MX347164B - Anticuerpos anti-il-36r. - Google Patents
Anticuerpos anti-il-36r.Info
- Publication number
- MX347164B MX347164B MX2014005759A MX2014005759A MX347164B MX 347164 B MX347164 B MX 347164B MX 2014005759 A MX2014005759 A MX 2014005759A MX 2014005759 A MX2014005759 A MX 2014005759A MX 347164 B MX347164 B MX 347164B
- Authority
- MX
- Mexico
- Prior art keywords
- antibodies
- therapeutic
- compositions
- same
- relates
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/715—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons
- G01N2333/7155—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/20—Dermatological disorders
- G01N2800/205—Scaling palpular diseases, e.g. psoriasis, pytiriasis
Abstract
La presente invención se refiere a anticuerpos anti-IL-36R y composiciones farmacéuticas que los contienen.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161560554P | 2011-11-16 | 2011-11-16 | |
US201261644111P | 2012-05-08 | 2012-05-08 | |
US201261713713P | 2012-10-15 | 2012-10-15 | |
PCT/US2012/064933 WO2013074569A1 (en) | 2011-11-16 | 2012-11-14 | Anti il-36r antibodies |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014005759A MX2014005759A (es) | 2014-09-08 |
MX347164B true MX347164B (es) | 2017-04-18 |
Family
ID=47215803
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014005759A MX347164B (es) | 2011-11-16 | 2012-11-14 | Anticuerpos anti-il-36r. |
Country Status (38)
Country | Link |
---|---|
US (3) | US9023995B2 (es) |
EP (2) | EP3536710A1 (es) |
JP (3) | JP6289375B2 (es) |
KR (3) | KR20200110476A (es) |
CN (3) | CN112812183A (es) |
AP (1) | AP2014007571A0 (es) |
AR (1) | AR089178A1 (es) |
AU (1) | AU2012339734B2 (es) |
BR (1) | BR112014011594B1 (es) |
CA (1) | CA2852994C (es) |
CL (1) | CL2014001123A1 (es) |
CO (1) | CO7020871A2 (es) |
CY (1) | CY1122278T1 (es) |
DK (1) | DK2780373T3 (es) |
EA (1) | EA031948B1 (es) |
EC (1) | ECSP14004976A (es) |
ES (1) | ES2755732T3 (es) |
FI (1) | FIC20230020I1 (es) |
FR (1) | FR23C1023I2 (es) |
HR (1) | HRP20191835T1 (es) |
HU (2) | HUE047437T2 (es) |
IL (2) | IL232100B (es) |
LT (2) | LT2780373T (es) |
MX (1) | MX347164B (es) |
MY (1) | MY195289A (es) |
NL (1) | NL301233I2 (es) |
PE (1) | PE20142041A1 (es) |
PH (1) | PH12014501108B1 (es) |
PL (1) | PL2780373T3 (es) |
PT (1) | PT2780373T (es) |
RS (1) | RS59248B1 (es) |
SG (1) | SG11201402283PA (es) |
SI (1) | SI2780373T1 (es) |
TW (1) | TWI573804B (es) |
UA (1) | UA115540C2 (es) |
UY (1) | UY34456A (es) |
WO (1) | WO2013074569A1 (es) |
ZA (1) | ZA201402491B (es) |
Families Citing this family (43)
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CA2858350A1 (en) | 2011-01-14 | 2013-07-19 | The Regents Of The University Of California | Therapeutic antibodies against ror-1 protein and methods for use of same |
AU2012339734B2 (en) | 2011-11-16 | 2017-02-16 | Boehringer Ingelheim International Gmbh | Anti IL-36R antibodies |
SI2817338T1 (sl) | 2012-02-24 | 2017-11-30 | Abbvie Stemcentrx Llc | Modulatorji DLL3 in postopki uporabe |
KR20220126813A (ko) * | 2014-03-14 | 2022-09-16 | 노파르티스 아게 | Lag-3에 대한 항체 분자 및 그의 용도 |
RU2582569C2 (ru) * | 2014-07-24 | 2016-04-27 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт особо чистых биопрепаратов" Федерального медико-биологического агентства | Днк, кодирующая полноразмерный антагонист рецептора интерлейкина-36 человека, днк, кодирующая полноразмерный антагонист рецептора интерлейкина-36 человека с с-концевым полигистидиновым тагом, плазмидный экспрессионный вектор (варианты), штамм бактерий escherichia coli bl21 star[de3] (рет-il36raf), - продуцент полноразмерного рецепторного антагониста интерлейкина-36 и штамм бактерий escherichia coli bl21 star[de3] (pet-il36raf-his), - продуцент полноразмерного рецепторного антагониста интерлейкина-36 с с-концевым полигистидиновым тагом |
MA41867A (fr) | 2015-04-01 | 2018-02-06 | Anaptysbio Inc | Anticorps dirigés contre l'immunoglobuline de cellule t et protéine 3 de mucine (tim-3) |
BR112017022086A2 (pt) * | 2015-04-15 | 2018-07-03 | Anaptysbio Inc | anticorpos dirigidos contra o receptor de interleucina 36 (il-36r) |
WO2016201282A2 (en) * | 2015-06-12 | 2016-12-15 | Ludwig Institute For Cancer Research Ltd | TGF-β3 SPECIFIC ANTIBODIES AND METHODS AND USES THEREOF |
JP6654773B2 (ja) * | 2015-12-25 | 2020-02-26 | 国立大学法人名古屋大学 | インターロイキン36受容体アンタゴニスト欠損症の治療薬 |
WO2018085469A2 (en) | 2016-11-01 | 2018-05-11 | Anaptysbio, Inc. | Antibodies directed against t cell immunoglobulin and mucin protein 3 (tim-3) |
MA47206A (fr) | 2017-01-09 | 2019-11-13 | Tesaro Inc | Méthodes de traitement du cancer au moyen d'anticorps anti-tim-3 |
EP3601350A1 (en) * | 2017-03-27 | 2020-02-05 | Boehringer Ingelheim International GmbH | Anti il-36r antibodies combination therapy |
EP3737366A4 (en) * | 2018-01-08 | 2022-07-27 | ChemoCentryx, Inc. | METHOD OF TREATMENT OF GENERALIZED PUSTULOUS PSORIASIS WITH AN ANTAGONIST OF CCR6 OR CXCR2 |
MX2020009544A (es) * | 2018-03-14 | 2020-10-05 | Boehringer Ingelheim Int | Uso de anticuerpos anti-il-36r para el tratamiento de la psoriasis pustulosa generalizada. |
KR20200131303A (ko) * | 2018-03-14 | 2020-11-23 | 베링거 인겔하임 인터내셔날 게엠베하 | 염증성 장질환의 치료를 위한 항-il-36r 항체의 용도 |
JP2021530970A (ja) * | 2018-07-16 | 2021-11-18 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | Ditraの非ヒト動物モデルおよびその使用 |
WO2020018503A2 (en) | 2018-07-16 | 2020-01-23 | Regeneron Pharmaceuticals, Inc. | Anti-il36r antibodies |
CN112638946A (zh) | 2018-08-16 | 2021-04-09 | 坎塔吉亚有限责任公司 | 抗il1rap抗体组合物 |
CN112839957A (zh) * | 2018-09-28 | 2021-05-25 | 协和麒麟株式会社 | Il-36抗体及其用途 |
KR20210107721A (ko) | 2018-12-21 | 2021-09-01 | 23앤드미 인코포레이티드 | 항-il-36 항체 및 이의 사용 방법 |
BR112021010789A2 (pt) | 2018-12-27 | 2021-08-31 | Boehringer Ingelheim International Gmbh | Anticorpos anti-il-36r para o tratamento de pustulose palmoplantar |
BR112021016198A2 (pt) * | 2019-03-08 | 2021-11-03 | Boehringer Ingelheim Int Gmbh | Formulações de anticorpo anti-il-36r |
US20220162326A1 (en) * | 2019-05-13 | 2022-05-26 | Regeneron Pharmaceuticals, Inc. | Anti-il36r antibodies |
WO2021112196A1 (ja) * | 2019-12-05 | 2021-06-10 | 学校法人東京薬科大学 | 筋組織の減少を抑制するための組成物 |
AR120913A1 (es) * | 2019-12-27 | 2022-03-30 | Teijin Pharma Ltd | Anticuerpo que inhibe específicamente la señalización de il-36r |
TW202208433A (zh) | 2020-05-19 | 2022-03-01 | 德商百靈佳殷格翰國際股份有限公司 | 用於治療異位性皮膚炎之抗il-36r抗體 |
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EP4289863A1 (en) * | 2020-12-17 | 2023-12-13 | Shanghai Huaota Biopharmaceutical Co., Ltd. | Bispecific antibody targeting il-17a and il-36r and application thereof |
WO2022150642A1 (en) | 2021-01-08 | 2022-07-14 | Anaptysbio, Inc. | Anti-interleukin 36 receptor (il-36r) therapy for hidradenitis suppurativa |
WO2022150644A1 (en) | 2021-01-08 | 2022-07-14 | Anaptysbio, Inc. | Anti-interleukin 36 receptor (il-36r) therapy for acne |
WO2022166977A1 (zh) * | 2021-02-08 | 2022-08-11 | 上海普铭生物科技有限公司 | 抗人il-36r抗体及其应用 |
TW202302644A (zh) | 2021-03-04 | 2023-01-16 | 德商百靈佳殷格翰國際股份有限公司 | 治療gpp之方法 |
WO2022192531A2 (en) | 2021-03-12 | 2022-09-15 | Boehringer Ingelheim International Gmbh | Biomarkers associated with anti-il-36r antibody treatment in generalized pustular psoriasis |
TW202309087A (zh) * | 2021-05-03 | 2023-03-01 | 德商百靈佳殷格翰國際股份有限公司 | 製備spesolimab之方法 |
EP4357361A1 (en) * | 2021-06-18 | 2024-04-24 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Anti-il-36r antibody and use thereof |
WO2023285362A1 (en) | 2021-07-12 | 2023-01-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of il-36 inhibitors for the treatment of netherton syndrome |
WO2023019232A1 (en) | 2021-08-13 | 2023-02-16 | Boehringer Ingelheim International Gmbh | Anti-il-36r antibodies for the treatment of a fibrotic condition |
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