MX370668B - Molécula de unión al antígeno para promover la pérdida de antígeno a través de fc gamma riib. - Google Patents

Molécula de unión al antígeno para promover la pérdida de antígeno a través de fc gamma riib.

Info

Publication number
MX370668B
MX370668B MX2014010140A MX2014010140A MX370668B MX 370668 B MX370668 B MX 370668B MX 2014010140 A MX2014010140 A MX 2014010140A MX 2014010140 A MX2014010140 A MX 2014010140A MX 370668 B MX370668 B MX 370668B
Authority
MX
Mexico
Prior art keywords
antigen
binding molecule
binding
gamma riib
molecule
Prior art date
Application number
MX2014010140A
Other languages
English (en)
Other versions
MX2014010140A (es
Inventor
Igawa Tomoyuki
Mimoto Futa
Kadono Shojiro
Maeda Atsuhiko
Haraya Kenta
Iwayanagi Yuki
Katada Hitoshi
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP2012/054624 external-priority patent/WO2012115241A1/ja
Priority claimed from PCT/JP2012/075092 external-priority patent/WO2013047752A1/ja
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of MX2014010140A publication Critical patent/MX2014010140A/es
Publication of MX370668B publication Critical patent/MX370668B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se refiere a las moléculas de unión al antígenos que contienen (i) un dominio de unión al antígeno cuya actividad de unión al antígeno varía dependiendo de las condiciones de concentración de iones, (ii) un dominio de unión a Fcy que tiene actividad de unión selectiva a FcyRllb, y (iii) un dominio de unión a FcRn que tiene una actividad de unión a FcRn bajo una condición de intervalo de pH ácido, y los métodos para disminuir la concentración plasmática del antígeno en comparación con antes de administrar la molécula, que incluye la etapa de administrar la molécula.
MX2014010140A 2012-02-24 2013-02-22 Molécula de unión al antígeno para promover la pérdida de antígeno a través de fc gamma riib. MX370668B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/JP2012/054624 WO2012115241A1 (ja) 2011-02-25 2012-02-24 FcγRIIb特異的Fc抗体
JP2012185866 2012-08-24
PCT/JP2012/075092 WO2013047752A1 (ja) 2011-09-30 2012-09-28 抗原の消失を促進する抗原結合分子
PCT/JP2013/054461 WO2013125667A1 (ja) 2012-02-24 2013-02-22 FcγRIIBを介して抗原の消失を促進する抗原結合分子

Publications (2)

Publication Number Publication Date
MX2014010140A MX2014010140A (es) 2014-09-12
MX370668B true MX370668B (es) 2019-12-19

Family

ID=49005844

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2014010140A MX370668B (es) 2012-02-24 2013-02-22 Molécula de unión al antígeno para promover la pérdida de antígeno a través de fc gamma riib.
MX2018013128A MX2018013128A (es) 2012-02-24 2014-08-22 Molecula de union al antigeno para promover la perdia de antigeno a traves de fc gamma riib.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2018013128A MX2018013128A (es) 2012-02-24 2014-08-22 Molecula de union al antigeno para promover la perdia de antigeno a traves de fc gamma riib.

Country Status (16)

Country Link
US (2) US20160046693A1 (es)
EP (2) EP3738980A1 (es)
JP (5) JP6138108B2 (es)
KR (3) KR102219987B1 (es)
CN (2) CN104244980B (es)
AU (3) AU2013223087B2 (es)
BR (1) BR112014020821B1 (es)
CA (1) CA2865158C (es)
DK (1) DK2818183T3 (es)
ES (1) ES2795419T3 (es)
HK (1) HK1201476A1 (es)
MX (2) MX370668B (es)
RU (1) RU2736349C2 (es)
SG (2) SG11201405137QA (es)
TW (4) TWI617577B (es)
WO (1) WO2013125667A1 (es)

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