MX368162B - Derivados de pirazolo[1,5-a]pirimidina sustituida con piperidina con actividad inhibidora sobre la replicacion del virus sincicial respiratorio (vsr). - Google Patents

Derivados de pirazolo[1,5-a]pirimidina sustituida con piperidina con actividad inhibidora sobre la replicacion del virus sincicial respiratorio (vsr).

Info

Publication number
MX368162B
MX368162B MX2017007429A MX2017007429A MX368162B MX 368162 B MX368162 B MX 368162B MX 2017007429 A MX2017007429 A MX 2017007429A MX 2017007429 A MX2017007429 A MX 2017007429A MX 368162 B MX368162 B MX 368162B
Authority
MX
Mexico
Prior art keywords
respiratory syncytial
syncytial virus
rsv
replication
inhibitory activity
Prior art date
Application number
MX2017007429A
Other languages
English (en)
Other versions
MX2017007429A (es
Inventor
Abdellah Tahri
Ludwig Paul Cooymans
Pierre Jean-Marie Bernard Raboisson
Sandrine Marie Helene Vendeville
Lili Hu
Tim Hugo Maria Jonckers
Samuël Dominique Demin
Original Assignee
Janssen Sciences Ireland Uc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Sciences Ireland Uc filed Critical Janssen Sciences Ireland Uc
Publication of MX2017007429A publication Critical patent/MX2017007429A/es
Publication of MX368162B publication Critical patent/MX368162B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La invención se refiere a compuestos de pirazolopirimidina bicíclicos sustituidos de fórmula (I) novedosos que tienen actividad antiviral, en particular, que tienen una actividad inhibidora sobre la replicación del virus sincicial respiratorio (VSR); la invención se refiere además a la preparación de tales compuestos novedosos, a composiciones que comprenden estos compuestos y a los compuestos para usarse en el tratamiento de la infección por el virus sincicial respiratorio. (ver Fórmula).
MX2017007429A 2014-12-08 2015-12-07 Derivados de pirazolo[1,5-a]pirimidina sustituida con piperidina con actividad inhibidora sobre la replicacion del virus sincicial respiratorio (vsr). MX368162B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14196782 2014-12-08
PCT/EP2015/078762 WO2016091774A1 (en) 2014-12-08 2015-12-07 Piperidine substituted pyrazolo[1,5-a]pyrimidine derivatives with inhibitory activity on the replication of the respiratory syncytial virus (rsv)

Publications (2)

Publication Number Publication Date
MX2017007429A MX2017007429A (es) 2017-09-28
MX368162B true MX368162B (es) 2019-09-20

Family

ID=52006929

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017007429A MX368162B (es) 2014-12-08 2015-12-07 Derivados de pirazolo[1,5-a]pirimidina sustituida con piperidina con actividad inhibidora sobre la replicacion del virus sincicial respiratorio (vsr).

Country Status (13)

Country Link
US (1) US9981976B2 (es)
EP (1) EP3230287B1 (es)
JP (2) JP2017537118A (es)
KR (1) KR102522832B1 (es)
CN (1) CN107001377B (es)
AU (1) AU2015359624B2 (es)
CA (1) CA2963051C (es)
EA (1) EA032081B1 (es)
ES (1) ES2704740T3 (es)
MX (1) MX368162B (es)
SG (1) SG11201704397VA (es)
WO (1) WO2016091774A1 (es)
ZA (1) ZA201703899B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2963054C (en) 2014-12-08 2023-03-14 Janssen Sciences Ireland Uc Piperidine substituted tricyclic pyrazolo[1,5-a]pyrimidine derivatives with inhibitory activity on the replication of the respiratory syncytial virus (rsv)
JO3637B1 (ar) 2015-04-28 2020-08-27 Janssen Sciences Ireland Uc مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv
TW201932470A (zh) 2017-11-29 2019-08-16 愛爾蘭商健生科學愛爾蘭無限公司 具有抗ｒｓｖ活性之吡唑并嘧啶
EP3746444B1 (en) 2018-01-31 2023-09-27 Janssen Sciences Ireland Unlimited Company Cycloalkyl substituted pyrazolopyrimidines having activity against rsv
ES2957316T3 (es) 2018-04-23 2024-01-17 Janssen Sciences Ireland Unlimited Co Compuestos heteroaromáticos que tienen actividad contra VSR
CA3115128A1 (en) * 2018-10-10 2020-04-16 Curovir Ab 2,6-dimethyl-n-((pyridin-4-yl)methyl)imidazo[1,2-b]pyridazin-8-amine and 2,5-dimethyl-n-[(pyridin-4-yl)methyl]pyrazolo[1,5-a]pyrimidin-7-amine derivatives for treating viral infections
MX2021006138A (es) * 2018-11-26 2021-06-23 Janssen Sciences Ireland Unlimited Co Otros compuestos heteroaromaticos que tienen actividad contra el vrs.
JPWO2020138015A1 (ja) 2018-12-27 2021-11-18 大正製薬株式会社 ピラゾロ［１，５−ａ］ピリミジン大環状化合物
AU2020214064B2 (en) * 2019-01-29 2022-10-20 Shandong Xuanzhu Pharma Co., Ltd. Hexone glucokinase inhibitor and use thereof
EP4083034A4 (en) * 2019-12-24 2023-12-06 Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd. ASSOCIATION WITH CHAD-INHIBITING EFFECT
KR102614659B1 (ko) * 2020-04-20 2023-12-19 주식회사 엘지화학 3-아자바이사이클로알킬 유도체 및 이를 포함하는 약제학적 조성물
CN113754640B (zh) * 2020-06-03 2023-02-14 山东轩竹医药科技有限公司 氘代的己酮糖激酶抑制剂及其用途
CN112724157B (zh) * 2021-01-23 2022-04-19 中国科学院新疆理化技术研究所 二氢噁唑并[5,4-d]吡咯并[1,2-a]嘧啶-9(5H)-酮类衍生物及用途
CA3223875A1 (en) * 2021-06-25 2022-12-29 Shigeru Matsuoka Heterocycloalkyl-substituted polyheteroazole derivatives as medicaments for treating and/or preventing rs virus infections
AR126789A1 (es) 2021-08-19 2023-11-15 Syngenta Crop Protection Ag Método para controlar plagas resistentes a diamidas y compuestos para esto

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU727572B2 (en) 1997-02-14 2000-12-14 Pola Chemical Industries Inc. Remedies/preventives for respiratory diseases
JP2005529919A (ja) * 2002-05-10 2005-10-06 スミスクライン ビーチャム コーポレーション 治療用化合物
JPWO2005030773A1 (ja) 2003-09-26 2006-12-07 大日本住友製薬株式会社 新規ピラゾロピリミジン誘導体
GB0327319D0 (en) 2003-11-24 2003-12-24 Pfizer Ltd Novel pharmaceuticals
NZ604345A (en) * 2010-06-24 2015-02-27 Gilead Sciences Inc Pyrazolo[1,5-a]pyrimidines as antiviral agents
JP6122868B2 (ja) 2011-12-22 2017-04-26 ギリアード サイエンシーズ， インコーポレイテッド 抗ウイルス剤としてのピラゾロ［１，５−ａ］ピリミジン
DK2838900T3 (da) * 2012-04-17 2019-10-14 Gilead Sciences Inc Forbindelser og fremgangsmåder til antiviral behandling
CA2963054C (en) 2014-12-08 2023-03-14 Janssen Sciences Ireland Uc Piperidine substituted tricyclic pyrazolo[1,5-a]pyrimidine derivatives with inhibitory activity on the replication of the respiratory syncytial virus (rsv)

Also Published As

Publication number Publication date
ZA201703899B (en) 2019-01-30
MX2017007429A (es) 2017-09-28
SG11201704397VA (en) 2017-06-29
AU2015359624B2 (en) 2020-01-02
US20170349591A1 (en) 2017-12-07
EA032081B1 (ru) 2019-04-30
WO2016091774A1 (en) 2016-06-16
CA2963051A1 (en) 2016-06-16
EP3230287A1 (en) 2017-10-18
KR20170090424A (ko) 2017-08-07
CN107001377A (zh) 2017-08-01
JP6628930B1 (ja) 2020-01-15
ES2704740T3 (es) 2019-03-19
US9981976B2 (en) 2018-05-29
AU2015359624A1 (en) 2017-04-13
EA201791274A1 (ru) 2017-10-31
JP2017537118A (ja) 2017-12-14
CA2963051C (en) 2023-10-17
CN107001377B (zh) 2019-09-10
EP3230287B1 (en) 2018-10-10
KR102522832B1 (ko) 2023-04-17
JP2020011991A (ja) 2020-01-23

Similar Documents

Publication Publication Date Title
MX2017007429A (es) Derivados de pirazolo[1,5-a]pirimidina sustituida con piperidina con actividad inhibidora sobre la replicacion del virus sincicial respiratorio (vsr).
PH12017501958A1 (en) Rsv antiviral pyrazolo- and triazolo-pyrimidine compounds
PH12018500437A1 (en) Novel pyrazolo [3,4-d] pyrimidine compounds or salt thereof
IL251285A0 (en) 3-substituted 5-amino-h6-triazolo[5,4-d]pyrimidine-7,2-dione compounds for the treatment and prevention of viral infection
PH12016502168A1 (en) Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
PH12015502780A1 (en) Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases
CL2013003051A1 (es) Compuestos derivados de pirazolo (4.3-d) pirimidinas, inhibidores de quinasa; composicion farmaceutica; y uso para el tratamiento de enfermedades y trastornos del aparato respiratorio
NZ733135A (en) Fused pyrimidine compounds for the treatment of hiv
AU2012358805A8 (en) Pyrazolo[1,5-a]pyrimidines as antiviral agents
MY179392A (en) Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases
EA201591255A1 (ru) ПРОИЗВОДНЫЕ ПИРРОЛО[2,3-d]ПИРИМИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-РОДСТВЕННЫХ КИНАЗ (JAK)
WO2015120237A3 (en) 4'-difluoromethyl substituted nucleoside derivatives as inhibitors of influenza rna replication
GEP20207172B (en) 1h-pyrazolo[4,3-b]pyridines as pde1 inhibitors
WO2015110491A3 (en) Pyrazolo[1,5-a]pyrimidines as antiviral compounds
MX2020011200A (es) Compuestos heteroaromaticos que tienen actividad contra vrs.
MX368323B (es) Derivados tricíclicos de pirazolo [1,5-a]pirimidina sustituidos con piperidina con actividad inhibidora en la replicación del virus sincitial respiratorio (vsr).
PH12020550673A1 (en) Pyrazolopyrimidines having activity against the respiratory syncytial virus (rsv)
WO2014198647A3 (en) Prodrug derivatives of substituted triazolopyridines
MX2020008061A (es) Pirazolopirimidinas sustituidas con cicloalquilo que tienen actividad contra vrs.
AU2014298561A8 (en) Substituted pyridine-piperazinyl analogues as RSV antiviral compounds

Legal Events

Date Code Title Description
FG Grant or registration