MA40895B1 - Synthèse de copanlisib et son sel de dichlorhydrate - Google Patents
Synthèse de copanlisib et son sel de dichlorhydrateInfo
- Publication number
- MA40895B1 MA40895B1 MA40895A MA40895A MA40895B1 MA 40895 B1 MA40895 B1 MA 40895B1 MA 40895 A MA40895 A MA 40895A MA 40895 A MA40895 A MA 40895A MA 40895 B1 MA40895 B1 MA 40895B1
- Authority
- MA
- Morocco
- Prior art keywords
- copanlisib
- copanisib
- dihydrochloride
- synthesis
- dihydrochloride salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/22—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/24—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La présente invention concerne un nouveau procédé de préparation du copanlisib, du dihydrochlorure de copanlisib ou d'hydrates de dihydrochlorure de copanlisib et de nouveaux composés intermédiaires, ainsi que l'utilisation de ces nouveaux composés intermédiaires pour la préparation dudit copanlisib, dudit dihydrochlorure de copanlisib ou desdits hydrates de dihydrochlorure de copanlisib. La présente invention concerne également des hydrates de dihydrochlorure de copanlisib en tant que composés chimiques.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14192203.9A EP3018127A1 (fr) | 2014-11-07 | 2014-11-07 | Synthèse de copanlisib et son sel de dichlorhydrate |
PCT/EP2015/075789 WO2016071435A2 (fr) | 2014-11-07 | 2015-11-05 | Synthèse du copanlisib et de son dihydrochlorure |
Publications (2)
Publication Number | Publication Date |
---|---|
MA40895A MA40895A (fr) | 2017-09-13 |
MA40895B1 true MA40895B1 (fr) | 2019-07-31 |
Family
ID=51866061
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA40895A MA40895B1 (fr) | 2014-11-07 | 2015-11-05 | Synthèse de copanlisib et son sel de dichlorhydrate |
Country Status (47)
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2168583A1 (fr) | 2008-09-24 | 2010-03-31 | Bayer Schering Pharma Aktiengesellschaft | Utilisation de 2,3-dihydroimidazo[1,2-c]quinazolines substituées pour le traitement du myélome |
EP2508525A1 (fr) | 2011-04-05 | 2012-10-10 | Bayer Pharma Aktiengesellschaft | Sels de 2,3-dihydroimidazo[1,2-C]quinazoline substitutés |
CU24400B1 (es) | 2013-04-08 | 2019-04-04 | Bayer Pharma AG | Una composición que comprende 2,3-dihidroimidazo[1,2-c]quinazolinas sustituidas |
EP3268490B1 (fr) | 2015-03-09 | 2020-07-08 | Bayer Pharma Aktiengesellschaft | Combinaisons contenant des 2,3-dihydroimidazo[1,2-c]quinazoline substituées |
JP6935415B2 (ja) | 2016-03-08 | 2021-09-15 | バイエル ファーマ アクチエンゲゼルシャフト | 2−アミノ−N−[7−メトキシ−2,3−ジヒドロイミダゾ−[1,2−c]キナゾリン−5−イル]ピリミジン−5−カルボキサミド類 |
EP3515911A1 (fr) | 2016-09-23 | 2019-07-31 | Bayer Pharma Aktiengesellschaft | Combinaison d'inhibiteurs de la pi3k |
WO2018215282A1 (fr) | 2017-05-26 | 2018-11-29 | Bayer Pharma Aktiengesellschaft | Combinaison d'inhibiteurs de bub1 et de pi3k |
WO2019002068A1 (fr) | 2017-06-28 | 2019-01-03 | Bayer Consumer Care Ag | Combinaison d'un inhibiteur de pi3k et d'un antagoniste du récepteur des androgènes |
HUE063178T2 (hu) | 2017-09-08 | 2023-12-28 | Bayer Pharma AG | Kopanlizib formulációi |
EP3498266A1 (fr) | 2017-12-15 | 2019-06-19 | Bayer Consumer Care AG | Formulations de copanlisib |
WO2023139125A1 (fr) | 2022-01-18 | 2023-07-27 | Synthon B.V. | Procédé amélioré de préparation de copanlisib |
WO2023218032A1 (fr) | 2022-05-13 | 2023-11-16 | Synthon B.V. | Formes solides de sels de copanlisib |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1003580A (en) | 1910-08-10 | 1911-09-19 | Remington Typewriter Co | Type-writing machine. |
US6221877B1 (en) * | 2000-04-12 | 2001-04-24 | Regents Of The University Of California | Substituted 4-phthalimidocarboxanilides as inhibitors of purine salvage phosphoribosyltransferases |
IT1319674B1 (it) * | 2000-12-01 | 2003-10-23 | Erregierre Spa | Processo per la preparazione dell'acido1-(aminometil)cicloesanacetico. |
TW565582B (en) * | 2001-04-13 | 2003-12-11 | Kaneka Corp | Diamine, acid dianhydride, and reactive group containing polyimide composition prepared therefrom and preparing them |
RU2004107485A (ru) * | 2001-08-15 | 2005-03-27 | Е.И.Дюпон де Немур энд Компани (US) | Орто-гетероциклические замещенные ариламиды для борьбы с беспозвоночными вредителями |
RU2326881C9 (ru) | 2002-09-30 | 2009-04-10 | Байер Фармасьютикалс Корпорейшн | Конденсированные производные азолпиримидина, обладающие свойствами ингибитора фосфатидилинозитол-3-киназы (pi3k) |
AR064106A1 (es) | 2006-12-05 | 2009-03-11 | Bayer Schering Pharma Ag | Derivados de 2,3-dihidroimidazo [1,2-c] quinazolina sustituida utiles para el tratamiento de enfermedades y trastornos hiper-proliferativos asociados con la angiogenesis |
JP5620275B2 (ja) * | 2008-01-14 | 2014-11-05 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | 超増殖性疾患及び脈管形成に関連する疾病を処理するために有用なスルホン置換された2,3−ジヒドロイミダゾ[1,2−c]キナゾリン誘導体類 |
EP2168583A1 (fr) | 2008-09-24 | 2010-03-31 | Bayer Schering Pharma Aktiengesellschaft | Utilisation de 2,3-dihydroimidazo[1,2-c]quinazolines substituées pour le traitement du myélome |
JO3733B1 (ar) | 2011-04-05 | 2021-01-31 | Bayer Ip Gmbh | استخدام 3,2-دايهيدروايميدازو[1, 2 -c]كوينازولينات مستبدلة |
EP2508525A1 (fr) | 2011-04-05 | 2012-10-10 | Bayer Pharma Aktiengesellschaft | Sels de 2,3-dihydroimidazo[1,2-C]quinazoline substitutés |
CU24400B1 (es) | 2013-04-08 | 2019-04-04 | Bayer Pharma AG | Una composición que comprende 2,3-dihidroimidazo[1,2-c]quinazolinas sustituidas |
WO2015082322A1 (fr) | 2013-12-03 | 2015-06-11 | Bayer Pharma Aktiengesellschaft | Combinaisons d'inhibiteurs de pi3k |
EP3018131A1 (fr) * | 2014-11-07 | 2016-05-11 | Bayer Pharma Aktiengesellschaft | Synthèse de copanlisib et son sel de dichlorhydrate |
CA2978807A1 (fr) | 2015-03-09 | 2016-09-15 | Bayer Pharma Aktiengesellschaft | Utilisation de 2,3-dihydroimidazo[1,2-c]quinazolines substituees |
EP3268490B1 (fr) | 2015-03-09 | 2020-07-08 | Bayer Pharma Aktiengesellschaft | Combinaisons contenant des 2,3-dihydroimidazo[1,2-c]quinazoline substituées |
MA43957A (fr) | 2016-02-01 | 2018-12-12 | Bayer Pharma AG | Biomarqueurs de copanlisib |
KR20180104129A (ko) | 2016-02-01 | 2018-09-19 | 바이엘 파마 악티엔게젤샤프트 | 코판리십 바이오마커 |
JP6935415B2 (ja) | 2016-03-08 | 2021-09-15 | バイエル ファーマ アクチエンゲゼルシャフト | 2−アミノ−N−[7−メトキシ−2,3−ジヒドロイミダゾ−[1,2−c]キナゾリン−5−イル]ピリミジン−5−カルボキサミド類 |
EP3515911A1 (fr) | 2016-09-23 | 2019-07-31 | Bayer Pharma Aktiengesellschaft | Combinaison d'inhibiteurs de la pi3k |
-
2014
- 2014-11-07 EP EP14192203.9A patent/EP3018127A1/fr not_active Withdrawn
-
2015
- 2015-11-04 JO JOP/2015/0274A patent/JO3644B1/ar active
- 2015-11-05 PL PL15790150T patent/PL3215493T3/pl unknown
- 2015-11-05 AU AU2015341788A patent/AU2015341788B2/en active Active
- 2015-11-05 UA UAA201705433A patent/UA122398C2/uk unknown
- 2015-11-05 TR TR2019/05217T patent/TR201905217T4/tr unknown
- 2015-11-05 PT PT15790150T patent/PT3215493T/pt unknown
- 2015-11-05 ME MEP-2019-107A patent/ME03358B/fr unknown
- 2015-11-05 US US15/524,581 patent/US10494372B2/en active Active
- 2015-11-05 CU CU2017000061A patent/CU24489B1/es unknown
- 2015-11-05 LT LTEP15790150.5T patent/LT3215493T/lt unknown
- 2015-11-05 EP EP15790150.5A patent/EP3215493B1/fr active Active
- 2015-11-05 WO PCT/EP2015/075789 patent/WO2016071435A2/fr active Application Filing
- 2015-11-05 ES ES15790150T patent/ES2721778T3/es active Active
- 2015-11-05 UY UY0001036392A patent/UY36392A/es not_active Application Discontinuation
- 2015-11-05 TN TN2017000179A patent/TN2017000179A1/en unknown
- 2015-11-05 DK DK15790150.5T patent/DK3215493T3/da active
- 2015-11-05 MY MYPI2017701550A patent/MY189852A/en unknown
- 2015-11-05 CR CR20170184A patent/CR20170184A/es unknown
- 2015-11-05 MX MX2017005893A patent/MX366904B/es active IP Right Grant
- 2015-11-05 HU HUE15790150A patent/HUE042866T2/hu unknown
- 2015-11-05 BR BR112017009470-3A patent/BR112017009470B1/pt active IP Right Grant
- 2015-11-05 CA CA2966800A patent/CA2966800C/fr active Active
- 2015-11-05 SG SG11201703702RA patent/SG11201703702RA/en unknown
- 2015-11-05 SI SI201530695T patent/SI3215493T1/sl unknown
- 2015-11-05 KR KR1020177014992A patent/KR102566834B1/ko active IP Right Grant
- 2015-11-05 MA MA40895A patent/MA40895B1/fr unknown
- 2015-11-05 EA EA201790983A patent/EA035558B1/ru not_active IP Right Cessation
- 2015-11-05 CN CN201580072735.8A patent/CN107278204B/zh active Active
- 2015-11-05 RS RS20190453A patent/RS58579B1/sr unknown
- 2015-11-05 NZ NZ731287A patent/NZ731287A/en unknown
- 2015-11-05 PE PE2017000818A patent/PE20170897A1/es unknown
- 2015-11-05 JP JP2017523881A patent/JP6691115B2/ja active Active
- 2015-11-06 AR ARP150103619A patent/AR102570A1/es unknown
- 2015-11-06 TW TW104136742A patent/TWI697495B/zh active
-
2017
- 2017-04-24 IL IL251874A patent/IL251874A0/en active IP Right Grant
- 2017-05-04 SA SA517381462A patent/SA517381462B1/ar unknown
- 2017-05-04 PH PH12017500833A patent/PH12017500833A1/en unknown
- 2017-05-05 SV SV2017005433A patent/SV2017005433A/es unknown
- 2017-05-05 DO DO2017000112A patent/DOP2017000112A/es unknown
- 2017-05-05 CO CONC2017/0004532A patent/CO2017004532A2/es unknown
- 2017-05-05 EC ECIEPI201727755A patent/ECSP17027755A/es unknown
- 2017-05-05 CL CL2017001131A patent/CL2017001131A1/es unknown
- 2017-05-05 NI NI201700054A patent/NI201700054A/es unknown
- 2017-06-06 ZA ZA2017/03867A patent/ZA201703867B/en unknown
-
2018
- 2018-04-19 HK HK18105077.5A patent/HK1245774A1/zh unknown
-
2019
- 2019-04-16 HR HRP20190720TT patent/HRP20190720T1/hr unknown
- 2019-04-23 CY CY20191100444T patent/CY1121602T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA40895B1 (fr) | Synthèse de copanlisib et son sel de dichlorhydrate | |
MA40301B1 (fr) | Composés indolecarboxamides utiles comme inhibiteurs de kinase | |
NZ732210A (en) | Novel fxr (nr1h4) modulating compounds | |
NZ748641A (en) | Fxr (nr1h4) modulating compounds | |
EA201792548A1 (ru) | 4-гидрокси-3-(гетероарил)пиридин-2-оновые агонисты apj для применения в лечении сердечно-сосудистых заболеваний | |
PH12019502286A1 (en) | Process for preparing an optically active pyrimidinium compounds | |
BR112017006253A2 (pt) | novos compostos | |
BR112016029333A2 (pt) | síntese de compostos de carbamoilpiridona policíclico | |
JO3466B1 (ar) | مواد ضابطة لتترا هيدرو بيريدوبيرازينات من gpr6 | |
MA41200B1 (fr) | Procédé pour la préparation d'un composé diarylthiohydantoïne | |
MA40302A1 (fr) | Dérivés de carbazole | |
MX2015011913A (es) | Moduladores de acido oxabiciclo[2.2.2] gpr120. | |
UA122882C2 (uk) | Синтез індазолів | |
PH12019502093A1 (en) | Novel ester compounds, method for the production thereof and use thereof | |
MX2019013979A (es) | Metodos para la preparacion de compuestos heterociclicos de 1,3-benzodioxol. | |
BR112017019850A2 (pt) | ?processo melhorado para a preparação de apremilast? | |
MX2016016730A (es) | Metodo para preparar un producto intermedio de eribulina. | |
BR112016022437A2 (pt) | Processo para preparação de (2s,5r)-6-(benziloxi)-7-oxo-1,6- diazabiciclo[3,2,1]octano-2-carboxilato de sódio | |
BR112016021910A2 (pt) | Processo de preparação de 3-(3-(4-(1-aminociclobutil)fenil)-5-fenil-3h-imidazo[4,5-b]piridin-2-il)piridin-2-amina | |
FR3062851B1 (fr) | Procede de preparation monotope de composes organo-iodes | |
MA43231B1 (fr) | Bloqueur des canaux sodiques | |
NZ727773A (en) | Metal-catalyzed asymmetric 1,4-conjugate addition of vinylboron compounds to 2-substituted-4-oxy- cyclopent-2-en-1-ones yielding prostaglandins and prostaglandin analogs | |
LT2012082A (lt) | Nauji fotochrominiai junginiai, jų gamybos būdas ir tarpiniai junginiai jiems gauti | |
GB2564185A (en) | Process for the preparation of derivatives of benzodioxole | |
IN2014CH00444A (fr) |