BR112017002923B8 - Processo para produção em grande escala de oxalato de 1-isopropil-3-{5-[1-(3-metoxipropil)piperidin-4-il]-[1,3,4]oxadiazol-2-il}-1h-indazole - Google Patents

Processo para produção em grande escala de oxalato de 1-isopropil-3-{5-[1-(3-metoxipropil)piperidin-4-il]-[1,3,4]oxadiazol-2-il}-1h-indazole

Info

Publication number
BR112017002923B8
BR112017002923B8 BR112017002923A BR112017002923A BR112017002923B8 BR 112017002923 B8 BR112017002923 B8 BR 112017002923B8 BR 112017002923 A BR112017002923 A BR 112017002923A BR 112017002923 A BR112017002923 A BR 112017002923A BR 112017002923 B8 BR112017002923 B8 BR 112017002923B8
Authority
BR
Brazil
Prior art keywords
methoxypropyl
oxadiazol
piperidin
isopropyl
scale production
Prior art date
Application number
BR112017002923A
Other languages
English (en)
Other versions
BR112017002923A2 (pt
BR112017002923B1 (pt
Inventor
Nirogi Ramakrishna
Rasheed Mohammed Abdul
Jasti Venkateswarlu
Original Assignee
Suven Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suven Life Sciences Ltd filed Critical Suven Life Sciences Ltd
Publication of BR112017002923A2 publication Critical patent/BR112017002923A2/pt
Publication of BR112017002923B1 publication Critical patent/BR112017002923B1/pt
Publication of BR112017002923B8 publication Critical patent/BR112017002923B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/06—Oxalic acid
    • C07C55/07—Salts thereof

Abstract

PROCESSO PARA PRODUÇÃO EM GRANDE ESCALA DE OXALATO DE 1-ISOPROPIL-3-{5-[1-(3-METOXIPROPIL)PIPERIDIN-4-IL]-[1,3,4]OXADIAZOL-2-IL}-1HINDAZOLE. A presente invenção se refere a um processo adequado para a adoção de fabricação em grande escala de oxalato de 1-isopropil-3-{5-[1-(3-metoxipropil) piperidin-4-ila]-[1,3,4]oxadiazol-2-il}-1H-indazole tendo a fórmula (I), o qual é um ligante seletivo de receptor 5-HT4 intencionado para o tratamento sintomático do Mal de Alzheimer e outras desordens da memória e da cognição como distúrbio de déficit de atenção e hiperatividade, mal de Parkinson e esquizofrenia.
BR112017002923A 2014-08-16 2014-10-23 Processo para produção em grande escala de oxalato de 1-isopropil-3-{5-[1-(3-metoxipropil)piperidin-4-il]-[1,3,4]oxadiazol-2-il}-1h-indazole BR112017002923B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN4009CH2014 2014-08-16
IN4009/CHE/2014 2014-08-16
PCT/IN2014/000677 WO2016027277A1 (en) 2014-08-16 2014-10-23 Process for large scale production of 1-isopropyl-3-{5- [1-(3-methoxypropyl) piperidin-4-yl]-[1,3,4]oxadiazol-2-yl}- 1h-indazole oxalate

Publications (3)

Publication Number Publication Date
BR112017002923A2 BR112017002923A2 (pt) 2017-12-05
BR112017002923B1 BR112017002923B1 (pt) 2022-09-27
BR112017002923B8 true BR112017002923B8 (pt) 2023-05-02

Family

ID=52339256

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017002923A BR112017002923B8 (pt) 2014-08-16 2014-10-23 Processo para produção em grande escala de oxalato de 1-isopropil-3-{5-[1-(3-metoxipropil)piperidin-4-il]-[1,3,4]oxadiazol-2-il}-1h-indazole

Country Status (26)

Country Link
US (1) US10005711B2 (pt)
EP (1) EP3180333B1 (pt)
JP (1) JP6397131B2 (pt)
KR (1) KR101865868B1 (pt)
CN (1) CN106604921B (pt)
AP (1) AP2017009755A0 (pt)
AU (1) AU2014404001B2 (pt)
BR (1) BR112017002923B8 (pt)
CA (1) CA2957498C (pt)
CY (1) CY1123567T1 (pt)
DK (1) DK3180333T3 (pt)
EA (1) EA030947B1 (pt)
ES (1) ES2819286T3 (pt)
HR (1) HRP20201478T1 (pt)
HU (1) HUE052083T2 (pt)
IL (1) IL250469B (pt)
LT (1) LT3180333T (pt)
MX (1) MX366033B (pt)
NZ (1) NZ728918A (pt)
PL (1) PL3180333T3 (pt)
PT (1) PT3180333T (pt)
RS (1) RS60804B1 (pt)
SG (1) SG11201701138UA (pt)
SI (1) SI3180333T1 (pt)
WO (1) WO2016027277A1 (pt)
ZA (1) ZA201700937B (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3866800A1 (en) * 2018-10-18 2021-08-25 Suven Life Sciences Limited New uses of a 5-ht4 receptor agonist

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10130196A (ja) * 1996-10-29 1998-05-19 Toray Dow Corning Silicone Co Ltd 脂肪酸クロライドの製造方法
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
MX2007007818A (es) * 2004-12-22 2007-09-11 Theravance Inc Compuestos de indazol-carboxamida.
PL2758394T3 (pl) * 2011-09-19 2015-08-31 Suven Life Sciences Ltd Związki heteroarylowe jako ligandy receptora 5-HT4
SG11201604849YA (en) 2013-12-16 2016-07-28 Suven Life Sciences Ltd INDAZOLE COMPOUNDS AS 5-HT<sb>4</sb> RECEPTOR AGONISTS

Also Published As

Publication number Publication date
DK3180333T3 (da) 2020-09-28
SI3180333T1 (sl) 2020-11-30
CA2957498A1 (en) 2016-02-25
LT3180333T (lt) 2020-10-12
CA2957498C (en) 2019-02-12
MX2017002042A (es) 2017-05-04
BR112017002923A2 (pt) 2017-12-05
EP3180333B1 (en) 2020-07-08
JP6397131B2 (ja) 2018-09-26
IL250469B (en) 2019-06-30
ZA201700937B (en) 2019-07-31
AU2014404001A1 (en) 2017-03-02
US10005711B2 (en) 2018-06-26
CN106604921A (zh) 2017-04-26
PL3180333T3 (pl) 2020-12-28
AU2014404001B2 (en) 2017-12-14
KR101865868B1 (ko) 2018-07-13
KR20170036788A (ko) 2017-04-03
PT3180333T (pt) 2020-09-17
NZ728918A (en) 2018-05-25
HUE052083T2 (hu) 2021-04-28
BR112017002923B1 (pt) 2022-09-27
RS60804B1 (sr) 2020-10-30
MX366033B (es) 2019-06-25
SG11201701138UA (en) 2017-03-30
WO2016027277A1 (en) 2016-02-25
IL250469A0 (en) 2017-03-30
HRP20201478T1 (hr) 2021-02-19
US20170283359A1 (en) 2017-10-05
JP2017524038A (ja) 2017-08-24
EA201790399A1 (ru) 2017-06-30
EP3180333A1 (en) 2017-06-21
CY1123567T1 (el) 2022-03-24
CN106604921B (zh) 2019-04-02
AP2017009755A0 (en) 2017-02-28
ES2819286T3 (es) 2021-04-15
EA030947B1 (ru) 2018-10-31

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Legal Events

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: AS CLASSIFICACOES ANTERIORES ERAM: C07D 413/04 , C07C 55/06 , C07D 413/14

Ipc: C07D 413/04 (2006.01), C07C 55/06 (2006.01), C07D

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 23/10/2014, OBSERVADAS AS CONDICOES LEGAIS

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

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