MX367083B - Oligomeros antisentido y conjugados con diana en la proteina-convertasa subtilisina/kexina tipo 9(pcsk9). - Google Patents
Oligomeros antisentido y conjugados con diana en la proteina-convertasa subtilisina/kexina tipo 9(pcsk9).Info
- Publication number
- MX367083B MX367083B MX2015017601A MX2015017601A MX367083B MX 367083 B MX367083 B MX 367083B MX 2015017601 A MX2015017601 A MX 2015017601A MX 2015017601 A MX2015017601 A MX 2015017601A MX 367083 B MX367083 B MX 367083B
- Authority
- MX
- Mexico
- Prior art keywords
- pcsk9
- antisense oligomers
- targeting pcsk9
- conjugates targeting
- conjugates
- Prior art date
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
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- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
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Abstract
La presente invención se refiere a compuestos oligoméricos y conjugados de los mismos con diana en el ARNm de la proproteína-convertasa subtilisina/kexina tipo 9 (PCSK9) en una célula, que conducen a una expresión reducida de PCSK9. La reducción de la expresión de PCSK9 resulta beneficiosa para una gama de trastornos médicos, tales como la hipercolesterolemia y trastornos relacionados.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13174092 | 2013-06-27 | ||
EP13192938 | 2013-11-14 | ||
PCT/EP2013/073858 WO2014076195A1 (en) | 2012-11-15 | 2013-11-14 | Oligonucleotide conjugates |
EP13192930 | 2013-11-14 | ||
EP14153253 | 2014-01-30 | ||
EP14168331 | 2014-05-14 | ||
PCT/EP2014/063757 WO2014207232A1 (en) | 2013-06-27 | 2014-06-27 | Antisense oligomers and conjugates targeting pcsk9 |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015017601A MX2015017601A (es) | 2016-04-07 |
MX367083B true MX367083B (es) | 2019-08-05 |
Family
ID=52141126
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015017601A MX367083B (es) | 2013-06-27 | 2014-06-27 | Oligomeros antisentido y conjugados con diana en la proteina-convertasa subtilisina/kexina tipo 9(pcsk9). |
MX2019006284A MX2019006284A (es) | 2013-06-27 | 2015-12-17 | Oligomeros antisentido y conjugados con diana en la proteina-convertasa subtilisina/kexina tipo 9(pcsk9). |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019006284A MX2019006284A (es) | 2013-06-27 | 2015-12-17 | Oligomeros antisentido y conjugados con diana en la proteina-convertasa subtilisina/kexina tipo 9(pcsk9). |
Country Status (30)
Country | Link |
---|---|
US (7) | US9879265B2 (es) |
EP (2) | EP3591054A1 (es) |
JP (2) | JP6255092B2 (es) |
KR (2) | KR101931089B1 (es) |
CN (2) | CN112263682A (es) |
AU (1) | AU2014300981B2 (es) |
BR (1) | BR112015032432B1 (es) |
CA (1) | CA2915316C (es) |
CL (1) | CL2015003728A1 (es) |
CY (1) | CY1122738T1 (es) |
DK (1) | DK3013959T3 (es) |
EA (1) | EA201592215A1 (es) |
ES (1) | ES2770667T3 (es) |
HK (1) | HK1221740A1 (es) |
HR (1) | HRP20200163T1 (es) |
HU (1) | HUE048738T2 (es) |
IL (1) | IL242875B (es) |
LT (1) | LT3013959T (es) |
MX (2) | MX367083B (es) |
MY (1) | MY183049A (es) |
NZ (1) | NZ715081A (es) |
PE (1) | PE20160158A1 (es) |
PH (1) | PH12015502761A1 (es) |
PL (1) | PL3013959T3 (es) |
PT (1) | PT3013959T (es) |
RS (1) | RS59986B1 (es) |
SG (2) | SG11201510656PA (es) |
SI (1) | SI3013959T1 (es) |
UA (1) | UA119643C2 (es) |
WO (1) | WO2014207232A1 (es) |
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JPWO2015108048A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
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RU2724527C2 (ru) | 2014-05-01 | 2020-06-23 | Ионис Фармасьютикалз, Инк. | Композиции и способы модулирования экспрессии рецептора гормона роста |
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CA2982825C (en) | 2015-08-06 | 2023-10-17 | F. Hoffmann-La Roche Ag | Processes for the preparation of galnac acid derivatives |
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WO2017084987A1 (en) | 2015-11-16 | 2017-05-26 | F. Hoffmann-La Roche Ag | GalNAc CLUSTER PHOSPHORAMIDITE |
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JP7012033B2 (ja) | 2016-06-17 | 2022-02-10 | エフ.ホフマン-ラ ロシュ アーゲー | インビトロ腎毒性スクリーニングアッセイ |
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MA45496A (fr) | 2016-06-17 | 2019-04-24 | Hoffmann La Roche | Molécules d'acide nucléique pour la réduction de l'arnm de padd5 ou pad7 pour le traitement d'une infection par l'hépatite b |
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CN110536964A (zh) | 2017-03-10 | 2019-12-03 | 国立研究开发法人国立成育医疗研究中心 | 反义寡核苷酸和糖原贮积病Ia型预防或治疗用组合物 |
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