MX367267B - Proceso para preparar 3-(3-(4-(1-aminociclobutil)fenil)-5-fenil-3h -imidazo[4,5-b]piridin-2-il)piridin-2-amina. - Google Patents

Proceso para preparar 3-(3-(4-(1-aminociclobutil)fenil)-5-fenil-3h -imidazo[4,5-b]piridin-2-il)piridin-2-amina.

Info

Publication number
MX367267B
MX367267B MX2016012485A MX2016012485A MX367267B MX 367267 B MX367267 B MX 367267B MX 2016012485 A MX2016012485 A MX 2016012485A MX 2016012485 A MX2016012485 A MX 2016012485A MX 367267 B MX367267 B MX 367267B
Authority
MX
Mexico
Prior art keywords
pyridin
phenyl
aminocyclobutyl
imidazo
amine
Prior art date
Application number
MX2016012485A
Other languages
English (en)
Other versions
MX2016012485A (es
Inventor
P Reed David
Mao Jianmin
Xie Chen Jian-
Bates Craig
Original Assignee
Arqule Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arqule Inc filed Critical Arqule Inc
Publication of MX2016012485A publication Critical patent/MX2016012485A/es
Publication of MX367267B publication Critical patent/MX367267B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se dirige a procesos para la síntesis de 3-(3-(4-(1-aminociclobutil)fenil)-5-fenil-3H-imidazo[4,5-b]piridi n-2-il)piridin-2-amina (ver Fórmula).
MX2016012485A 2014-03-24 2015-03-24 Proceso para preparar 3-(3-(4-(1-aminociclobutil)fenil)-5-fenil-3h -imidazo[4,5-b]piridin-2-il)piridin-2-amina. MX367267B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461969546P 2014-03-24 2014-03-24
PCT/US2015/022177 WO2015148464A1 (en) 2014-03-24 2015-03-24 Process of preparing 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3h-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine

Publications (2)

Publication Number Publication Date
MX2016012485A MX2016012485A (es) 2016-12-16
MX367267B true MX367267B (es) 2019-08-12

Family

ID=54141455

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016012485A MX367267B (es) 2014-03-24 2015-03-24 Proceso para preparar 3-(3-(4-(1-aminociclobutil)fenil)-5-fenil-3h -imidazo[4,5-b]piridin-2-il)piridin-2-amina.

Country Status (16)

Country Link
US (2) US9464083B2 (es)
EP (1) EP3122748B1 (es)
JP (1) JP6578298B2 (es)
KR (1) KR20160135234A (es)
CN (1) CN106459036B (es)
AU (1) AU2015236273B2 (es)
BR (1) BR112016021910A2 (es)
CA (1) CA2938923A1 (es)
DK (1) DK3122748T3 (es)
ES (1) ES2692243T3 (es)
IL (2) IL247480A (es)
MX (1) MX367267B (es)
RU (1) RU2677478C2 (es)
TW (1) TWI662033B (es)
WO (1) WO2015148464A1 (es)
ZA (1) ZA201605598B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018013430A2 (en) 2016-07-12 2018-01-18 Arisan Therapeutics Inc. Heterocyclic compounds for the treatment of arenavirus infection
EP3661909B1 (en) * 2017-08-02 2023-08-16 Merck Sharp & Dohme LLC Novel substituted phenyl compounds as indoleamine 2,3-dioxygenase (ido) inhibitors
US11103493B2 (en) 2017-08-02 2021-08-31 Merck Sharp & Dohme Corp. Substituted pyridinyl compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors
WO2023168291A1 (en) * 2022-03-02 2023-09-07 Terremoto Biosciences, Inc. Covalent modifiers of akt1 and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9801526D0 (sv) * 1998-04-29 1998-04-29 Astra Ab New compounds
US6403588B1 (en) * 2000-04-27 2002-06-11 Yamanouchi Pharmaceutical Co., Ltd. Imidazopyridine derivatives
CN1173975C (zh) * 2000-04-27 2004-11-03 山之内制药株式会社 咪唑并吡啶衍生物
US7442709B2 (en) * 2003-08-21 2008-10-28 Osi Pharmaceuticals, Inc. N3-substituted imidazopyridine c-Kit inhibitors
AU2004268950A1 (en) * 2003-08-21 2005-03-10 Osi Pharmaceuticals, Inc. N3-substituted imidazopyridine-derivatives as c-kit inhibitors
EP2004625B1 (en) * 2006-03-22 2009-12-30 Vertex Pharmaceuticals Incorporated C-met protein kinase inhibitors for the treatment of proliferative disorders
DK2519522T3 (en) * 2009-12-30 2014-12-08 Arqule Inc SUBSTITUTED IDAZOPYRIDINYL AMINOPYRIDINE COMPOUNDS
JP5959330B2 (ja) * 2011-06-17 2016-08-02 田辺三菱製薬株式会社 新規抗血小板薬
AU2012272937B2 (en) 2011-06-24 2016-09-29 Arqule, Inc Substituted imidazopyridinyl-aminopyridine compounds
US8815854B2 (en) 2011-06-24 2014-08-26 Arqule, Inc. Substituted imidazopyridinyl compounds
WO2013078254A1 (en) * 2011-11-22 2013-05-30 Array Biopharma Inc. Bicyclic heteroaryl derivatives as kinase inhibitors

Also Published As

Publication number Publication date
AU2015236273A1 (en) 2016-08-25
US20160376270A1 (en) 2016-12-29
CN106459036A (zh) 2017-02-22
EP3122748A1 (en) 2017-02-01
CA2938923A1 (en) 2015-10-01
RU2016141426A (ru) 2018-04-25
KR20160135234A (ko) 2016-11-25
ES2692243T3 (es) 2018-11-30
RU2677478C2 (ru) 2019-01-17
TW201623301A (zh) 2016-07-01
IL247480A (en) 2017-07-31
US9834556B2 (en) 2017-12-05
IL253239B (en) 2018-04-30
IL253239A0 (en) 2017-08-31
US9464083B2 (en) 2016-10-11
JP6578298B2 (ja) 2019-09-18
RU2016141426A3 (es) 2018-11-19
WO2015148464A1 (en) 2015-10-01
ZA201605598B (en) 2018-12-19
EP3122748A4 (en) 2017-09-27
MX2016012485A (es) 2016-12-16
CN106459036B (zh) 2021-07-16
JP2017516749A (ja) 2017-06-22
DK3122748T3 (en) 2018-11-05
US20150266876A1 (en) 2015-09-24
TWI662033B (zh) 2019-06-11
AU2015236273B2 (en) 2019-03-28
BR112016021910A2 (pt) 2017-08-15
EP3122748B1 (en) 2018-09-26

Similar Documents

Publication Publication Date Title
MX2020001278A (es) Sintesis de compuestos de carbamoilpiridona policiclica.
PH12017500833A1 (en) Synthesis of copanlisib and its dihydrochloride salt
TW201129555A (en) Process for the manufacture of dabigatrane etexilate
JO3487B1 (ar) تخليق كوبانليسيب وملح الدايهيدروكلوريد الخاص به
JOP20170101B1 (ar) توليف مركبات إندازول
PH12014501712A1 (en) Novel morpholinyl derivatives useful as mogat-2-inhibitors
PH12018550165A1 (en) An improved process for the preparation of butorphanol tartrate
MX367267B (es) Proceso para preparar 3-(3-(4-(1-aminociclobutil)fenil)-5-fenil-3h -imidazo[4,5-b]piridin-2-il)piridin-2-amina.
IN2014MU01192A (es)
MX2016015624A (es) Proceso para la preparacion de derivados de tiazol.
IN2014MU00195A (es)
GB2564185A (en) Process for the preparation of derivatives of benzodioxole
IN2014MU00194A (es)
IN2014MU01196A (es)
IN2014CH00444A (es)
IN2014MU00072A (es)
MX364769B (es) Proceso para producir 2-fenil-1, 3-benzoxazoles.
NZ728915A (en) Process for large scale production of n-[4-(1- cyclobutyl piperidin-4-yloxy) phenyl]-2-(morpholin-4-yl) acetamide dihydrochloride
MY190171A (en) Synthesis of indazoles
MX2016010549A (es) Indol- y bencimidazolcarboxamidas como insecticidas y acaricidas.
IN2014MU00858A (es)
IN2014MU01195A (es)
IN2013CH05863A (es)
MX365384B (es) Metodo de sintesis de derivados de 9-alilcamptotecina.
IN2014MU00069A (es)

Legal Events

Date Code Title Description
FG Grant or registration