MX366033B - Proceso para produccion a gran escala de oxalato de 1-isopropil-3-{5-[1-(3-metoxipropil) piperidin-4-il]-[1,3,4]oxadia zol-2-il}-1h-indazol. - Google Patents
Proceso para produccion a gran escala de oxalato de 1-isopropil-3-{5-[1-(3-metoxipropil) piperidin-4-il]-[1,3,4]oxadia zol-2-il}-1h-indazol.Info
- Publication number
- MX366033B MX366033B MX2017002042A MX2017002042A MX366033B MX 366033 B MX366033 B MX 366033B MX 2017002042 A MX2017002042 A MX 2017002042A MX 2017002042 A MX2017002042 A MX 2017002042A MX 366033 B MX366033 B MX 366033B
- Authority
- MX
- Mexico
- Prior art keywords
- methoxypropyl
- oxadiazol
- piperidin
- large scale
- isopropyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
- C07C55/06—Oxalic acid
- C07C55/07—Salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
La presente invención se relaciona con un proceso adecuado para su adopción en la fabricación a gran escala de oxalato de 1-isopropil-3-{5-[1-(3-metoxipropil)piperidin-4-il]-[1,3,4]oxadia zol-2-il}-1H-indazol de fórmula (I), el cual es un ligando receptor 5-HT4 selectivo dirigido al tratamiento sintomático de la enfermedad de Alzheimer y otros trastornos de la memoria y la cognición como el déficit de atención e hiperactividad, la enfermedad de Parkinson y la esquizofrenia.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN4009CH2014 | 2014-08-16 | ||
| PCT/IN2014/000677 WO2016027277A1 (en) | 2014-08-16 | 2014-10-23 | Process for large scale production of 1-isopropyl-3-{5- [1-(3-methoxypropyl) piperidin-4-yl]-[1,3,4]oxadiazol-2-yl}- 1h-indazole oxalate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2017002042A MX2017002042A (es) | 2017-05-04 |
| MX366033B true MX366033B (es) | 2019-06-25 |
Family
ID=52339256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017002042A MX366033B (es) | 2014-08-16 | 2014-10-23 | Proceso para produccion a gran escala de oxalato de 1-isopropil-3-{5-[1-(3-metoxipropil) piperidin-4-il]-[1,3,4]oxadia zol-2-il}-1h-indazol. |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US10005711B2 (es) |
| EP (1) | EP3180333B1 (es) |
| JP (1) | JP6397131B2 (es) |
| KR (1) | KR101865868B1 (es) |
| CN (1) | CN106604921B (es) |
| AP (1) | AP2017009755A0 (es) |
| AU (1) | AU2014404001B2 (es) |
| BR (1) | BR112017002923B8 (es) |
| CA (1) | CA2957498C (es) |
| CY (1) | CY1123567T1 (es) |
| DK (1) | DK3180333T3 (es) |
| EA (1) | EA030947B1 (es) |
| ES (1) | ES2819286T3 (es) |
| HR (1) | HRP20201478T1 (es) |
| HU (1) | HUE052083T2 (es) |
| IL (1) | IL250469B (es) |
| LT (1) | LT3180333T (es) |
| MX (1) | MX366033B (es) |
| NZ (1) | NZ728918A (es) |
| PL (1) | PL3180333T3 (es) |
| PT (1) | PT3180333T (es) |
| RS (1) | RS60804B1 (es) |
| SG (1) | SG11201701138UA (es) |
| SI (1) | SI3180333T1 (es) |
| WO (1) | WO2016027277A1 (es) |
| ZA (1) | ZA201700937B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20230155613A (ko) * | 2018-10-18 | 2023-11-10 | 수벤 라이프 사이언시스 리미티드 | 5-ht4 수용체 작용제의 새로운 용도 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10130196A (ja) * | 1996-10-29 | 1998-05-19 | Toray Dow Corning Silicone Co Ltd | 脂肪酸クロライドの製造方法 |
| TW200533348A (en) * | 2004-02-18 | 2005-10-16 | Theravance Inc | Indazole-carboxamide compounds as 5-ht4 receptor agonists |
| MX2007007818A (es) * | 2004-12-22 | 2007-09-11 | Theravance Inc | Compuestos de indazol-carboxamida. |
| CN103380131B (zh) * | 2011-09-19 | 2015-12-02 | 苏文生命科学有限公司 | 作为5-ht4受体配体的杂芳基化合物 |
| DK3099675T3 (en) | 2013-12-16 | 2018-05-22 | Suven Life Sciences Ltd | INDAZOLIC COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS |
-
2014
- 2014-10-23 PL PL14825191T patent/PL3180333T3/pl unknown
- 2014-10-23 PT PT148251911T patent/PT3180333T/pt unknown
- 2014-10-23 RS RS20201102A patent/RS60804B1/sr unknown
- 2014-10-23 MX MX2017002042A patent/MX366033B/es active IP Right Grant
- 2014-10-23 NZ NZ728918A patent/NZ728918A/en unknown
- 2014-10-23 JP JP2017527994A patent/JP6397131B2/ja active Active
- 2014-10-23 BR BR112017002923A patent/BR112017002923B8/pt active IP Right Grant
- 2014-10-23 SI SI201431655T patent/SI3180333T1/sl unknown
- 2014-10-23 WO PCT/IN2014/000677 patent/WO2016027277A1/en active Application Filing
- 2014-10-23 HU HUE14825191A patent/HUE052083T2/hu unknown
- 2014-10-23 AU AU2014404001A patent/AU2014404001B2/en active Active
- 2014-10-23 EA EA201790399A patent/EA030947B1/ru unknown
- 2014-10-23 LT LTEP14825191.1T patent/LT3180333T/lt unknown
- 2014-10-23 SG SG11201701138UA patent/SG11201701138UA/en unknown
- 2014-10-23 ES ES14825191T patent/ES2819286T3/es active Active
- 2014-10-23 CA CA2957498A patent/CA2957498C/en active Active
- 2014-10-23 EP EP14825191.1A patent/EP3180333B1/en active Active
- 2014-10-23 KR KR1020177005809A patent/KR101865868B1/ko active IP Right Grant
- 2014-10-23 US US15/504,224 patent/US10005711B2/en active Active
- 2014-10-23 DK DK14825191.1T patent/DK3180333T3/da active
- 2014-10-23 CN CN201480081243.0A patent/CN106604921B/zh active Active
- 2014-10-23 AP AP2017009755A patent/AP2017009755A0/en unknown
-
2017
- 2017-02-06 IL IL250469A patent/IL250469B/en active IP Right Grant
- 2017-02-07 ZA ZA2017/00937A patent/ZA201700937B/en unknown
-
2020
- 2020-09-15 CY CY20201100871T patent/CY1123567T1/el unknown
- 2020-09-16 HR HRP20201478TT patent/HRP20201478T1/hr unknown
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