MX368323B - Derivados tricíclicos de pirazolo [1,5-a]pirimidina sustituidos con piperidina con actividad inhibidora en la replicación del virus sincitial respiratorio (vsr). - Google Patents

Derivados tricíclicos de pirazolo [1,5-a]pirimidina sustituidos con piperidina con actividad inhibidora en la replicación del virus sincitial respiratorio (vsr).

Info

Publication number
MX368323B
MX368323B MX2017007430A MX2017007430A MX368323B MX 368323 B MX368323 B MX 368323B MX 2017007430 A MX2017007430 A MX 2017007430A MX 2017007430 A MX2017007430 A MX 2017007430A MX 368323 B MX368323 B MX 368323B
Authority
MX
Mexico
Prior art keywords
respiratory syncytial
syncytial virus
rsv
replication
inhibitory activity
Prior art date
Application number
MX2017007430A
Other languages
English (en)
Other versions
MX2017007430A (es
Inventor
Abdellah Tahri
Pierre Jean-Marie Bernard Raboisson
Sandrine Marie Helene Vendeville
Lili Hu
Tim Hugo Maria Jonckers
Samuël Dominique Demin
Original Assignee
Janssen Sciences Ireland Uc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Sciences Ireland Uc filed Critical Janssen Sciences Ireland Uc
Publication of MX2017007430A publication Critical patent/MX2017007430A/es
Publication of MX368323B publication Critical patent/MX368323B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

La invención se refiere a nuevos compuestos de pirazolo-pirimidina tricíclicos sustituidos de fórmula (I-a) o (I-b) que tienen actividad antivírica, en particular, que tienen una actividad inhibidora sobre la replicación del virus sincitial respiratorio (VSR); la invención se refiere además a la preparación de tales compuestos novedosos, a composiciones que comprenden estos compuestos y a los compuestos para usarse en el tratamiento de una infección provocada por el virus sincitial respiratorio. (ver Fórmulas).
MX2017007430A 2014-12-08 2015-12-07 Derivados tricíclicos de pirazolo [1,5-a]pirimidina sustituidos con piperidina con actividad inhibidora en la replicación del virus sincitial respiratorio (vsr). MX368323B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14196789 2014-12-08
PCT/EP2015/078796 WO2016091791A1 (en) 2014-12-08 2015-12-07 Piperidine substituted tricyclic pyrazolo[1,5-a]pyrimidine derivatives with inhibitory activity on the replication of the respiratory syncytial virus (rsv)

Publications (2)

Publication Number Publication Date
MX2017007430A MX2017007430A (es) 2017-09-28
MX368323B true MX368323B (es) 2019-09-27

Family

ID=52006930

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2017007430A MX368323B (es) 2014-12-08 2015-12-07 Derivados tricíclicos de pirazolo [1,5-a]pirimidina sustituidos con piperidina con actividad inhibidora en la replicación del virus sincitial respiratorio (vsr).

Country Status (13)

Country Link
US (1) US10131673B2 (es)
EP (1) EP3230288B1 (es)
JP (1) JP6703989B2 (es)
KR (1) KR102486023B1 (es)
CN (1) CN107207512B (es)
AU (1) AU2015359562B2 (es)
CA (1) CA2963054C (es)
EA (1) EA030636B1 (es)
ES (1) ES2711334T3 (es)
MX (1) MX368323B (es)
SG (1) SG11201704508WA (es)
WO (1) WO2016091791A1 (es)
ZA (1) ZA201703900B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA032081B1 (ru) 2014-12-08 2019-04-30 Янссен Сайенсиз Айрлэнд Юси ЗАМЕЩЕННЫЕ ПИПЕРИДИНОМ ПРОИЗВОДНЫЕ ПИРАЗОЛО[1,5-a]ПИРИМИДИНА С ИНГИБИРУЮЩЕЙ АКТИВНОСТЬЮ В ОТНОШЕНИИ РЕПЛИКАЦИИ РЕСПИРАТОРНО-СИНЦИТИАЛЬНОГО ВИРУСА (RSV)
CA3087926A1 (en) * 2018-01-31 2019-08-08 Janssen Sciences Ireland Unlimited Company Cycloalkyl substituted pyrazolopyrimidines having activity against rsv
EP3903788A4 (en) 2018-12-27 2022-09-07 Taisho Pharmaceutical Co., Ltd. PYRAZOLO[1,5-A] PYRIMIDINE MACROCYCLIC COMPOUND

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201591390A1 (ru) * 2010-06-24 2016-06-30 Джилид Сайэнс, Инк. Пиразол[1,5-a]пиримидины для противовирусного лечения
US8633198B1 (en) * 2011-09-20 2014-01-21 Nant Holdings Ip, Llc Small molecule inhibitors of influenza A RNA-dependent RNA polymerase
EP2794611B1 (en) * 2011-12-22 2017-10-11 Gilead Sciences, Inc. Pyrazolo[1,5-a]pyrimidines as antiviral agents
CN106986869A (zh) * 2012-04-17 2017-07-28 吉利德科学公司 用于抗病毒治疗的化合物和方法
EA032081B1 (ru) 2014-12-08 2019-04-30 Янссен Сайенсиз Айрлэнд Юси ЗАМЕЩЕННЫЕ ПИПЕРИДИНОМ ПРОИЗВОДНЫЕ ПИРАЗОЛО[1,5-a]ПИРИМИДИНА С ИНГИБИРУЮЩЕЙ АКТИВНОСТЬЮ В ОТНОШЕНИИ РЕПЛИКАЦИИ РЕСПИРАТОРНО-СИНЦИТИАЛЬНОГО ВИРУСА (RSV)

Also Published As

Publication number Publication date
EP3230288A1 (en) 2017-10-18
AU2015359562A1 (en) 2017-04-13
CA2963054C (en) 2023-03-14
CN107207512A (zh) 2017-09-26
SG11201704508WA (en) 2017-06-29
EA030636B1 (ru) 2018-09-28
CN107207512B (zh) 2019-09-10
ZA201703900B (en) 2019-07-31
KR102486023B1 (ko) 2023-01-05
KR20170094180A (ko) 2017-08-17
ES2711334T3 (es) 2019-05-03
JP2017536393A (ja) 2017-12-07
JP6703989B2 (ja) 2020-06-03
WO2016091791A1 (en) 2016-06-16
CA2963054A1 (en) 2016-06-16
EA201791276A1 (ru) 2017-09-29
AU2015359562B2 (en) 2020-01-16
US20170349602A1 (en) 2017-12-07
US10131673B2 (en) 2018-11-20
EP3230288B1 (en) 2018-11-21
MX2017007430A (es) 2017-09-28

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