995-04-15

Family

ID=27583057

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89900628T ATE120466T1 (de) 1987-12-09 1988-12-02 Makrozyklische verbindungen.

Country Status (16)

Country Link
EP (2) EP0323042A1 (de)
JP (1) JP2799208B2 (de)
KR (1) KR900700494A (de)
CN (1) CN1033458A (de)
AT (1) ATE120466T1 (de)
AU (1) AU630866B2 (de)
CA (1) CA1339128C (de)
DE (1) DE3853477T2 (de)
DK (1) DK387889D0 (de)
ES (1) ES2071681T3 (de)
FI (1) FI90550C (de)
IE (1) IE66163B1 (de)
IL (1) IL88629A (de)
NO (1) NO893166L (de)
NZ (1) NZ227251A (de)
WO (1) WO1989005304A1 (de)

Families Citing this family (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1982004094A1 (en) * 1981-05-19 1982-11-25 Leivenzon Simon Indicating means for a door operator device
DE68921934T2 (de) * 1988-06-29 1995-10-19 Merck & Co Inc Immunsuppressives Agens.
US5290772A (en) * 1988-06-29 1994-03-01 Merck & Co., Inc. Immunosuppressant agent
ATE131536T1 (de) * 1988-08-01 1995-12-15 Fujisawa Pharmaceutical Co Fr-901154- und fr-901155-derivate, verfahren zu ihrer herstellung
EP0356399A3 (de) * 1988-08-26 1991-03-20 Sandoz Ag Substituierte 4-Azatricyclo (22.3.1.04.9) octacos-18-en-Derivate, Verfahren zu ihrer Herstellung und die sie enthaltenden pharmazeutischen Zusammensetzungen
EP0358508A3 (de) * 1988-09-08 1991-03-20 Merck & Co. Inc. Verbindung zur Unterdrückung der Immunabwehr
FR2639637A1 (fr) * 1988-11-29 1990-06-01 Sandoz Sa Derives cycliques et leurs metabolites, leur preparation et leur utilisation comme medicaments
US4975372A (en) * 1989-01-13 1990-12-04 Merck & Co., Inc. Microbial transformation product of L-683,590
EP0378317A3 (de) * 1989-01-13 1990-11-28 Merck & Co. Inc. Mikrobisches Umbildungsprodukt von L-679,934
US5268370A (en) * 1989-01-13 1993-12-07 Merck & Co., Inc. Microbial transformation product of L-679,934
EP0378320A3 (de) * 1989-01-13 1990-11-28 Merck & Co. Inc. Mikrobielles Umwandlungsprodukt
EP0388153B1 (de) * 1989-03-15 1994-12-28 Merck & Co. Inc. Immunosuppressives Mittel
CA2014841A1 (en) * 1989-04-21 1990-10-21 Byron H. Arison Macrolides having immunosuppressive activity
US5068323A (en) * 1989-04-21 1991-11-26 Merck & Co., Inc. Thermally re-arranged FK-506 derivatives having immunosuppressant activity
CA2018710A1 (en) * 1989-06-13 1990-12-13 Shieh-Shung T. Chen L-683,590 microbial transformation product
US5138052A (en) * 1989-06-13 1992-08-11 Merck & Co., Inc. L-683,590 microbial transformation product
KR920700212A (ko) * 1989-06-14 1992-02-19 쟝 크라머·한스 루돌프 하우스 헤테로원자-함유 트리사이클릭 화합물
US5200411A (en) * 1989-06-14 1993-04-06 Sandoz, Ltd. Heteroatoms-containing tricyclic compounds
EP0413532A3 (en) * 1989-08-18 1991-05-15 Fisons Plc Macrocyclic compounds
WO1991002736A1 (en) * 1989-08-18 1991-03-07 Fisons Plc Macrocyclic compounds
GR1001225B (el) * 1989-09-14 1993-06-30 Fisons Plc Νέαι μακροκυκλικαί ενώσεις και νέα μέ?οδος χρήσεως τους.
KR0159766B1 (ko) * 1989-10-16 1998-12-01 후지사와 토모키치로 양모제 조성물
US5215995A (en) * 1989-10-16 1993-06-01 Fujisawa Pharmaceutical Co., Ltd. Hair revitalizing agent
ATE126803T1 (de) * 1989-11-09 1995-09-15 Sandoz Ag Heteroatome enthaltende tricyclische verbindungen.
US5352671A (en) * 1989-11-09 1994-10-04 Sandoz Ltd. Heteroatoms-containing tricyclic compounds
IE904050A1 (en) * 1989-11-13 1991-05-22 Merck & Co Inc Aminomacrolides and derivatives having immunosuppressive¹activity
US5208228A (en) * 1989-11-13 1993-05-04 Merck & Co., Inc. Aminomacrolides and derivatives having immunosuppressive activity
GB8925797D0 (en) * 1989-11-15 1990-01-04 Fisons Plc Compositions
EP0444829A3 (en) * 1990-02-27 1992-06-03 Fisons Plc Immunosuppressive compounds
US5064835A (en) * 1990-03-01 1991-11-12 Merck & Co., Inc. Hydroxymacrolide derivatives having immunosuppressive activity
US5260301A (en) * 1990-03-01 1993-11-09 Fujisawa Pharmaceutical Co., Ltd. Pharmaceutical solution containing FK-506
EP0594600A1 (de) * 1990-03-13 1994-05-04 FISONS plc Immunosuppressive makrozyklische verbindungen
US5296489A (en) * 1990-03-13 1994-03-22 Fisons Immunosuppressive macrocyclic compounds
EP0455427A1 (de) * 1990-04-30 1991-11-06 Merck & Co. Inc. Deoxyaycrolid-Derivate mit immunsuppressiver Wirkung
JPH05507915A (ja) * 1990-06-11 1993-11-11 藤沢薬品工業株式会社 特発性血小板減少性紫斑病およびバセドウ病治療薬製造のためのfk506等のマクロライド化合物の用途
US5643901A (en) * 1990-06-11 1997-07-01 Fujisawa Pharmaceutical Co., Ltd. Medicament for treating idiopathic thrombocytopenic purpura
US5190950A (en) * 1990-06-25 1993-03-02 Merck & Co., Inc. Antagonists of immunosuppressive macrolides
GB9014136D0 (en) * 1990-06-25 1990-08-15 Fujisawa Pharmaceutical Co Tricyclo compounds,a process for their production and a pharmaceutical composition containing the same
US5342935A (en) * 1990-06-25 1994-08-30 Merck & Co., Inc. Antagonists of immunosuppressive macrolides
CA2044846A1 (en) * 1990-06-25 1991-12-26 Thomas R. Beattie Antagonists of immunosuppressive macrolides
US5210030A (en) * 1990-06-25 1993-05-11 Merck & Co., Inc. Process for selectively acylating immunomycin
MY110418A (en) * 1990-07-02 1998-05-30 Novartis Ag Heteroatoms-containing tricyclic compounds.
GB9014681D0 (en) * 1990-07-02 1990-08-22 Fujisawa Pharmaceutical Co Tricyclo compounds,a process for their production and a pharmaceutical composition containing the same
EP0466365A3 (en) 1990-07-03 1992-04-15 Merck & Co. Inc. Novel immunosuppressant fermentation products of a microorganism
GB9014881D0 (en) * 1990-07-05 1990-08-22 Fujisawa Pharmaceutical Co Tricyclo compounds,a process for their production and a pharmaceutical composition containing the same
GB2245561A (en) * 1990-07-05 1992-01-08 Fujisawa Pharmaceutical Co Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
US5023263A (en) * 1990-08-09 1991-06-11 American Home Products Corporation 42-oxorapamycin
US5023262A (en) * 1990-08-14 1991-06-11 American Home Products Corporation Hydrogenated rapamycin derivatives
WO1992003441A1 (en) * 1990-08-18 1992-03-05 Fisons Plc Macrocyclic compounds
GB2247620A (en) * 1990-09-07 1992-03-11 Fujisawa Pharmaceutical Co The use of macrolide compounds for cytomegalovirus infection
US5143918A (en) * 1990-10-11 1992-09-01 Merck & Co., Inc. Halomacrolides and derivatives having immunosuppressive activity
EP0480623A1 (de) * 1990-10-11 1992-04-15 Merck & Co. Inc. Halomakrolide und Derivate mit immunosuppressiver Wirkung
GB2249027A (en) * 1990-10-23 1992-04-29 Fujisawa Pharmaceutical Co Use of macrolide compounds for hepatic failure
US5348966A (en) * 1990-10-24 1994-09-20 Fujisawa Pharmaceutical Co., Ltd. Method for treating pyoderma and Sezary's syndrome using FK 506 and related compounds
CA2054128A1 (en) * 1990-10-29 1992-04-30 Kevin M. Byrne Process for the production of analogues of immunomycin
PH31204A (en) * 1990-11-02 1998-05-05 Fujisawa Pharmaceutical Co Pharmaceutical composition.
IE65341B1 (en) * 1990-11-08 1995-10-18 Fujisawa Pharmaceutical Co Suspensions containing tricyclic compounds
GB2249787A (en) * 1990-11-19 1992-05-20 Fujisawa Pharmaceutical Co Lactone compounds
GB9027471D0 (en) * 1990-12-19 1991-02-06 Fujisawa Pharmaceutical Co Novel compound
GB2252041A (en) * 1991-01-23 1992-07-29 Fujisawa Pharmaceutical Co Use of macrolide compounds in treatment of autoimmune myocarditis
WO1992013862A1 (en) * 1991-02-05 1992-08-20 Fujisawa Pharmaceutical Co., Ltd. Lactone compounds
WO1992018506A1 (en) * 1991-04-11 1992-10-29 Pfizer, Inc. Novel immunosuppressant agent from streptomyces braegensis
DK0581959T3 (da) * 1991-04-26 2001-01-29 Fujisawa Pharmaceutical Co Anvendelse af makrolidforbindelser til øjensygdomme
US5162334A (en) * 1991-05-13 1992-11-10 Merck & Co., Inc. Amino O-alkyl, O-alkenyl and O-alkynlmacrolides having immunosuppressive activity
US5250678A (en) 1991-05-13 1993-10-05 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
US5565560A (en) * 1991-05-13 1996-10-15 Merck & Co., Inc. O-Aryl,O-alkyl,O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
CA2071332A1 (en) * 1991-06-25 1992-12-26 Laszlo R. Treiber C-21 hydroxylated fk-506 antagonist
US5225403A (en) * 1991-06-25 1993-07-06 Merck & Co., Inc. C-21 hydroxylated FK-506 antagonist
US5198358A (en) * 1991-08-28 1993-03-30 Merck & Co., Inc. Microorganism for producing C-31 desmethyl FR-900520 cyclic hemiketal immunosuppressant agent
US5149701A (en) * 1991-08-01 1992-09-22 Merck & Co., Inc. C-31 methylated FR-900520 cyclic hemiketal immunosuppressant agents
US5273979A (en) * 1991-08-01 1993-12-28 Merck & Co., Inc. C-31 desmethyl FR-900520 cyclic hemiketal immunosuppressant agent
US5189042A (en) * 1991-08-22 1993-02-23 Merck & Co. Inc. Fluoromacrolides having immunosuppressive activity
US5708002A (en) * 1991-09-05 1998-01-13 Abbott Laboratories Macrocyclic immunomodulators
KR100351222B1 (ko) * 1991-09-05 2002-09-05 아보트 러보러터리즈 매크로사이클릭 면역 조절제 및 이의 제조방법
US5252732A (en) * 1991-09-09 1993-10-12 Merck & Co., Inc. D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity
US5208241A (en) * 1991-09-09 1993-05-04 Merck & Co., Inc. N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity
ZA926812B (en) 1991-09-09 1993-04-28 Merck & Co Inc O-heteroaryl,o-alkylheteroaryl,o-alkenylheteroaryl and o-alkynylheteroaryl macrolides having immunosupressive activity
US5817333A (en) * 1991-10-31 1998-10-06 Fujisawa Pharmaceutical Co., Ltd. Liposome preparation containing a tricyclic compound
US5164399A (en) * 1991-11-18 1992-11-17 American Home Products Corporation Rapamycin pyrazoles
US5221625A (en) * 1992-01-10 1993-06-22 Merck & Co., Inc. Cyclcic FR-900520 microbial biotransformation agent
GB9203265D0 (en) * 1992-02-15 1992-04-01 Fisons Plc Pharmaceutically active compound
JP2563080B2 (ja) * 1992-03-02 1996-12-11 フアイザー・インコーポレイテツド マクロライドの糖誘導体
CA2091194A1 (en) * 1992-04-08 1993-10-09 Richard D. Connell 2-oxo-ethyl derivatives as immunosuppressants
US5284840A (en) * 1992-06-12 1994-02-08 Merck & Co., Inc. Alkylidene macrolides having immunosuppressive activity
US5284877A (en) * 1992-06-12 1994-02-08 Merck & Co., Inc. Alkyl and alkenyl macrolides having immunosuppressive activity
US5264355A (en) * 1992-07-02 1993-11-23 Merck & Co., Inc. Methlating enzyme from streptomyces MA6858
GB9218027D0 (en) * 1992-08-25 1992-10-14 Fisons Plc Novel method of treatment
GB9218597D0 (en) * 1992-08-25 1992-10-14 Fisons Plc Novel method of treatment
GB9218797D0 (en) * 1992-09-04 1992-10-21 Fisons Plc Pharmacologically active compounds
CA2106034A1 (en) * 1992-09-24 1994-03-25 Ralph J. Russo 21-norrapamycin
US5268281A (en) * 1992-09-28 1993-12-07 Merck & Co., Inc. Cyclic FR-900520 microbial biotransformation agent
US5268282A (en) * 1992-09-28 1993-12-07 Merck & Co., Inc. Cyclic FR-900520 microbial biotransformation agent
US5290689A (en) * 1992-09-28 1994-03-01 Merck & Co., Inc. New cyclic FR-900520 microbial biotransformation agent
US5283183A (en) * 1992-09-28 1994-02-01 Merck & Co., Inc. Cyclic FR-900520 microbial biotransformation agent
US5258389A (en) * 1992-11-09 1993-11-02 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
DE69326015T2 (de) * 1992-11-18 2000-02-03 Fujisawa Pharmaceutical Co Pharmazeutische zubereitung mit verlängerter wirkung
GB9227055D0 (en) * 1992-12-29 1993-02-24 Fujisawa Pharmaceutical Co New use
US5310901A (en) * 1993-03-05 1994-05-10 Merck & Co., Inc. O-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynlheteroarylrapamycin derivatives
US5310903A (en) * 1993-03-05 1994-05-10 Merck & Co., Inc. Imidazolidyl rapamycin derivatives
GB2279006A (en) * 1993-06-03 1994-12-21 Fujisawa Pharmaceutical Co Treatment of amyotrophic lateral sclerosis
US5359060A (en) * 1993-07-06 1994-10-25 Pfizer, Inc. Phosponated derivatives of macrolides
US5612350A (en) * 1993-11-30 1997-03-18 Abbott Laboratories Macrocyclic immunomodulators with novel cyclohexyl ring replacements
US5880280A (en) * 1994-06-15 1999-03-09 Merck & Co., Inc. Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppressive activity
US5693648A (en) * 1994-09-30 1997-12-02 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides having immunosuppressive activity
CN1089233C (zh) 1994-10-26 2002-08-21 诺瓦蒂斯有限公司 药物组合物
AR004480A1 (es) * 1995-04-06 1998-12-16 Amico Derin C D Compuestos de ascomicina que poseen actividad antiinflamatoria, pro cedimiento para prepararlos, uso de dichos compuestos para preparar agentesfarmaceuticos y composiciones farmaceuticas que los incluyen
EP2198858B1 (de) 1998-03-26 2011-06-29 Astellas Pharma Inc. Retardpräparat mit Makroliden wie Tacrolimus
US6503737B1 (en) * 1998-10-02 2003-01-07 Kosan Biosciences, Inc. Isolated nucleic acids relating to the fkbA gene within the FK-520 polyketide synthase gene cluster
GB9826656D0 (en) 1998-12-03 1999-01-27 Novartis Ag Organic compounds
US7063857B1 (en) 1999-04-30 2006-06-20 Sucampo Ag Use of macrolide compounds for the treatment of dry eye
US20070032853A1 (en) 2002-03-27 2007-02-08 Hossainy Syed F 40-O-(2-hydroxy)ethyl-rapamycin coated stent
US7807211B2 (en) 1999-09-03 2010-10-05 Advanced Cardiovascular Systems, Inc. Thermal treatment of an implantable medical device
US6790228B2 (en) 1999-12-23 2004-09-14 Advanced Cardiovascular Systems, Inc. Coating for implantable devices and a method of forming the same
US6569867B2 (en) 1999-10-01 2003-05-27 Kosan Biosciences, Inc. Polyketide derivatives
AR035411A1 (es) * 2000-12-29 2004-05-26 Fujisawa Pharmaceutical Co Uso de un derivado de tacrolimus para fabricar un agente neurotrofico, composiciones y articulos de fabricacion o kits que lo comprenden, metodo para fabricar un agente que lo comprende y tejidos e injertos con una celula nerviosa tratada con este compuesto
KR100512021B1 (ko) * 2002-07-25 2005-09-02 신득용 Fk506을 이용한 세포의 노화를 억제하는 방법 및 배양배지
AU2003901023A0 (en) * 2003-03-04 2003-03-20 Fujisawa Pharmaceutical Co., Ltd. New use
US20050118344A1 (en) 2003-12-01 2005-06-02 Pacetti Stephen D. Temperature controlled crimping
WO2005067928A1 (en) * 2004-01-20 2005-07-28 Astellas Pharma Inc. Method for treating erectile dysfunction
EP1860438B1 (de) 2005-08-12 2009-11-18 Astellas Pharma Inc. Verfahren zur identifizierung des zielproteins eines wirkstoffs und verfahren zum screening eines therapeutischen wirkstoffs gegen diabetes mittels des zielproteins
JP2009203162A (ja) * 2006-06-05 2009-09-10 Astellas Pharma Inc マクロライド化合物の新規製造法
CA2660804A1 (en) 2006-08-31 2008-03-06 Astellas Pharma Inc. Reverse targeting lipid vesicle
TW200932240A (en) 2007-10-25 2009-08-01 Astellas Pharma Inc Pharmaceutical composition containing lipophilic substance which inhibits IL-2 production
EP2658855A2 (de) 2010-12-31 2013-11-06 Acies Bio d.o.o. Neue polyketidverbindungen und verfahren zu ihrer herstellung
EP2567959B1 (de) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridin-4-carbonsäureamid-derivate als kinaseinhibitoren
US10143682B2 (en) 2014-10-28 2018-12-04 Koushi Yamaguchi Medicine for improving state of pregnancy, and use thereof
CN106074367A (zh) * 2016-07-20 2016-11-09 中山大学中山眼科中心 含fk506类化合物/fkbp蛋白二聚体的药物组合物及其制备方法
KR20190075120A (ko) 2016-11-10 2019-06-28 노파르티스 아게 Bmp 강화제
US20210228551A1 (en) 2018-08-10 2021-07-29 Koushi Yamaguchi Therapeutic agent for humoral immunity-related diseases in maternofetal relationship
WO2020129348A1 (ja) 2018-12-18 2020-06-25 晃史 山口 不妊・不育症または妊娠状態を改善するための薬剤

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4894366A (en) 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
US4650803A (en) * 1985-12-06 1987-03-17 University Of Kansas Prodrugs of rapamycin
DE68921934T2 (de) * 1988-06-29 1995-10-19 Merck & Co Inc Immunsuppressives Agens.
ATE131536T1 (de) * 1988-08-01 1995-12-15 Fujisawa Pharmaceutical Co Fr-901154- und fr-901155-derivate, verfahren zu ihrer herstellung
EP0356399A3 (de) * 1988-08-26 1991-03-20 Sandoz Ag Substituierte 4-Azatricyclo (22.3.1.04.9) octacos-18-en-Derivate, Verfahren zu ihrer Herstellung und die sie enthaltenden pharmazeutischen Zusammensetzungen

Also Published As

Publication number Publication date
ES2071681T3 (es) 1995-07-01
NZ227251A (en) 1990-02-26
DE3853477D1 (de) 1995-05-04
FI90550B (fi) 1993-11-15
IE66163B1 (en) 1995-12-13
AU630866B2 (en) 1992-11-12
DE3853477T2 (de) 1995-11-09
AU2822889A (en) 1989-07-05
EP0323042A1 (de) 1989-07-05
IE883662L (en) 1989-06-09
EP0346427A1 (de) 1989-12-20
CA1339128C (en) 1997-07-29
NO893166D0 (no) 1989-08-04
DK387889A (da) 1989-08-08
JP2799208B2 (ja) 1998-09-17
IL88629A (en) 1994-04-12
NO893166L (no) 1989-08-04
WO1989005304A1 (en) 1989-06-15
FI893750A0 (fi) 1989-08-09
EP0346427B1 (de) 1995-03-29
FI90550C (fi) 1994-02-25
JPH02502463A (ja) 1990-08-09
CN1033458A (zh) 1989-06-21
DK387889D0 (da) 1989-08-08
KR900700494A (ko) 1990-08-13

Similar Documents

Publication Publication Date Title
ATE120466T1 (de) Makrozyklische verbindungen.
HK1011689A1 (en) Bis(3,4-dialkylbenzylidene) sorbitol acetals and compositions containing same
IL114829A (en) Biphenyl isoxazole sulfonamide derivatives and pharmaceutical compositions containing the same
HUT67691A (en) 7-(substituted)-8-(substituted)-9-[(substituted-glycyl)amido]6-demethyl-6-deoxytetracyclines, pharmaceutical compositions containing them and process to prepare them
HUT55032A (en) Process for producing 19-norsteroids comprising carbon chain substituted in 11beta position by amide or carbamagte group, as well as pharmaceutical compositions comprising such compounds as active ingredient
ATE161717T1 (de) Antivirale mittel
MY103602A (en) Heterocyclic compounds
ATE110721T1 (de) 2-alkyl-3-benzoylbenzofurane und diese enthaltende pharmazeutische zusammensetzungen.
IL90724A0 (en) Novel esters and pharmaceutical compositions containing same
ES2062406T3 (es) Nuevos compuestos de morfolinol, su preparacion y uso.
GR3017916T3 (en) 3,4-Disubstituted phenyl-heterocycles and their use.
NZ228803A (en) Sulphonanilides and anti-hypertensive compositions
ATE34740T1 (de) (bis(hydroxymethyl)methyl)-isochinolinderivate, verfahren zu ihrer herstellung und pharmazeutische zubereitungen, die sie enthalten.
ATE93524T1 (de) Mitomycinanaloge, verfahren zu ihrer herstellung und pharmazeutische zubereitungen.
FI903511A0 (fi) Pyrrolo (2,1-b) tiazolderivat.
MY102247A (en) Phosphorylated acylglycosides, their preparation and use

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee